RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000102393	Gene ID	2717	Accession	4296
Symbol	GLA	Alias	GALA	Full Name	galactosidase alpha
Status	Confidence	Length	10210 bases	Strand	Minus strand
Position	X : 101397803 - 101408012	RNA binding domain	N.A.
Summary	This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
28430823	Modulation the alternative splicing of GLA (IVS4+919G>A) in Fabry disease.	Wen-Hsin Chang	2017-01-01	PloS one

Name	Transcript ID	bp	Protein	Translation ID
GLA-210	ENST00000674142	1978	No protein	-
GLA-203	ENST00000468823	3748	No protein	-
GLA-217	ENST00000710365	1743	454aa	ENSP00000518234
GLA-207	ENST00000493905	1358	222aa	ENSP00000476935
GLA-201	ENST00000218516	1318	429aa	ENSP00000218516
GLA-202	ENST00000466414	1431	No protein	-
GLA-204	ENST00000479445	1909	No protein	-
GLA-208	ENST00000649178	1424	470aa	ENSP00000498186
GLA-214	ENST00000675968	4163	No protein	-
GLA-212	ENST00000675592	1092	363aa	ENSP00000502239
GLA-215	ENST00000676156	1254	417aa	ENSP00000501730
GLA-216	ENST00000676372	1356	270aa	ENSP00000502805
GLA-209	ENST00000674127	1474	222aa	ENSP00000501044
GLA-213	ENST00000675799	1420	199aa	ENSP00000502661
GLA-206	ENST00000486121	1300	222aa	ENSP00000501124
GLA-205	ENST00000480513	1180	199aa	ENSP00000497055
GLA-211	ENST00000674634	1089	362aa	ENSP00000502629

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003824	enables catalytic activity	1	IDA	Homo_sapiens(9606)	Function
GO:0004557	enables alpha-galactosidase activity	3	IBA,IDA,IMP	Homo_sapiens(9606)	Function
GO:0005102	enables signaling receptor binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005576	located_in extracellular region	3	IDA,IMP,TAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IMP	Homo_sapiens(9606)	Component
GO:0005764	located_in lysosome	2	IMP,TAS	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IMP	Homo_sapiens(9606)	Component
GO:0009311	involved_in oligosaccharide metabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0016139	involved_in glycoside catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0016787	enables hydrolase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0016936	enables galactoside binding	1	IEA	Homo_sapiens(9606)	Function
GO:0017041	enables galactosylgalactosylglucosylceramidase activity	2	IDA,IMP	Homo_sapiens(9606)	Function
GO:0035578	located_in azurophil granule lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0042803	enables protein homodimerization activity	1	IDA	Homo_sapiens(9606)	Function
GO:0043202	located_in lysosomal lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0045019	involved_in negative regulation of nitric oxide biosynthetic process	1	ISS	Homo_sapiens(9606)	Process
GO:0046477	involved_in glycosylceramide catabolic process	1	ISS	Homo_sapiens(9606)	Process
GO:0046479	involved_in glycosphingolipid catabolic process	3	IDA,IMP,TAS	Homo_sapiens(9606)	Process
GO:0051001	involved_in negative regulation of nitric-oxide synthase activity	1	ISS	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component