RBP Type
Canonical_RBPs
Diseases
N.A.
Drug
N.A.
Main interacting RNAs
N.A.
Moonlighting functions
Transmemebrane
Localizations
Nucleoli
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000104691 Gene ID
7993
Accession
30307
Symbol
UBXN8
Alias
REP8;UBXD6;D8S2298E
Full Name
UBX domain protein 8
Status
Confidence
Length
37876 bases
Strand
Plus strand
Position
8 : 30729131 - 30767006
RNA binding domain
RNase_H
Summary
p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000483433
RNase_H
PF00075
1e-06
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
Name
Transcript ID
bp
Protein
Translation ID
UBXN8-209
ENST00000620074
1991
310aa
ENSP00000477532
UBXN8-205
ENST00000522968
813
248aa
ENSP00000483433
UBXN8-208
ENST00000616306
571
No protein
-
UBXN8-201
ENST00000265616
1451
270aa
ENSP00000479216
UBXN8-203
ENST00000380154
1624
42aa
ENSP00000482772
UBXN8-202
ENST00000341403
1202
229aa
ENSP00000478502
UBXN8-207
ENST00000615729
702
233aa
ENSP00000481635
UBXN8-204
ENST00000518059
493
94aa
ENSP00000480065
UBXN8-210
ENST00000620706
654
No protein
-
UBXN8-206
ENST00000613013
528
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000104691 homo_sapiens ENSP00000379457 19.2308 12.3077 homo_sapiens ENSP00000479216 46.2963 29.6296 ENSG00000104691 homo_sapiens ENSP00000261942 21.3483 10.1124 homo_sapiens ENSP00000479216 35.1852 16.6667 ENSG00000104691 homo_sapiens ENSP00000296328 17.9959 9.20245 homo_sapiens ENSP00000479216 32.5926 16.6667 ENSG00000104691 homo_sapiens ENSP00000364240 22.8571 11.7857 homo_sapiens ENSP00000479216 23.7037 12.2222
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000104691 homo_sapiens ENSP00000479216 88.8889 87.7778 nomascus_leucogenys ENSNLEP00000043983 84.507 83.4507 ENSG00000104691 homo_sapiens ENSP00000479216 90.3704 90 pan_paniscus ENSPPAP00000021884 81.8792 81.5436 ENSG00000104691 homo_sapiens ENSP00000479216 95.9259 95.9259 pongo_abelii ENSPPYP00000020726 96.6418 96.6418 ENSG00000104691 homo_sapiens ENSP00000479216 91.1111 90.7407 pan_troglodytes ENSPTRP00000080038 80.6557 80.3279 ENSG00000104691 homo_sapiens ENSP00000479216 90 88.5185 gorilla_gorilla ENSGGOP00000045529 78.6408 77.3463 ENSG00000104691 homo_sapiens ENSP00000479216 69.6296 52.5926 ornithorhynchus_anatinus ENSOANP00000053784 59.1195 44.6541 ENSG00000104691 homo_sapiens ENSP00000479216 65.9259 52.963 sarcophilus_harrisii ENSSHAP00000010145 54.4342 43.7309 ENSG00000104691 homo_sapiens ENSP00000479216 81.1111 73.7037 choloepus_hoffmanni ENSCHOP00000005451 80.8118 73.4317 ENSG00000104691 homo_sapiens ENSP00000479216 85.5556 74.8148 dasypus_novemcinctus ENSDNOP00000012576 84.3066 73.7226 ENSG00000104691 homo_sapiens ENSP00000479216 81.8519 69.2593 dasypus_novemcinctus ENSDNOP00000034786 82.7715 70.0375 ENSG00000104691 homo_sapiens ENSP00000479216 