Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000105329 Gene ID 7040 Accession 11766
Symbol TGFB1 Alias CED;LAP;DPD1;TGFB;IBDIMDE;TGFbeta;TGF-beta1 Full Name transforming growth factor beta 1
Status Confidence Length 23600 bases Strand Minus strand
Position 19 : 41330323 - 41353922 RNA binding domain N.A.
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
33941855 The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling. Panagiotis Papoutsoglou 2021-05-01 Oncogene

Transcripts

Name Transcript ID bp Protein Translation ID
TGFB1-203 ENST00000598758 559 No protein -
TGFB1-201 ENST00000221930 2780 390aa ENSP00000221930
TGFB1-204 ENST00000600196 1250 370aa ENSP00000504008
TGFB1-205 ENST00000677934 1084 306aa ENSP00000504769
TGFB1-202 ENST00000597453 392 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
65091Colorectal Neoplasms1E-824836286
88167Migraine Disorders8E-723793025
91636Colorectal Neoplasms4E-727145994
102510Colorectal Neoplasms1E-826965516

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000165involved_in MAPK cascade1IMPHomo_sapiens(9606)Process
GO:0001570involved_in vasculogenesis1ISSHomo_sapiens(9606)Process
GO:0001837acts_upstream_of_or_within epithelial to mesenchymal transition2IDAHomo_sapiens(9606)Process
GO:0001843involved_in neural tube closure1ISSHomo_sapiens(9606)Process
GO:0001933involved_in negative regulation of protein phosphorylation1IDAHomo_sapiens(9606)Process
GO:0001934involved_in positive regulation of protein phosphorylation1IDAHomo_sapiens(9606)Process
GO:0002040acts_upstream_of sprouting angiogenesis1IMPHomo_sapiens(9606)Process
GO:0002062involved_in chondrocyte differentiation1IDAHomo_sapiens(9606)Process
GO:0002244involved_in hematopoietic progenitor cell differentiation1IDAHomo_sapiens(9606)Process
GO:0002248involved_in connective tissue replacement involved in inflammatory response wound healing1TASHomo_sapiens(9606)Process
GO:0002859involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target1IDAHomo_sapiens(9606)Process
GO:0003179involved_in heart valve morphogenesis1ISSHomo_sapiens(9606)Process
GO:0003180involved_in aortic valve morphogenesis1IMPHomo_sapiens(9606)Process
GO:0003823enables antigen binding1IPIHomo_sapiens(9606)Function
GO:0005114enables type II transforming growth factor beta receptor binding3IDA,IMP,IPIHomo_sapiens(9606)Function
GO:0005125enables cytokine activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1TASHomo_sapiens(9606)Component
GO:0005615is_active_in extracellular space3IBA,IC,IDAHomo_sapiens(9606)Component
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005796located_in Golgi lumen1TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1TASHomo_sapiens(9606)Component
GO:0005902colocalizes_with microvillus1IDAHomo_sapiens(9606)Component
GO:0006611involved_in protein export from nucleus1IDAHomo_sapiens(9606)Process
GO:0006754involved_in ATP biosynthetic process1IDAHomo_sapiens(9606)Process
GO:0006796involved_in phosphate-containing compound metabolic process1IDAHomo_sapiens(9606)Process
GO:0006954involved_in inflammatory response1IDAHomo_sapiens(9606)Process
GO:0007173involved_in epidermal growth factor receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0007179involved_in transforming growth factor beta receptor signaling pathway3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0007435involved_in salivary gland morphogenesis1IEPHomo_sapiens(9606)Process
GO:0007507involved_in heart development1ISSHomo_sapiens(9606)Process
GO:0008083enables growth factor activity1IMPHomo_sapiens(9606)Function
GO:0008284involved_in positive regulation of cell population proliferation2IDA,IMPHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation2IDA,IMPHomo_sapiens(9606)Process
GO:0009611involved_in response to wounding1IEPHomo_sapiens(9606)Process
GO:0009986located_in cell surface1IMPHomo_sapiens(9606)Component
GO:0010575involved_in positive regulation of vascular endothelial growth factor production1TASHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression4IDA,IGI,IMP,ISSHomo_sapiens(9606)Process
GO:0010629acts_upstream_of_or_within negative regulation of gene expression5IDA,IGI,ISSHomo_sapiens(9606)Process
GO:0010716involved_in negative regulation of extracellular matrix disassembly1TASHomo_sapiens(9606)Process
GO:0010718involved_in positive regulation of epithelial to mesenchymal transition2IDA,NASHomo_sapiens(9606)Process
GO:0010742involved_in macrophage derived foam cell differentiation1ICHomo_sapiens(9606)Process
GO:0010763involved_in positive regulation of fibroblast migration1IDAHomo_sapiens(9606)Process
