RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	ncRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000119922	Gene ID	3433	Accession	5409
Symbol	IFIT2	Alias	P54;G10P2;IFI54;ISG54;cig42;IFI-54;IFIT-2;ISG-54;GARG-39;IFI-54K;ISG-54K;ISG-54K	Full Name	interferon induced protein with tetratricopeptide repeats 2
Status	Confidence	Length	25578 bases	Strand	Plus strand
Position	10 : 89283694 - 89309271	RNA binding domain	N.A.
Summary	Enables RNA binding activity. Involved in negative regulation of protein binding activity; positive regulation of apoptotic process; and response to virus. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
No data available in table

RNA binding proteomes (RBPomes)

Show entries

Search:

Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
29636419	CARIC_PMID29636419_Hela_human	Hela	Xichen Bao	2018 Apr 24	doi: 10.1073/pnas.1718406115.?Epub 2018 Apr 10
30528433	XRNAX_PMID30528433_Hs_HeLa	HeLa	Jakob Trendel	2019 Jan 10	doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30824702	PtexRIC_PMID30824702_293T_human	293T	Erika C Urdaneta	2019 Mar 1	doi: 10.1038/s41467-019-08942-3
32313943	eRIC_PMID32313943_eRIC_human		Michael Backlund	2020 May 21	doi: 10.1093/nar/gkaa256
33235359	RIC_PMID33235359_humanRIC.superset.2021		Fatima Gebauer	2021 Mar	doi: 10.1038/s41576-020-00302-y
33693821	PP.enrichment.RIC_PMID33693821_Hela_human	Hela	Zheng Zhang	2021 Jun 21	doi: 10.1093/nar/gkab156
33735607	ChIRP.MS_PMID33735607_human		Bingfei Yu	2021 Apr 1	doi: 10.1016/j.cell.2021.02.015.?Epub 2021 Mar 17
35427468	qRIC_PMID35427468_293T_human	293T	Carlos Henrique Vieira-Vieira	2022 Jun 2	doi: 10.1016/j.molcel.2022.03.024.?Epub 2022 Apr 14
35451177	PhotoCAX.MS_PMID35451177_293T_human	293T	Huixin Luo	2022 Jul 4	doi: 10.1002/anie.202202008

Showing 1 to 10 of 11 entries

Previous1 2Next

Literatures on RNA binding capacity

Show entries

Search:

Pubmed ID	Title	Author	Time	Journal
23237964	The broad-spectrum antiviral functions of IFIT and IFITM proteins.	S Michael Diamond	2013-01-01	Nature reviews. Immunology
23317505	tRNA binding, structure, and localization of the human interferon-induced protein IFIT5.	E George Katibah	2013-02-21	Molecular cell
24098121	Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.	Matthias Habjan	2013-01-01	PLoS pathogens
24371270	Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs.	Parimal Kumar	2014-03-01	Nucleic acids research
24400006	Sensing microbial RNA in the cytosol.	Nicolas Vabret	2013-12-25	Frontiers in immunology
24653722	IFITs: Emerging Roles as Key Anti-Viral Proteins.	I Gregory Vladimer	2014-01-01	Frontiers in immunology
24909568	IFIT1: A dual sensor and effector molecule that detects non-2'-O methylated viral RNA and inhibits its translation.	S Michael Diamond	2014-10-01	Cytokine & growth factor reviews
26916433	When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins.	W Daisy Leung	2016-02-01	Current opinion in structural biology
27856145	Sequence-Specific Sensing of Nucleic Acids.	Nicolas Vabret	2017-01-01	Trends in immunology
29554348	IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.	C Renata Fleith	2018-06-01	Nucleic acids research

Showing 1 to 10 of 20 entries

Previous1 2Next

Transcripts

Show entries

Search:

Name	Transcript ID	bp	Protein	Translation ID
IFIT2-201	ENST00000371826	3393	472aa	ENSP00000360891
IFIT2-202	ENST00000611722	2497	200aa	ENSP00000484770
IFIT2-203	ENST00000638108	3703	472aa	ENSP00000490935
IFIT2-204	ENST00000679606	382	No protein	-
IFIT2-205	ENST00000679608	484	No protein	-
IFIT2-206	ENST00000679619	651	145aa	ENSP00000505260
IFIT2-207	ENST00000679734	3382	448aa	ENSP00000506258
IFIT2-208	ENST00000679755	3418	448aa	ENSP00000506663
IFIT2-209	ENST00000680381	3337	448aa	ENSP00000506516
IFIT2-210	ENST00000680558	282	No protein	-

