RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000106268	Gene ID	4521	Accession	8048
Symbol	NUDT1	Alias	MTH1	Full Name	nudix hydrolase 1
Status	Confidence	Length	8920 bases	Strand	Plus strand
Position	7 : 2242226 - 2251145	RNA binding domain	N.A.
Summary	Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
NUDT1-203	ENST00000356714	658	156aa	ENSP00000349148
NUDT1-204	ENST00000397046	712	156aa	ENSP00000380239
NUDT1-205	ENST00000397048	783	179aa	ENSP00000380241
NUDT1-207	ENST00000454650	822	37aa	ENSP00000405334
NUDT1-201	ENST00000339737	698	156aa	ENSP00000343439
NUDT1-202	ENST00000343985	771	179aa	ENSP00000339503
NUDT1-206	ENST00000397049	714	156aa	ENSP00000380242
NUDT1-208	ENST00000471348	263	No protein	-
NUDT1-209	ENST00000487426	872	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001669	located_in acrosomal vesicle	1	IEA	Homo_sapiens(9606)	Component
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005615	located_in extracellular space	1	IEA	Homo_sapiens(9606)	Component
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005739	located_in mitochondrion	1	IDA	Homo_sapiens(9606)	Component
GO:0005759	located_in mitochondrial matrix	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006152	involved_in purine nucleoside catabolic process	1	IDA	Homo_sapiens(9606)	Process
GO:0006281	involved_in DNA repair	1	IC	Homo_sapiens(9606)	Process
GO:0006979	involved_in response to oxidative stress	1	TAS	Homo_sapiens(9606)	Process
GO:0008413	enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0008584	involved_in male gonad development	1	IEA	Homo_sapiens(9606)	Process
GO:0008828	enables dATP diphosphatase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0016818	enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1	IDA	Homo_sapiens(9606)	Function
GO:0030515	enables snoRNA binding	1	ISS	Homo_sapiens(9606)	Function
GO:0031965	located_in nuclear membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0035539	enables 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0042262	involved_in DNA protection	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0046686	involved_in response to cadmium ion	1	IEA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0047693	enables ATP diphosphatase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0106377	enables 2-hydroxy-ATP hydrolase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0106378	enables 2-hydroxy-dATP hydrolase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0106431	enables N6-methyl-(d)ATP hydrolase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0106433	enables O6-methyl-dGTP hydrolase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0140933	NOT enables 5-(N(7)-methylguanosine 5-triphospho)-[mRNA] hydrolase activity	1	ISS	Homo_sapiens(9606)	Function