76.6667 67.037 echinops_telfairi ENSETEP00000014779 75.5474 66.0584 ENSG00000104691 homo_sapiens ENSP00000479216 92.5926 90 callithrix_jacchus ENSCJAP00000054806 92.5926 90 ENSG00000104691 homo_sapiens ENSP00000479216 96.2963 95.1852 cercocebus_atys ENSCATP00000042403 96.6543 95.539 ENSG00000104691 homo_sapiens ENSP00000479216 96.6667 95.9259 macaca_fascicularis ENSMFAP00000038861 96.6667 95.9259 ENSG00000104691 homo_sapiens ENSP00000479216 91.4815 89.2593 macaca_mulatta ENSMMUP00000056557 64.4909 62.9243 ENSG00000104691 homo_sapiens ENSP00000479216 78.5185 74.8148 macaca_nemestrina ENSMNEP00000029210 84.4622 80.4781 ENSG00000104691 homo_sapiens ENSP00000479216 96.6667 95.5556 papio_anubis ENSPANP00000018588 83.9228 82.9582 ENSG00000104691 homo_sapiens ENSP00000479216 96.6667 94.8148 mandrillus_leucophaeus ENSMLEP00000027535 96.6667 94.8148 ENSG00000104691 homo_sapiens ENSP00000479216 74.0741 67.4074 tursiops_truncatus ENSTTRP00000000093 73.2601 66.6667 ENSG00000104691 homo_sapiens ENSP00000479216 90.7407 84.0741 vulpes_vulpes ENSVVUP00000026997 65.3333 60.5333 ENSG00000104691 homo_sapiens ENSP00000479216 84.0741 74.4444 mus_spretus MGP_SPRETEiJ_P0087620 82.2464 72.8261 ENSG00000104691 homo_sapiens ENSP00000479216 88.5185 81.1111 equus_asinus ENSEASP00005024923 86.5942 79.3478 ENSG00000104691 homo_sapiens ENSP00000479216 81.8519 74.8148 capra_hircus ENSCHIP00000025164 80.0725 73.1884 ENSG00000104691 homo_sapiens ENSP00000479216 88.1481 78.1481 loxodonta_africana ENSLAFP00000005587 86.2319 76.4493 ENSG00000104691 homo_sapiens ENSP00000479216 89.6296 83.3333 panthera_leo ENSPLOP00000002258 87.6812 81.5217 ENSG00000104691 homo_sapiens ENSP00000479216 70.7407 64.0741 panthera_leo ENSPLOP00000015035 85.2679 77.2321 ENSG00000104691 homo_sapiens ENSP00000479216 90.3704 83.3333 ailuropoda_melanoleuca ENSAMEP00000001687 88.4058 81.5217 ENSG00000104691 homo_sapiens ENSP00000479216 88.5185 81.4815 bos_indicus_hybrid ENSBIXP00005005463 86.9091 80 ENSG00000104691 homo_sapiens ENSP00000479216 79.2593 70 oryctolagus_cuniculus ENSOCUP00000037657 43.8525 38.7295 ENSG00000104691 homo_sapiens ENSP00000479216 87.7778 80.3704 equus_caballus ENSECAP00000010723 86.8132 79.4872 ENSG00000104691 homo_sapiens ENSP00000479216 90 83.3333 canis_lupus_familiaris ENSCAFP00845022727 88.3636 81.8182 ENSG00000104691 homo_sapiens ENSP00000479216 89.2593 82.963 panthera_pardus ENSPPRP00000027592 87.3188 81.1594 ENSG00000104691 homo_sapiens ENSP00000479216 74.0741 67.037 marmota_marmota_marmota ENSMMMP00000015933 79.3651 71.8254 ENSG00000104691 homo_sapiens ENSP00000479216 89.2593 81.1111 balaenoptera_musculus ENSBMSP00010019615 87.9562 79.927 ENSG00000104691 homo_sapiens ENSP00000479216 81.1111 68.5185 cavia_porcellus ENSCPOP00000028676 79.6364 67.2727 ENSG00000104691 homo_sapiens