Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Transmemebrane
Localizations Nucleoli
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000104691 Gene ID 7993 Accession 30307
Symbol UBXN8 Alias REP8;UBXD6;D8S2298E Full Name UBX domain protein 8
Status Confidence Length 37876 bases Strand Plus strand
Position 8 : 30729131 - 30767006 RNA binding domain RNase_H
Summary p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000483433 RNase_H PF00075 1e-06 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
UBXN8-209 ENST00000620074 1991 310aa ENSP00000477532
UBXN8-205 ENST00000522968 813 248aa ENSP00000483433
UBXN8-208 ENST00000616306 571 No protein -
UBXN8-201 ENST00000265616 1451 270aa ENSP00000479216
UBXN8-203 ENST00000380154 1624 42aa ENSP00000482772
UBXN8-202 ENST00000341403 1202 229aa ENSP00000478502
UBXN8-207 ENST00000615729 702 233aa ENSP00000481635
UBXN8-204 ENST00000518059 493 94aa ENSP00000480065
UBXN8-210 ENST00000620706 654 No protein -
UBXN8-206 ENST00000613013 528 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000104691homo_sapiensENSP0000037945719.230812.3077homo_sapiensENSP0000047921646.296329.6296
ENSG00000104691homo_sapiensENSP0000026194221.348310.1124homo_sapiensENSP0000047921635.185216.6667
ENSG00000104691homo_sapiensENSP0000029632817.99599.20245homo_sapiensENSP0000047921632.592616.6667
ENSG00000104691homo_sapiensENSP0000036424022.857111.7857homo_sapiensENSP0000047921623.703712.2222

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000104691homo_sapiensENSP0000047921688.888987.7778nomascus_leucogenysENSNLEP0000004398384.50783.4507
ENSG00000104691homo_sapiensENSP0000047921690.370490pan_paniscusENSPPAP0000002188481.879281.5436
ENSG00000104691homo_sapiensENSP0000047921695.925995.9259pongo_abeliiENSPPYP0000002072696.641896.6418
ENSG00000104691homo_sapiensENSP0000047921691.111190.7407pan_troglodytesENSPTRP0000008003880.655780.3279
ENSG00000104691homo_sapiensENSP000004792169088.5185gorilla_gorillaENSGGOP0000004552978.640877.3463
ENSG00000104691homo_sapiensENSP0000047921669.629652.5926ornithorhynchus_anatinusENSOANP0000005378459.119544.6541
ENSG00000104691homo_sapiensENSP0000047921665.925952.963sarcophilus_harrisiiENSSHAP0000001014554.434243.7309
ENSG00000104691homo_sapiensENSP0000047921681.111173.7037choloepus_hoffmanniENSCHOP0000000545180.811873.4317
ENSG00000104691homo_sapiensENSP0000047921685.555674.8148dasypus_novemcinctusENSDNOP0000001257684.306673.7226
ENSG00000104691homo_sapiensENSP0000047921681.851969.2593dasypus_novemcinctusENSDNOP0000003478682.771570.0375
ENSG00000104691homo_sapiensENSP0000047921676.666767.037echinops_telfairiENSETEP0000001477975.547466.0584
ENSG00000104691homo_sapiensENSP0000047921692.592690callithrix_jacchusENSCJAP0000005480692.592690
ENSG00000104691homo_sapiensENSP0000047921696.296395.1852cercocebus_atysENSCATP0000004240396.654395.539
ENSG00000104691homo_sapiensENSP0000047921696.666795.9259macaca_fascicularisENSMFAP0000003886196.666795.9259
ENSG00000104691homo_sapiensENSP0000047921691.481589.2593macaca_mulattaENSMMUP0000005655764.490962.9243
