RBPWorld - a comprehensive database of RNA Binding Proteins

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Functions and Diseases

RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Description

Ensembl ID	ENSG00000106348	Gene ID	3614	Accession	6052
Symbol	IMPDH1	Alias	IMPD;RP10;IMPD1;LCA11;IMPDH-I;sWSS2608	Full Name	inosine monophosphate dehydrogenase 1
Status	Confidence	Length	17976 bases	Strand	Minus strand
Position	7 : 128392277 - 128410252	RNA binding domain	N.A.
Summary	The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

RNA binding domains (RBDs)

Protein	Domain	Pfam ID	E-value	Domain number

RNA binding proteomes (RBPomes)

Pubmed ID	Full Name	Cell	Author	Time	Doi

Literatures on RNA binding capacity

Pubmed ID	Title	Author	Time	Journal

Transcripts

Name	Transcript ID	bp	Protein	Translation ID
IMPDH1-207	ENST00000469328	2295	190aa	ENSP00000420756
IMPDH1-211	ENST00000484496	2422	No protein	-
IMPDH1-204	ENST00000419067	2431	566aa	ENSP00000399400
IMPDH1-201	ENST00000338791	2611	599aa	ENSP00000345096
IMPDH1-202	ENST00000348127	2503	563aa	ENSP00000265385
IMPDH1-214	ENST00000496200	2283	489aa	ENSP00000420803
IMPDH1-203	ENST00000354269	2580	589aa	ENSP00000346219
IMPDH1-208	ENST00000470772	1888	513aa	ENSP00000417296
IMPDH1-217	ENST00000648462	1606	509aa	ENSP00000496892
IMPDH1-210	ENST00000480861	1765	509aa	ENSP00000420185
IMPDH1-205	ENST00000460045	671	No protein	-
IMPDH1-216	ENST00000497868	952	289aa	ENSP00000419609
IMPDH1-206	ENST00000468842	587	No protein	-
IMPDH1-212	ENST00000489263	598	184aa	ENSP00000418592
IMPDH1-215	ENST00000496487	544	No protein	-
IMPDH1-213	ENST00000491376	748	No protein	-
IMPDH1-209	ENST00000473463	590	69aa	ENSP00000420469

Gene Model

Click here to download ENSG00000106348's gene model file

Pathways

Pathway ID	Pathway Name	Source

Phenotypes

ensgID	Trait	pValue	Pubmed ID

GWAS

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Protein-Protein Interaction (PPI)

Click here to download ENSG00000106348's PPI file

Paralogs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Orthologs

Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Gene Ontology

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000166	enables nucleotide binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003676	enables nucleic acid binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003677	enables DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003938	enables IMP dehydrogenase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005576	located_in extracellular region	1	TAS	Homo_sapiens(9606)	Component
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006177	involved_in GMP biosynthetic process	1	IEA	Homo_sapiens(9606)	Process
GO:0006183	involved_in GTP biosynthetic process	1	IBA	Homo_sapiens(9606)	Process
GO:0034774	located_in secretory granule lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0035578	located_in azurophil granule lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:1904813	located_in ficolin-1-rich granule lumen	1	TAS	Homo_sapiens(9606)	Component

Expression