ENSP00000479216 90 83.3333 felis_catus ENSFCAP00000040600 88.0435 81.5217 ENSG00000104691 homo_sapiens ENSP00000479216 75.5556 69.2593 ursus_americanus ENSUAMP00000027586 86.8085 79.5745 ENSG00000104691 homo_sapiens ENSP00000479216 64.0741 49.6296 monodelphis_domestica ENSMODP00000056903 48.4594 37.535 ENSG00000104691 homo_sapiens ENSP00000479216 88.5185 82.2222 bison_bison_bison ENSBBBP00000013628 86.9091 80.7273 ENSG00000104691 homo_sapiens ENSP00000479216 88.1481 80 monodon_monoceros ENSMMNP00015013582 86.5455 78.5455 ENSG00000104691 homo_sapiens ENSP00000479216 87.7778 79.2593 sus_scrofa ENSSSCP00000016789 85.8696 77.5362 ENSG00000104691 homo_sapiens ENSP00000479216 92.2222 87.037 microcebus_murinus ENSMICP00000037844 90.2174 85.1449 ENSG00000104691 homo_sapiens ENSP00000479216 80.3704 71.4815 octodon_degus ENSODEP00000005820 80.0738 71.2177 ENSG00000104691 homo_sapiens ENSP00000479216 80.3704 70.3704 jaculus_jaculus ENSJJAP00000006833 82.197 71.9697 ENSG00000104691 homo_sapiens ENSP00000479216 88.8889 82.5926 ovis_aries_rambouillet ENSOARP00020008512 87.2727 81.0909 ENSG00000104691 homo_sapiens ENSP00000479216 90 82.963 ursus_maritimus ENSUMAP00000009545 88.0435 81.1594 ENSG00000104691 homo_sapiens ENSP00000479216 82.963 75.1852 ochotona_princeps ENSOPRP00000014729 82.0513 74.359 ENSG00000104691 homo_sapiens ENSP00000479216 88.1481 80.3704 delphinapterus_leucas ENSDLEP00000008727 86.5455 78.9091 ENSG00000104691 homo_sapiens ENSP00000479216 87.4074 80.7407 physeter_catodon ENSPCTP00005028147 85.8182 79.2727 ENSG00000104691 homo_sapiens ENSP00000479216 84.8148 74.8148 mus_caroli MGP_CAROLIEiJ_P0084147 82.6715 72.9242 ENSG00000104691 homo_sapiens ENSP00000479216 84.4444 74.0741 mus_musculus ENSMUSP00000092992 82.3105 72.2022 ENSG00000104691 homo_sapiens ENSP00000479216 72.963 65.5556 dipodomys_ordii ENSDORP00000018889 83.8298 75.3191 ENSG00000104691 homo_sapiens ENSP00000479216 35.1852 31.4815 mustela_putorius_furo ENSMPUP00000010161 81.8966 73.2759 ENSG00000104691 homo_sapiens ENSP00000479216 88.5185 85.1852 aotus_nancymaae ENSANAP00000010802 93.7255 90.1961 ENSG00000104691 homo_sapiens ENSP00000479216 70.7407 68.8889 saimiri_boliviensis_boliviensis ENSSBOP00000023163 93.1707 90.7317 ENSG00000104691 homo_sapiens ENSP00000479216 74.8148 67.4074 vicugna_pacos ENSVPAP00000010241 73.7226 66.4234 ENSG00000104691 homo_sapiens ENSP00000479216 96.6667 94.4444 chlorocebus_sabaeus ENSCSAP00000011908 97.026 94.7955 ENSG00000104691 homo_sapiens ENSP00000479216 32.2222 25.1852 tupaia_belangeri ENSTBEP00000005642 50 39.0805 ENSG00000104691 homo_sapiens ENSP00000479216 86.2963 75.1852 mesocricetus_auratus ENSMAUP00000013159 84.4203 73.5507 ENSG00000104691 homo_sapiens ENSP00000479216 88.1481 80.3704 phocoena_sinus ENSPSNP00000025956 86.5455 78.9091 