RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000104884	Gene ID	2068	Accession	3434
Symbol	ERCC2	Alias	EM9;TTD;XPD;TTD1;COFS2;TFIIH	Full Name	ERCC excision repair 2, TFIIH core complex helicase subunit
Status	Confidence	Length	21082 bases	Strand	Minus strand
Position	19 : 45349837 - 45370918	RNA binding domain	ResIII
Summary	The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]