RBP Type	Canonical_RBPs
Diseases	CancerFlavivirusesSARS-COV-2DengueZika
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	DataSet_01_134 DataSet_01_38

Ensembl ID	ENSG00000110321	Gene ID	1982	Accession	3297
Symbol	EIF4G2	Alias	P97;AAG1;DAP5;NAT1	Full Name	eukaryotic translation initiation factor 4 gamma 2
Status	Confidence	Length	11891 bases	Strand	Minus strand
Position	11 : 10797050 - 10808940	RNA binding domain	W2 , MIF4G , MA3
Summary	Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]