Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000102974 Gene ID 10664 Accession 13723
Symbol CTCF Alias MRD21;FAP108;CFAP108 Full Name CCCTC-binding factor
Status Confidence Length 76711 bases Strand Plus strand
Position 16 : 67562467 - 67639177 RNA binding domain N.A.
Summary This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
25716334 Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci. Mathieu Lemire 2015-02-26 Nature communications
34486654 Plant 3D Chromatin Organization: Important Insights from Chromosome Conformation Capture Analyses of the Last 10 Years. Xinxin Zhang 2021-12-10 Plant & cell physiology
26156556 The extended AT-hook is a novel RNA binding motif. Michael Filarsky 2015-01-01 RNA biology
33168103 Chromosome structural variation in tumorigenesis: mechanisms of formation and carcinogenesis. Wen-Jun Wang 2020-11-10 Epigenetics & chromatin
33411704 Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress. J Bettina Lehman 2021-01-01 PLoS genetics
21787381 An integrated strategy for identification of both sharp and broad peaks from next-generation sequencing data. Weiqun Peng 2011-07-25 Genome biology
18985277 Epigenetic mechanisms in mammals. K J Kim 2009-02-01 Cellular and molecular life sciences : CMLS
34722514 Emerging Roles of Repetitive and Repeat-Containing RNA in Nuclear and Chromatin Organization and Gene Expression. Giuseppe Trigiante 2021-01-01 Frontiers in cell and developmental biology
24280869 Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia. E Jost 2014-06-01 Leukemia
34268302 SP1-Mediated Upregulation of Long Noncoding RNA ZFAS1 Involved in Non-syndromic Cleft Lip and Palate via Inactivating WNT/β-Catenin Signaling Pathway. Shiyu Chen 2021-01-01 Frontiers in cell and developmental biology
24696455 CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53. Ricardo Saldaña-Meyer 2014-04-01 Genes & development
31522988 RNA Interactions Are Essential for CTCF-Mediated Genome Organization. Ricardo Saldaña-Meyer 2019-11-07 Molecular cell
34019588 Epigenomic regulation of human T-cell leukemia virus by chromatin-insulator CTCF. Xiaogang Cheng 2021-05-01 PLoS pathogens
21930510 Genome-wide prediction and analysis of human chromatin boundary elements. Jianrong Wang 2012-01-01 Nucleic acids research
36357561 Immune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility. Miriam Cerván-Martín 2022-11-10 Communications biology
27638884 CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions. Elisa Fiorito 2016-12-15 Nucleic acids research
36746940 Widespread contribution of transposable elements to the rewiring of mammalian 3D genomes. K N Mayank Choudhary 2023-02-06 Nature communications
27482468 Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions. Haiquan Li 2016-01-01 NPJ genomic medicine
35832620 Predicting 3D chromatin interactions from DNA sequence using Deep Learning. S Robert Piecyk 2022-01-01 Computational and structural biotechnology journal
26715761 Epigenome-wide effects of vitamin D and their impact on the transcriptome of human monocytes involve CTCF. Sabine Seuter 2016-05-19 Nucleic acids research
23203885 Factorbook.org: a Wiki-based database for transcription factor-binding data generated by the ENCODE consortium. Jie Wang 2013-01-01 Nucleic acids research

Transcripts

Name Transcript ID bp Protein Translation ID
CTCF-215 ENST00000646076 3989 727aa ENSP00000494538
CTCF-210 ENST00000644852 734 163aa ENSP00000495115
CTCF-201 ENST00000264010 3814 727aa ENSP00000264010
CTCF-202 ENST00000401394 2797 399aa ENSP00000384707
CTCF-217 ENST00000646771 3706 725aa ENSP00000494443
CTCF-206 ENST00000642847 1174 135aa ENSP00000495923
CTCF-209 ENST00000644753 3713 727aa ENSP00000493495
CTCF-205 ENST00000642819 3975 727aa ENSP00000494408
CTCF-212 ENST00000645306 3662 725aa ENSP00000495218
CTCF-208 ENST00000643892 3783 638aa ENSP00000494358
CTCF-214 ENST00000645699 3521 727aa ENSP00000495348
CTCF-203 ENST00000566078 1302 No protein -
CTCF-207 ENST00000642943 4802 No protein -
CTCF-213 ENST00000645409 4271 No protein -
CTCF-216 ENST00000646566 3952 No protein -
CTCF-211 ENST00000644950 2833 No protein -
CTCF-204 ENST00000642420 2131 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
17242Cholesterol, HDL2.203e-00819060910
17253Cholesterol, HDL7.721e-00619060910

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000102974homo_sapiensENSP0000037852635.626524.0786homo_sapiensENSP0000026401019.94513.4801
ENSG00000102974homo_sapiensENSP0000050963331.117819.6375homo_sapiensENSP0000026401014.16788.94085
ENSG00000102974homo_sapiensENSP0000038831126.082517.0103homo_sapiensENSP0000026401034.800522.696
ENSG00000102974homo_sapiensENSP0000024391458.823545.7014homo_sapiensENSP0000026401053.645141.6781
