Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug Drug
Main interacting RNAs ncRNA
Moonlighting functions Transmemebrane
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000101916 Gene ID 51311 Accession 15632
Symbol TLR8 Alias CD288;IMD98;TLR-8;hTLR8 Full Name toll like receptor 8
Status Confidence Length 16550 bases Strand Plus strand
Position X : 12906620 - 12923169 RNA binding domain N.A.
Summary The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
34677064 Immunogenicity of In Vitro-Transcribed RNA. Xin Mu 2021-11-02 Accounts of chemical research
37513775 The Potential of Probiotics as Ingestible Adjuvants and Immune Modulators for Antiviral Immunity and Management of SARS-CoV-2 Infection and COVID-19. Sophie Tomkinson 2023-07-11 Pathogens (Basel, Switzerland)
30699960 RNA Modifications Modulate Activation of Innate Toll-Like Receptors. Isabel Freund 2019-01-29 Genes
32933031 Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy. R Alain Thierry 2020-09-11 Journal of clinical medicine
27988432 TLRs, future potential therapeutic targets for RA. A Hatem Elshabrawy 2017-02-01 Autoimmunity reviews
25431922 Looking into a conceptual framework of ROS-miRNA-atrial fibrillation. Seahyoung Lee 2014-11-26 International journal of molecular sciences
24062747 Aberrant Type I Interferon Regulation in Autoimmunity: Opposite Directions in MS and SLE, Shaped by Evolution and Body Ecology. T Anthony Reder 2013-09-17 Frontiers in immunology
27455396 Discriminating self from non-self in nucleic acid sensing. Martin Schlee 2016-09-01 Nature reviews. Immunology
23965954 Principles of miRNA-target regulation in metazoan models. Epaminondas Doxakis 2013-08-07 International journal of molecular sciences
27769507 Endogenous Retroelements and the Host Innate Immune Sensors. X Mu 2016-01-01 Advances in immunology
36986379 IFN-Induced PARPs-Sensors of Foreign Nucleic Acids? Katharina Biaesch 2023-03-14 Pathogens (Basel, Switzerland)
28987220 Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness. R Michael Edwards 2017-10-01 The Journal of allergy and clinical immunology
33650968 In vivo reconstitution finds multivalent RNA-RNA interactions as drivers of mesh-like condensates. Weirui Ma 2021-03-02 eLife
28530246 Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9. Jelka Pohar 2017-05-22 Nature communications
34414672 Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll-like receptors 7 and 8. Andreas Port 2021-10-01 Pharmacology research & perspectives
36267192 mRNA vaccines: A novel weapon to control infectious diseases. Yuying Tian 2022-01-01 Frontiers in microbiology
31778653 TLR8 Is a Sensor of RNase T2 Degradation Products. Wilhelm Greulich 2019-11-27 Cell
25487859 Base modification strategies to modulate immune stimulation by an siRNA. P Anne Rachel Valenzuela 2015-01-19 Chembiochem : a European journal of chemical biology

Transcripts

Name Transcript ID bp Protein Translation ID
TLR8-201 ENST00000218032 4216 1041aa ENSP00000218032
TLR8-202 ENST00000311912 3367 1059aa ENSP00000312082

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
63725Celiac Disease6E-820190752

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000101916homo_sapiensENSP0000037003459.485242.04homo_sapiensENSP0000021803259.942442.3631
ENSG00000101916homo_sapiensENSP0000030686430.609218.8707homo_sapiensENSP0000021803219.788712.1998