ENSG00000104691homo_sapiensENSP0000047921678.518574.8148macaca_nemestrinaENSMNEP0000002921084.462280.4781
ENSG00000104691homo_sapiensENSP0000047921696.666795.5556papio_anubisENSPANP0000001858883.922882.9582
ENSG00000104691homo_sapiensENSP0000047921696.666794.8148mandrillus_leucophaeusENSMLEP0000002753596.666794.8148
ENSG00000104691homo_sapiensENSP0000047921674.074167.4074tursiops_truncatusENSTTRP0000000009373.260166.6667
ENSG00000104691homo_sapiensENSP0000047921690.740784.0741vulpes_vulpesENSVVUP0000002699765.333360.5333
ENSG00000104691homo_sapiensENSP0000047921684.074174.4444mus_spretusMGP_SPRETEiJ_P008762082.246472.8261
ENSG00000104691homo_sapiensENSP0000047921688.518581.1111equus_asinusENSEASP0000502492386.594279.3478
ENSG00000104691homo_sapiensENSP0000047921681.851974.8148capra_hircusENSCHIP0000002516480.072573.1884
ENSG00000104691homo_sapiensENSP0000047921688.148178.1481loxodonta_africanaENSLAFP0000000558786.231976.4493
ENSG00000104691homo_sapiensENSP0000047921689.629683.3333panthera_leoENSPLOP0000000225887.681281.5217
ENSG00000104691homo_sapiensENSP0000047921670.740764.0741panthera_leoENSPLOP0000001503585.267977.2321
ENSG00000104691homo_sapiensENSP0000047921690.370483.3333ailuropoda_melanoleucaENSAMEP0000000168788.405881.5217
ENSG00000104691homo_sapiensENSP0000047921688.518581.4815bos_indicus_hybridENSBIXP0000500546386.909180
ENSG00000104691homo_sapiensENSP0000047921679.259370oryctolagus_cuniculusENSOCUP0000003765743.852538.7295
ENSG00000104691homo_sapiensENSP0000047921687.777880.3704equus_caballusENSECAP0000001072386.813279.4872
ENSG00000104691homo_sapiensENSP000004792169083.3333canis_lupus_familiarisENSCAFP0084502272788.363681.8182
ENSG00000104691homo_sapiensENSP0000047921689.259382.963panthera_pardusENSPPRP0000002759287.318881.1594
ENSG00000104691homo_sapiensENSP0000047921674.074167.037marmota_marmota_marmotaENSMMMP0000001593379.365171.8254
ENSG00000104691homo_sapiensENSP0000047921689.259381.1111balaenoptera_musculusENSBMSP0001001961587.956279.927
ENSG00000104691homo_sapiensENSP0000047921681.111168.5185cavia_porcellusENSCPOP0000002867679.636467.2727
ENSG00000104691homo_sapiensENSP000004792169083.3333felis_catusENSFCAP0000004060088.043581.5217
ENSG00000104691homo_sapiensENSP0000047921675.555669.2593ursus_americanusENSUAMP0000002758686.808579.5745
ENSG00000104691homo_sapiensENSP0000047921664.074149.6296monodelphis_domesticaENSMODP0000005690348.459437.535
ENSG00000104691homo_sapiensENSP0000047921688.518582.2222bison_bison_bisonENSBBBP0000001362886.909180.7273
ENSG00000104691homo_sapiensENSP0000047921688.148180monodon_monocerosENSMMNP0001501358286.545578.5455
ENSG00000104691homo_sapiensENSP0000047921687.777879.2593sus_scrofaENSSSCP0000001678985.869677.5362
ENSG00000104691homo_sapiensENSP0000047921692.222287.037microcebus_murinusENSMICP0000003784490.217485.1449
ENSG00000104691homo_sapiensENSP0000047921680.370471.4815octodon_degusENSODEP0000000582080.073871.2177
ENSG00000104691homo_sapiensENSP0000047921680.370470.3704jaculus_jaculusENSJJAP0000000683382.19771.9697
ENSG00000104691homo_sapiensENSP0000047921688.888982.5926ovis_aries_rambouilletENSOARP0002000851287.272781.0909