ENSG00000102974homo_sapiensENSP0000030121519.104510.597homo_sapiensENSP0000026401017.60669.76616
ENSG00000102974homo_sapiensENSP0000036690228.488416.7151homo_sapiensENSP0000026401026.960115.8184
ENSG00000102974homo_sapiensENSP0000037864233.086422.2222homo_sapiensENSP0000026401018.431912.3796
ENSG00000102974homo_sapiensENSP0000033877035.029123.4012homo_sapiensENSP0000026401033.149922.1458
ENSG00000102974homo_sapiensENSP0000046103229.987619.083homo_sapiensENSP0000026401033.287521.1829
ENSG00000102974homo_sapiensENSP0000047784125.037314.6051homo_sapiensENSP0000026401023.108713.4801
ENSG00000102974homo_sapiensENSP0000035667425.646113.5189homo_sapiensENSP0000026401017.74429.35351
ENSG00000102974homo_sapiensENSP0000027061729.047118.4845homo_sapiensENSP0000026401034.800522.1458
ENSG00000102974homo_sapiensENSP0000028746130.620homo_sapiensENSP0000026401021.045413.7552
ENSG00000102974homo_sapiensENSP0000050784530.562319.0709homo_sapiensENSP0000026401034.387921.458
ENSG00000102974homo_sapiensENSP0000037970230.678520.2065homo_sapiensENSP0000026401028.610718.8446
ENSG00000102974homo_sapiensENSP0000032501834.839621.8659homo_sapiensENSP0000026401032.874820.6327
ENSG00000102974homo_sapiensENSP0000032394539.432225.8675homo_sapiensENSP0000026401017.193911.2792
ENSG00000102974homo_sapiensENSP0000038031519.609412.1875homo_sapiensENSP0000026401034.525421.458
ENSG00000102974homo_sapiensENSP0000050829834.620521.9707homo_sapiensENSP0000026401035.763422.696
ENSG00000102974homo_sapiensENSP0000048026226.537217.4757homo_sapiensENSP0000026401022.558514.8556
ENSG00000102974homo_sapiensENSP0000031753423.214310.7143homo_sapiensENSP0000026401016.09357.42779
ENSG00000102974homo_sapiensENSP0000048372026.525815.9624homo_sapiensENSP0000026401031.086718.707
ENSG00000102974homo_sapiensENSP0000042072738.003524.1681homo_sapiensENSP0000026401029.848718.9821
ENSG00000102974homo_sapiensENSP0000042102837.59424.0602homo_sapiensENSP0000026401020.632713.205
ENSG00000102974homo_sapiensENSP0000039879811.97676.88924homo_sapiensENSP0000026401031.086717.8817
ENSG00000102974homo_sapiensENSP0000031118338.554226.506homo_sapiensENSP0000026401026.409918.1568
ENSG00000102974homo_sapiensENSP0000023012225.53816.2123homo_sapiensENSP0000026401024.484215.5433
ENSG00000102974homo_sapiensENSP0000035193922.209812.9464homo_sapiensENSP0000026401027.372815.956
ENSG00000102974homo_sapiensENSP0000022345926.811617.7536homo_sapiensENSP0000026401010.17886.74003
ENSG00000102974homo_sapiensENSP0000044554935.772423.5772homo_sapiensENSP0000026401036.313623.934
ENSG00000102974homo_sapiensENSP0000033414627.175217.9976homo_sapiensENSP0000026401031.361820.7703
ENSG00000102974homo_sapiensENSP0000047296929.050918.9815homo_sapiensENSP0000026401034.525422.5585
ENSG00000102974homo_sapiensENSP0000046958219.488812.4601homo_sapiensENSP0000026401033.562621.458
ENSG00000102974homo_sapiensENSP0000046205429.326918.2692homo_sapiensENSP0000026401016.781310.4539
ENSG00000102974homo_sapiensENSP0000042186314.43118.51064homo_sapiensENSP0000026401021.45812.6547
ENSG00000102974homo_sapiensENSP0000030061922.75414.6935homo_sapiensENSP0000026401037.276524.0715

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000102974homo_sapiensENSP0000026401054.883154.8831nomascus_leucogenysENSNLEP00000005767100100
ENSG00000102974homo_sapiensENSP00000264010100100pan_paniscusENSPPAP00000041797100100
ENSG00000102974homo_sapiensENSP00000264010100100pongo_abeliiENSPPYP00000008429100100
ENSG00000102974homo_sapiensENSP00000264010100100pan_troglodytesENSPTRP00000014062100100
ENSG00000102974homo_sapiensENSP00000264010100100gorilla_gorillaENSGGOP00000001047100100
ENSG00000102974homo_sapiensENSP0000026401094.497991.6094ornithorhynchus_anatinusENSOANP0000004704094.497991.6094
ENSG00000102974homo_sapiensENSP0000026401096.698895.1857ornithorhynchus_anatinusENSOANP0000003385796.565995.0549
ENSG00000102974homo_sapiensENSP0000026401096.423794.4979sarcophilus_harrisiiENSSHAP0000002882096.423794.4979
ENSG00000102974homo_sapiensENSP0000026401089.133487.0702notamacropus_eugeniiENSMEUP0000000522889.256287.1901
ENSG00000102974homo_sapiensENSP0000026401081.29380.6052choloepus_hoffmanniENSCHOP0000000993581.40580.7163
ENSG00000102974homo_sapiensENSP0000026401099.449899.3122dasypus_novemcinctusENSDNOP0000002936599.313299.1758
ENSG00000102974homo_sapiensENSP0000026401088.03387.6204erinaceus_europaeusENSEEUP0000001351988.154387.741
ENSG00000102974homo_sapiensENSP0000026401085.832285.282echinops_telfairiENSETEP0000001437585.950485.3995
ENSG00000102974homo_sapiensENSP0000026401099.724999.5873callithrix_jacchusENSCJAP0000002971399.724999.5873
ENSG00000102974homo_sapiensENSP0000026401099.862499.7249cercocebus_atysENSCATP0000004032799.862499.7249