ENSG00000101916homo_sapiensENSP0000021553939.504125.6198homo_sapiensENSP0000021803222.958714.8895
ENSG00000101916homo_sapiensENSP0000036308939.809323.0036homo_sapiensENSP0000021803232.084518.5399
ENSG00000101916homo_sapiensENSP0000034424237.188221.9955homo_sapiensENSP0000021803215.75419.31796
ENSG00000101916homo_sapiensENSP0000029159241.634226.07homo_sapiensENSP0000021803210.27866.43612
ENSG00000101916homo_sapiensENSP0000036715737.090923.6364homo_sapiensENSP000002180329.798276.244
ENSG00000101916homo_sapiensENSP0000037988038.996120.4633homo_sapiensENSP000002180329.702215.09126
ENSG00000101916homo_sapiensENSP0000032862536.994221.0983homo_sapiensENSP0000021803224.591714.025
ENSG00000101916homo_sapiensENSP0000030892538.101120.8385homo_sapiensENSP0000021803229.68316.2344
ENSG00000101916homo_sapiensENSP0000029679542.035425.5531homo_sapiensENSP0000021803236.503422.1902
ENSG00000101916homo_sapiensENSP0000049635540.792523.7762homo_sapiensENSP0000021803233.621519.5965
ENSG00000101916homo_sapiensENSP0000033266834.560923.2295homo_sapiensENSP0000021803211.71957.87704
ENSG00000101916homo_sapiensENSP0000029838631.830217.6393homo_sapiensENSP0000021803223.054812.7762
ENSG00000101916homo_sapiensENSP0000049442539.413323.0867homo_sapiensENSP0000021803229.68317.3871
ENSG00000101916homo_sapiensENSP0000026006138.217524.4713homo_sapiensENSP0000021803224.303615.562
ENSG00000101916homo_sapiensENSP0000035493239.694721.5013homo_sapiensENSP0000021803229.971216.2344
ENSG00000101916homo_sapiensENSP0000036118532.909117.4545homo_sapiensENSP0000021803217.38719.2219
ENSG00000101916homo_sapiensENSP0000030324831.439917.1731homo_sapiensENSP0000021803222.862612.488
ENSG00000101916homo_sapiensENSP0000029463512.9117.69848homo_sapiensENSP0000021803215.46599.2219
ENSG00000101916homo_sapiensENSP0000042471836.557820.2261homo_sapiensENSP0000021803227.953915.4659
ENSG00000101916homo_sapiensENSP0000025644739.485623.9032homo_sapiensENSP0000021803225.07215.1777

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000101916homo_sapiensENSP0000021803298.751298.1748nomascus_leucogenysENSNLEP0000001110998.751298.1748
ENSG00000101916homo_sapiensENSP0000021803299.903999.7118pan_paniscusENSPPAP0000003378499.903999.7118
ENSG00000101916homo_sapiensENSP0000021803299.327698.367pongo_abeliiENSPPYP0000002251297.639396.695
ENSG00000101916homo_sapiensENSP0000021803299.807999.5197pan_troglodytesENSPTRP0000006254698.111497.8281
ENSG00000101916homo_sapiensENSP0000021803299.807999.6158gorilla_gorillaENSGGOP0000001202198.111497.9226
ENSG00000101916homo_sapiensENSP0000021803277.809863.3045ornithorhynchus_anatinusENSOANP0000003995677.437963.0019
ENSG00000101916homo_sapiensENSP0000021803277.233464.8415sarcophilus_harrisiiENSSHAP0000001645477.382164.9663
ENSG00000101916homo_sapiensENSP0000021803260.806951.1047notamacropus_eugeniiENSMEUP0000001499961.635851.8014
ENSG00000101916homo_sapiensENSP0000021803285.302676.561choloepus_hoffmanniENSCHOP0000000749284.170675.545
ENSG00000101916homo_sapiensENSP0000021803285.686878.2901dasypus_novemcinctusENSDNOP0000003074186.017478.5921
ENSG00000101916homo_sapiensENSP0000021803281.17270.6052erinaceus_europaeusENSEEUP0000000610880.938770.4023
ENSG00000101916homo_sapiensENSP0000021803264.265158.4054echinops_telfairiENSETEP0000000183964.700258.8008