ENSG00000104691homo_sapiensENSP000004792169082.963ursus_maritimusENSUMAP0000000954588.043581.1594
ENSG00000104691homo_sapiensENSP0000047921682.96375.1852ochotona_princepsENSOPRP0000001472982.051374.359
ENSG00000104691homo_sapiensENSP0000047921688.148180.3704delphinapterus_leucasENSDLEP0000000872786.545578.9091
ENSG00000104691homo_sapiensENSP0000047921687.407480.7407physeter_catodonENSPCTP0000502814785.818279.2727
ENSG00000104691homo_sapiensENSP0000047921684.814874.8148mus_caroliMGP_CAROLIEiJ_P008414782.671572.9242
ENSG00000104691homo_sapiensENSP0000047921684.444474.0741mus_musculusENSMUSP0000009299282.310572.2022
ENSG00000104691homo_sapiensENSP0000047921672.96365.5556dipodomys_ordiiENSDORP0000001888983.829875.3191
ENSG00000104691homo_sapiensENSP0000047921635.185231.4815mustela_putorius_furoENSMPUP0000001016181.896673.2759
ENSG00000104691homo_sapiensENSP0000047921688.518585.1852aotus_nancymaaeENSANAP0000001080293.725590.1961
ENSG00000104691homo_sapiensENSP0000047921670.740768.8889saimiri_boliviensis_boliviensisENSSBOP0000002316393.170790.7317
ENSG00000104691homo_sapiensENSP0000047921674.814867.4074vicugna_pacosENSVPAP0000001024173.722666.4234
ENSG00000104691homo_sapiensENSP0000047921696.666794.4444chlorocebus_sabaeusENSCSAP0000001190897.02694.7955
ENSG00000104691homo_sapiensENSP0000047921632.222225.1852tupaia_belangeriENSTBEP000000056425039.0805
ENSG00000104691homo_sapiensENSP0000047921686.296375.1852mesocricetus_auratusENSMAUP0000001315984.420373.5507
ENSG00000104691homo_sapiensENSP0000047921688.148180.3704phocoena_sinusENSPSNP0000002595686.545578.9091
ENSG00000104691homo_sapiensENSP0000047921688.888980.3704camelus_dromedariusENSCDRP0000502701987.272778.9091
ENSG00000104691homo_sapiensENSP0000047921679.629675.5556carlito_syrichtaENSTSYP0000000122487.044582.5911
ENSG00000104691homo_sapiensENSP0000047921689.629683.3333panthera_tigris_altaicaENSPTIP0000000613787.681281.5217
ENSG00000104691homo_sapiensENSP0000047921686.296375.1852rattus_norvegicusENSRNOP0000002034784.420373.5507
ENSG00000104691homo_sapiensENSP0000047921685.555681.1111prolemur_simusENSPSMP0000001099287.169882.6415
ENSG00000104691homo_sapiensENSP0000047921672.592663.3333microtus_ochrogasterENSMOCP0000000388388.288377.027
ENSG00000104691homo_sapiensENSP0000047921649.629645.5556sorex_araneusENSSARP0000001150381.212174.5455
ENSG00000104691homo_sapiensENSP0000047921687.407477.4074peromyscus_maniculatus_bairdiiENSPEMP0000002359985.198675.4513
ENSG00000104691homo_sapiensENSP0000047921688.518582.2222bos_mutusENSBMUP0000002354286.909180.7273
ENSG00000104691homo_sapiensENSP0000047921683.333373.3333mus_spicilegusENSMSIP0000000879482.116872.2628
ENSG00000104691homo_sapiensENSP0000047921684.074173.3333mus_spicilegusENSMSIP0000003085081.949571.4801
ENSG00000104691homo_sapiensENSP0000047921686.666776.2963cricetulus_griseus_chok1gshdENSCGRP0000102719884.782674.6377
ENSG00000104691homo_sapiensENSP000004792167064.4444pteropus_vampyrusENSPVAP0000001659370.260264.684
ENSG00000104691homo_sapiensENSP0000047921688.148179.6296myotis_lucifugusENSMLUP0000001535786.545578.1818
