RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	Stress granucle
BulkPerturb-seq

Ensembl ID	ENSG00000113712	Gene ID	1452	Accession	2451
Symbol	CSNK1A1	Alias	CK1;CK1a;CKIa;HLCDGP1;PRO2975;HEL-S-77p	Full Name	casein kinase 1 alpha 1
Status	Confidence	Length	58490 bases	Strand	Minus strand
Position	5 : 149492982 - 149551471	RNA binding domain	N.A.
Summary	Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
CSNK1A1-201	ENST00000261798	5444	365aa	ENSP00000261798
CSNK1A1-202	ENST00000377843	5360	337aa	ENSP00000367074
CSNK1A1-212	ENST00000657001	4902	325aa	ENSP00000499757
CSNK1A1-207	ENST00000515768	2570	353aa	ENSP00000421689
CSNK1A1-210	ENST00000606719	2476	368aa	ENSP00000475319
CSNK1A1-213	ENST00000657462	2052	77aa	ENSP00000499532
CSNK1A1-215	ENST00000661952	2413	77aa	ENSP00000499647
CSNK1A1-204	ENST00000504676	1772	236aa	ENSP00000426747
CSNK1A1-205	ENST00000515435	1856	264aa	ENSP00000427031
CSNK1A1-216	ENST00000662268	1848	No protein	-
CSNK1A1-214	ENST00000657706	3315	426aa	ENSP00000499284
CSNK1A1-211	ENST00000606826	800	184aa	ENSP00000475969
CSNK1A1-203	ENST00000503350	1099	167aa	ENSP00000425366
CSNK1A1-209	ENST00000606299	599	83aa	ENSP00000475633
CSNK1A1-217	ENST00000670598	867	150aa	ENSP00000499782
CSNK1A1-208	ENST00000523203	775	78aa	ENSP00000430252
CSNK1A1-206	ENST00000515748	620	89aa	ENSP00000421268

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
86669	Esophageal Neoplasms	5E-9	21642993

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000776	located_in kinetochore	1	IEA	Homo_sapiens(9606)	Component
GO:0004672	enables protein kinase activity	2	ISS,TAS	Homo_sapiens(9606)	Function
GO:0004674	enables protein serine/threonine kinase activity	6	EXP,IBA,IDA,IMP,ISS,TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005813	located_in centrosome	1	IDA	Homo_sapiens(9606)	Component
GO:0005819	located_in spindle	1	ISS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005929	located_in cilium	1	TAS	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:0007030	involved_in Golgi organization	1	IMP	Homo_sapiens(9606)	Process
GO:0007049	involved_in cell cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0007165	involved_in signal transduction	1	IBA	Homo_sapiens(9606)	Process
GO:0007166	involved_in cell surface receptor signaling pathway	1	TAS	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0016055	involved_in Wnt signaling pathway	1	TAS	Homo_sapiens(9606)	Process
GO:0016607	located_in nuclear speck	1	IDA	Homo_sapiens(9606)	Component
GO:0018105	involved_in peptidyl-serine phosphorylation	3	IBA,IDA,IMP	Homo_sapiens(9606)	Process
GO:0019082	involved_in viral protein processing	1	TAS	Homo_sapiens(9606)	Process
GO:0030877	part_of beta-catenin destruction complex	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:0032436	involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0036064	located_in ciliary basal body	1	ISS	Homo_sapiens(9606)	Component
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	1	NAS	Homo_sapiens(9606)	Process
GO:0045095	colocalizes_with keratin filament	1	IDA	Homo_sapiens(9606)	Component
GO:0045104	involved_in intermediate filament cytoskeleton organization	1	IMP	Homo_sapiens(9606)	Process
GO:0051301	involved_in cell division	1	IEA	Homo_sapiens(9606)	Process
GO:0090090	involved_in negative regulation of canonical Wnt signaling pathway	3	IBA,IC,IMP	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:1900226	involved_in negative regulation of NLRP3 inflammasome complex assembly	1	ISS	Homo_sapiens(9606)	Process
GO:1904424	involved_in regulation of GTP binding	1	IMP	Homo_sapiens(9606)	Process