ENSG00000101916homo_sapiensENSP0000021803296.061592.6993callithrix_jacchusENSCJAP0000000714196.061592.6993
ENSG00000101916homo_sapiensENSP0000021803297.982796.5418cercocebus_atysENSCATP0000004346796.317394.9008
ENSG00000101916homo_sapiensENSP0000021803297.790696.4457macaca_fascicularisENSMFAP0000000553098.167896.8177
ENSG00000101916homo_sapiensENSP0000021803298.078896.6378macaca_mulattaENSMMUP0000001872098.173196.7308
ENSG00000101916homo_sapiensENSP0000021803297.598596.0615macaca_nemestrinaENSMNEP0000000324695.939694.4287
ENSG00000101916homo_sapiensENSP0000021803297.886796.5418papio_anubisENSPANP0000000679896.404995.0804
ENSG00000101916homo_sapiensENSP0000021803297.790696.2536mandrillus_leucophaeusENSMLEP0000002650196.128494.6176
ENSG00000101916homo_sapiensENSP0000021803284.43876.561tursiops_truncatusENSTTRP0000000302683.396675.6167
ENSG00000101916homo_sapiensENSP0000021803285.782977.6177vulpes_vulpesENSVVUP0000002625086.030877.842
ENSG00000101916homo_sapiensENSP0000021803281.652370.0288mus_spretusMGP_SPRETEiJ_P009715782.364370.6395
ENSG00000101916homo_sapiensENSP0000021803286.263277.1374equus_asinusENSEASP0000503736686.263277.1374
ENSG00000101916homo_sapiensENSP0000021803283.669573.9673capra_hircusENSCHIP0000001632880.276570.9677
ENSG00000101916homo_sapiensENSP0000021803285.302677.4256loxodonta_africanaENSLAFP0000000982686.213678.2524
ENSG00000101916homo_sapiensENSP0000021803285.97577.2334panthera_leoENSPLOP0000002930186.140577.3821
ENSG00000101916homo_sapiensENSP0000021803285.398776.8492ailuropoda_melanoleucaENSAMEP0000002082685.56376.9971
ENSG00000101916homo_sapiensENSP0000021803283.765673.9673bos_indicus_hybridENSBIXP0000502962984.414374.5402
ENSG00000101916homo_sapiensENSP0000021803268.587956.9645oryctolagus_cuniculusENSOCUP0000002678269.320457.5728
ENSG00000101916homo_sapiensENSP0000021803285.97576.8492equus_caballusENSECAP0000008921586.223577.0713
ENSG00000101916homo_sapiensENSP0000021803285.686877.2334canis_lupus_familiarisENSCAFP0084503928185.934577.4566
ENSG00000101916homo_sapiensENSP0000021803286.167177.4256panthera_pardusENSPPRP0000002069786.084477.3512
ENSG00000101916homo_sapiensENSP0000021803277.425669.7406marmota_marmota_marmotaENSMMMP0000000478286.480777.897
ENSG00000101916homo_sapiensENSP0000021803284.245976.3689balaenoptera_musculusENSBMSP0001002614984.734376.8116
ENSG00000101916homo_sapiensENSP0000021803283.765674.7358cavia_porcellusENSCPOP0000001795984.251275.1691
ENSG00000101916homo_sapiensENSP0000021803285.97577.2334felis_catusENSFCAP0000001755086.140577.3821
ENSG00000101916homo_sapiensENSP0000021803285.494777.1374ursus_americanusENSUAMP0000003516185.659377.2859
ENSG00000101916homo_sapiensENSP0000021803276.176863.5927monodelphis_domesticaENSMODP0000002162675.667963.1679
ENSG00000101916homo_sapiensENSP0000021803283.285373.6792bison_bison_bisonENSBBBP0000000258083.125673.5379
ENSG00000101916homo_sapiensENSP0000021803284.245975.9846monodon_monocerosENSMMNP0001502143184.734376.4251
ENSG00000101916homo_sapiensENSP0000021803283.093273.487sus_scrofaENSSSCP0000006258681.526972.1018
ENSG00000101916homo_sapiensENSP0000021803287.415979.1547microcebus_murinusENSMICP0000001316887.753179.46
ENSG00000101916homo_sapiensENSP0000021803284.245975.5043jaculus_jaculusENSJJAP0000000221185.06376.2367
ENSG00000101916homo_sapiensENSP0000021803283.573573.8713ovis_aries_rambouilletENSOARP0002003246880.930271.5349
ENSG00000101916homo_sapiensENSP0000021803285.494777.0413ursus_maritimusENSUMAP0000000680685.659377.1896
ENSG00000101916homo_sapiensENSP0000021803284.34276.2728delphinapterus_leucasENSDLEP0000002760484.830976.715
ENSG00000101916homo_sapiensENSP0000021803283.381475.9846physeter_catodonENSPCTP0000502111783.864776.4251
ENSG00000101916homo_sapiensENSP0000021803281.844470.7012mus_caroliMGP_CAROLIEiJ_P009338782.558171.3178
ENSG00000101916homo_sapiensENSP0000021803282.132670.7012mus_musculusENSMUSP0000010779382.848871.3178
ENSG00000101916homo_sapiensENSP0000021803284.918475.8886mustela_putorius_furoENSMPUP0000000253881.324772.6771
ENSG00000101916homo_sapiensENSP0000021803296.253692.8914aotus_nancymaaeENSANAP0000002543095.70292.3591
ENSG00000101916homo_sapiensENSP0000021803295.38991.9308saimiri_boliviensis_boliviensisENSSBOP0000003786993.767790.3683
ENSG00000101916homo_sapiensENSP0000021803284.43876.4649vicugna_pacosENSVPAP0000000030383.87475.9542
ENSG00000101916homo_sapiensENSP0000021803297.886796.6378chlorocebus_sabaeusENSCSAP0000001902997.980896.7308
ENSG00000101916homo_sapiensENSP0000021803270.893465.2257tupaia_belangeriENSTBEP0000000957970.352764.7283
ENSG00000101916homo_sapiensENSP0000021803281.940471.0855mesocricetus_auratusENSMAUP0000000385482.976771.9844
ENSG00000101916homo_sapiensENSP0000021803284.149975.9846phocoena_sinusENSPSNP0000002176784.637776.4251
ENSG00000101916homo_sapiensENSP0000021803284.726276.9452camelus_dromedariusENSCDRP0000501461981.818274.3043
ENSG00000101916homo_sapiensENSP0000021803284.726276.1768panthera_tigris_altaicaENSPTIP0000001879983.601975.1659
ENSG00000101916homo_sapiensENSP0000021803281.748370.5091rattus_norvegicusENSRNOP0000006604082.701771.3314
ENSG00000101916homo_sapiensENSP0000021803285.494777.7137prolemur_simusENSPSMP0000003741987.771279.783
ENSG00000101916homo_sapiensENSP0000021803280.883869.7406microtus_ochrogasterENSMOCP0000001286781.589170.3488
ENSG00000101916homo_sapiensENSP0000021803281.844471.3737peromyscus_maniculatus_bairdiiENSPEMP0000000164182.638272.066
ENSG00000101916homo_sapiensENSP0000021803283.669573.9673bos_mutusENSBMUP0000001954484.317574.5402
ENSG00000101916homo_sapiensENSP0000021803281.940470.1249mus_spicilegusENSMSIP0000002514882.65570.7364
ENSG00000101916homo_sapiensENSP0000021803281.748370.7012cricetulus_griseus_chok1gshdENSCGRP0000100419182.862771.665
ENSG00000101916homo_sapiensENSP0000021803260.90354.3708pteropus_vampyrusENSPVAP0000000890860.037953.5985
ENSG00000101916homo_sapiensENSP0000021803279.538969.7406myotis_lucifugusENSMLUP0000001160279.538969.7406
ENSG00000101916homo_sapiensENSP0000021803276.56165.0336vombatus_ursinusENSVURP0001002927076.56165.0336
ENSG00000101916homo_sapiensENSP0000021803280.499570.4131rhinolophus_ferrumequinumENSRFEP0001002510780.654570.5486
ENSG00000101916homo_sapiensENSP0000021803284.726275.9846neovison_visonENSNVIP0000002554084.889376.1309
ENSG00000101916homo_sapiensENSP0000021803280.595671.4697heterocephalus_glaber_femaleENSHGLP0000000170281.933672.6562
ENSG00000101916homo_sapiensENSP0000021803295.004893.3718rhinopithecus_bietiENSRBIP0000002402397.342595.6693
ENSG00000101916homo_sapiensENSP0000021803285.686877.3295canis_lupus_dingoENSCAFP0002000326085.934577.553
ENSG00000101916homo_sapiensENSP0000021803285.87976.8492sciurus_vulgarisENSSVLP0000502711084.739375.8294