Showing 1 to 10 of 15 entries

Previous1 2Next

Gene Model

Click here to download ENSG00000119922's gene model file

Phenotypes

Show entries

Search:

ensgID	Trait	pValue	Pubmed ID
54218	Proteins	3.7480000E-005	-

Showing 1 to 1 of 1 entries

Previous1Next

GWAS

Show entries

Search:

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000119922	rs4934470	10	89307681	Blood protein levels	29875488	0.21	EFO_0007937

Showing 1 to 1 of 1 entries

Previous1Next

Protein-Protein Interaction (PPI)

Click here to download ENSG00000119922's PPI file

Paralogs

Show entries

Search:

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000119922	homo_sapiens	ENSP00000360883	66.5306	54.4898	homo_sapiens	ENSP00000360891	69.0678	56.5678
ENSG00000119922	homo_sapiens	ENSP00000360860	61.4108	43.7759	homo_sapiens	ENSP00000360891	62.7119	44.7034
ENSG00000119922	homo_sapiens	ENSP00000360874	60.1266	42.616	homo_sapiens	ENSP00000360891	60.3814	42.7966
ENSG00000119922	homo_sapiens	ENSP00000360869	61.0879	43.9331	homo_sapiens	ENSP00000360891	61.8644	44.4915

Showing 1 to 4 of 4 entries

Previous1Next

Orthologs

Show entries

Search:

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000119922	homo_sapiens	ENSP00000360891	97.6695	97.2458	nomascus_leucogenys	ENSNLEP00000022521	97.0526	96.6316
ENSG00000119922	homo_sapiens	ENSP00000360891	99.3644	99.1525	pan_paniscus	ENSPPAP00000009452	99.3644	99.1525
ENSG00000119922	homo_sapiens	ENSP00000360891	98.7288	98.3051	pongo_abelii	ENSPPYP00000002853	98.7288	98.3051
ENSG00000119922	homo_sapiens	ENSP00000360891	99.3644	99.1525	pan_troglodytes	ENSPTRP00000004778	99.3644	99.1525
ENSG00000119922	homo_sapiens	ENSP00000360891	99.3644	98.9407	gorilla_gorilla	ENSGGOP00000038592	99.3644	98.9407
ENSG00000119922	homo_sapiens	ENSP00000360891	63.7712	45.5508	ornithorhynchus_anatinus	ENSOANP00000037513	61.5542	43.9673
ENSG00000119922	homo_sapiens	ENSP00000360891	58.4746	40.2542	ornithorhynchus_anatinus	ENSOANP00000011762	60.9272	41.9426
ENSG00000119922	homo_sapiens	ENSP00000360891	62.9237	44.4915	ornithorhynchus_anatinus	ENSOANP00000047495	61.6183	43.5685
ENSG00000119922	homo_sapiens	ENSP00000360891	73.7288	62.9237	choloepus_hoffmanni	ENSCHOP00000005207	78.0269	66.5919
ENSG00000119922	homo_sapiens	ENSP00000360891	80.7203	71.6102	dasypus_novemcinctus	ENSDNOP00000025526	80.7203	71.6102

Showing 1 to 10 of 512 entries

Previous1 2 3 4 5…52Next

Gene Ontology

Show entries

Search:

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005829	is_active_in cytosol	2	IBA,TAS	Homo_sapiens(9606)	Component
GO:0009615	involved_in response to virus	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005783	located_in endoplasmic reticulum	1	IDA	Homo_sapiens(9606)	Component
GO:0008637	involved_in apoptotic mitochondrial changes	1	TAS	Homo_sapiens(9606)	Process
GO:0032091	involved_in negative regulation of protein binding	1	IDA	Homo_sapiens(9606)	Process
GO:0043065	involved_in positive regulation of apoptotic process	1	IDA	Homo_sapiens(9606)	Process
GO:0051607	involved_in defense response to virus	1	IBA	Homo_sapiens(9606)	Process

Showing 1 to 10 of 11 entries

Previous1 2Next

Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression