RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	TF
Localizations	Nucleoli
BulkPerturb-seq

Ensembl ID	ENSG00000104221	Gene ID	55290	Accession	17298
Symbol	BRF2	Alias	BRFU;TFIIIB50	Full Name	BRF2 RNA polymerase III transcription initiation factor subunit
Status	Confidence	Length	6594 bases	Strand	Minus strand
Position	8 : 37843268 - 37849861	RNA binding domain	TF_Zn_Ribbon
Summary	This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000429554	TF_Zn_Ribbon	PF08271	3.4e-08	1
ENSP00000430193	TF_Zn_Ribbon	PF08271	3.4e-08	1
ENSP00000430107	TF_Zn_Ribbon	PF08271	1.9e-07	1
ENSP00000220659	TF_Zn_Ribbon	PF08271	5.2e-07	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
21518452	RNA polymerase III transcription in cancer: the BRF2 connection.	Stephanie Cabarcas	2011-04-25	Molecular cancer
17670747	The protein kinase CK2 phosphorylates SNAP190 to negatively regulate SNAPC DNA binding and human U6 transcription by RNA polymerase III.	Liping Gu	2007-09-21	The Journal of biological chemistry
35110532	Manipulation of RNA polymerase III by Herpes Simplex Virus-1.	E Sarah Dremel	2022-02-02	Nature communications
27378302	Heat*seq: an interactive web tool for high-throughput sequencing experiment comparison with public data.	Guillaume Devailly	2016-11-01	Bioinformatics (Oxford, England)

Name	Transcript ID	bp	Protein	Translation ID
BRF2-201	ENST00000220659	2560	419aa	ENSP00000220659
BRF2-202	ENST00000520601	1192	202aa	ENSP00000430107
BRF2-203	ENST00000521170	550	72aa	ENSP00000430193
BRF2-204	ENST00000522539	473	72aa	ENSP00000429554

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000126	part_of transcription factor TFIIIB complex	1	IMP	Homo_sapiens(9606)	Component
GO:0001006	enables RNA polymerase III type 3 promoter sequence-specific DNA binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0006352	involved_in DNA-templated transcription initiation	1	IBA	Homo_sapiens(9606)	Process
GO:0006359	involved_in regulation of transcription by RNA polymerase III	1	IMP	Homo_sapiens(9606)	Process
GO:0017025	enables TBP-class protein binding	1	IBA	Homo_sapiens(9606)	Function
GO:0034599	involved_in cellular response to oxidative stress	1	IMP	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0070897	involved_in transcription preinitiation complex assembly	1	IEA	Homo_sapiens(9606)	Process
GO:0097550	part_of transcription preinitiation complex	1	IBA	Homo_sapiens(9606)	Component