ENSG00000104691 homo_sapiens ENSP00000479216 88.8889 80.3704 camelus_dromedarius ENSCDRP00005027019 87.2727 78.9091 ENSG00000104691 homo_sapiens ENSP00000479216 79.6296 75.5556 carlito_syrichta ENSTSYP00000001224 87.0445 82.5911 ENSG00000104691 homo_sapiens ENSP00000479216 89.6296 83.3333 panthera_tigris_altaica ENSPTIP00000006137 87.6812 81.5217 ENSG00000104691 homo_sapiens ENSP00000479216 86.2963 75.1852 rattus_norvegicus ENSRNOP00000020347 84.4203 73.5507 ENSG00000104691 homo_sapiens ENSP00000479216 85.5556 81.1111 prolemur_simus ENSPSMP00000010992 87.1698 82.6415 ENSG00000104691 homo_sapiens ENSP00000479216 72.5926 63.3333 microtus_ochrogaster ENSMOCP00000003883 88.2883 77.027 ENSG00000104691 homo_sapiens ENSP00000479216 49.6296 45.5556 sorex_araneus ENSSARP00000011503 81.2121 74.5455 ENSG00000104691 homo_sapiens ENSP00000479216 87.4074 77.4074 peromyscus_maniculatus_bairdii ENSPEMP00000023599 85.1986 75.4513 ENSG00000104691 homo_sapiens ENSP00000479216 88.5185 82.2222 bos_mutus ENSBMUP00000023542 86.9091 80.7273 ENSG00000104691 homo_sapiens ENSP00000479216 83.3333 73.3333 mus_spicilegus ENSMSIP00000008794 82.1168 72.2628 ENSG00000104691 homo_sapiens ENSP00000479216 84.0741 73.3333 mus_spicilegus ENSMSIP00000030850 81.9495 71.4801 ENSG00000104691 homo_sapiens ENSP00000479216 86.6667 76.2963 cricetulus_griseus_chok1gshd ENSCGRP00001027198 84.7826 74.6377 ENSG00000104691 homo_sapiens ENSP00000479216 70 64.4444 pteropus_vampyrus ENSPVAP00000016593 70.2602 64.684 ENSG00000104691 homo_sapiens ENSP00000479216 88.1481 79.6296 myotis_lucifugus ENSMLUP00000015357 86.5455 78.1818 ENSG00000104691 homo_sapiens ENSP00000479216 41.4815 32.963 vombatus_ursinus ENSVURP00010015682 63.2768 50.2825 ENSG00000104691 homo_sapiens ENSP00000479216 89.6296 84.0741 rhinolophus_ferrumequinum ENSRFEP00010005456 88.3212 82.8467 ENSG00000104691 homo_sapiens ENSP00000479216 80.7407 72.963 neovison_vison ENSNVIP00000017559 78.9855 71.3768 ENSG00000104691 homo_sapiens ENSP00000479216 88.1481 81.8519 bos_taurus ENSBTAP00000067731 86.5455 80.3636 ENSG00000104691 homo_sapiens ENSP00000479216 85.5556 76.2963 heterocephalus_glaber_female ENSHGLP00000032984 84.6154 75.4579 ENSG00000104691 homo_sapiens ENSP00000479216 96.6667 95.5556 rhinopithecus_bieti ENSRBIP00000014625 97.026 95.9108 ENSG00000104691 homo_sapiens ENSP00000479216 62.2222 52.5926 canis_lupus_dingo ENSCAFP00020001278 68.8525 58.1967 ENSG00000104691 homo_sapiens ENSP00000479216 84.4444 76.6667 sciurus_vulgaris ENSSVLP00005024737 84.4444 76.6667 ENSG00000104691 homo_sapiens ENSP00000479216 61.8519 49.2593 phascolarctos_cinereus ENSPCIP00000021161 72.2944 57.5758 ENSG00000104691 homo_sapiens ENSP00000479216 50.7407 42.5926 procavia_capensis ENSPCAP00000003689 50.7407 42.5926 ENSG00000104691 homo_sapiens