RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000108094	Gene ID	8453	Accession	2552
Symbol	CUL2	Alias	NA	Full Name	cullin 2
Status	Confidence	Length	118503 bases	Strand	Minus strand
Position	10 : 35008504 - 35127006	RNA binding domain	N.A.
Summary	Enables ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within protein catabolic process. Located in nucleoplasm. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
35189958	circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-κB signaling pathway.	Shangyou Zheng	2022-02-21	Journal of experimental & clinical cancer research : CR

Name	Transcript ID	bp	Protein	Translation ID
CUL2-210	ENST00000626172	4116	706aa	ENSP00000485986
CUL2-201	ENST00000374746	3867	694aa	ENSP00000363878
CUL2-209	ENST00000537177	4223	758aa	ENSP00000444856
CUL2-236	ENST00000690123	3984	682aa	ENSP00000508924
CUL2-203	ENST00000374749	4183	745aa	ENSP00000363881
CUL2-202	ENST00000374748	4312	745aa	ENSP00000363880
CUL2-204	ENST00000374751	4233	745aa	ENSP00000363883
CUL2-246	ENST00000691974	3187	745aa	ENSP00000508908
CUL2-229	ENST00000688571	3026	758aa	ENSP00000509574
CUL2-237	ENST00000690393	2934	745aa	ENSP00000510691
CUL2-235	ENST00000690092	2599	711aa	ENSP00000508675
CUL2-205	ENST00000374754	2828	90aa	ENSP00000363886
CUL2-226	ENST00000688252	4690	No protein	-
CUL2-241	ENST00000691272	2739	240aa	ENSP00000508531
CUL2-223	ENST00000687282	3567	No protein	-
CUL2-227	ENST00000688390	3575	No protein	-
CUL2-239	ENST00000691201	2663	716aa	ENSP00000509778
CUL2-232	ENST00000689036	2204	No protein	-
CUL2-222	ENST00000687194	2818	242aa	ENSP00000509491
CUL2-225	ENST00000688044	2871	No protein	-
CUL2-240	ENST00000691263	2717	742aa	ENSP00000510240
CUL2-244	ENST00000691858	2750	240aa	ENSP00000509932
CUL2-245	ENST00000691962	2663	394aa	ENSP00000508699
CUL2-230	ENST00000688705	2079	No protein	-
CUL2-247	ENST00000692456	2515	No protein	-
CUL2-211	ENST00000673636	2839	745aa	ENSP00000501215
CUL2-224	ENST00000687524	2738	753aa	ENSP00000510171
CUL2-249	ENST00000693739	2691	242aa	ENSP00000508657
CUL2-248	ENST00000692866	3623	No protein	-
CUL2-219	ENST00000686302	1707	472aa	ENSP00000510342
CUL2-216	ENST00000685681	2792	166aa	ENSP00000508572
CUL2-206	ENST00000421317	2646	764aa	ENSP00000414095
CUL2-213	ENST00000684965	2238	256aa	ENSP00000509100
CUL2-242	ENST00000691457	3182	141aa	ENSP00000509618
CUL2-228	ENST00000688541	2183	242aa	ENSP00000509171
CUL2-234	ENST00000689705	643	101aa	ENSP00000508869
CUL2-233	ENST00000689330	1734	249aa	ENSP00000509501
CUL2-218	ENST00000686271	582	No protein	-
CUL2-220	ENST00000686748	895	148aa	ENSP00000509655
CUL2-238	ENST00000690789	883	112aa	ENSP00000510162
CUL2-215	ENST00000685488	1073	49aa	ENSP00000510204
CUL2-243	ENST00000691635	796	238aa	ENSP00000509428
CUL2-221	ENST00000686903	1147	249aa	ENSP00000508936
CUL2-212	ENST00000684955	777	87aa	ENSP00000508946
CUL2-207	ENST00000468804	712	141aa	ENSP00000509962
CUL2-214	ENST00000685421	699	204aa	ENSP00000509605
CUL2-217	ENST00000686156	847	204aa	ENSP00000509166
CUL2-231	ENST00000688736	948	204aa	ENSP00000510643
CUL2-208	ENST00000478044	483	78aa	ENSP00000509576

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
13328	Parkinson Disease	3.32E-5	19915575
13349	Parkinson Disease	1.48E-5	19915575
13350	Parkinson Disease	2.68E-5	19915575
13358	Parkinson Disease	2.13E-5	19915575
13365	Parkinson Disease	2.2E-5	19915575
13366	Parkinson Disease	1.43E-5	19915575
13374	Parkinson Disease	2.14E-5	19915575
13375	Parkinson Disease	2.31E-5	19915575

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000082	involved_in G1/S transition of mitotic cell cycle	1	TAS	Homo_sapiens(9606)	Process
GO:0004842	enables ubiquitin-protein transferase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005730	located_in nucleolus	1	IEA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0016567	involved_in protein ubiquitination	3	IBA,IEA,TAS	Homo_sapiens(9606)	Process
GO:0019005	part_of SCF ubiquitin ligase complex	1	IBA	Homo_sapiens(9606)	Component
GO:0030674	enables protein-macromolecule adaptor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0030891	part_of VCB complex	1	IEA	Homo_sapiens(9606)	Component
GO:0031146	involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0031462	part_of Cul2-RING ubiquitin ligase complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0031625	enables ubiquitin protein ligase binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0044877	enables protein-containing complex binding	1	IEA	Homo_sapiens(9606)	Function
GO:0097193	involved_in intrinsic apoptotic signaling pathway	1	TAS	Homo_sapiens(9606)	Process