Functions and Diseases

RBP Type Canonical_RBPs
Diseases CHIKVSARS-COV-OC43FlavivirusesHIVIAVSARS-COV-2SINVDengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions DUB
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000103194 Gene ID 9100 Accession 12608
Symbol USP10 Alias UBPO Full Name ubiquitin specific peptidase 10
Status Confidence Length 79928 bases Strand Plus strand
Position 16 : 84699995 - 84779922 RNA binding domain PAM2
Summary Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000455712 PAM2 PF07145 4.7e-05 1
ENSP00000219473 PAM2 PF07145 0.00045 1
ENSP00000457411 PAM2 PF07145 0.00045 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
37425931 Identification of small molecule inhibitors of G3BP-driven stress granule formation. D Brian Freibaum 2023-06-28 bioRxiv : the preprint server for biology
34096786 RNA Binding Proteins As Regulators of Oxidative Stress Identified by a Targeted CRISPR-Cas9 Single Guide RNA Library. J David Turner 2021-06-01 The CRISPR journal
36279435 Yin and yang regulation of stress granules by Caprin-1. Dan Song 2022-11-01 Proceedings of the National Academy of Sciences of the United States of America
32302570 Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization. W David Sanders 2020-04-16 Cell
32382008 The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53. Chen Hu 2020-05-07 Cell death & disease
35007165 USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43 by Promoting Stress Granule Clearance. Masahiko Takahashi 2022-03-17 Molecular and cellular biology
23141719 Modulation of hepatitis C virus RNA abundance and virus release by dispersion of processing bodies and enrichment of stress granules. T Cara Pager 2013-01-20 Virology
36305426 Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2-host protein-protein interaction network. Vandana Ravindran 2022-11-19 Briefings in bioinformatics
37161291 Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH. Tim Schulte 2023-05-01 Open biology

Transcripts

Name Transcript ID bp Protein Translation ID
USP10-201 ENST00000219473 3328 798aa ENSP00000219473
USP10-205 ENST00000562743 888 No protein -
USP10-216 ENST00000569511 571 No protein -
USP10-203 ENST00000562092 254 No protein -
USP10-210 ENST00000563892 570 158aa ENSP00000458089
USP10-202 ENST00000540269 3070 62aa ENSP00000445589
USP10-211 ENST00000564566 561 No protein -
USP10-204 ENST00000562283 569 141aa ENSP00000455712
USP10-207 ENST00000563048 1315 35aa ENSP00000454902
USP10-219 ENST00000570191 2717 802aa ENSP00000457411
USP10-208 ENST00000563386 590 63aa ENSP00000454943
USP10-215 ENST00000569038 730 208aa ENSP00000462762
USP10-218 ENST00000570053 502 150aa ENSP00000454751
USP10-213 ENST00000566512 575 No protein -
USP10-206 ENST00000563023 574 No protein -
USP10-209 ENST00000563433 540 No protein -
USP10-212 ENST00000566378 465 No protein -
USP10-217 ENST00000569925 572 76aa ENSP00000454987
USP10-214 ENST00000567526 330 110aa ENSP00000455865

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
7457Luteinizing Hormone3.77231425680388E-517903292
7468Luteinizing Hormone5.27716206514623E-517903292
21118Altruism3.959e-005-
21119Altruism3.959e-005-
21129Altruism3.208e-005-
69664Asthma9E-627611488
74929Alzheimer Disease6E-627770636
96907Everolimus6E-624009623

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000103194homo_sapiensENSP0000038285823.572313.3657homo_sapiensENSP0000021947324.310813.7845
ENSG00000103194homo_sapiensENSP0000043314611.29156.12546homo_sapiensENSP0000021947319.172910.401
ENSG00000103194homo_sapiensENSP0000026160131.781417.2065homo_sapiensENSP0000021947319.674210.6516
ENSG00000103194homo_sapiensENSP0000026149733.523820.1905homo_sapiensENSP0000021947322.055113.2832
ENSG00000103194homo_sapiensENSP0000021968912.35217.47041homo_sapiensENSP0000021947320.927312.6566
ENSG00000103194homo_sapiensENSP000002943838.893134.46565homo_sapiensENSP0000021947329.19814.6617
ENSG00000103194homo_sapiensENSP0000048533726.037716.0377homo_sapiensENSP0000021947317.293210.6516
ENSG00000103194homo_sapiensENSP0000042296927.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042537527.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042377727.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042209727.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042288727.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042321127.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042736627.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042595527.547216.9811homo_sapiensENSP0000021947318.295711.2782
ENSG00000103194homo_sapiensENSP0000042262127.924517.1698homo_sapiensENSP0000021947318.546411.4035
ENSG00000103194homo_sapiensENSP0000041439227.924517.1698homo_sapiensENSP0000021947318.546411.4035
ENSG00000103194homo_sapiensENSP0000038944327.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042221627.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042311527.924517.1698homo_sapiensENSP0000021947318.546411.4035
ENSG00000103194homo_sapiensENSP0000042726427.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042350327.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042558227.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000041062126.582316.4557homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000040088027.735817.1698homo_sapiensENSP0000021947318.421111.4035
ENSG00000103194homo_sapiensENSP0000042407734.972720.2186homo_sapiensENSP000002194738.020054.63659
ENSG00000103194homo_sapiensENSP0000040376027.924517.3585homo_sapiensENSP0000021947318.546411.5288
ENSG00000103194homo_sapiensENSP0000048532326.792516.4151homo_sapiensENSP0000021947317.794510.9023
ENSG00000103194homo_sapiensENSP0000048536426.415116.0377homo_sapiensENSP0000021947317.543910.6516
ENSG00000103194homo_sapiensENSP0000033332927.547216.7925homo_sapiensENSP0000021947318.295711.1529
ENSG00000103194homo_sapiensENSP0000048524326.792516.2264homo_sapiensENSP0000021947317.794510.7769
ENSG00000103194homo_sapiensENSP0000048530627.547216.7925homo_sapiensENSP0000021947318.295711.1529
ENSG00000103194homo_sapiensENSP0000035698129.380515.2212homo_sapiensENSP0000021947320.80210.7769
ENSG00000103194homo_sapiensENSP0000042339017.41519.63855homo_sapiensENSP0000021947319.924811.0276
ENSG00000103194homo_sapiensENSP0000030223921.019711.8068homo_sapiensENSP0000021947329.448616.5414
ENSG00000103194homo_sapiensENSP0000026018729.752117.3554homo_sapiensENSP0000021947322.556413.1579
ENSG00000103194homo_sapiensENSP0000042437222.358711.6708homo_sapiensENSP0000021947322.80711.9048
ENSG00000103194homo_sapiensENSP0000025418117.6799.54447homo_sapiensENSP0000021947320.426111.0276
ENSG00000103194homo_sapiensENSP0000050723925.581414.0988homo_sapiensENSP0000021947322.055112.1554
ENSG00000103194homo_sapiensENSP0000030196212.91798.28267homo_sapiensENSP0000021947321.303313.6591
ENSG00000103194homo_sapiensENSP0000040111915.0499.26091homo_sapiensENSP0000021947321.177913.0326
ENSG00000103194homo_sapiensENSP0000035983020.96611.5258homo_sapiensENSP0000021947323.934813.1579
ENSG00000103194homo_sapiensENSP0000048363134.703220.3196homo_sapiensENSP0000021947319.047611.1529
ENSG00000103194homo_sapiensENSP0000025754829.400417.0213homo_sapiensENSP0000021947319.047611.0276
ENSG00000103194homo_sapiensENSP0000025839918.692510.6231homo_sapiensENSP0000021947322.932313.0326
ENSG00000103194homo_sapiensENSP0000025849925.983114.0449homo_sapiensENSP0000021947323.18312.5313
ENSG00000103194homo_sapiensENSP0000043467635.029918.5629homo_sapiensENSP0000021947314.66177.76942
ENSG00000103194homo_sapiensENSP0000026396610.31294.63499homo_sapiensENSP0000021947311.15295.01253
ENSG00000103194homo_sapiensENSP0000030089614.33928.35411homo_sapiensENSP0000021947328.822116.792
ENSG00000103194homo_sapiensENSP0000046038012.58896.82788homo_sapiensENSP0000021947322.180512.0301
ENSG00000103194homo_sapiensENSP0000036631122.065212.9348homo_sapiensENSP0000021947325.438614.9123
ENSG00000103194homo_sapiensENSP0000036968128.076918.4615homo_sapiensENSP0000021947318.295712.0301
ENSG00000103194homo_sapiensENSP0000038304414.22227.28889homo_sapiensENSP0000021947320.050110.2757
ENSG00000103194homo_sapiensENSP0000051300913.60847.1115homo_sapiensENSP0000021947319.423610.1504
ENSG00000103194homo_sapiensENSP000003435262011.8471homo_sapiensENSP0000021947319.674211.6541
ENSG00000103194homo_sapiensENSP0000050295210.67966.22977homo_sapiensENSP0000021947316.54149.64912
ENSG00000103194homo_sapiensENSP0000028037722.6313.4557homo_sapiensENSP0000021947327.819516.5414
ENSG00000103194homo_sapiensENSP0000030926213.71988.21256homo_sapiensENSP0000021947317.794510.6516
ENSG00000103194homo_sapiensENSP0000026556022.014513.3956homo_sapiensENSP0000021947326.566416.1654
ENSG00000103194homo_sapiensENSP0000036150621.11611.0503homo_sapiensENSP0000021947324.185512.6566
ENSG00000103194homo_sapiensENSP0000043187617.485310.2161homo_sapiensENSP0000021947322.305813.0326
ENSG00000103194homo_sapiensENSP000003675589.553645.20752homo_sapiensENSP0000021947330.576416.6667
ENSG00000103194homo_sapiensENSP000003428129.354215.00978homo_sapiensENSP0000021947329.949916.0401
ENSG00000103194homo_sapiensENSP0000042333326.30115.3305homo_sapiensENSP0000021947323.433613.6591
ENSG00000103194homo_sapiensENSP0000030343418.522110.9405homo_sapiensENSP0000021947324.185514.2857
ENSG00000103194homo_sapiensENSP0000021579433.333318.8172homo_sapiensENSP0000021947315.53888.77193
ENSG00000103194homo_sapiensENSP0000034353512.88576.9873homo_sapiensENSP0000021947317.79459.64912
ENSG00000103194homo_sapiensENSP0000022926810.72265.36131homo_sapiensENSP0000021947311.52885.76441
ENSG00000103194homo_sapiensENSP0000039526016.04059.75434homo_sapiensENSP0000021947327.819516.9173
ENSG00000103194homo_sapiensENSP0000028519914.87098.90472homo_sapiensENSP0000021947320.927312.5313
ENSG00000103194homo_sapiensENSP000003815776.457983.07389homo_sapiensENSP0000021947328.696713.6591

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000103194homo_sapiensENSP0000021947398.997598.7469nomascus_leucogenysENSNLEP0000004617998.503798.2544
ENSG00000103194homo_sapiensENSP0000021947398.997598.7469pan_paniscusENSPPAP0000000729198.503798.2544
ENSG00000103194homo_sapiensENSP0000021947398.872298.7469pongo_abeliiENSPPYP0000003680298.379198.2544
ENSG00000103194homo_sapiensENSP0000021947398.997598.7469pan_troglodytesENSPTRP0000007985998.503798.2544
ENSG00000103194homo_sapiensENSP0000021947399.373499.3734gorilla_gorillaENSGGOP0000001247598.877898.8778
ENSG00000103194homo_sapiensENSP0000021947387.343479.8246ornithorhynchus_anatinusENSOANP0000003569282.582975.4739
ENSG00000103194homo_sapiensENSP0000021947383.834678.5714sarcophilus_harrisiiENSSHAP0000000791079.548274.5541
ENSG00000103194homo_sapiensENSP0000021947369.799563.7845notamacropus_eugeniiENSMEUP0000000012572.905866.623
ENSG00000103194homo_sapiensENSP0000021947372.180569.5489choloepus_hoffmanniENSCHOP0000000441972.727370.0758
ENSG00000103194homo_sapiensENSP0000021947392.105388.2206dasypus_novemcinctusENSDNOP0000002914792.105388.2206
ENSG00000103194homo_sapiensENSP0000021947388.721884.0852erinaceus_europaeusENSEEUP0000001180488.583.875
ENSG00000103194homo_sapiensENSP0000021947368.671762.782echinops_telfairiENSETEP0000000960781.547674.5536
ENSG00000103194homo_sapiensENSP0000021947397.243195.4887callithrix_jacchusENSCJAP0000000742896.758195.0125
ENSG00000103194homo_sapiensENSP0000021947398.872297.7444cercocebus_atysENSCATP0000002236198.379197.2569
ENSG00000103194homo_sapiensENSP0000021947375.18871.4286cercocebus_atysENSCATP0000002423485.348581.0811
ENSG00000103194homo_sapiensENSP0000021947399.248198.3709macaca_fascicularisENSMFAP0000003328896.585495.7317
ENSG00000103194homo_sapiensENSP0000021947398.872297.7444macaca_mulattaENSMMUP0000006029698.379197.2569
ENSG00000103194homo_sapiensENSP0000021947398.872297.8697macaca_nemestrinaENSMNEP0000000554898.379197.3815
ENSG00000103194homo_sapiensENSP0000021947333.58432.4561macaca_nemestrinaENSMNEP0000000411692.733689.6194
ENSG00000103194homo_sapiensENSP0000021947398.746997.4937papio_anubisENSPANP0000004347098.254497.0075
ENSG00000103194homo_sapiensENSP0000021947398.746997.8697mandrillus_leucophaeusENSMLEP0000000187798.254497.3815
ENSG00000103194homo_sapiensENSP0000021947384.210580.5764tursiops_truncatusENSTTRP0000001138084.528380.8805
ENSG00000103194homo_sapiensENSP0000021947390.726886.0902vulpes_vulpesENSVVUP0000004267089.826385.2357
ENSG00000103194homo_sapiensENSP0000021947389.097783.8346mus_spretusMGP_SPRETEiJ_P008972889.659584.3632
ENSG00000103194homo_sapiensENSP0000021947391.102887.9699equus_asinusENSEASP0000504038388.014584.9879
ENSG00000103194homo_sapiensENSP0000021947387.59483.9599equus_asinusENSEASP0000503472088.369284.7029
ENSG00000103194homo_sapiensENSP0000021947362.155455.7644capra_hircusENSCHIP0000002279073.481565.9259
ENSG00000103194homo_sapiensENSP0000021947390.476287.7193capra_hircusENSCHIP0000003165790.476287.7193
ENSG00000103194homo_sapiensENSP0000021947392.105387.8446loxodonta_africanaENSLAFP0000001174992.105387.8446
ENSG00000103194homo_sapiensENSP0000021947391.729387.7193panthera_leoENSPLOP0000000847791.729387.7193
ENSG00000103194homo_sapiensENSP0000021947392.230687.8446ailuropoda_melanoleucaENSAMEP0000002960490.864286.5432
ENSG00000103194homo_sapiensENSP0000021947390.601587.4687bos_indicus_hybridENSBIXP0000500327290.37587.25
ENSG00000103194homo_sapiensENSP0000021947383.458677.193oryctolagus_cuniculusENSOCUP0000003625180.825274.7573
ENSG00000103194homo_sapiensENSP0000021947391.353488.4712equus_caballusENSECAP0000001612288.256785.4722
ENSG00000103194homo_sapiensENSP0000021947392.982588.9724canis_lupus_familiarisENSCAFP0084500652087.294183.5294
ENSG00000103194homo_sapiensENSP0000021947391.729387.7193panthera_pardusENSPPRP0000001417891.729387.7193
ENSG00000103194homo_sapiensENSP0000021947390.852186.8421marmota_marmota_marmotaENSMMMP0000001288192.005187.9442
ENSG00000103194homo_sapiensENSP0000021947390.726887.594balaenoptera_musculusENSBMSP0001002385689.937986.8323
ENSG00000103194homo_sapiensENSP0000021947383.333377.3183cavia_porcellusENSCPOP0000001125185.256479.1026
ENSG00000103194homo_sapiensENSP0000021947392.105387.7193felis_catusENSFCAP0000003049675.384671.7949
ENSG00000103194homo_sapiensENSP0000021947390.852186.7168ursus_americanusENSUAMP0000000374191.42587.2636
ENSG00000103194homo_sapiensENSP0000021947387.343481.4536monodelphis_domesticaENSMODP0000000582087.783481.864
ENSG00000103194homo_sapiensENSP0000021947379.19872.5564monodelphis_domesticaENSMODP0000002601083.487476.4861
ENSG00000103194homo_sapiensENSP0000021947390.100387.218bison_bison_bisonENSBBBP0000001058589.427986.5672
ENSG00000103194homo_sapiensENSP0000021947390.476286.9674monodon_monocerosENSMMNP0001500313989.689486.2112
ENSG00000103194homo_sapiensENSP0000021947389.348485.589sus_scrofaENSSSCP0000000288288.571484.8447
ENSG00000103194homo_sapiensENSP0000021947381.954977.193microcebus_murinusENSMICP0000004367788.979683.8095
ENSG00000103194homo_sapiensENSP0000021947395.112892.6065microcebus_murinusENSMICP0000001148494.638492.1446
ENSG00000103194homo_sapiensENSP0000021947389.223183.7093octodon_degusENSODEP0000000603689.447283.9196
ENSG00000103194homo_sapiensENSP0000021947382.957476.0652jaculus_jaculusENSJJAP0000002250787.91580.6109
ENSG00000103194homo_sapiensENSP0000021947391.102885.213jaculus_jaculusENSJJAP0000000915591.331785.4271
ENSG00000103194homo_sapiensENSP0000021947390.476287.7193ovis_aries_rambouilletENSOARP0002001021378.138575.7576
ENSG00000103194homo_sapiensENSP0000021947390.726886.4662ursus_maritimusENSUMAP0000001011090.274386.0349
ENSG00000103194homo_sapiensENSP0000021947349.624145.99ochotona_princepsENSOPRP0000001312260.550556.1162
ENSG00000103194homo_sapiensENSP0000021947388.721884.5865delphinapterus_leucasENSDLEP0000000092285.198681.2274
ENSG00000103194homo_sapiensENSP0000021947390.100387.0927physeter_catodonENSPCTP0000500617089.316886.3354
ENSG00000103194homo_sapiensENSP0000021947388.345983.4586mus_caroliMGP_CAROLIEiJ_P008621088.902983.9849
ENSG00000103194homo_sapiensENSP0000021947388.847183.3333mus_musculusENSMUSP0000012359089.407383.8588
ENSG00000103194homo_sapiensENSP0000021947385.58982.0802dipodomys_ordiiENSDORP0000002000788.586384.9546
ENSG00000103194homo_sapiensENSP0000021947391.353487.4687mustela_putorius_furoENSMPUP0000000866891.239187.3592
ENSG00000103194homo_sapiensENSP0000021947397.368496.2406aotus_nancymaaeENSANAP0000001449296.882895.7606
ENSG00000103194homo_sapiensENSP0000021947397.869796.7419saimiri_boliviensis_boliviensisENSSBOP0000000112297.260396.1395
ENSG00000103194homo_sapiensENSP0000021947385.58983.3333vicugna_pacosENSVPAP0000001000686.237483.9646
ENSG00000103194homo_sapiensENSP0000021947398.120397.2431chlorocebus_sabaeusENSCSAP0000001487798.863697.9798
ENSG00000103194homo_sapiensENSP0000021947378.571475.0627tupaia_belangeriENSTBEP0000000418779.266875.7269
ENSG00000103194homo_sapiensENSP0000021947314.035113.2832mesocricetus_auratusENSMAUP0000002581698.245692.9825
ENSG00000103194homo_sapiensENSP0000021947390.476287.3434phocoena_sinusENSPSNP0000002772189.689486.5839
ENSG00000103194homo_sapiensENSP0000021947391.729389.3484camelus_dromedariusENSCDRP0000500244891.589.125
ENSG00000103194homo_sapiensENSP0000021947393.734390.6015carlito_syrichtaENSTSYP0000003356493.383390.2622
ENSG00000103194homo_sapiensENSP0000021947375.939872.807panthera_tigris_altaicaENSPTIP0000001308892.944889.1104