ENSG00000102974homo_sapiensENSP0000026401099.862499.7249macaca_fascicularisENSMFAP0000000855799.862499.7249
ENSG00000102974homo_sapiensENSP0000026401099.862499.7249macaca_mulattaENSMMUP0000001282799.862499.7249
ENSG00000102974homo_sapiensENSP0000026401099.862499.7249macaca_nemestrinaENSMNEP0000002597099.862499.7249
ENSG00000102974homo_sapiensENSP0000026401099.862499.7249papio_anubisENSPANP0000001857099.862499.7249
ENSG00000102974homo_sapiensENSP0000026401099.862499.7249mandrillus_leucophaeusENSMLEP0000003403099.862499.7249
ENSG00000102974homo_sapiensENSP0000026401099.587399.4498tursiops_truncatusENSTTRP0000000870499.587399.4498
ENSG00000102974homo_sapiensENSP0000026401099.449899.3122vulpes_vulpesENSVVUP0000001650899.724199.5862
ENSG00000102974homo_sapiensENSP0000026401099.449899.1747mus_spretusMGP_SPRETEiJ_P008932598.233797.962
ENSG00000102974homo_sapiensENSP0000026401099.724999.3122equus_asinusENSEASP0000503721299.724999.3122
ENSG00000102974homo_sapiensENSP0000026401099.724999.4498capra_hircusENSCHIP0000001157899.724999.4498
ENSG00000102974homo_sapiensENSP0000026401099.174798.8996loxodonta_africanaENSLAFP0000000597199.174798.8996
ENSG00000102974homo_sapiensENSP0000026401099.587399.3122panthera_leoENSPLOP0000002380699.587399.3122
ENSG00000102974homo_sapiensENSP0000026401099.587399.4498ailuropoda_melanoleucaENSAMEP0000001844299.587399.4498
ENSG00000102974homo_sapiensENSP0000026401099.724999.4498bos_indicus_hybridENSBIXP0000501889699.724999.4498
ENSG00000102974homo_sapiensENSP0000026401099.862499.7249oryctolagus_cuniculusENSOCUP0000003631398.37498.2385
ENSG00000102974homo_sapiensENSP0000026401099.724999.3122equus_caballusENSECAP0000007424499.587999.1758
ENSG00000102974homo_sapiensENSP0000026401099.724999.5873canis_lupus_familiarisENSCAFP0084501026499.724999.5873
ENSG00000102974homo_sapiensENSP0000026401099.587399.3122panthera_pardusENSPPRP0000002408599.587399.3122
ENSG00000102974homo_sapiensENSP0000026401029.711129.7111marmota_marmota_marmotaENSMMMP0000001694599.082699.0826
ENSG00000102974homo_sapiensENSP0000026401020.357619.5323marmota_marmota_marmotaENSMMMP0000001695991.35887.6543
ENSG00000102974homo_sapiensENSP0000026401099.312299.0371balaenoptera_musculusENSBMSP0001002508099.586299.3103
ENSG00000102974homo_sapiensENSP0000026401096.698895.8735cavia_porcellusENSCPOP0000000960098.874898.0309
ENSG00000102974homo_sapiensENSP0000026401099.449899.1747felis_catusENSFCAP0000000322199.449899.1747
ENSG00000102974homo_sapiensENSP0000026401099.449899.3122ursus_americanusENSUAMP0000002017899.313299.1758
ENSG00000102974homo_sapiensENSP0000026401096.836394.6355monodelphis_domesticaENSMODP0000000712996.703394.5055
ENSG00000102974homo_sapiensENSP0000026401099.724999.4498bison_bison_bisonENSBBBP0000002154699.724999.4498
ENSG00000102974homo_sapiensENSP0000026401099.587399.4498monodon_monocerosENSMMNP0001500283599.587399.4498
ENSG00000102974homo_sapiensENSP0000026401099.449899.3122sus_scrofaENSSSCP0000001981496.271696.1385
ENSG00000102974homo_sapiensENSP0000026401010099.7249microcebus_murinusENSMICP0000003575210099.7249
ENSG00000102974homo_sapiensENSP0000026401098.899698.6245octodon_degusENSODEP0000002212998.763798.489
ENSG00000102974homo_sapiensENSP0000026401099.587399.1747jaculus_jaculusENSJJAP0000002055599.450599.0385
ENSG00000102974homo_sapiensENSP0000026401099.724999.4498ovis_aries_rambouilletENSOARP0002002881299.724999.4498
ENSG00000102974homo_sapiensENSP0000026401099.174799.0371ursus_maritimusENSUMAP0000002714599.448399.3103
ENSG00000102974homo_sapiensENSP0000026401088.445788.4457ochotona_princepsENSOPRP0000001229199.381899.3818
ENSG00000102974homo_sapiensENSP0000026401099.587399.4498delphinapterus_leucasENSDLEP0000000109199.587399.4498
ENSG00000102974homo_sapiensENSP0000026401099.449899.3122physeter_catodonENSPCTP0000501736099.449899.3122
ENSG00000102974homo_sapiensENSP0000026401099.312299.0371mus_caroliMGP_CAROLIEiJ_P008582898.097897.8261
ENSG00000102974homo_sapiensENSP0000026401099.449899.1747mus_musculusENSMUSP0000000584198.233797.962
ENSG00000102974homo_sapiensENSP0000026401095.185793.8102dipodomys_ordiiENSDORP0000002484496.783295.3846
ENSG00000102974homo_sapiensENSP0000026401099.312299.1747mustela_putorius_furoENSMPUP0000000634599.586299.4483
ENSG00000102974homo_sapiensENSP0000026401010099.7249aotus_nancymaaeENSANAP0000001902210099.7249
ENSG00000102974homo_sapiensENSP0000026401099.862499.7249saimiri_boliviensis_boliviensisENSSBOP0000002925799.862499.7249
ENSG00000102974homo_sapiensENSP0000026401091.059290.9216vicugna_pacosENSVPAP0000000409699.399499.2493
ENSG00000102974homo_sapiensENSP0000026401099.724999.4498chlorocebus_sabaeusENSCSAP0000000027599.724999.4498
