RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000116525	Gene ID	55223	Accession	25574
Symbol	TRIM62	Alias	DEAR1	Full Name	tripartite motif containing 62
Status	Confidence	Length	36645 bases	Strand	Minus strand
Position	1 : 33145399 - 33182043	RNA binding domain	SPRY
Summary	Enables identical protein binding activity; transcription coactivator activity; and ubiquitin-protein transferase activity. Involved in several processes, including negative regulation of viral transcription; positive regulation of NF-kappaB transcription factor activity; and positive regulation of antifungal innate immune response. Is active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000441173	SPRY	PF00622	1.7e-14	1
ENSP00000291416	SPRY	PF00622	2.8e-14	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
32341648	Association of DEAR1 Tagging Single Nucleotide Polymorphisms With Breast Cancer in a Sample of Colombian Population: A Case Control Study.	P Angela Beltrán	2020-01-01	Breast cancer : basic and clinical research

Name	Transcript ID	bp	Protein	Translation ID
TRIM62-201	ENST00000291416	3817	475aa	ENSP00000291416
TRIM62-204	ENST00000543586	1638	354aa	ENSP00000441173
TRIM62-202	ENST00000485148	806	No protein	-
TRIM62-203	ENST00000486583	306	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003713	enables transcription coactivator activity	1	IDA	Homo_sapiens(9606)	Function
GO:0004842	enables ubiquitin-protein transferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	3	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0008270	enables zinc ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0010719	involved_in negative regulation of epithelial to mesenchymal transition	1	IEA	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	1	IBA	Homo_sapiens(9606)	Process
GO:0019076	involved_in viral release from host cell	1	IMP	Homo_sapiens(9606)	Process
GO:0032897	involved_in negative regulation of viral transcription	1	IDA	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0043123	involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0044314	involved_in protein K27-linked ubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0045087	involved_in innate immune response	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0045893	involved_in positive regulation of DNA-templated transcription	1	IEA	Homo_sapiens(9606)	Process
GO:0046596	involved_in regulation of viral entry into host cell	1	IDA	Homo_sapiens(9606)	Process
GO:0051091	involved_in positive regulation of DNA-binding transcription factor activity	1	IMP	Homo_sapiens(9606)	Process
GO:0051092	involved_in positive regulation of NF-kappaB transcription factor activity	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0061630	enables ubiquitin protein ligase activity	1	IBA	Homo_sapiens(9606)	Function
GO:1905036	involved_in positive regulation of antifungal innate immune response	1	IDA	Homo_sapiens(9606)	Process