Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions E3 ligase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000114166 Gene ID 8850 Accession 8638
Symbol KAT2B Alias CAF;PCAF;P/CAF Full Name lysine acetyltransferase 2B
Status Confidence Length 113959 bases Strand Plus strand
Position 3 : 20040446 - 20154404 RNA binding domain N.A.
Summary CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34547289 CENP-B promotes the centromeric localization of ZFAT to control transcription of noncoding RNA. Shuhei Ishikura 2021-10-01 The Journal of biological chemistry
33330099 Long Noncoding RNA AFAP1-AS1 Is a Critical Regulator of Nasopharyngeal Carcinoma Tumorigenicity. Min Fang 2020-01-01 Frontiers in oncology

Transcripts

Name Transcript ID bp Protein Translation ID
KAT2B-201 ENST00000263754 4410 832aa ENSP00000263754
KAT2B-202 ENST00000426228 571 No protein -
KAT2B-205 ENST00000469085 394 No protein -
KAT2B-203 ENST00000468111 593 No protein -
KAT2B-204 ENST00000468400 675 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
48033Autistic Disorder6.3254000E-006-
48782Autistic Disorder3.1664000E-005-
61106Everolimus7E-624009623
79847Staphylococcus aureus9E-926569114
81775Substance-Related Disorders4E-1026202629
83139Alcohol Drinking4E-724376456
83140Arterial Pressure4E-724376456
99783Stroke8E-627997041
100795Mental Disorders5E-620889312
106186Stress Disorders, Post-Traumatic8E-624677629