ENSG00000102974homo_sapiensENSP0000026401079.229777.9917tupaia_belangeriENSTBEP0000000753582.051380.7692
ENSG00000102974homo_sapiensENSP0000026401099.449899.0371mesocricetus_auratusENSMAUP0000001095198.770598.3607
ENSG00000102974homo_sapiensENSP0000026401099.587399.4498phocoena_sinusENSPSNP0000002771499.587399.4498
ENSG00000102974homo_sapiensENSP0000026401099.587399.4498camelus_dromedariusENSCDRP0000501923399.587399.4498
ENSG00000102974homo_sapiensENSP0000026401010099.8624carlito_syrichtaENSTSYP0000000702410099.8624
ENSG00000102974homo_sapiensENSP0000026401099.587399.3122panthera_tigris_altaicaENSPTIP0000001682999.587399.3122
ENSG00000102974homo_sapiensENSP0000026401099.449899.1747rattus_norvegicusENSRNOP0000007909896.271696.0053
ENSG00000102974homo_sapiensENSP0000026401099.724999.4498prolemur_simusENSPSMP0000001387699.724999.4498
ENSG00000102974homo_sapiensENSP0000026401099.449899.0371microtus_ochrogasterENSMOCP0000002503898.905698.4952
ENSG00000102974homo_sapiensENSP0000026401099.449898.8996sorex_araneusENSSARP0000000563499.586899.0358
ENSG00000102974homo_sapiensENSP0000026401099.312299.0371peromyscus_maniculatus_bairdiiENSPEMP0000002028298.633998.3607
ENSG00000102974homo_sapiensENSP0000026401099.724999.4498bos_mutusENSBMUP0000000451499.724999.4498
ENSG00000102974homo_sapiensENSP0000026401099.449899.1747mus_spicilegusENSMSIP0000001937797.177496.9086
ENSG00000102974homo_sapiensENSP0000026401099.449898.8996cricetulus_griseus_chok1gshdENSCGRP0000100509298.635798.09
ENSG00000102974homo_sapiensENSP0000026401098.899698.6245pteropus_vampyrusENSPVAP0000001565699.584599.3075
ENSG00000102974homo_sapiensENSP0000026401099.587398.6245myotis_lucifugusENSMLUP0000000476199.450598.489
ENSG00000102974homo_sapiensENSP0000026401096.561294.6355vombatus_ursinusENSVURP0001002802296.561294.6355
ENSG00000102974homo_sapiensENSP0000026401099.587399.3122rhinolophus_ferrumequinumENSRFEP0001002566099.587399.3122
ENSG00000102974homo_sapiensENSP0000026401099.587399.4498neovison_visonENSNVIP0000001248399.587399.4498
ENSG00000102974homo_sapiensENSP0000026401099.724999.4498bos_taurusENSBTAP0000001827999.724999.4498
ENSG00000102974homo_sapiensENSP0000026401099.724999.3122heterocephalus_glaber_femaleENSHGLP0000001504095.899595.5026
ENSG00000102974homo_sapiensENSP0000026401099.862499.7249rhinopithecus_bietiENSRBIP0000002154399.862499.7249
ENSG00000102974homo_sapiensENSP0000026401099.449899.3122canis_lupus_dingoENSCAFP0002002302299.724199.5862
ENSG00000102974homo_sapiensENSP0000026401099.449899.3122sciurus_vulgarisENSSVLP0000502914099.449899.3122
ENSG00000102974homo_sapiensENSP0000026401096.561294.6355phascolarctos_cinereusENSPCIP0000002313696.561294.6355
ENSG00000102974homo_sapiensENSP0000026401099.037198.6245procavia_capensisENSPCAP0000000875999.173698.7603
ENSG00000102974homo_sapiensENSP0000026401099.174798.0743nannospalax_galiliENSNGAP0000000479797.432496.3513
ENSG00000102974homo_sapiensENSP0000026401099.724999.4498bos_grunniensENSBGRP0000004210799.724999.4498
ENSG00000102974homo_sapiensENSP0000026401099.862499.5873chinchilla_lanigeraENSCLAP0000001233699.725399.4505
ENSG00000102974homo_sapiensENSP0000026401099.587399.0371cervus_hanglu_yarkandensisENSCHYP0000001631299.587399.0371
ENSG00000102974homo_sapiensENSP0000026401099.449899.3122catagonus_wagneriENSCWAP0000000596699.449899.3122
ENSG00000102974homo_sapiensENSP0000026401099.724999.5873ictidomys_tridecemlineatusENSSTOP0000001743099.724999.5873
ENSG00000102974homo_sapiensENSP0000026401099.449899.1747otolemur_garnettiiENSOGAP0000001065099.313299.0385
ENSG00000102974homo_sapiensENSP0000026401086.382485.5571cebus_imitatorENSCCAP0000000041992.899492.0118
ENSG00000102974homo_sapiensENSP0000026401099.724999.5873urocitellus_parryiiENSUPAP0001000107399.724999.5873
ENSG00000102974homo_sapiensENSP0000026401099.724999.4498moschus_moschiferusENSMMSP0000000200599.724999.4498
ENSG00000102974homo_sapiensENSP0000026401099.862499.7249rhinopithecus_roxellanaENSRROP0000002933699.862499.7249
ENSG00000102974homo_sapiensENSP0000026401099.449899.1747mus_pahariMGP_PahariEiJ_P005408198.233797.962
ENSG00000102974homo_sapiensENSP0000026401099.862499.5873propithecus_coquereliENSPCOP0000002719599.862499.5873
ENSG00000102974homo_sapiensENSP0000026401067.262756.6713petromyzon_marinusENSPMAP0000000468975.696663.7771
ENSG00000102974homo_sapiensENSP0000026401019.394817.8817eptatretus_burgeriENSEBUP0000000017490.967783.871
ENSG00000102974homo_sapiensENSP0000026401084.181676.4787callorhinchus_miliiENSCMIP000000460368577.2222
ENSG00000102974homo_sapiensENSP0000026401092.297188.033latimeria_chalumnaeENSLACP0000001117486.804782.7943
ENSG00000102974homo_sapiensENSP0000026401083.493876.8913lepisosteus_oculatusENSLOCP0000000833882.58576.0544