ENSG00000104691homo_sapiensENSP0000047921641.481532.963vombatus_ursinusENSVURP0001001568263.276850.2825
ENSG00000104691homo_sapiensENSP0000047921689.629684.0741rhinolophus_ferrumequinumENSRFEP0001000545688.321282.8467
ENSG00000104691homo_sapiensENSP0000047921680.740772.963neovison_visonENSNVIP0000001755978.985571.3768
ENSG00000104691homo_sapiensENSP0000047921688.148181.8519bos_taurusENSBTAP0000006773186.545580.3636
ENSG00000104691homo_sapiensENSP0000047921685.555676.2963heterocephalus_glaber_femaleENSHGLP0000003298484.615475.4579
ENSG00000104691homo_sapiensENSP0000047921696.666795.5556rhinopithecus_bietiENSRBIP0000001462597.02695.9108
ENSG00000104691homo_sapiensENSP0000047921662.222252.5926canis_lupus_dingoENSCAFP0002000127868.852558.1967
ENSG00000104691homo_sapiensENSP0000047921684.444476.6667sciurus_vulgarisENSSVLP0000502473784.444476.6667
ENSG00000104691homo_sapiensENSP0000047921661.851949.2593phascolarctos_cinereusENSPCIP0000002116172.294457.5758
ENSG00000104691homo_sapiensENSP0000047921650.740742.5926procavia_capensisENSPCAP0000000368950.740742.5926
ENSG00000104691homo_sapiensENSP0000047921685.555679.2593nannospalax_galiliENSNGAP0000001594783.695777.5362
ENSG00000104691homo_sapiensENSP0000047921688.518582.2222bos_grunniensENSBGRP0000004002186.909180.7273
ENSG00000104691homo_sapiensENSP0000047921684.074174.8148chinchilla_lanigeraENSCLAP0000000139582.545573.4545
ENSG00000104691homo_sapiensENSP0000047921688.148182.5926cervus_hanglu_yarkandensisENSCHYP0000003511486.545581.0909
ENSG00000104691homo_sapiensENSP0000047921688.518580catagonus_wagneriENSCWAP0000001815186.594278.2609
ENSG00000104691homo_sapiensENSP0000047921687.407478.5185ictidomys_tridecemlineatusENSSTOP0000002369885.198676.5343
ENSG00000104691homo_sapiensENSP000004792168078.1481cebus_imitatorENSCCAP0000001052594.323192.1397
ENSG00000104691homo_sapiensENSP0000047921671.481563.3333urocitellus_parryiiENSUPAP0001002127784.649175
ENSG00000104691homo_sapiensENSP0000047921677.407471.8519moschus_moschiferusENSMMSP0000000138391.266484.7162
ENSG00000104691homo_sapiensENSP0000047921697.03795.1852rhinopithecus_roxellanaENSRROP0000002656397.397895.539
ENSG00000104691homo_sapiensENSP0000047921687.03775.9259mus_pahariMGP_PahariEiJ_P004704583.333372.695
ENSG00000104691homo_sapiensENSP0000047921691.111184.8148propithecus_coquereliENSPCOP0000000846189.130482.971
ENSG00000104691homo_sapiensENSP0000047921630.370414.0741caenorhabditis_elegansH40L08.1.118.46858.55856
ENSG00000104691homo_sapiensENSP0000047921633.703715.1852drosophila_melanogasterFBpp030981419.61218.83621
ENSG00000104691homo_sapiensENSP0000047921627.777814.0741ciona_intestinalisENSCINP0000000862121.929811.1111
ENSG00000104691homo_sapiensENSP000004792166043.3333lepisosteus_oculatusENSLOCP0000001319357.857141.7857
ENSG00000104691homo_sapiensENSP0000047921653.703737.037clupea_harengusENSCHAP0000002316347.854833.0033
ENSG00000104691homo_sapiensENSP0000047921654.814838.1481danio_rerioENSDARP0000013555854.411837.8676
ENSG00000104691homo_sapiensENSP0000047921655.925940carassius_auratusENSCARP0000006583547.484333.9623