ENSG00000101916homo_sapiensENSP0000021803277.329566.0903phascolarctos_cinereusENSPCIP0000004075377.329566.0903
ENSG00000101916homo_sapiensENSP0000021803285.206575.6004nannospalax_galiliENSNGAP0000002319185.783476.1122
ENSG00000101916homo_sapiensENSP0000021803284.822375.7925chinchilla_lanigeraENSCLAP0000002532985.31476.2319
ENSG00000101916homo_sapiensENSP0000021803283.669573.9673cervus_hanglu_yarkandensisENSCHYP0000003591184.317574.5402
ENSG00000101916homo_sapiensENSP0000021803283.477474.0634catagonus_wagneriENSCWAP0000002375884.205474.7093
ENSG00000101916homo_sapiensENSP0000021803285.87976.7531ictidomys_tridecemlineatusENSSTOP0000000543686.044376.9009
ENSG00000101916homo_sapiensENSP0000021803285.590874.928otolemur_garnettiiENSOGAP0000002171485.590874.928
ENSG00000101916homo_sapiensENSP0000021803295.965492.123cebus_imitatorENSCCAP0000001245194.334390.5571
ENSG00000101916homo_sapiensENSP0000021803285.782976.561urocitellus_parryiiENSUPAP0001000282586.280277.0048
ENSG00000101916homo_sapiensENSP0000021803283.477473.6792moschus_moschiferusENSMMSP0000001574684.123974.2498
ENSG00000101916homo_sapiensENSP0000021803297.790696.1575rhinopithecus_roxellanaENSRROP0000001167797.790696.1575
ENSG00000101916homo_sapiensENSP0000021803282.324770.1249mus_pahariMGP_PahariEiJ_P009098883.042670.7364
ENSG00000101916homo_sapiensENSP0000021803287.608180.0192propithecus_coquereliENSPCOP0000001544287.776780.1732
ENSG00000101916homo_sapiensENSP0000021803265.6148.415latimeria_chalumnaeENSLACP0000001890767.224449.6063
ENSG00000101916homo_sapiensENSP0000021803262.151846.3016lepisosteus_oculatusENSLOCP0000001220662.271446.3908
ENSG00000101916homo_sapiensENSP0000021803262.824245.9174lepisosteus_oculatusENSLOCP0000001221763.618746.4981
ENSG00000101916homo_sapiensENSP0000021803246.013428.9145clupea_harengusENSCHAP0000002027046.146428.9981
ENSG00000101916homo_sapiensENSP0000021803244.956829.8751carassius_auratusENSCARP0000003219746.199430.7009
ENSG00000101916homo_sapiensENSP0000021803247.454431.7964astyanax_mexicanusENSAMXP0000002631947.683431.9498
ENSG00000101916homo_sapiensENSP0000021803246.781932.0845esox_luciusENSELUP0000002860247.281632.4272
ENSG00000101916homo_sapiensENSP0000021803263.304544.3804esox_luciusENSELUP0000003707263.980644.8544
ENSG00000101916homo_sapiensENSP0000021803246.685931.1239electrophorus_electricusENSEEEP0000000422947.553831.7025
ENSG00000101916homo_sapiensENSP0000021803246.781932.4688oncorhynchus_kisutchENSOKIP0000509905847.007732.6255
ENSG00000101916homo_sapiensENSP0000021803262.632143.1316oncorhynchus_kisutchENSOKIP0000501757762.934443.3398
ENSG00000101916homo_sapiensENSP0000021803262.247843.1316oncorhynchus_kisutchENSOKIP0000504186859.833841.4589
ENSG00000101916homo_sapiensENSP0000021803247.166231.9885oncorhynchus_kisutchENSOKIP0000506935547.531532.2362
ENSG00000101916homo_sapiensENSP0000021803247.070132.4688oncorhynchus_mykissENSOMYP0000005957547.297332.6255
ENSG00000101916homo_sapiensENSP0000021803247.358332.3727oncorhynchus_mykissENSOMYP0000000866847.632932.5604
ENSG00000101916homo_sapiensENSP0000021803261.479342.7474oncorhynchus_mykissENSOMYP0000006092462.868443.7132
ENSG00000101916homo_sapiensENSP0000021803262.4443.5159oncorhynchus_mykissENSOMYP0000010644962.862743.8104
ENSG00000101916homo_sapiensENSP0000021803261.959742.5552salmo_salarENSSSAP0000003575062.318842.8019
ENSG00000101916homo_sapiensENSP0000021803263.112443.9962salmo_salarENSSSAP0000010599763.478344.2512