ENSP00000479216 85.5556 79.2593 nannospalax_galili ENSNGAP00000015947 83.6957 77.5362 ENSG00000104691 homo_sapiens ENSP00000479216 88.5185 82.2222 bos_grunniens ENSBGRP00000040021 86.9091 80.7273 ENSG00000104691 homo_sapiens ENSP00000479216 84.0741 74.8148 chinchilla_lanigera ENSCLAP00000001395 82.5455 73.4545 ENSG00000104691 homo_sapiens ENSP00000479216 88.1481 82.5926 cervus_hanglu_yarkandensis ENSCHYP00000035114 86.5455 81.0909 ENSG00000104691 homo_sapiens ENSP00000479216 88.5185 80 catagonus_wagneri ENSCWAP00000018151 86.5942 78.2609 ENSG00000104691 homo_sapiens ENSP00000479216 87.4074 78.5185 ictidomys_tridecemlineatus ENSSTOP00000023698 85.1986 76.5343 ENSG00000104691 homo_sapiens ENSP00000479216 80 78.1481 cebus_imitator ENSCCAP00000010525 94.3231 92.1397 ENSG00000104691 homo_sapiens ENSP00000479216 71.4815 63.3333 urocitellus_parryii ENSUPAP00010021277 84.6491 75 ENSG00000104691 homo_sapiens ENSP00000479216 77.4074 71.8519 moschus_moschiferus ENSMMSP00000001383 91.2664 84.7162 ENSG00000104691 homo_sapiens ENSP00000479216 97.037 95.1852 rhinopithecus_roxellana ENSRROP00000026563 97.3978 95.539 ENSG00000104691 homo_sapiens ENSP00000479216 87.037 75.9259 mus_pahari MGP_PahariEiJ_P0047045 83.3333 72.695 ENSG00000104691 homo_sapiens ENSP00000479216 91.1111 84.8148 propithecus_coquereli ENSPCOP00000008461 89.1304 82.971 ENSG00000104691 homo_sapiens ENSP00000479216 30.3704 14.0741 caenorhabditis_elegans H40L08.1.1 18.4685 8.55856 ENSG00000104691 homo_sapiens ENSP00000479216 33.7037 15.1852 drosophila_melanogaster FBpp0309814 19.6121 8.83621 ENSG00000104691 homo_sapiens ENSP00000479216 27.7778 14.0741 ciona_intestinalis ENSCINP00000008621 21.9298 11.1111 ENSG00000104691 homo_sapiens ENSP00000479216 60 43.3333 lepisosteus_oculatus ENSLOCP00000013193 57.8571 41.7857 ENSG00000104691 homo_sapiens ENSP00000479216 53.7037 37.037 clupea_harengus ENSCHAP00000023163 47.8548 33.0033 ENSG00000104691 homo_sapiens ENSP00000479216 54.8148 38.1481 danio_rerio ENSDARP00000135558 54.4118 37.8676 ENSG00000104691 homo_sapiens ENSP00000479216 55.9259 40 carassius_auratus ENSCARP00000065835 47.4843 33.9623 ENSG00000104691 homo_sapiens ENSP00000479216 54.8148 38.8889 astyanax_mexicanus ENSAMXP00000010263 53.8182 38.1818 ENSG00000104691 homo_sapiens ENSP00000479216 54.0741 38.1481 ictalurus_punctatus ENSIPUP00000003065 52.8986 37.3188 ENSG00000104691 homo_sapiens ENSP00000479216 57.7778 40.3704 esox_lucius ENSELUP00000018450 56.3177 39.3502 ENSG00000104691 homo_sapiens ENSP00000479216 54.0741 39.2593 electrophorus_electricus ENSEEEP00000017805 52.7076 38.2671 ENSG00000104691 homo_sapiens ENSP00000479216 51.1111 37.7778 oncorhynchus_kisutch ENSOKIP00005107330 48.7633 36.0424 ENSG00000104691 homo_sapiens ENSP00000479216 57.7778 41.8519 oncorhynchus_mykiss ENSOMYP00000058745 