ENSG00000104691homo_sapiensENSP0000047921654.814838.8889astyanax_mexicanusENSAMXP0000001026353.818238.1818
ENSG00000104691homo_sapiensENSP0000047921654.074138.1481ictalurus_punctatusENSIPUP0000000306552.898637.3188
ENSG00000104691homo_sapiensENSP0000047921657.777840.3704esox_luciusENSELUP0000001845056.317739.3502
ENSG00000104691homo_sapiensENSP0000047921654.074139.2593electrophorus_electricusENSEEEP0000001780552.707638.2671
ENSG00000104691homo_sapiensENSP0000047921651.111137.7778oncorhynchus_kisutchENSOKIP0000510733048.763336.0424
ENSG00000104691homo_sapiensENSP0000047921657.777841.8519oncorhynchus_mykissENSOMYP0000005874552.525338.0471
ENSG00000104691homo_sapiensENSP0000047921644.814830salmo_salarENSSSAP0000003444835.798823.9645
ENSG00000104691homo_sapiensENSP0000047921657.777841.4815salmo_truttaENSSTUP0000001500756.317740.4332
ENSG00000104691homo_sapiensENSP0000047921658.518537.037xenopus_tropicalisENSXETP0000002069862.450639.5257
ENSG00000104691homo_sapiensENSP0000047921659.629640.7407erpetoichthys_calabaricusENSECRP0000001135357.913739.5683
ENSG00000104691homo_sapiensENSP0000047921657.777841.1111hucho_huchoENSHHUP0000004831856.317740.0722
ENSG00000104691homo_sapiensENSP0000047921657.777839.6296pygocentrus_nattereriENSPNAP0000003558056.115138.4892
ENSG00000104691homo_sapiensENSP0000047921612.22226.2963ciona_savignyiENSCSAVP0000000056010.31255.3125
ENSG00000104691homo_sapiensENSP0000047921617.0378.88889ciona_savignyiENSCSAVP0000000056138.655520.1681
ENSG00000104691homo_sapiensENSP0000047921657.777841.4815oncorhynchus_tshawytschaENSOTSP0000503560054.929639.4366
ENSG00000104691homo_sapiensENSP0000047921657.777841.4815oncorhynchus_tshawytschaENSOTSP0000506298854.929639.4366
ENSG00000104691homo_sapiensENSP0000047921648.888931.4815denticeps_clupeoidesENSDCDP0000004791058.928637.9464
ENSG00000104691homo_sapiensENSP0000047921655.555638.8889cyprinus_carpio_carpioENSCCRP0000013346455.147138.6029
ENSG00000104691homo_sapiensENSP0000047921655.555638.8889sinocyclocheilus_grahamiENSSGRP0000008318755.147138.6029
ENSG00000104691homo_sapiensENSP0000047921659.629640.3704paramormyrops_kingsleyaeENSPKIP0000001102856.690138.3803
ENSG00000104691homo_sapiensENSP0000047921657.777841.4815scleropages_formosusENSSFOP0001500919956.115140.2878
ENSG00000104691homo_sapiensENSP0000047921661.851942.5926leptobrachium_leishanenseENSLLEP0000001817157.586239.6552

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000151part_of ubiquitin ligase complex1ISSHomo_sapiens(9606)Component
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005783is_active_in endoplasmic reticulum2IBA,IDAHomo_sapiens(9606)Component
GO:0005789located_in endoplasmic reticulum membrane1IDAHomo_sapiens(9606)Component
GO:0007338involved_in single fertilization1TASHomo_sapiens(9606)Process
GO:0030433involved_in ubiquitin-dependent ERAD pathway2IBA,IMPHomo_sapiens(9606)Process
GO:0030674enables protein-macromolecule adaptor activity1ISSHomo_sapiens(9606)Function
GO:0043130enables ubiquitin binding1IBAHomo_sapiens(9606)Function

Expression