ENSG00000103194homo_sapiensENSP0000021947388.596584.3358rattus_norvegicusENSRNOP0000007982976.515272.8355
ENSG00000103194homo_sapiensENSP0000021947394.110392.3559prolemur_simusENSPSMP0000001063094.110392.3559
ENSG00000103194homo_sapiensENSP0000021947314.160413.6591microtus_ochrogasterENSMOCP0000001803999.122895.614
ENSG00000103194homo_sapiensENSP0000021947390.601586.2155peromyscus_maniculatus_bairdiiENSPEMP0000000110791.172886.7591
ENSG00000103194homo_sapiensENSP0000021947390.100387.0927bos_mutusENSBMUP0000001886589.427986.4428
ENSG00000103194homo_sapiensENSP0000021947388.847183.4586mus_spicilegusENSMSIP0000002205289.407383.9849
ENSG00000103194homo_sapiensENSP0000021947390.977485.7143cricetulus_griseus_chok1gshdENSCGRP0000101628691.435886.1461
ENSG00000103194homo_sapiensENSP0000021947385.964983.3333pteropus_vampyrusENSPVAP0000000912081.183478.6982
ENSG00000103194homo_sapiensENSP0000021947390.726886.5915myotis_lucifugusENSMLUP0000001735490.954886.809
ENSG00000103194homo_sapiensENSP0000021947382.330876.5664vombatus_ursinusENSVURP0001002748687.019980.9272
ENSG00000103194homo_sapiensENSP0000021947392.606589.8496rhinolophus_ferrumequinumENSRFEP0001001658092.490689.7372
ENSG00000103194homo_sapiensENSP0000021947392.230688.3459neovison_visonENSNVIP0000000926792.230688.3459
ENSG00000103194homo_sapiensENSP0000021947390.100387.218bos_taurusENSBTAP0000007450589.762886.8914
ENSG00000103194homo_sapiensENSP0000021947386.716881.9549heterocephalus_glaber_femaleENSHGLP0000002357283.474178.8902
ENSG00000103194homo_sapiensENSP0000021947398.997598.1203rhinopithecus_bietiENSRBIP0000002999598.503797.6309
ENSG00000103194homo_sapiensENSP0000021947392.857188.9724canis_lupus_dingoENSCAFP0002000492193.090589.196
ENSG00000103194homo_sapiensENSP0000021947330.952429.8246sciurus_vulgarisENSSVLP0000501868598.015994.4444
ENSG00000103194homo_sapiensENSP0000021947330.576429.4486sciurus_vulgarisENSSVLP0000501955696.825493.254
ENSG00000103194homo_sapiensENSP0000021947390.726886.4662sciurus_vulgarisENSSVLP0000503233491.069286.7924
ENSG00000103194homo_sapiensENSP0000021947385.964979.3233phascolarctos_cinereusENSPCIP0000001770886.39879.7229
ENSG00000103194homo_sapiensENSP0000021947382.581579.0727procavia_capensisENSPCAP0000001503680.072976.6707
ENSG00000103194homo_sapiensENSP0000021947387.468782.8321nannospalax_galiliENSNGAP0000002043987.359282.7284
ENSG00000103194homo_sapiensENSP0000021947390.601587.7193bos_grunniensENSBGRP0000002505990.37587.5
ENSG00000103194homo_sapiensENSP0000021947389.473784.2105chinchilla_lanigeraENSCLAP0000000162090.494385.1711
ENSG00000103194homo_sapiensENSP0000021947390.977487.8446cervus_hanglu_yarkandensisENSCHYP0000000284178.401775.7019
ENSG00000103194homo_sapiensENSP0000021947389.097785.0877catagonus_wagneriENSCWAP0000001126188.54384.5579
ENSG00000103194homo_sapiensENSP0000021947391.478787.594ictidomys_tridecemlineatusENSSTOP0000001390992.639688.7056
ENSG00000103194homo_sapiensENSP0000021947381.20376.0652otolemur_garnettiiENSOGAP0000001553883.076977.8205
ENSG00000103194homo_sapiensENSP0000021947393.734391.604otolemur_garnettiiENSOGAP0000000839693.734391.604
ENSG00000103194homo_sapiensENSP0000021947397.61996.3659cebus_imitatorENSCCAP0000000520697.132295.8853
ENSG00000103194homo_sapiensENSP0000021947392.230688.0952urocitellus_parryiiENSUPAP0001002790892.578688.4277
ENSG00000103194homo_sapiensENSP0000021947390.726887.594moschus_moschiferusENSMMSP0000001154790.613387.4844
ENSG00000103194homo_sapiensENSP0000021947398.997598.1203rhinopithecus_roxellanaENSRROP0000000150398.503797.6309
ENSG00000103194homo_sapiensENSP0000021947388.847184.4612mus_pahariMGP_PahariEiJ_P005446189.407384.9937
ENSG00000103194homo_sapiensENSP0000021947394.235691.1028propithecus_coquereliENSPCOP0000000573194.235691.1028
ENSG00000103194homo_sapiensENSP0000021947354.260740.3509eptatretus_burgeriENSEBUP0000001649351.794338.5167
ENSG00000103194homo_sapiensENSP0000021947374.185563.1579callorhinchus_miliiENSCMIP0000003078569.893759.5041
ENSG00000103194homo_sapiensENSP0000021947373.558966.0401latimeria_chalumnaeENSLACP0000000899478.058570.0798
ENSG00000103194homo_sapiensENSP0000021947372.055163.4085lepisosteus_oculatusENSLOCP0000000513463.676656.0354
ENSG00000103194homo_sapiensENSP0000021947371.052660.7769clupea_harengusENSCHAP0000005653063.636454.4332
