| RBP Type |
Non-canonical_RBPs |
| Diseases |
N.A. |
| Drug |
N.A. |
| Main interacting RNAs |
N.A. |
| Moonlighting functions |
Metabolic enzyme |
| Localizations |
N.A. |
|
BulkPerturb-seq
|
|
| Ensembl ID | ENSG00000111684 | Gene ID |
10162 |
Accession |
30244 |
| Symbol |
LPCAT3 |
Alias |
C3F;LPCAT;LPSAT;OACT5;nessy;MBOAT5;LPLAT5;LPLAT12 |
Full Name |
lysophosphatidylcholine acyltransferase 3 |
| Status |
Confidence |
Length |
42293 bases |
Strand |
Minus strand |
| Position |
12 : 6976185 - 7018477 |
RNA binding domain |
N.A. |
| Summary |
Enables 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphoethanolamine O-acyltransferase activity; and 1-acylglycerophosphoserine O-acyltransferase activity. Involved in phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; and phosphatidylserine acyl-chain remodeling. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022] |
RNA binding domains (RBDs)
| Protein |
Domain |
Pfam ID |
E-value |
Domain number |
RNA binding proteomes (RBPomes)
| Pubmed ID |
Full Name |
Cell |
Author |
Time |
Doi |
Literatures on RNA binding capacity
| Pubmed ID |
Title |
Author |
Time |
Journal |
| Name |
Transcript ID |
bp |
Protein |
Translation ID |
| LPCAT3-201 |
ENST00000261407 |
2235 |
487aa |
ENSP00000261407 |
| LPCAT3-203 |
ENST00000535479 |
2902 |
347aa |
ENSP00000438765 |
| LPCAT3-202 |
ENST00000535021 |
802 |
No protein |
- |
| LPCAT3-210 |
ENST00000540090 |
974 |
85aa |
ENSP00000442454 |
| LPCAT3-211 |
ENST00000543794 |
1099 |
158aa |
ENSP00000443166 |
| LPCAT3-204 |
ENST00000536797 |
1412 |
198aa |
ENSP00000440550 |
| LPCAT3-206 |
ENST00000537179 |
1135 |
No protein |
- |
| LPCAT3-208 |
ENST00000538987 |
527 |
No protein |
- |
| LPCAT3-209 |
ENST00000540060 |
562 |
No protein |
- |
| LPCAT3-213 |
ENST00000620843 |
541 |
No protein |
- |
| LPCAT3-205 |
ENST00000536971 |
564 |
No protein |
- |
| LPCAT3-212 |
ENST00000545459 |
486 |
No protein |
- |
| LPCAT3-207 |
ENST00000538910 |
571 |
64aa |
ENSP00000437827 |
| Pathway ID |
Pathway Name |
Source |
| | |
| ensgID |
Trait |
pValue |
Pubmed ID |
| 96974 | Fatty Acids | 3E-30 | 25500335 |
| 96975 | Linoleic Acid | 3E-30 | 25500335 |
| ensgID | SNP | Chromosome | Position |
Trait | PubmedID | Or or BEAT |
EFO ID |
|---|
Protein-Protein Interaction (PPI)
| Ensembl ID |
Source |
Target |
| Species |
Protein ID |
Perc_pos |
Perc_id |
Species |
Protein ID |
Perc_pos |
Perc_id |
| Ensembl ID |
Source |
Target |
| Species |
Protein ID |
Perc_pos |
Perc_id |
Species |
Protein ID |
Perc_pos |
Perc_id |
| Go ID |
Go term |
No. evidence |
Entries |
Species |
Category |
| GO:0003841 | enables 1-acylglycerol-3-phosphate O-acyltransferase activity | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0005789 | located_in endoplasmic reticulum membrane | 2 | IDA,TAS | Homo_sapiens(9606) | Component |
| GO:0006656 | involved_in phosphatidylcholine biosynthetic process | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0016020 | located_in membrane | 2 | HDA,IBA | Homo_sapiens(9606) | Component |
| GO:0030258 | involved_in lipid modification | 1 | IBA | Homo_sapiens(9606) | Process |
| GO:0034378 | involved_in chylomicron assembly | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0034379 | involved_in very-low-density lipoprotein particle assembly | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0036150 | involved_in phosphatidylserine acyl-chain remodeling | 3 | IDA,IMP,TAS | Homo_sapiens(9606) | Process |
| GO:0036151 | involved_in phosphatidylcholine acyl-chain remodeling | 4 | IDA,IMP,ISS,TAS | Homo_sapiens(9606) | Process |
| GO:0036152 | involved_in phosphatidylethanolamine acyl-chain remodeling | 3 | IDA,IMP,TAS | Homo_sapiens(9606) | Process |
| GO:0036335 | involved_in intestinal stem cell homeostasis | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0045540 | involved_in regulation of cholesterol biosynthetic process | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0045797 | involved_in positive regulation of intestinal cholesterol absorption | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0047144 | enables 2-acylglycerol-3-phosphate O-acyltransferase activity | 1 | TAS | Homo_sapiens(9606) | Function |
| GO:0047184 | enables 1-acylglycerophosphocholine O-acyltransferase activity | 3 | IBA,IDA,IMP | Homo_sapiens(9606) | Function |
| GO:0050728 | involved_in negative regulation of inflammatory response | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0071617 | enables lysophospholipid acyltransferase activity | 1 | IBA | Homo_sapiens(9606) | Function |
| GO:0090158 | involved_in endoplasmic reticulum membrane organization | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0106262 | enables 1-acylglycerophosphoethanolamine O-acyltransferase activity | 2 | IDA,ISS | Homo_sapiens(9606) | Function |
| GO:0106263 | enables 1-acylglycerophosphoserine O-acyltransferase activity | 1 | IDA | Homo_sapiens(9606) | Function |
| GO:1903573 | involved_in negative regulation of response to endoplasmic reticulum stress | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:1905885 | involved_in positive regulation of triglyceride transport | 1 | ISS | Homo_sapiens(9606) | Process |