ENSG00000102974homo_sapiensENSP0000026401084.731877.9917clupea_harengusENSCHAP0000002672471.461765.7773
ENSG00000102974homo_sapiensENSP0000026401083.631478.1293danio_rerioENSDARP0000007359576.190571.1779
ENSG00000102974homo_sapiensENSP0000026401083.081277.304carassius_auratusENSCARP0000005955676.262670.9596
ENSG00000102974homo_sapiensENSP0000026401083.493877.1664carassius_auratusENSCARP0000009071271.580266.1557
ENSG00000102974homo_sapiensENSP0000026401083.906577.9917astyanax_mexicanusENSAMXP0000002111074.481169.2308
ENSG00000102974homo_sapiensENSP0000026401084.319177.5791ictalurus_punctatusENSIPUP0000000551270.867165.2023
ENSG00000102974homo_sapiensENSP0000026401081.980774.9656esox_luciusENSELUP0000001670474.568.125
ENSG00000102974homo_sapiensENSP0000026401079.642472.2146esox_luciusENSELUP000000114727568.0052
ENSG00000102974homo_sapiensENSP0000026401080.742874.4154electrophorus_electricusENSEEEP0000004872274.116268.3081
ENSG00000102974homo_sapiensENSP0000026401079.504872.2146oncorhynchus_kisutchENSOKIP0000504779869.975863.5593
ENSG00000102974homo_sapiensENSP0000026401081.843274.8281oncorhynchus_kisutchENSOKIP0000507263074.468168.0851
ENSG00000102974homo_sapiensENSP0000026401079.229772.3521oncorhynchus_kisutchENSOKIP000051170207568.4896
ENSG00000102974homo_sapiensENSP0000026401082.393475.5158oncorhynchus_kisutchENSOKIP0000500269274.688368.4539
ENSG00000102974homo_sapiensENSP0000026401079.092272.3521oncorhynchus_mykissENSOMYP0000010499473.341867.0918
ENSG00000102974homo_sapiensENSP0000026401079.642472.3521oncorhynchus_mykissENSOMYP0000004517575.194868.3117
ENSG00000102974homo_sapiensENSP0000026401081.705674.6905oncorhynchus_mykissENSOMYP0000000129174.064867.7057
ENSG00000102974homo_sapiensENSP0000026401081.980775.3783oncorhynchus_mykissENSOMYP0000003057874.40768.4145
ENSG00000102974homo_sapiensENSP0000026401082.118375.3783salmo_salarENSSSAP0000015081174.905968.7578
ENSG00000102974homo_sapiensENSP0000026401079.229772.3521salmo_salarENSSSAP0000012013071.910165.6679
ENSG00000102974homo_sapiensENSP0000026401079.367372.2146salmo_salarENSSSAP0000014195572.305865.7895
ENSG00000102974homo_sapiensENSP0000026401081.980775.2407salmo_salarENSSSAP0000007477572.41866.4642
ENSG00000102974homo_sapiensENSP0000026401081.843274.9656salmo_truttaENSSTUP0000001680674.468168.2103
ENSG00000102974homo_sapiensENSP0000026401078.954672.077salmo_truttaENSSTUP0000011452471.7565.5
ENSG00000102974homo_sapiensENSP0000026401081.843275.6534salmo_truttaENSSTUP0000006339774.65569.0088
ENSG00000102974homo_sapiensENSP0000026401079.367372.2146salmo_truttaENSSTUP0000008201771.945165.4613
ENSG00000102974homo_sapiensENSP0000026401081.29373.1774gadus_morhuaENSGMOP0000000679670.609363.5603
ENSG00000102974homo_sapiensENSP0000026401064.09958.597fundulus_heteroclitusENSFHEP0000001558069.760563.7725
ENSG00000102974homo_sapiensENSP0000026401078.679571.9395fundulus_heteroclitusENSFHEP0000002775775.761669.2715
ENSG00000102974homo_sapiensENSP0000026401080.05572.6272poecilia_reticulataENSPREP0000001032670.036163.5379
ENSG00000102974homo_sapiensENSP0000026401078.817171.8019poecilia_reticulataENSPREP0000000167175.394768.6842
ENSG00000102974homo_sapiensENSP0000026401078.817171.6644xiphophorus_maculatusENSXMAP0000003119176.095669.1899
ENSG00000102974homo_sapiensENSP0000026401079.917572.4897xiphophorus_maculatusENSXMAP0000001641163.220957.3449
ENSG00000102974homo_sapiensENSP0000026401077.166469.326oryzias_latipesENSORLP0000001101774.50266.9323
ENSG00000102974homo_sapiensENSP0000026401041.127937.0014oryzias_latipesENSORLP0000002298679.946571.9251
ENSG00000102974homo_sapiensENSP0000026401080.330172.4897cyclopterus_lumpusENSCLMP0000501068369.606762.8129
ENSG00000102974homo_sapiensENSP0000026401067.812960.6602cyclopterus_lumpusENSCLMP0000504892383.701274.8727
ENSG00000102974homo_sapiensENSP0000026401042.365940.1651oreochromis_niloticusENSONIP0000000723091.940387.1642
ENSG00000102974homo_sapiensENSP0000026401081.017972.4897oreochromis_niloticusENSONIP0000004309363.606956.9114
ENSG00000102974homo_sapiensENSP0000026401079.229771.3893haplochromis_burtoniENSHBUP0000001319582.403474.2489
ENSG00000102974homo_sapiensENSP0000026401076.616269.6011haplochromis_burtoniENSHBUP0000000400382.396474.8521
ENSG00000102974homo_sapiensENSP0000026401079.229770.9766astatotilapia_callipteraENSACLP0000000645177.211869.1689
ENSG00000102974homo_sapiensENSP0000026401081.017972.4897astatotilapia_callipteraENSACLP0000002315566.478659.4808
ENSG00000102974homo_sapiensENSP0000026401081.29373.5901sparus_aurataENSSAUP0001005255366.3360.0449
ENSG00000102974homo_sapiensENSP0000026401079.504871.5268sparus_aurataENSSAUP0001006430075.85368.2415
ENSG00000102974homo_sapiensENSP0000026401068.500761.8982lates_calcariferENSLCAP0001000420872.913665.8858
