Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions E3 ligase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000119401 Gene ID 22954 Accession 16380
Symbol TRIM32 Alias HT2A;BBS11;TATIP;LGMD2H;LGMDR8 Full Name tripartite motif containing 32
Status Confidence Length 13996 bases Strand Plus strand
Position 9 : 116687305 - 116701300 RNA binding domain N.A.
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
36240265 Germline immortality relies on TRIM32-mediated turnover of a maternal mRNA activator in C. elegans. D Tosin Oyewale 2022-10-14 Science advances
33503896 The Role of E3s in Regulating Pluripotency of Embryonic Stem Cells and Induced Pluripotent Stem Cells. Yahong Wu 2021-01-25 International journal of molecular sciences

Transcripts

Name Transcript ID bp Protein Translation ID
TRIM32-203 ENST00000450136 3715 653aa ENSP00000408292
TRIM32-201 ENST00000373983 3688 653aa ENSP00000363095
TRIM32-202 ENST00000411410 699 172aa ENSP00000412603

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000209involved_in protein polyubiquitination1IDAHomo_sapiens(9606)Process
GO:0001894involved_in tissue homeostasis1IEAHomo_sapiens(9606)Process
GO:0003713enables transcription coactivator activity1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1ISSHomo_sapiens(9606)Function
GO:0004842enables ubiquitin-protein transferase activity1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1ISSHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005863colocalizes_with striated muscle myosin thick filament1ISSHomo_sapiens(9606)Component
GO:0006511involved_in ubiquitin-dependent protein catabolic process1IMPHomo_sapiens(9606)Process
GO:0007014involved_in actin ubiquitination1IEAHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding1IEAHomo_sapiens(9606)Function
GO:0009411involved_in response to UV1ISSHomo_sapiens(9606)Process
GO:0010508involved_in positive regulation of autophagy1IDAHomo_sapiens(9606)Process
GO:0010994involved_in free ubiquitin chain polymerization1IDAHomo_sapiens(9606)Process
GO:0016567involved_in protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0017022enables myosin binding1ISSHomo_sapiens(9606)Function
GO:0030307involved_in positive regulation of cell growth1IDAHomo_sapiens(9606)Process
GO:0030335involved_in positive regulation of cell migration1IDAHomo_sapiens(9606)Process
GO:0030957enables Tat protein binding1TASHomo_sapiens(9606)Function
GO:0031369enables translation initiation factor binding1ISSHomo_sapiens(9606)Function
GO:0032897involved_in negative regulation of viral transcription1IDAHomo_sapiens(9606)Process
GO:0034612involved_in response to tumor necrosis factor1ISSHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1IDAHomo_sapiens(9606)Process
GO:0043130enables ubiquitin binding1IDAHomo_sapiens(9606)Function
GO:0043621enables protein self-association1IDAHomo_sapiens(9606)Function
GO:0044790involved_in suppression of viral release by host1IDAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response2IDA,TASHomo_sapiens(9606)Process
GO:0045444involved_in fat cell differentiation1ISSHomo_sapiens(9606)Process
GO:0045666involved_in positive regulation of neuron differentiation1ISSHomo_sapiens(9606)Process
GO:0045732involved_in positive regulation of protein catabolic process1ISSHomo_sapiens(9606)Process
GO:0045787involved_in positive regulation of cell cycle1IDAHomo_sapiens(9606)Process
GO:0045862involved_in positive regulation of proteolysis1IDAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0046716involved_in muscle cell cellular homeostasis1IEAHomo_sapiens(9606)Process
GO:0048147involved_in negative regulation of fibroblast proliferation1ISSHomo_sapiens(9606)Process
GO:0050769involved_in positive regulation of neurogenesis1ISSHomo_sapiens(9606)Process
GO:0051091involved_in positive regulation of DNA-binding transcription factor activity1IDAHomo_sapiens(9606)Process
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity3IBA,IDA,ISSHomo_sapiens(9606)Process
GO:0051155involved_in positive regulation of striated muscle cell differentiation1IEAHomo_sapiens(9606)Process
GO:0061564involved_in axon development1IEAHomo_sapiens(9606)Process
GO:0061630enables ubiquitin protein ligase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0070936involved_in protein K48-linked ubiquitination1IBAHomo_sapiens(9606)Process
GO:1902230involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage1IDAHomo_sapiens(9606)Process
GO:1903265involved_in positive regulation of tumor necrosis factor-mediated signaling pathway1IEAHomo_sapiens(9606)Process
GO:1903883involved_in positive regulation of interleukin-17-mediated signaling pathway1IEAHomo_sapiens(9606)Process
GO:1903886involved_in positive regulation of chemokine (C-C motif) ligand 20 production1IEAHomo_sapiens(9606)Process
GO:2000147involved_in positive regulation of cell motility1ISSHomo_sapiens(9606)Process

Expression