ENSG00000103194homo_sapiensENSP0000021947371.679261.7794danio_rerioENSDARP0000014982763.697154.8998
ENSG00000103194homo_sapiensENSP0000021947368.170458.8972carassius_auratusENSCARP0000005529561.192452.8684
ENSG00000103194homo_sapiensENSP0000021947370.551461.1529carassius_auratusENSCARP0000013164263.615855.1412
ENSG00000103194homo_sapiensENSP0000021947364.285755.2632astyanax_mexicanusENSAMXP0000001757067.411357.9501
ENSG00000103194homo_sapiensENSP0000021947370.80260.6516ictalurus_punctatusENSIPUP0000000860464.942555.6322
ENSG00000103194homo_sapiensENSP0000021947370.300861.0276esox_luciusENSELUP0000007710159.935952.0299
ENSG00000103194homo_sapiensENSP0000021947371.553960.6516electrophorus_electricusENSEEEP0000004209065.182655.2511
ENSG00000103194homo_sapiensENSP0000021947373.057663.0326oncorhynchus_kisutchENSOKIP0000511395265.579356.5804
ENSG00000103194homo_sapiensENSP0000021947373.057662.9073oncorhynchus_kisutchENSOKIP0000510738566.2557.0455
ENSG00000103194homo_sapiensENSP0000021947373.057662.406oncorhynchus_mykissENSOMYP0000008733865.212555.7047
ENSG00000103194homo_sapiensENSP0000021947373.057662.9073oncorhynchus_mykissENSOMYP0000000303165.653256.5315
ENSG00000103194homo_sapiensENSP0000021947373.308362.9073salmo_salarENSSSAP0000011122565.730356.4045
ENSG00000103194homo_sapiensENSP0000021947373.433662.6566salmo_salarENSSSAP0000011891565.256155.6793
ENSG00000103194homo_sapiensENSP0000021947373.558963.0326salmo_truttaENSSTUP0000011168165.513456.1384
ENSG00000103194homo_sapiensENSP0000021947373.433662.9073salmo_truttaENSSTUP0000009984465.916856.4679
ENSG00000103194homo_sapiensENSP0000021947365.413555.2632gadus_morhuaENSGMOP0000004365271.40960.3283
ENSG00000103194homo_sapiensENSP0000021947372.305862.406fundulus_heteroclitusENSFHEP0000001224765.717556.7198
ENSG00000103194homo_sapiensENSP0000021947370.676759.3985poecilia_reticulataENSPREP0000003428664.753254.4202
ENSG00000103194homo_sapiensENSP0000021947372.681761.7794xiphophorus_maculatusENSXMAP0000003609166.134656.2144
ENSG00000103194homo_sapiensENSP0000021947371.804561.2782oryzias_latipesENSORLP0000003168364.96655.4422
ENSG00000103194homo_sapiensENSP0000021947372.556462.0301cyclopterus_lumpusENSCLMP0000504521365.795556.25
ENSG00000103194homo_sapiensENSP0000021947372.180562.1554oreochromis_niloticusENSONIP0000003754364.57455.6054
ENSG00000103194homo_sapiensENSP0000021947373.308363.5338haplochromis_burtoniENSHBUP0000001139466.552957.6792
ENSG00000103194homo_sapiensENSP0000021947373.308363.5338astatotilapia_callipteraENSACLP0000000309266.552957.6792
ENSG00000103194homo_sapiensENSP0000021947371.428661.4035sparus_aurataENSSAUP0001005357965.592656.3867
ENSG00000103194homo_sapiensENSP0000021947372.556462.1554lates_calcariferENSLCAP0001003590265.571956.1721
ENSG00000103194homo_sapiensENSP0000021947380.200570.4261xenopus_tropicalisENSXETP0000007269274.245965.1972
ENSG00000103194homo_sapiensENSP0000021947384.586578.3208chrysemys_picta_belliiENSCPBP0000003381681.620375.5744
ENSG00000103194homo_sapiensENSP0000021947383.709377.8195sphenodon_punctatusENSSPUP0000001033286.528580.4404
ENSG00000103194homo_sapiensENSP0000021947385.087778.4461crocodylus_porosusENSCPRP0000500927985.087778.4461
ENSG00000103194homo_sapiensENSP0000021947381.829674.3108laticauda_laticaudataENSLLTP0000000669783.290875.6378
ENSG00000103194homo_sapiensENSP0000021947382.706875.188notechis_scutatusENSNSUP0000002648683.756376.1421
ENSG00000103194homo_sapiensENSP0000021947382.706875.3133pseudonaja_textilisENSPTXP0000001415683.756376.269
ENSG00000103194homo_sapiensENSP0000021947384.085278.0702anas_platyrhynchos_platyrhynchosENSAPLP0000002344483.9877.9725
ENSG00000103194homo_sapiensENSP0000021947383.959978.1955gallus_gallusENSGALP0001000914682.007376.377
ENSG00000103194homo_sapiensENSP0000021947382.706875.8145meleagris_gallopavoENSMGAP0000001857384.183777.1684
ENSG00000103194homo_sapiensENSP0000021947382.330875.6892serinus_canariaENSSCAP0000000885184.015377.2379
ENSG00000103194homo_sapiensENSP0000021947383.082776.6917parus_majorENSPMJP0000001857684.24477.7637
ENSG00000103194homo_sapiensENSP0000021947343.358437.9699anolis_carolinensisENSACAP0000001434976.718467.184
ENSG00000103194homo_sapiensENSP0000021947373.308363.5338neolamprologus_brichardiENSNBRP0000001374466.552957.6792
ENSG00000103194homo_sapiensENSP0000021947382.832175.0627naja_najaENSNNAP0000002894881.705874.042