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000124part_of SAGA complex1NASHomo_sapiens(9606)Component
GO:0000432involved_in positive regulation of transcription from RNA polymerase II promoter by glucose1IEAHomo_sapiens(9606)Process
GO:0000776located_in kinetochore1IEAHomo_sapiens(9606)Component
GO:0000977enables RNA polymerase II transcription regulatory region sequence-specific DNA binding1IEAHomo_sapiens(9606)Function
GO:0003682enables chromatin binding1ISSHomo_sapiens(9606)Function
GO:0003712enables transcription coregulator activity1IPIHomo_sapiens(9606)Function
GO:0003713enables transcription coactivator activity1IDAHomo_sapiens(9606)Function
GO:0004145enables diamine N-acetyltransferase activity1IEAHomo_sapiens(9606)Function
GO:0004402enables histone acetyltransferase activity3EXP,IDA,IMPHomo_sapiens(9606)Function
GO:0004468enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor2IDA,ISSHomo_sapiens(9606)Function
GO:0004861enables cyclin-dependent protein serine/threonine kinase inhibitor activity1ISSHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus2IDA,ISSHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005813located_in centrosome1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0006094involved_in gluconeogenesis1IEAHomo_sapiens(9606)Process
GO:0006282involved_in regulation of DNA repair1NASHomo_sapiens(9606)Process
GO:0006338involved_in chromatin remodeling3IBA,IDA,NASHomo_sapiens(9606)Process
GO:0006351involved_in DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0006355involved_in regulation of DNA-templated transcription2ISS,NASHomo_sapiens(9606)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II1ISSHomo_sapiens(9606)Process
GO:0006473involved_in protein acetylation1IDAHomo_sapiens(9606)Process
GO:0007049involved_in cell cycle1IEAHomo_sapiens(9606)Process
GO:0007507involved_in heart development1ISSHomo_sapiens(9606)Process
GO:0007613involved_in memory1IEAHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1IDAHomo_sapiens(9606)Process
GO:0010484enables histone H3 acetyltransferase activity1IBAHomo_sapiens(9606)Function
GO:0010835involved_in regulation of protein ADP-ribosylation1IDAHomo_sapiens(9606)Process
GO:0010976involved_in positive regulation of neuron projection development1IEAHomo_sapiens(9606)Process
GO:0016407enables acetyltransferase activity1IDAHomo_sapiens(9606)Function
GO:0016573involved_in histone acetylation1NASHomo_sapiens(9606)Process
GO:0018076involved_in N-terminal peptidyl-lysine acetylation1IDAHomo_sapiens(9606)Process
GO:0018393involved_in internal peptidyl-lysine acetylation1IDAHomo_sapiens(9606)Process
GO:0018394involved_in peptidyl-lysine acetylation1IDAHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding1ISSHomo_sapiens(9606)Function
GO:0031063involved_in regulation of histone deacetylation1ISSHomo_sapiens(9606)Process
GO:0031672located_in A band1IEAHomo_sapiens(9606)Component
GO:0031674located_in I band1IEAHomo_sapiens(9606)Component
GO:0032869involved_in cellular response to insulin stimulus1IDAHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex2IDA,IPIHomo_sapiens(9606)Component
GO:0034599involved_in cellular response to oxidative stress1IEAHomo_sapiens(9606)Process
GO:0035035enables histone acetyltransferase binding1IEAHomo_sapiens(9606)Function
GO:0035521involved_in monoubiquitinated histone deubiquitination1ISSHomo_sapiens(9606)Process
GO:0035522involved_in monoubiquitinated histone H2A deubiquitination1ISSHomo_sapiens(9606)Process
GO:0035563involved_in positive regulation of chromatin binding1IEAHomo_sapiens(9606)Process
GO:0042311involved_in vasodilation1IEAHomo_sapiens(9606)Process
GO:0042641located_in actomyosin1IEAHomo_sapiens(9606)Component
GO:0042826enables histone deacetylase binding1IPIHomo_sapiens(9606)Function
GO:0043484involved_in regulation of RNA splicing1NASHomo_sapiens(9606)Process
GO:0043966involved_in histone H3 acetylation3IBA,IDA,NASHomo_sapiens(9606)Process
GO:0043992enables histone H3K9 acetyltransferase activity1IEAHomo_sapiens(9606)Function
GO:0044154involved_in histone H3-K14 acetylation1ISSHomo_sapiens(9606)Process
GO:0045722involved_in positive regulation of gluconeogenesis1IEAHomo_sapiens(9606)Process
GO:0045723involved_in positive regulation of fatty acid biosynthetic process1IDAHomo_sapiens(9606)Process
GO:0045736involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity1IEAHomo_sapiens(9606)Process
GO:0045815involved_in transcription initiation-coupled chromatin remodeling1TASHomo_sapiens(9606)Process
GO:0045821involved_in positive regulation of glycolytic process1IEAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1NASHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II2IBA,IDAHomo_sapiens(9606)Process
GO:0045995involved_in regulation of embryonic development1ISSHomo_sapiens(9606)Process
GO:0046600involved_in negative regulation of centriole replication1IDAHomo_sapiens(9606)Process
GO:0048511involved_in rhythmic process1IEAHomo_sapiens(9606)Process
GO:0051302involved_in regulation of cell division1ISSHomo_sapiens(9606)Process
GO:0051726involved_in regulation of cell cycle1ISSHomo_sapiens(9606)Process
GO:0060173involved_in limb development1ISSHomo_sapiens(9606)Process
GO:0061733enables peptide-lysine-N-acetyltransferase activity2IDA,TASHomo_sapiens(9606)Function
GO:0071374involved_in cellular response to parathyroid hormone stimulus1IEAHomo_sapiens(9606)Process
GO:0072686located_in mitotic spindle1NASHomo_sapiens(9606)Component
GO:0090043involved_in regulation of tubulin deacetylation1ISSHomo_sapiens(9606)Process
GO:0140297enables DNA-binding transcription factor binding1IPIHomo_sapiens(9606)Function
GO:0140672part_of ATAC complex3IBA,IDA,ISOHomo_sapiens(9606)Component
GO:1902425involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore1IDAHomo_sapiens(9606)Process
GO:2000233involved_in negative regulation of rRNA processing1IDAHomo_sapiens(9606)Process

Expression