Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzymeTransmemebrane
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000103056 Gene ID 55512 Accession 14240
Symbol SMPD3 Alias Full Name
Status Confidence Length 90182 bases Strand Minus strand
Position 16 : 68358327 - 68448508 RNA binding domain Exo_endo_phos
Summary

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000455955 Exo_endo_phos PF03372 1.4e-05 1
ENSP00000219334 Exo_endo_phos PF03372 1.6e-05 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
SMPD3-201 ENST00000219334 5271 655aa ENSP00000219334
SMPD3-212 ENST00000574662 1755 207aa ENSP00000459317
SMPD3-211 ENST00000568373 2073 638aa ENSP00000457422
SMPD3-203 ENST00000563226 2093 647aa ENSP00000455955
SMPD3-204 ENST00000563396 608 No protein -
SMPD3-209 ENST00000567223 530 No protein -
SMPD3-206 ENST00000566009 586 No protein -
SMPD3-210 ENST00000567811 576 No protein -
SMPD3-205 ENST00000563455 546 No protein -
SMPD3-207 ENST00000566466 582 No protein -
SMPD3-208 ENST00000566723 524 No protein -
SMPD3-202 ENST00000561749 627 93aa ENSP00000457236

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
17267Cholesterol, HDL3.851e-00519060910
42669Platelet Function Tests6.2152386E-006-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000137located_in Golgi cis cisterna1IEAHomo_sapiens(9606)Component
GO:0000139located_in Golgi membrane1IEAHomo_sapiens(9606)Component
GO:0001786enables phosphatidylserine binding1ISSHomo_sapiens(9606)Function
GO:0001932involved_in regulation of protein phosphorylation1IEAHomo_sapiens(9606)Process
GO:0001958involved_in endochondral ossification1IEAHomo_sapiens(9606)Process
GO:0002244involved_in hematopoietic progenitor cell differentiation1IEAHomo_sapiens(9606)Process
GO:0002685involved_in regulation of leukocyte migration1IEAHomo_sapiens(9606)Process
GO:0003433involved_in chondrocyte development involved in endochondral bone morphogenesis1IEAHomo_sapiens(9606)Process
GO:0004767enables sphingomyelin phosphodiesterase activity3IBA,IDA,ISSHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1IEAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane2ISS,TASHomo_sapiens(9606)Component
GO:0006672involved_in ceramide metabolic process1IEAHomo_sapiens(9606)Process
GO:0006684involved_in sphingomyelin metabolic process2IBA,ISSHomo_sapiens(9606)Process
GO:0006685involved_in sphingomyelin catabolic process1IDAHomo_sapiens(9606)Process
GO:0008081enables phosphoric diester hydrolase activity1IDAHomo_sapiens(9606)Function
GO:0015774involved_in polysaccharide transport1IEAHomo_sapiens(9606)Process
GO:0030072involved_in peptide hormone secretion1IEAHomo_sapiens(9606)Process
GO:0030282involved_in bone mineralization1IEAHomo_sapiens(9606)Process
GO:0030509involved_in BMP signaling pathway1IEAHomo_sapiens(9606)Process
GO:0032963involved_in collagen metabolic process1IEAHomo_sapiens(9606)Process
GO:0035264involved_in multicellular organism growth1IEAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IEAHomo_sapiens(9606)Function
GO:0043491involved_in protein kinase B signaling1IEAHomo_sapiens(9606)Process
GO:0045840involved_in positive regulation of mitotic nuclear division1IEAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0048008involved_in platelet-derived growth factor receptor signaling pathway1IEAHomo_sapiens(9606)Process
GO:0048286involved_in lung alveolus development1IEAHomo_sapiens(9606)Process
GO:0048661involved_in positive regulation of smooth muscle cell proliferation1IEAHomo_sapiens(9606)Process
GO:0061035involved_in regulation of cartilage development1IEAHomo_sapiens(9606)Process
GO:0061751enables neutral sphingomyelin phosphodiesterase activity1IEAHomo_sapiens(9606)Function
GO:0070300enables phosphatidic acid binding1ISSHomo_sapiens(9606)Function
GO:0070301involved_in cellular response to hydrogen peroxide1IEAHomo_sapiens(9606)Process
GO:0070314involved_in G1 to G0 transition1IEAHomo_sapiens(9606)Process
GO:0071286involved_in cellular response to magnesium ion1IEAHomo_sapiens(9606)Process
GO:0071356involved_in cellular response to tumor necrosis factor1IEAHomo_sapiens(9606)Process
GO:0071461involved_in cellular response to redox state1IEAHomo_sapiens(9606)Process
GO:0071897involved_in DNA biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0085029involved_in extracellular matrix assembly1IEAHomo_sapiens(9606)Process
GO:0090520involved_in sphingolipid mediated signaling pathway1IEAHomo_sapiens(9606)Process
GO:0097187involved_in dentinogenesis1IEAHomo_sapiens(9606)Process
GO:0098868involved_in bone growth1IEAHomo_sapiens(9606)Process
GO:0140014involved_in mitotic nuclear division1IEAHomo_sapiens(9606)Process
GO:0140052involved_in cellular response to oxidised low-density lipoprotein particle stimulus1IEAHomo_sapiens(9606)Process
GO:1900126involved_in negative regulation of hyaluronan biosynthetic process1IEAHomo_sapiens(9606)Process
GO:1901653involved_in cellular response to peptide1IEAHomo_sapiens(9606)Process
GO:1903543involved_in positive regulation of exosomal secretion1ISSHomo_sapiens(9606)Process

Expression