ENSG00000103194homo_sapiensENSP0000021947384.962479.198podarcis_muralisENSPMRP0000001702183.292477.6413
ENSG00000103194homo_sapiensENSP0000021947382.456175.5639geospiza_fortisENSGFOP0000000518484.35977.3077
ENSG00000103194homo_sapiensENSP0000021947383.333376.5664taeniopygia_guttataENSTGUP0000000436684.283977.4398
ENSG00000103194homo_sapiensENSP0000021947373.18361.5288erpetoichthys_calabaricusENSECRP0000001869364.888954.5556
ENSG00000103194homo_sapiensENSP0000021947372.180561.6541kryptolebias_marmoratusENSKMAP0000000925565.903956.2929
ENSG00000103194homo_sapiensENSP0000021947384.210577.9449salvator_merianaeENSSMRP0000000813384.741578.4363
ENSG00000103194homo_sapiensENSP0000021947371.679261.5288oryzias_javanicusENSOJAP0000004413464.852655.6689
ENSG00000103194homo_sapiensENSP0000021947371.177961.2782amphilophus_citrinellusENSACIP0000000098870.471560.67
ENSG00000103194homo_sapiensENSP0000021947373.558963.0326dicentrarchus_labraxENSDLAP0000504352666.553357.0295
ENSG00000103194homo_sapiensENSP0000021947373.308363.1579amphiprion_perculaENSAPEP0000001637666.477357.2727
ENSG00000103194homo_sapiensENSP0000021947370.050159.7744oryzias_sinensisENSOSIP0000000698662.879653.6558
ENSG00000103194homo_sapiensENSP0000021947354.511350pelodiscus_sinensisENSPSIP0000001845481.920975.1412
ENSG00000103194homo_sapiensENSP0000021947384.837178.3208gopherus_evgoodeiENSGEVP0000502469682.2675.9417
ENSG00000103194homo_sapiensENSP0000021947350.250647.7444chelonoidis_abingdoniiENSCABP0000000744091.76287.1854
ENSG00000103194homo_sapiensENSP0000021947373.558963.2832seriola_dumeriliENSSDUP0000002409966.704557.3864
ENSG00000103194homo_sapiensENSP0000021947372.305861.6541cottoperca_gobioENSCGOP0000005169363.129153.8293
ENSG00000103194homo_sapiensENSP0000021947384.210578.4461struthio_camelus_australisENSSCUP0000001707484.316278.5445
ENSG00000103194homo_sapiensENSP0000021947384.586578.6967anser_brachyrhynchusENSABRP0000001586985.877979.8982
ENSG00000103194homo_sapiensENSP0000021947371.177960.2757gasterosteus_aculeatusENSGACP0000002083368.023957.6048
ENSG00000103194homo_sapiensENSP0000021947370.80261.6541cynoglossus_semilaevisENSCSEP0000000262164.277655.9727
ENSG00000103194homo_sapiensENSP0000021947372.681762.1554poecilia_formosaENSPFOP0000000228766.2156.621
ENSG00000103194homo_sapiensENSP0000021947371.929862.5313myripristis_murdjanENSMMDP0000500227965.079456.576
ENSG00000103194homo_sapiensENSP0000021947372.305862.406sander_luciopercaENSSLUP0000002136265.050756.1443
ENSG00000103194homo_sapiensENSP0000021947384.210577.8195strigops_habroptilaENSSHBP0000501365185.171178.7072
ENSG00000103194homo_sapiensENSP0000021947380.325874.4361strigops_habroptilaENSSHBP0000500039584.453278.2609
ENSG00000103194homo_sapiensENSP0000021947373.308363.1579amphiprion_ocellarisENSAOCP0000003191266.477357.2727
ENSG00000103194homo_sapiensENSP0000021947385.21379.0727terrapene_carolina_triunguisENSTMTP0000001736282.624576.6707
ENSG00000103194homo_sapiensENSP0000021947385.21379.0727terrapene_carolina_triunguisENSTMTP0000001995282.624576.6707
ENSG00000103194homo_sapiensENSP0000021947372.932362.5313hucho_huchoENSHHUP0000007054063.398754.3573
ENSG00000103194homo_sapiensENSP0000021947373.308363.0326hucho_huchoENSHHUP0000002719165.072355.9511
ENSG00000103194homo_sapiensENSP0000021947372.055161.5288betta_splendensENSBSLP0000002981365.340955.7955
ENSG00000103194homo_sapiensENSP0000021947371.553961.7794pygocentrus_nattereriENSPNAP0000002908365.707756.7319
ENSG00000103194homo_sapiensENSP0000021947372.681761.7794anabas_testudineusENSATEP0000000601964.088454.4751
ENSG00000103194homo_sapiensENSP0000021947373.308363.1579seriola_lalandi_dorsalisENSSLDP0000001686666.552957.3379
ENSG00000103194homo_sapiensENSP0000021947371.804561.6541labrus_bergyltaENSLBEP0000003488164.81955.6561
ENSG00000103194homo_sapiensENSP0000021947373.308363.5338pundamilia_nyerereiENSPNYP0000001784866.552957.6792
ENSG00000103194homo_sapiensENSP0000021947371.929861.2782mastacembelus_armatusENSMAMP0000004465064.858855.2542
ENSG00000103194homo_sapiensENSP0000021947373.308363.2832stegastes_partitusENSSPAP0000000740766.552957.4516
ENSG00000103194homo_sapiensENSP0000021947366.79256.015oncorhynchus_tshawytschaENSOTSP0000507053462.339252.2807
ENSG00000103194homo_sapiensENSP0000021947373.18362.6566oncorhynchus_tshawytschaENSOTSP0000506337266.138256.6251