ENSG00000102974homo_sapiensENSP0000026401091.059286.5199xenopus_tropicalisENSXETP0000003406690.190785.6948
ENSG00000102974homo_sapiensENSP0000026401096.286195.0481chrysemys_picta_belliiENSCPBP0000001787896.286195.0481
ENSG00000102974homo_sapiensENSP0000026401094.497992.8473sphenodon_punctatusENSSPUP0000002285695.815994.1423
ENSG00000102974homo_sapiensENSP0000026401096.286194.9106crocodylus_porosusENSCPRP0000500059195.238193.8775
ENSG00000102974homo_sapiensENSP0000026401094.77392.022laticauda_laticaudataENSLLTP0000000551094.254491.5185
ENSG00000102974homo_sapiensENSP0000026401014.71813.3425notechis_scutatusENSNSUP0000001022369.934663.3987
ENSG00000102974homo_sapiensENSP0000026401094.77392.022pseudonaja_textilisENSPTXP0000002626394.254491.5185
ENSG00000102974homo_sapiensENSP0000026401094.77392.022pseudonaja_textilisENSPTXP0000001148691.379388.7268
ENSG00000102974homo_sapiensENSP0000026401095.323293.6726anas_platyrhynchos_platyrhynchosENSAPLP0000001972493.775492.1516
ENSG00000102974homo_sapiensENSP0000026401095.460893.6726gallus_gallusENSGALP0001003329286.104284.4913
ENSG00000102974homo_sapiensENSP0000026401090.371488.7208meleagris_gallopavoENSMGAP0000000177393.456691.7496
ENSG00000102974homo_sapiensENSP0000026401095.598493.6726serinus_canariaENSSCAP0000000755492.05390.1987
ENSG00000102974homo_sapiensENSP0000026401095.598493.5351parus_majorENSPMJP0000001894192.666790.6667
ENSG00000102974homo_sapiensENSP0000026401094.497992.7098anolis_carolinensisENSACAP0000000104790.394788.6842
ENSG00000102974homo_sapiensENSP0000026401079.642471.3893neolamprologus_brichardiENSNBRP0000001199876.790568.8329
ENSG00000102974homo_sapiensENSP0000026401081.017972.6272neolamprologus_brichardiENSNBRP0000001471767.545960.5505
ENSG00000102974homo_sapiensENSP0000026401095.048192.4347naja_najaENSNNAP0000002320094.52891.9289
ENSG00000102974homo_sapiensENSP0000026401095.735993.8102podarcis_muralisENSPMRP0000001233495.735993.8102
ENSG00000102974homo_sapiensENSP0000026401095.735993.5351geospiza_fortisENSGFOP0000001670692.890.6667
ENSG00000102974homo_sapiensENSP0000026401095.735993.5351taeniopygia_guttataENSTGUP0000000577892.890.6667
ENSG00000102974homo_sapiensENSP0000026401086.932681.1554erpetoichthys_calabaricusENSECRP0000001052579.59774.3073
ENSG00000102974homo_sapiensENSP0000026401018.431918.1568kryptolebias_marmoratusENSKMAP0000001154789.333388
ENSG00000102974homo_sapiensENSP0000026401080.05571.3893kryptolebias_marmoratusENSKMAP0000001161269.285761.7857
ENSG00000102974homo_sapiensENSP0000026401095.735993.8102salvator_merianaeENSSMRP0000001111289.230887.4359
ENSG00000102974homo_sapiensENSP0000026401050.894146.4924oryzias_javanicusENSOJAP0000004978882.589375.4464
ENSG00000102974homo_sapiensENSP0000026401079.779972.2146oryzias_javanicusENSOJAP0000000049170.991464.2595
ENSG00000102974homo_sapiensENSP0000026401041.953240.1651amphilophus_citrinellusENSACIP0000000351686.647782.9545
ENSG00000102974homo_sapiensENSP0000026401075.240769.6011amphilophus_citrinellusENSACIP0000002260384.153877.8462
ENSG00000102974homo_sapiensENSP0000026401078.954671.5268dicentrarchus_labraxENSDLAP0000502650578.308370.9413
ENSG00000102974homo_sapiensENSP0000026401073.177466.2999dicentrarchus_labraxENSDLAP0000502026279.760172.2639
ENSG00000102974homo_sapiensENSP0000026401081.29373.0399amphiprion_perculaENSAPEP0000002740468.641161.6725
ENSG00000102974homo_sapiensENSP0000026401078.954671.8019amphiprion_perculaENSAPEP0000001886876.533369.6
ENSG00000102974homo_sapiensENSP0000026401080.192672.9023oryzias_sinensisENSOSIP0000000369668.7562.5
ENSG00000102974homo_sapiensENSP0000026401077.166469.4635oryzias_sinensisENSOSIP0000004142272.10864.91
ENSG00000102974homo_sapiensENSP0000026401096.286194.773pelodiscus_sinensisENSPSIP0000000379695.49893.9973
ENSG00000102974homo_sapiensENSP0000026401096.423795.1857chelonoidis_abingdoniiENSCABP0000000438696.423795.1857
ENSG00000102974homo_sapiensENSP0000026401081.017973.1774seriola_dumeriliENSSDUP0000002769468.488461.8605
ENSG00000102974homo_sapiensENSP0000026401076.478768.088seriola_dumeriliENSSDUP0000002606774.232366.0881
ENSG00000102974homo_sapiensENSP0000026401077.854269.4635cottoperca_gobioENSCGOP0000003687673.221265.3299
ENSG00000102974homo_sapiensENSP0000026401095.873594.3604struthio_camelus_australisENSSCUP0000002244594.316692.8281
ENSG00000102974homo_sapiensENSP0000026401095.460893.8102anser_brachyrhynchusENSABRP0000000449793.910792.2869
ENSG00000102974homo_sapiensENSP0000026401076.478769.6011gasterosteus_aculeatusENSGACP0000000327073.83867.1979
ENSG00000102974homo_sapiensENSP0000026401077.166469.326gasterosteus_aculeatusENSGACP0000002094179.014170.9859
ENSG00000102974homo_sapiensENSP0000026401079.229770.564cynoglossus_semilaevisENSCSEP0000002935875.789567.5