GO:0010800involved_in positive regulation of peptidyl-threonine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0010862involved_in positive regulation of pathway-restricted SMAD protein phosphorylation1IDAHomo_sapiens(9606)Process
GO:0010936involved_in negative regulation of macrophage cytokine production1IDAHomo_sapiens(9606)Process
GO:0014008involved_in positive regulation of microglia differentiation1ISSHomo_sapiens(9606)Process
GO:0016202involved_in regulation of striated muscle tissue development1ISSHomo_sapiens(9606)Process
GO:0016477involved_in cell migration1IDAHomo_sapiens(9606)Process
GO:0017015involved_in regulation of transforming growth factor beta receptor signaling pathway1IDAHomo_sapiens(9606)Process
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0021915involved_in neural tube development1ISSHomo_sapiens(9606)Process
GO:0022408involved_in negative regulation of cell-cell adhesion1IDAHomo_sapiens(9606)Process
GO:0030214involved_in hyaluronan catabolic process1IDAHomo_sapiens(9606)Process
GO:0030308involved_in negative regulation of cell growth1IDAHomo_sapiens(9606)Process
GO:0030334involved_in regulation of cell migration1TASHomo_sapiens(9606)Process
GO:0030335involved_in positive regulation of cell migration2IDA,IMPHomo_sapiens(9606)Process
GO:0031012located_in extracellular matrix1ISSHomo_sapiens(9606)Component
GO:0031093located_in platelet alpha granule lumen1TASHomo_sapiens(9606)Component
GO:0031293involved_in membrane protein intracellular domain proteolysis1IDAHomo_sapiens(9606)Process
GO:0031334involved_in positive regulation of protein-containing complex assembly1IDAHomo_sapiens(9606)Process
GO:0031663involved_in lipopolysaccharide-mediated signaling pathway1IDAHomo_sapiens(9606)Process
GO:0032355involved_in response to estradiol1IDAHomo_sapiens(9606)Process
GO:0032570involved_in response to progesterone1IDAHomo_sapiens(9606)Process
GO:0032740involved_in positive regulation of interleukin-17 production1IDAHomo_sapiens(9606)Process
GO:0032755acts_upstream_of positive regulation of interleukin-6 production2IMPHomo_sapiens(9606)Process
GO:0032760involved_in positive regulation of tumor necrosis factor production1IMPHomo_sapiens(9606)Process
GO:0032801involved_in receptor catabolic process1IDAHomo_sapiens(9606)Process
GO:0032930involved_in positive regulation of superoxide anion generation1IDAHomo_sapiens(9606)Process
GO:0032967involved_in positive regulation of collagen biosynthetic process3IDA,IGI,IMPHomo_sapiens(9606)Process
GO:0033138involved_in positive regulation of peptidyl-serine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0034713enables type I transforming growth factor beta receptor binding2IMP,IPIHomo_sapiens(9606)Function
GO:0034714enables type III transforming growth factor beta receptor binding2IMP,IPIHomo_sapiens(9606)Function
GO:0035307involved_in positive regulation of protein dephosphorylation1IDAHomo_sapiens(9606)Process
GO:0035800enables deubiquitinase activator activity1IDAHomo_sapiens(9606)Function
GO:0042127involved_in regulation of cell population proliferation1IBAHomo_sapiens(9606)Process
GO:0042306involved_in regulation of protein import into nucleus1ISSHomo_sapiens(9606)Process
GO:0042307involved_in positive regulation of protein import into nucleus1IDAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043117involved_in positive regulation of vascular permeability1IDAHomo_sapiens(9606)Process
GO:0043406involved_in positive regulation of MAP kinase activity1IDAHomo_sapiens(9606)Process
GO:0043491involved_in protein kinase B signaling1IMPHomo_sapiens(9606)Process
GO:0043536involved_in positive regulation of blood vessel endothelial cell migration1IDAHomo_sapiens(9606)Process
GO:0043537involved_in negative regulation of blood vessel endothelial cell migration1IDAHomo_sapiens(9606)Process
GO:0043552involved_in positive regulation of phosphatidylinositol 3-kinase activity1IDAHomo_sapiens(9606)Process
GO:0045066involved_in regulatory T cell differentiation1IDAHomo_sapiens(9606)Process
GO:0045216involved_in cell-cell junction organization1IDAHomo_sapiens(9606)Process
GO:0045596involved_in negative regulation of cell differentiation1IEPHomo_sapiens(9606)Process
GO:0045599involved_in negative regulation of fat cell differentiation1IDAHomo_sapiens(9606)Process
GO:0045662involved_in negative regulation of myoblast differentiation1IDAHomo_sapiens(9606)Process
GO:0045786involved_in negative regulation of cell cycle1IDAHomo_sapiens(9606)Process
GO:0045892involved_in negative regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription2IDA,ISSHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0048298acts_upstream_of_or_within positive regulation of isotype switching to IgA isotypes1IDAHomo_sapiens(9606)Process
