RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000107854	Gene ID	80351	Accession	15677
Symbol	TNKS2	Alias	TNKL;ARTD6;TANK2;pART6;PARP5B;PARP5C;PARP-5b;PARP-5c	Full Name	tankyrase 2
Status	Confidence	Length	67050 bases	Strand	Plus strand
Position	10 : 91798426 - 91865475	RNA binding domain	PARP
Summary	Enables NAD+ ADP-ribosyltransferase activity; enzyme binding activity; and protein ADP-ribosylase activity. Involved in several processes, including protein ADP-ribosylation; protein localization to chromosome, telomeric region; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000360689	PARP	PF00644	2.2e-24	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
TNKS2-201	ENST00000371627	6242	1166aa	ENSP00000360689
TNKS2-202	ENST00000710380	6242	1179aa	ENSP00000518237

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000139	located_in Golgi membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0000209	involved_in protein polyubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0000242	located_in pericentriolar material	1	IDA	Homo_sapiens(9606)	Component
GO:0000781	located_in chromosome, telomeric region	1	TAS	Homo_sapiens(9606)	Component
GO:0003950	enables NAD+ ADP-ribosyltransferase activity	3	IBA,IDA,TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005635	located_in nuclear envelope	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0016055	involved_in Wnt signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0016779	enables nucleotidyltransferase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0019899	enables enzyme binding	1	IPI	Homo_sapiens(9606)	Function
GO:0032212	involved_in positive regulation of telomere maintenance via telomerase	1	TAS	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0048471	located_in perinuclear region of cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0070198	involved_in protein localization to chromosome, telomeric region	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0070212	involved_in protein poly-ADP-ribosylation	1	IDA	Homo_sapiens(9606)	Process
GO:0070213	involved_in protein auto-ADP-ribosylation	1	IDA	Homo_sapiens(9606)	Process
GO:0090263	involved_in positive regulation of canonical Wnt signaling pathway	3	IBA,IMP,TAS	Homo_sapiens(9606)	Process
GO:1904355	involved_in positive regulation of telomere capping	3	IBA,IDA,IMP	Homo_sapiens(9606)	Process
GO:1904357	involved_in negative regulation of telomere maintenance via telomere lengthening	1	IMP	Homo_sapiens(9606)	Process
GO:1990404	enables NAD+-protein ADP-ribosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function