RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Description

Ensembl ID	ENSG00000117569	Gene ID	58155	Accession	17662
Symbol	PTBP2	Alias		Full Name
Status	Confidence	Length	102074 bases	Strand	Plus strand
Position	1 : 96721665 - 96823738	RNA binding domain	RRM_5 , RRM_8 , RRM_1
Summary

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000359216	RRM_1	PF00076	5.7e-31	1
ENSP00000359216	RRM_1	PF00076	5.7e-31	2
ENSP00000359216	RRM_1	PF00076	5.7e-31	3
ENSP00000359216	RRM_5	PF13893	6e-55	4
ENSP00000359216	RRM_5	PF13893	6e-55	5
ENSP00000359216	RRM_5	PF13893	6e-55	6
ENSP00000359216	RRM_8	PF11835	3.2e-15	7
ENSP00000359217	RRM_1	PF00076	2.5e-31	1
ENSP00000359217	RRM_1	PF00076	2.5e-31	2
ENSP00000359217	RRM_1	PF00076	2.5e-31	3
ENSP00000359217	RRM_5	PF13893	8.4e-54	4
ENSP00000359217	RRM_5	PF13893	8.4e-54	5
ENSP00000359217	RRM_8	PF11835	3.4e-15	6
ENSP00000412788	RRM_1	PF00076	5.9e-31	1
ENSP00000412788	RRM_1	PF00076	5.9e-31	2
ENSP00000412788	RRM_1	PF00076	5.9e-31	3
ENSP00000412788	RRM_5	PF13893	6.1e-55	4
ENSP00000412788	RRM_5	PF13893	6.1e-55	5
ENSP00000412788	RRM_5	PF13893	6.1e-55	6
ENSP00000412788	RRM_8	PF11835	3.3e-15	7
ENSP00000477024	RRM_1	PF00076	5.4e-31	1
ENSP00000477024	RRM_1	PF00076	5.4e-31	2
ENSP00000477024	RRM_1	PF00076	5.4e-31	3
ENSP00000477024	RRM_5	PF13893	6.1e-55	4
ENSP00000477024	RRM_5	PF13893	6.1e-55	5
ENSP00000477024	RRM_5	PF13893	6.1e-55	6
ENSP00000477024	RRM_8	PF11835	3.1e-15	7
ENSP00000501559	RRM_1	PF00076	1.8e-31	1
ENSP00000501559	RRM_1	PF00076	1.8e-31	2
ENSP00000501559	RRM_1	PF00076	1.8e-31	3
ENSP00000501559	RRM_5	PF13893	5.9e-54	4
ENSP00000501559	RRM_5	PF13893	5.9e-54	5
ENSP00000501559	RRM_8	PF11835	3e-15	6
ENSP00000501681	RRM_1	PF00076	2.1e-12	1
ENSP00000501681	RRM_5	PF13893	4.5e-11	2
ENSP00000501681	RRM_8	PF11835	4.6e-15	3
ENSP00000501744	RRM_1	PF00076	8.4e-25	1
ENSP00000501744	RRM_1	PF00076	8.4e-25	2
ENSP00000501744	RRM_5	PF13893	1.5e-52	3
ENSP00000501744	RRM_5	PF13893	1.5e-52	4
ENSP00000501744	RRM_8	PF11835	2.7e-15	5
ENSP00000501779	RRM_1	PF00076	2.5e-31	1
ENSP00000501779	RRM_1	PF00076	2.5e-31	2
ENSP00000501779	RRM_1	PF00076	2.5e-31	3
ENSP00000501779	RRM_5	PF13893	7.7e-54	4
ENSP00000501779	RRM_5	PF13893	7.7e-54	5
ENSP00000501779	RRM_8	PF11835	3.5e-15	6
ENSP00000501834	RRM_1	PF00076	2.9e-12	1
ENSP00000501834	RRM_5	PF13893	6.2e-11	2
ENSP00000501834	RRM_8	PF11835	5.3e-15	3
ENSP00000502522	RRM_1	PF00076	2.2e-12	1
ENSP00000502522	RRM_5	PF13893	4.8e-11	2
ENSP00000502522	RRM_8	PF11835	4.8e-15	3
ENSP00000502536	RRM_1	PF00076	8.1e-27	1
ENSP00000502536	RRM_1	PF00076	8.1e-27	2
ENSP00000502536	RRM_1	PF00076	8.1e-27	3
ENSP00000502536	RRM_5	PF13893	4.1e-52	4
ENSP00000502536	RRM_5	PF13893	4.1e-52	5
ENSP00000502536	RRM_5	PF13893	4.1e-52	6
ENSP00000502536	RRM_8	PF11835	3.5e-12	7
ENSP00000502818	RRM_1	PF00076	2.3e-31	1
ENSP00000502818	RRM_1	PF00076	2.3e-31	2
ENSP00000502818	RRM_1	PF00076	2.3e-31	3
ENSP00000502818	RRM_5	PF13893	7.7e-54	4
ENSP00000502818	RRM_5	PF13893	7.7e-54	5
ENSP00000502818	RRM_8	PF11835	3.3e-15	6