ENSG00000102974homo_sapiensENSP0000026401079.504873.0399cynoglossus_semilaevisENSCSEP0000003290966.284460.8945
ENSG00000102974homo_sapiensENSP0000026401079.917572.6272poecilia_formosaENSPFOP0000002570669.915863.5379
ENSG00000102974homo_sapiensENSP0000026401078.817171.5268poecilia_formosaENSPFOP0000000147475.693568.6922
ENSG00000102974homo_sapiensENSP0000026401080.880373.1774myripristis_murdjanENSMMDP0000503874869.833763.1829
ENSG00000102974homo_sapiensENSP0000026401079.092271.3893myripristis_murdjanENSMMDP0000500038176.259968.8329
ENSG00000102974homo_sapiensENSP0000026401079.229770.564sander_luciopercaENSSLUP0000005516375.097866.884
ENSG00000102974homo_sapiensENSP0000026401081.017973.5901sander_luciopercaENSSLUP0000003896968.408862.1371
ENSG00000102974homo_sapiensENSP0000026401095.598493.8102strigops_habroptilaENSSHBP0000500328295.46793.6813
ENSG00000102974homo_sapiensENSP0000026401095.185793.3975strigops_habroptilaENSSHBP0000500117895.054993.2692
ENSG00000102974homo_sapiensENSP0000026401081.155473.0399amphiprion_ocellarisENSAOCP0000000346968.684561.8161
ENSG00000102974homo_sapiensENSP0000026401078.954671.8019amphiprion_ocellarisENSAOCP0000002059776.533369.6
ENSG00000102974homo_sapiensENSP0000026401096.423795.0481terrapene_carolina_triunguisENSTMTP0000001341196.423795.0481
ENSG00000102974homo_sapiensENSP0000026401096.286194.9106terrapene_carolina_triunguisENSTMTP0000001325496.286194.9106
ENSG00000102974homo_sapiensENSP0000026401081.430574.2779hucho_huchoENSHHUP0000007889474.747568.1818
ENSG00000102974homo_sapiensENSP0000026401079.504871.8019hucho_huchoENSHHUP0000006478375.162667.8804
ENSG00000102974homo_sapiensENSP0000026401082.118375.9285hucho_huchoENSHHUP0000005789474.81269.1729
ENSG00000102974homo_sapiensENSP0000026401079.092271.8019hucho_huchoENSHHUP0000003403575.065368.1462
ENSG00000102974homo_sapiensENSP0000026401079.917571.6644betta_splendensENSBSLP0000001797568.514261.4387
ENSG00000102974homo_sapiensENSP0000026401083.768977.7166pygocentrus_nattereriENSPNAP0000001179574.268368.9024
ENSG00000102974homo_sapiensENSP0000026401079.504871.8019anabas_testudineusENSATEP0000000328075.85368.5039
ENSG00000102974homo_sapiensENSP0000026401074.965669.0509anabas_testudineusENSATEP0000000559575.694469.7222
ENSG00000102974homo_sapiensENSP0000026401079.779971.6644seriola_lalandi_dorsalisENSSLDP0000002343874.935467.3127
ENSG00000102974homo_sapiensENSP0000026401021.45818.0193seriola_lalandi_dorsalisENSSLDP0000000257175.728263.5922
ENSG00000102974homo_sapiensENSP0000026401018.844618.0193seriola_lalandi_dorsalisENSSLDP0000000253391.333387.3333
ENSG00000102974homo_sapiensENSP0000026401078.817170.1513labrus_bergyltaENSLBEP0000003258277.016168.5484
ENSG00000102974homo_sapiensENSP0000026401073.452567.2627labrus_bergyltaENSLBEP0000000667776.614170.1578
ENSG00000102974homo_sapiensENSP0000026401081.017972.6272pundamilia_nyerereiENSPNYP0000002463767.545960.5505
ENSG00000102974homo_sapiensENSP0000026401019.257218.707pundamilia_nyerereiENSPNYP0000001952692.715290.0662
ENSG00000102974homo_sapiensENSP0000026401019.94516.7813pundamilia_nyerereiENSPNYP0000001950674.742362.8866
ENSG00000102974homo_sapiensENSP0000026401079.229771.6644mastacembelus_armatusENSMAMP0000006433575.989468.7335
ENSG00000102974homo_sapiensENSP0000026401081.155473.7276mastacembelus_armatusENSMAMP0000006335365.193459.2265
ENSG00000102974homo_sapiensENSP0000026401081.29373.4525stegastes_partitusENSSPAP0000000534467.697661.1684
ENSG00000102974homo_sapiensENSP0000026401079.367372.077stegastes_partitusENSSPAP0000001322376.423869.404
ENSG00000102974homo_sapiensENSP0000026401079.229772.077oncorhynchus_tshawytschaENSOTSP0000502639469.818263.5152
ENSG00000102974homo_sapiensENSP0000026401082.118375.3783oncorhynchus_tshawytschaENSOTSP0000506030974.531868.4145
ENSG00000102974homo_sapiensENSP0000026401018.569515.8184oncorhynchus_tshawytschaENSOTSP0000503566467.839257.7889
ENSG00000102974homo_sapiensENSP0000026401081.568174.553oncorhynchus_tshawytschaENSOTSP0000503266072.141165.9367
ENSG00000102974homo_sapiensENSP0000026401080.880373.0399acanthochromis_polyacanthusENSAPOP0000001907369.668262.9147
ENSG00000102974homo_sapiensENSP0000026401078.404471.3893acanthochromis_polyacanthusENSAPOP0000003374676.612969.7581
ENSG00000102974homo_sapiensENSP0000026401095.598493.9477aquila_chrysaetos_chrysaetosENSACCP0002000522492.666791.0667
ENSG00000102974homo_sapiensENSP0000026401078.954671.1142nothobranchius_furzeriENSNFUP0001501886275.526368.0263
ENSG00000102974homo_sapiensENSP0000026401078.404470.8391nothobranchius_furzeriENSNFUP0001502419969.512262.8049
ENSG00000102974homo_sapiensENSP0000026401078.954671.2517cyprinodon_variegatusENSCVAP0000000789776.127368.7003
