RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000110048	Gene ID	5007	Accession	8503
Symbol	OSBP	Alias	OSBP1	Full Name	oxysterol binding protein
Status	Confidence	Length	41377 bases	Strand	Minus strand
Position	11 : 59574398 - 59615774	RNA binding domain	N.A.
Summary	Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
37252940	IFITM1 enhances nonenveloped viral RNA replication by facilitating cholesterol transport to the Golgi.	Kumiko Ishikawa-Sasaki	2023-05-01	PLoS pathogens
24512803	Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.	Hongliang Wang	2014-05-01	Gastroenterology

Name	Transcript ID	bp	Protein	Translation ID
OSBP-201	ENST00000263847	4713	807aa	ENSP00000263847
OSBP-202	ENST00000525357	991	171aa	ENSP00000432399
OSBP-203	ENST00000528903	873	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
49208	Child Development Disorders, Pervasive	3.3131000E-005	-
49243	Child Development Disorders, Pervasive	3.3131000E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000139	located_in Golgi membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005730	located_in nucleolus	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005789	located_in endoplasmic reticulum membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IDA	Homo_sapiens(9606)	Component
GO:0005802	located_in trans-Golgi network	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	is_active_in cytosol	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0005886	is_active_in plasma membrane	1	IBA	Homo_sapiens(9606)	Component
GO:0006686	involved_in sphingomyelin biosynthetic process	1	IMP	Homo_sapiens(9606)	Process
GO:0006699	involved_in bile acid biosynthetic process	1	TAS	Homo_sapiens(9606)	Process
GO:0008142	enables oxysterol binding	1	TAS	Homo_sapiens(9606)	Function
GO:0015248	enables sterol transporter activity	2	IBA,TAS	Homo_sapiens(9606)	Function
GO:0015914	involved_in phospholipid transport	1	IDA	Homo_sapiens(9606)	Process
GO:0015918	involved_in sterol transport	1	IDA	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0019904	enables protein domain specific binding	1	IPI	Homo_sapiens(9606)	Function
GO:0030054	located_in cell junction	1	IDA	Homo_sapiens(9606)	Component
GO:0032367	involved_in intracellular cholesterol transport	1	IMP	Homo_sapiens(9606)	Process
GO:0032934	enables sterol binding	1	IBA	Homo_sapiens(9606)	Function
GO:0035627	involved_in ceramide transport	1	IMP	Homo_sapiens(9606)	Process
GO:0035774	involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	1	IEA	Homo_sapiens(9606)	Process
GO:0042531	involved_in positive regulation of tyrosine phosphorylation of STAT protein	1	IEA	Homo_sapiens(9606)	Process
GO:0043231	is_active_in intracellular membrane-bounded organelle	1	IBA	Homo_sapiens(9606)	Component
GO:0048471	located_in perinuclear region of cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0070273	enables phosphatidylinositol-4-phosphate binding	1	IDA	Homo_sapiens(9606)	Function
GO:0097038	is_active_in perinuclear endoplasmic reticulum	1	IBA	Homo_sapiens(9606)	Component
GO:0120009	involved_in intermembrane lipid transfer	1	IEA	Homo_sapiens(9606)	Process
GO:0120015	enables sterol transfer activity	1	IDA	Homo_sapiens(9606)	Function
GO:1904411	involved_in positive regulation of secretory granule organization	1	IEA	Homo_sapiens(9606)	Process