Showing 1 to 66 of 66 entries

RNA binding proteomes (RBPomes)

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Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
27040163	serIC_PMID27040163_Hs_K562	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
27040163	serIC_PMID27040163_Hs_K562.1	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
27453046	RBDmap_PMID_27453046_Hs_HeLa	HeLa	Alfredo Castello	2016 Aug 18	doi: 10.1016/j.molcel.2016.06.029.?Epub 2016 Jul 21
29636419	CARIC_PMID29636419_Hs_CARIC		Rongbing Huang	2018 Apr 24	doi: 10.1073/pnas.1718406115
30352994	eRIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8
30352994	RIC_PMID30352994_Hs_JURKAT.2018	JURKAT	Joel I Perez-Perri	2018 Oct 23	doi: 10.1038/s41467-018-06557-8

Showing 1 to 10 of 15 entries

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Literatures on RNA binding capacity

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Pubmed ID	Title	Author	Time	Journal
18380784	MSY2 and polypyrimidine tract binding protein 2 stabilize mRNAs in the mammalian testis.	Mingang Xu	2008-09-01	International journal of andrology
24239855	Nonsense-mediated mRNA decay: inter-individual variability and human disease.	Son Lam Nguyen	2014-10-01	Neuroscience and biobehavioral reviews
24286314	Characterization of a novel posttranslational modification in polypyrimidine tract-binding proteins by SUMO1.	Wei Han	2014-04-01	BMB reports
25739334	Excess of rare variants in genes that are key epigenetic regulators of spermatogenesis in the patients with non-obstructive azoospermia.	Zesong Li	2015-03-05	Scientific reports
26683835	Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study.	Shafqat Ahmad	2015-12-18	BMC medical genetics
29851470	Post-Translational Modifications in Polypyrimidine Tract Binding Proteins PTBP1 and PTBP2.	M Jeffrey Pina	2018-07-03	Biochemistry
30944420	Identification of a 1p21 independent functional variant for abdominal obesity.	Lu Liu	2019-12-01	International journal of obesity (2005)
32327736	Impaired expression of the COSMOC/MOCOS gene unit in ASD patient stem cells.	Pauline Rontani	2021-05-01	Molecular psychiatry
33951281	The many facets of miR-223 in cancer: Oncosuppressor, oncogenic driver, therapeutic target, and biomarker of response.	Andrea Favero	2021-11-01	Wiley interdisciplinary reviews. RNA
34184986	5'-UTR SNP of FGF13 causes translational defect and intellectual disability.	Xingyu Pan	2021-06-29	eLife

Showing 1 to 10 of 15 entries

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Transcripts

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Search:

Name	Transcript ID	bp	Protein	Translation ID
PTBP2-201	ENST00000370197	3057	537aa	ENSP00000359216
PTBP2-202	ENST00000370198	3054	536aa	ENSP00000359217
PTBP2-203	ENST00000426398	3153	540aa	ENSP00000412788
PTBP2-204	ENST00000459735	791	No protein	-
PTBP2-205	ENST00000460706	1129	No protein	-
PTBP2-206	ENST00000462433	365	No protein	-
PTBP2-207	ENST00000476419	1691	356aa	ENSP00000501834
PTBP2-208	ENST00000476783	779	No protein	-
PTBP2-209	ENST00000482253	2029	44aa	ENSP00000501971
PTBP2-210	ENST00000492905	776	No protein	-