ENSG00000103194homo_sapiensENSP0000021947373.18363.0326acanthochromis_polyacanthusENSAPOP0000003367166.288357.0942
ENSG00000103194homo_sapiensENSP0000021947384.711878.6967aquila_chrysaetos_chrysaetosENSACCP0002000508285.678179.5944
ENSG00000103194homo_sapiensENSP0000021947373.18362.1554nothobranchius_furzeriENSNFUP0001503986662.863353.3907
ENSG00000103194homo_sapiensENSP0000021947372.431161.6541cyprinodon_variegatusENSCVAP0000001983265.906556.1003
ENSG00000103194homo_sapiensENSP0000021947373.18362.2807denticeps_clupeoidesENSDCDP0000001718866.439156.5415
ENSG00000103194homo_sapiensENSP0000021947372.932362.782larimichthys_croceaENSLCRP0000501996166.211656.9966
ENSG00000103194homo_sapiensENSP0000021947371.553961.1529takifugu_rubripesENSTRUP0000006560964.886455.4545
ENSG00000103194homo_sapiensENSP0000021947382.456175.9398ficedula_albicollisENSFALP0000003119384.467377.792
ENSG00000103194homo_sapiensENSP0000021947372.180561.2782hippocampus_comesENSHCOP0000000212666.130956.1424
ENSG00000103194homo_sapiensENSP0000021947370.80260.9023cyprinus_carpio_carpioENSCCRP0000015041562.224753.5242
ENSG00000103194homo_sapiensENSP0000021947371.804562.2807cyprinus_carpio_carpioENSCCRP0000010892664.52755.9685
ENSG00000103194homo_sapiensENSP0000021947384.586578.3208coturnix_japonicaENSCJPP0000501809985.551379.2142
ENSG00000103194homo_sapiensENSP0000021947372.681762.1554poecilia_latipinnaENSPLAP0000001497667.677957.8763
ENSG00000103194homo_sapiensENSP0000021947368.295759.2732sinocyclocheilus_grahamiENSSGRP0000005236460.825952.7902
ENSG00000103194homo_sapiensENSP0000021947362.40652.8822sinocyclocheilus_grahamiENSSGRP0000003868462.327952.816
ENSG00000103194homo_sapiensENSP0000021947373.308363.5338maylandia_zebraENSMZEP0000501881066.552957.6792
ENSG00000103194homo_sapiensENSP0000021947369.172959.1479tetraodon_nigroviridisENSTNIP0000001221067.481757.7017
ENSG00000103194homo_sapiensENSP0000021947368.295758.0201paramormyrops_kingsleyaeENSPKIP0000000864366.789256.7402
ENSG00000103194homo_sapiensENSP0000021947369.172960.401paramormyrops_kingsleyaeENSPKIP0000002712155.927148.8349
ENSG00000103194homo_sapiensENSP0000021947368.79758.396scleropages_formosusENSSFOP0001503029565.748555.8084
ENSG00000103194homo_sapiensENSP0000021947370.80260.0251scleropages_formosusENSSFOP0001502369864.86854.9943
ENSG00000103194homo_sapiensENSP0000021947381.077770.802leptobrachium_leishanenseENSLLEP0000003814679.581869.4957
ENSG00000103194homo_sapiensENSP0000021947372.431162.5313scophthalmus_maximusENSSMAP0000000024265.163556.257
ENSG00000103194homo_sapiensENSP0000021947369.674259.1479oryzias_melastigmaENSOMEP0000002234361.846552.5028

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0002039enables p53 binding1IPIHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0004197enables cysteine-type endopeptidase activity1IMPHomo_sapiens(9606)Function
GO:0004843enables cysteine-type deubiquitinase activity4IBA,IDA,IMP,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005769is_active_in early endosome2IBA,IDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0006511involved_in ubiquitin-dependent protein catabolic process1IEAHomo_sapiens(9606)Process
GO:0006914involved_in autophagy1IEAHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response1IMPHomo_sapiens(9606)Process
GO:0010506involved_in regulation of autophagy2IBA,IDAHomo_sapiens(9606)Process
GO:0016579involved_in protein deubiquitination4IBA,IDA,IMP,TASHomo_sapiens(9606)Process
GO:0019985involved_in translesion synthesis1TASHomo_sapiens(9606)Process
GO:0030330involved_in DNA damage response, signal transduction by p53 class mediator2IBA,IMPHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0043124involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling1IMPHomo_sapiens(9606)Process
GO:0044325enables transmembrane transporter binding1IDAHomo_sapiens(9606)Function
GO:0045111located_in intermediate filament cytoskeleton1IDAHomo_sapiens(9606)Component
GO:0062030involved_in negative regulation of stress granule assembly1IDAHomo_sapiens(9606)Process
GO:0071347involved_in cellular response to interleukin-11IMPHomo_sapiens(9606)Process
GO:0072344involved_in rescue of stalled ribosome1IDAHomo_sapiens(9606)Process
GO:0140678enables molecular function inhibitor activity1IDAHomo_sapiens(9606)Function

Expression