52.5253 38.0471 ENSG00000104691 homo_sapiens ENSP00000479216 44.8148 30 salmo_salar ENSSSAP00000034448 35.7988 23.9645 ENSG00000104691 homo_sapiens ENSP00000479216 57.7778 41.4815 salmo_trutta ENSSTUP00000015007 56.3177 40.4332 ENSG00000104691 homo_sapiens ENSP00000479216 58.5185 37.037 xenopus_tropicalis ENSXETP00000020698 62.4506 39.5257 ENSG00000104691 homo_sapiens ENSP00000479216 59.6296 40.7407 erpetoichthys_calabaricus ENSECRP00000011353 57.9137 39.5683 ENSG00000104691 homo_sapiens ENSP00000479216 57.7778 41.1111 hucho_hucho ENSHHUP00000048318 56.3177 40.0722 ENSG00000104691 homo_sapiens ENSP00000479216 57.7778 39.6296 pygocentrus_nattereri ENSPNAP00000035580 56.1151 38.4892 ENSG00000104691 homo_sapiens ENSP00000479216 12.2222 6.2963 ciona_savignyi ENSCSAVP00000000560 10.3125 5.3125 ENSG00000104691 homo_sapiens ENSP00000479216 17.037 8.88889 ciona_savignyi ENSCSAVP00000000561 38.6555 20.1681 ENSG00000104691 homo_sapiens ENSP00000479216 57.7778 41.4815 oncorhynchus_tshawytscha ENSOTSP00005035600 54.9296 39.4366 ENSG00000104691 homo_sapiens ENSP00000479216 57.7778 41.4815 oncorhynchus_tshawytscha ENSOTSP00005062988 54.9296 39.4366 ENSG00000104691 homo_sapiens ENSP00000479216 48.8889 31.4815 denticeps_clupeoides ENSDCDP00000047910 58.9286 37.9464 ENSG00000104691 homo_sapiens ENSP00000479216 55.5556 38.8889 cyprinus_carpio_carpio ENSCCRP00000133464 55.1471 38.6029 ENSG00000104691 homo_sapiens ENSP00000479216 55.5556 38.8889 sinocyclocheilus_grahami ENSSGRP00000083187 55.1471 38.6029 ENSG00000104691 homo_sapiens ENSP00000479216 59.6296 40.3704 paramormyrops_kingsleyae ENSPKIP00000011028 56.6901 38.3803 ENSG00000104691 homo_sapiens ENSP00000479216 57.7778 41.4815 scleropages_formosus ENSSFOP00015009199 56.1151 40.2878 ENSG00000104691 homo_sapiens ENSP00000479216 61.8519 42.5926 leptobrachium_leishanense ENSLLEP00000018171 57.5862 39.6552
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000151 part_of ubiquitin ligase complex 1 ISS Homo_sapiens(9606) Component GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 1 IBA Homo_sapiens(9606) Component GO:0005654 located_in nucleoplasm 1 IDA Homo_sapiens(9606) Component GO:0005730 located_in nucleolus 1 IDA Homo_sapiens(9606) Component GO:0005783 is_active_in endoplasmic reticulum 2 IBA,IDA Homo_sapiens(9606) Component GO:0005789 located_in endoplasmic reticulum membrane 1 IDA Homo_sapiens(9606) Component GO:0007338 involved_in single fertilization 1 TAS Homo_sapiens(9606) Process GO:0030433 involved_in ubiquitin-dependent ERAD pathway 2 IBA,IMP Homo_sapiens(9606) Process GO:0030674 enables protein-macromolecule adaptor activity 1 ISS Homo_sapiens(9606) Function GO:0043130 enables ubiquitin binding 1 IBA Homo_sapiens(9606) Function
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