Showing 1 to 10 of 24 entries

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Gene Model

Click here to download ENSG00000117569's gene model file

Phenotypes

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ensgID	Trait	pValue	Pubmed ID
3101	Apolipoproteins B	8.98864954564198E-8	17903299
6013	Hematocrit	4.83866279167832E-8	17903294
6212	Erythrocyte Indices	2.17398929211236E-7	17903294
6249	Erythrocyte Indices	1.47448186571125E-7	17903294
6260	Erythrocyte Indices	2.45467930212154E-43	17903294
9416	Echocardiography	1.80636967508423E-6	17903301
11591	Mental Competency	1.26776776269341E-11	17903295
11601	Mental Competency	3.84439680038885E-17	17903295
11615	Mental Competency	5.35358853092926E-15	17903295
11666	Audiometry, Pure-Tone	3.38005229971184E-8	-

Showing 1 to 10 of 30 entries

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GWAS

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ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
ENSG00000117569	rs61786416	1	96817982	Reaction time	29844566	0.0098016	EFO_0008393

Showing 1 to 1 of 1 entries

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Protein-Protein Interaction (PPI)

Click here to download ENSG00000117569's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000117569	homo_sapiens	ENSP00000390625	43.1734	26.7528	homo_sapiens	ENSP00000502818	44.0678	27.307
ENSG00000117569	homo_sapiens	ENSP00000358532	14.9959	8.63896	homo_sapiens	ENSP00000502818	34.6516	19.9623
ENSG00000117569	homo_sapiens	ENSP00000221419	40.5773	24.2784	homo_sapiens	ENSP00000502818	45.0094	26.9303
ENSG00000117569	homo_sapiens	ENSP00000363375	80.7252	68.3206	homo_sapiens	ENSP00000502818	79.661	67.42
ENSG00000117569	homo_sapiens	ENSP00000349428	82.0467	71.6338	homo_sapiens	ENSP00000502818	86.064	75.1412

Showing 1 to 5 of 5 entries

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000117569	homo_sapiens	ENSP00000502818	100	100	nomascus_leucogenys	ENSNLEP00000033336	98.8827	98.8827
ENSG00000117569	homo_sapiens	ENSP00000502818	100	100	pan_paniscus	ENSPPAP00000034217	98.8827	98.8827
ENSG00000117569	homo_sapiens	ENSP00000502818	100	100	pongo_abelii	ENSPPYP00000001311	98.8827	98.8827
ENSG00000117569	homo_sapiens	ENSP00000502818	95.4802	94.162	pan_troglodytes	ENSPTRP00000087365	93.3702	92.081
ENSG00000117569	homo_sapiens	ENSP00000502818	100	100	gorilla_gorilla	ENSGGOP00000000648	98.8827	98.8827
ENSG00000117569	homo_sapiens	ENSP00000502818	100	98.8701	ornithorhynchus_anatinus	ENSOANP00000007379	99.0672	97.9478
ENSG00000117569	homo_sapiens	ENSP00000502818	100	99.8117	sarcophilus_harrisii	ENSSHAP00000019093	99.812	99.6241
ENSG00000117569	homo_sapiens	ENSP00000502818	59.1337	58.1921	notamacropus_eugenii	ENSMEUP00000003964	59.3573	58.4121
ENSG00000117569	homo_sapiens	ENSP00000502818	76.8362	76.8362	choloepus_hoffmanni	ENSCHOP00000006404	75.9777	75.9777
ENSG00000117569	homo_sapiens	ENSP00000502818	100	100	dasypus_novemcinctus	ENSDNOP00000027061	99.812	99.812

Showing 1 to 10 of 278 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0003729	enables mRNA binding	1	IBA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005681	part_of spliceosomal complex	1	IEA	Homo_sapiens(9606)	Component
GO:0006376	involved_in mRNA splice site recognition	1	IEA	Homo_sapiens(9606)	Process
GO:0033119	involved_in negative regulation of RNA splicing	1	IDA	Homo_sapiens(9606)	Process
GO:0043484	involved_in regulation of RNA splicing	1	IBA	Homo_sapiens(9606)	Process
GO:2000177	involved_in regulation of neural precursor cell proliferation	1	IEA	Homo_sapiens(9606)	Process

Showing 1 to 8 of 8 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression