RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Ensembl ID	ENSG00000114030	Gene ID	3836	Accession	6394
Symbol	KPNA1	Alias	RCH2;SRP1;IPOA5;NPI-1	Full Name	karyopherin subunit alpha 1
Status	Confidence	Length	93044 bases	Strand	Minus strand
Position	3 : 122421902 - 122514945	RNA binding domain	N.A.
Summary	The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
KPNA1-201	ENST00000344337	6888	538aa	ENSP00000343701
KPNA1-205	ENST00000470904	3060	No protein	-
KPNA1-204	ENST00000466923	3316	No protein	-
KPNA1-208	ENST00000485027	1843	182aa	ENSP00000420013
KPNA1-210	ENST00000494339	1923	182aa	ENSP00000418394
KPNA1-203	ENST00000465882	1062	328aa	ENSP00000419890
KPNA1-202	ENST00000464940	582	No protein	-
KPNA1-207	ENST00000482287	727	214aa	ENSP00000417166
KPNA1-206	ENST00000476916	575	169aa	ENSP00000417319
KPNA1-209	ENST00000493510	596	174aa	ENSP00000419257

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000018	involved_in regulation of DNA recombination	1	TAS	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,ISS	Homo_sapiens(9606)	Component
GO:0005643	part_of nuclear pore	1	TAS	Homo_sapiens(9606)	Component
GO:0005654	is_active_in nucleoplasm	4	IBA,IDA,NAS,TAS	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	3	IDA,NAS,TAS	Homo_sapiens(9606)	Component
GO:0006606	involved_in protein import into nucleus	1	ISS	Homo_sapiens(9606)	Process
GO:0006607	involved_in NLS-bearing protein import into nucleus	1	IBA	Homo_sapiens(9606)	Process
GO:0008139	enables nuclear localization sequence binding	1	IBA	Homo_sapiens(9606)	Function
GO:0014069	located_in postsynaptic density	1	IEA	Homo_sapiens(9606)	Component
GO:0014841	involved_in skeletal muscle satellite cell proliferation	1	IEA	Homo_sapiens(9606)	Process
GO:0014901	involved_in satellite cell activation involved in skeletal muscle regeneration	1	IEA	Homo_sapiens(9606)	Process
GO:0030425	located_in dendrite	1	ISS	Homo_sapiens(9606)	Component
GO:0042564	part_of NLS-dependent protein nuclear import complex	1	IPI	Homo_sapiens(9606)	Component
GO:0042981	involved_in regulation of apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0060828	involved_in regulation of canonical Wnt signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0061608	enables nuclear import signal receptor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0098978	located_in glutamatergic synapse	1	IEA	Homo_sapiens(9606)	Component
GO:0099527	involved_in postsynapse to nucleus signaling pathway	1	IBA	Homo_sapiens(9606)	Process