GO:0048535involved_in lymph node development1ISSHomo_sapiens(9606)Process
GO:0048642involved_in negative regulation of skeletal muscle tissue development1IDAHomo_sapiens(9606)Process
GO:0048661involved_in positive regulation of smooth muscle cell proliferation1IDAHomo_sapiens(9606)Process
GO:0050680involved_in negative regulation of epithelial cell proliferation2IDA,IMPHomo_sapiens(9606)Process
GO:0050714involved_in positive regulation of protein secretion1IDAHomo_sapiens(9606)Process
GO:0050729involved_in positive regulation of inflammatory response1IMPHomo_sapiens(9606)Process
GO:0050731involved_in positive regulation of peptidyl-tyrosine phosphorylation1IDAHomo_sapiens(9606)Process
GO:0050921involved_in positive regulation of chemotaxis1IDAHomo_sapiens(9606)Process
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity1IMPHomo_sapiens(9606)Process
GO:0051247involved_in positive regulation of protein metabolic process1IDAHomo_sapiens(9606)Process
GO:0051781involved_in positive regulation of cell division1IEAHomo_sapiens(9606)Process
GO:0051897involved_in positive regulation of protein kinase B signaling1IDAHomo_sapiens(9606)Process
GO:0055010involved_in ventricular cardiac muscle tissue morphogenesis1ISSHomo_sapiens(9606)Process
GO:0060312involved_in regulation of blood vessel remodeling2NAS,TASHomo_sapiens(9606)Process
GO:0060389involved_in pathway-restricted SMAD protein phosphorylation1IDAHomo_sapiens(9606)Process
GO:0060390involved_in regulation of SMAD protein signal transduction1IDAHomo_sapiens(9606)Process
GO:0060391involved_in positive regulation of SMAD protein signal transduction1IDAHomo_sapiens(9606)Process
GO:0061912involved_in selective autophagy1IMPHomo_sapiens(9606)Process
GO:0062023located_in collagen-containing extracellular matrix1HDAHomo_sapiens(9606)Component
GO:0070168involved_in negative regulation of biomineral tissue development1IDAHomo_sapiens(9606)Process
GO:0070374involved_in positive regulation of ERK1 and ERK2 cascade1IDAHomo_sapiens(9606)Process
GO:0070723involved_in response to cholesterol1IDAHomo_sapiens(9606)Process
GO:0071404involved_in cellular response to low-density lipoprotein particle stimulus1IMPHomo_sapiens(9606)Process
GO:0071407involved_in cellular response to organic cyclic compound1IDAHomo_sapiens(9606)Process
GO:0071456involved_in cellular response to hypoxia1IMPHomo_sapiens(9606)Process
GO:0071560involved_in cellular response to transforming growth factor beta stimulus2IDA,IGIHomo_sapiens(9606)Process
GO:0072562located_in blood microparticle1HDAHomo_sapiens(9606)Component
GO:0085029involved_in extracellular matrix assembly1IDAHomo_sapiens(9606)Process
GO:0090263involved_in positive regulation of canonical Wnt signaling pathway2IDA,IMPHomo_sapiens(9606)Process
GO:0097191involved_in extrinsic apoptotic signaling pathway1IDAHomo_sapiens(9606)Process
GO:1900126involved_in negative regulation of hyaluronan biosynthetic process1IDAHomo_sapiens(9606)Process
GO:1900182involved_in positive regulation of protein localization to nucleus1IDAHomo_sapiens(9606)Process
GO:1901203acts_upstream_of positive regulation of extracellular matrix assembly2ISS,TASHomo_sapiens(9606)Process
GO:1901666involved_in positive regulation of NAD+ ADP-ribosyltransferase activity1IDAHomo_sapiens(9606)Process
GO:1902893NOT involved_in regulation of miRNA transcription1IMPHomo_sapiens(9606)Process
GO:1902894involved_in negative regulation of miRNA transcription1IMPHomo_sapiens(9606)Process
GO:1902895involved_in positive regulation of miRNA transcription1IDAHomo_sapiens(9606)Process
GO:1903077involved_in negative regulation of protein localization to plasma membrane1IDAHomo_sapiens(9606)Process
GO:1904894involved_in positive regulation of receptor signaling pathway via STAT1IDAHomo_sapiens(9606)Process
GO:1905005NOT involved_in regulation of epithelial to mesenchymal transition involved in endocardial cushion formation1ISSHomo_sapiens(9606)Process
GO:1905313involved_in transforming growth factor beta receptor signaling pathway involved in heart development1ISSHomo_sapiens(9606)Process
GO:1990402involved_in embryonic liver development1ISSHomo_sapiens(9606)Process
GO:2000343involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production1IMPHomo_sapiens(9606)Process
GO:2000353involved_in positive regulation of endothelial cell apoptotic process1IMPHomo_sapiens(9606)Process
GO:2000636involved_in positive regulation of primary miRNA processing1IDAHomo_sapiens(9606)Process
GO:2000679involved_in positive regulation of transcription regulatory region DNA binding1IDAHomo_sapiens(9606)Process
GO:2000727involved_in positive regulation of cardiac muscle cell differentiation1IDAHomo_sapiens(9606)Process

Expression