RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	Stress granule or P-bodyNucleoli
BulkPerturb-seq

Ensembl ID	ENSG00000112742	Gene ID	7272	Accession	12401
Symbol	TTK	Alias	ESK;PYT;CT96;MPH1;MPS1;MPS1L1	Full Name	TTK protein kinase
Status	Confidence	Length	38641 bases	Strand	Plus strand
Position	6 : 80003887 - 80042527	RNA binding domain	N.A.
Summary	This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
32530571	TTK regulates proliferation and apoptosis of gastric cancer cells through the Akt-mTOR pathway.	Hongxia Huang	2020-08-01	FEBS open bio
27618777	Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancer.	Ruoyu Miao	2016-09-13	Scientific reports

Name	Transcript ID	bp	Protein	Translation ID
TTK-208	ENST00000509894	3725	856aa	ENSP00000422936
TTK-201	ENST00000230510	3477	856aa	ENSP00000230510
TTK-202	ENST00000369798	2966	857aa	ENSP00000358813
TTK-207	ENST00000509313	530	79aa	ENSP00000421406
TTK-204	ENST00000502580	541	139aa	ENSP00000424851
TTK-209	ENST00000511260	549	150aa	ENSP00000421636
TTK-205	ENST00000504040	569	175aa	ENSP00000427483
TTK-203	ENST00000430061	580	No protein	-
TTK-210	ENST00000515751	584	No protein	-
TTK-206	ENST00000504590	748	No protein	-
TTK-211	ENST00000627129	240	79aa	ENSP00000487202

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
30648	Erythrocyte Count	9.1560000E-005	-
30673	Erythrocyte Count	7.2910000E-005	-
30695	Erythrocyte Count	3.5620000E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000776	is_active_in kinetochore	1	IBA	Homo_sapiens(9606)	Component
GO:0004674	enables protein serine/threonine kinase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0004712	enables protein serine/threonine/tyrosine kinase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0004713	enables protein tyrosine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005819	located_in spindle	1	TAS	Homo_sapiens(9606)	Component
GO:0007051	involved_in spindle organization	1	TAS	Homo_sapiens(9606)	Process
GO:0007052	involved_in mitotic spindle organization	1	TAS	Homo_sapiens(9606)	Process
GO:0007059	involved_in chromosome segregation	1	IBA	Homo_sapiens(9606)	Process
GO:0007094	involved_in mitotic spindle assembly checkpoint signaling	1	IBA	Homo_sapiens(9606)	Process
GO:0008284	involved_in positive regulation of cell population proliferation	1	TAS	Homo_sapiens(9606)	Process
GO:0010862	involved_in positive regulation of pathway-restricted SMAD protein phosphorylation	1	TAS	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0016321	involved_in female meiosis chromosome segregation	1	IEA	Homo_sapiens(9606)	Process
GO:0018105	involved_in peptidyl-serine phosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0018107	involved_in peptidyl-threonine phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0018108	involved_in peptidyl-tyrosine phosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0033316	involved_in meiotic spindle assembly checkpoint signaling	1	IBA	Homo_sapiens(9606)	Process
GO:0034501	involved_in protein localization to kinetochore	1	IBA	Homo_sapiens(9606)	Process
GO:0042802	enables identical protein binding	1	IEA	Homo_sapiens(9606)	Function
GO:0043515	enables kinetochore binding	1	IEA	Homo_sapiens(9606)	Function
GO:0046777	involved_in protein autophosphorylation	1	IEA	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:1903096	involved_in protein localization to meiotic spindle midzone	1	IEA	Homo_sapiens(9606)	Process