ENSG00000102974homo_sapiensENSP0000026401068.500763.2737cyprinodon_variegatusENSCVAP0000000220275.226669.4864
ENSG00000102974homo_sapiensENSP0000026401083.906577.4415denticeps_clupeoidesENSDCDP0000005685575.49569.6782
ENSG00000102974homo_sapiensENSP0000026401078.404470.4264larimichthys_croceaENSLCRP0000504435581.312473.0385
ENSG00000102974homo_sapiensENSP0000026401081.29373.4525larimichthys_croceaENSLCRP0000502990168.961562.3104
ENSG00000102974homo_sapiensENSP0000026401074.690567.2627takifugu_rubripesENSTRUP0000004599879.154571.2828
ENSG00000102974homo_sapiensENSP0000026401095.735993.6726ficedula_albicollisENSFALP0000000747992.890.8
ENSG00000102974homo_sapiensENSP0000026401078.404470.4264hippocampus_comesENSHCOP0000001919776.203268.4492
ENSG00000102974homo_sapiensENSP0000026401083.493877.304cyprinus_carpio_carpioENSCCRP0000004427876.065270.4261
ENSG00000102974homo_sapiensENSP0000026401083.631477.5791cyprinus_carpio_carpioENSCCRP0000004431076.47870.9434
ENSG00000102974homo_sapiensENSP0000026401089.27187.4828coturnix_japonicaENSCJPP0000501376994.606492.7114
ENSG00000102974homo_sapiensENSP0000026401079.779972.4897poecilia_latipinnaENSPLAP0000000087869.795463.4176
ENSG00000102974homo_sapiensENSP0000026401078.817171.6644poecilia_latipinnaENSPLAP0000002762275.693568.8243
ENSG00000102974homo_sapiensENSP0000026401082.943676.8913sinocyclocheilus_grahamiENSSGRP0000009723177.506471.8509
ENSG00000102974homo_sapiensENSP0000026401083.218777.304sinocyclocheilus_grahamiENSSGRP0000003336969.063964.1553
ENSG00000102974homo_sapiensENSP0000026401081.017972.6272maylandia_zebraENSMZEP0000503051669.952562.7078
ENSG00000102974homo_sapiensENSP0000026401079.092271.1142maylandia_zebraENSMZEP0000501749976.259968.5676
ENSG00000102974homo_sapiensENSP0000026401077.991770.4264tetraodon_nigroviridisENSTNIP0000001218083.875775.7396
ENSG00000102974homo_sapiensENSP0000026401081.980773.0399paramormyrops_kingsleyaeENSPKIP0000000303579.150170.5179
ENSG00000102974homo_sapiensENSP0000026401086.244877.1664scleropages_formosusENSSFOP0001501738578.082269.863
ENSG00000102974homo_sapiensENSP0000026401085.28278.4044scleropages_formosusENSSFOP0001502201173.897567.938
ENSG00000102974homo_sapiensENSP0000026401087.895583.6314leptobrachium_leishanenseENSLLEP0000003282181.091477.1574
ENSG00000102974homo_sapiensENSP0000026401075.653467.1252scophthalmus_maximusENSSMAP0000000100669.620361.7722
ENSG00000102974homo_sapiensENSP0000026401081.155473.4525scophthalmus_maximusENSSMAP0000003727068.684562.1653
ENSG00000102974homo_sapiensENSP0000026401075.790967.2627oryzias_melastigmaENSOMEP0000002269473.076964.8541
ENSG00000102974homo_sapiensENSP0000026401080.192672.4897oryzias_melastigmaENSOMEP0000001983970.752463.9563

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II2IBA,IDAHomo_sapiens(9606)Process
GO:0000775located_in chromosome, centromeric region1IDAHomo_sapiens(9606)Component
GO:0000793located_in condensed chromosome1IDAHomo_sapiens(9606)Component
GO:0000976enables transcription cis-regulatory region binding1IDAHomo_sapiens(9606)Function
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0001221enables transcription coregulator binding1IPIHomo_sapiens(9606)Function
GO:0001227enables DNA-binding transcription repressor activity, RNA polymerase II-specific1IDAHomo_sapiens(9606)Function
GO:0001673located_in male germ cell nucleus1IEAHomo_sapiens(9606)Component
GO:0003700enables DNA-binding transcription factor activity2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0006306involved_in DNA methylation1IEAHomo_sapiens(9606)Process
GO:0006349involved_in regulation of gene expression by genomic imprinting1IEAHomo_sapiens(9606)Process
GO:0007059involved_in chromosome segregation1IEAHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding1TASHomo_sapiens(9606)Function
GO:0008285involved_in negative regulation of cell population proliferation1IMPHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0040029involved_in epigenetic regulation of gene expression2IBA,IMPHomo_sapiens(9606)Process
GO:0043035enables chromatin insulator sequence binding2IBA,IDAHomo_sapiens(9606)Function
GO:0043565enables sequence-specific DNA binding1IDAHomo_sapiens(9606)Function
GO:0044027involved_in negative regulation of gene expression via CpG island methylation1IEAHomo_sapiens(9606)Process
GO:0045892involved_in negative regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0070602involved_in regulation of centromeric sister chromatid cohesion1NASHomo_sapiens(9606)Process
GO:0071459involved_in protein localization to chromosome, centromeric region1IMPHomo_sapiens(9606)Process
GO:0071514involved_in genomic imprinting1IDAHomo_sapiens(9606)Process
GO:0140588involved_in chromatin looping1IDAHomo_sapiens(9606)Process

Expression