ENSG00000101916homo_sapiensENSP0000021803246.205632.1806salmo_salarENSSSAP0000005797646.428632.3359
ENSG00000101916homo_sapiensENSP0000021803246.589831.7964salmo_salarENSSSAP0000010046446.905232.0116
ENSG00000101916homo_sapiensENSP0000021803245.917431.9885salmo_truttaENSSTUP0000000975345.697931.8356
ENSG00000101916homo_sapiensENSP0000021803263.400644.2843salmo_truttaENSSTUP0000001867763.768144.5411
ENSG00000101916homo_sapiensENSP0000021803246.685931.7964salmo_truttaENSSTUP0000009757846.911231.9498
ENSG00000101916homo_sapiensENSP0000021803261.575442.5552salmo_truttaENSSTUP0000003198261.932442.8019
ENSG00000101916homo_sapiensENSP0000021803213.16049.60615gadus_morhuaENSGMOP0000004102962.557145.6621
ENSG00000101916homo_sapiensENSP0000021803256.29240.2498gadus_morhuaENSGMOP0000002455759.73542.7115
ENSG00000101916homo_sapiensENSP0000021803257.156640.7301gadus_morhuaENSGMOP0000006843858.105541.4062
ENSG00000101916homo_sapiensENSP0000021803257.636940.3458gadus_morhuaENSGMOP0000001234258.139540.6977
ENSG00000101916homo_sapiensENSP0000021803257.156639.8655gadus_morhuaENSGMOP0000003634358.162340.567
ENSG00000101916homo_sapiensENSP0000021803256.772339.9616gadus_morhuaENSGMOP0000004525058.112140.9046
ENSG00000101916homo_sapiensENSP0000021803257.925142.171fundulus_heteroclitusENSFHEP0000003385158.317242.4565
ENSG00000101916homo_sapiensENSP0000021803257.348741.4025fundulus_heteroclitusENSFHEP0000001561259.462242.9283
ENSG00000101916homo_sapiensENSP0000021803259.269942.3631xiphophorus_maculatusENSXMAP0000000443560.136542.9825
ENSG00000101916homo_sapiensENSP0000021803258.789642.3631oryzias_latipesENSORLP0000002227658.902842.4447
ENSG00000101916homo_sapiensENSP0000021803259.269941.4986cyclopterus_lumpusENSCLMP0000503212159.961141.9825
ENSG00000101916homo_sapiensENSP0000021803258.117241.5946oreochromis_niloticusENSONIP0000007484457.400441.0816
ENSG00000101916homo_sapiensENSP0000021803259.36642.4592oreochromis_niloticusENSONIP0000006812159.423142.5
ENSG00000101916homo_sapiensENSP0000021803260.134543.4198oreochromis_niloticusENSONIP0000006648460.366443.5873
ENSG00000101916homo_sapiensENSP0000021803212.19988.64553haplochromis_burtoniENSHBUP0000002036350.197635.5731
ENSG00000101916homo_sapiensENSP0000021803215.56211.2392haplochromis_burtoniENSHBUP0000001350962.307745
ENSG00000101916homo_sapiensENSP0000021803258.309342.171astatotilapia_callipteraENSACLP0000000976358.647342.4155
ENSG00000101916homo_sapiensENSP0000021803259.36643.5159astatotilapia_callipteraENSACLP0000000978759.710143.7681
ENSG00000101916homo_sapiensENSP0000021803255.619640.7301astatotilapia_callipteraENSACLP0000000978359.202543.3538
ENSG00000101916homo_sapiensENSP0000021803259.077842.8434sparus_aurataENSSAUP0001003684061.544.6
ENSG00000101916homo_sapiensENSP0000021803259.269943.0355lates_calcariferENSLCAP0001001334359.498643.2015
ENSG00000101916homo_sapiensENSP0000021803267.050951.3929xenopus_tropicalisENSXETP0000007768667.050951.3929
ENSG00000101916homo_sapiensENSP0000021803267.050950.3362xenopus_tropicalisENSXETP0000006258567.309550.5304
ENSG00000101916homo_sapiensENSP0000021803271.661957.0605chrysemys_picta_belliiENSCPBP0000001725872.427257.6699
ENSG00000101916homo_sapiensENSP0000021803259.654242.2671chrysemys_picta_belliiENSCPBP0000001726262.66444.3996
ENSG00000101916homo_sapiensENSP0000021803264.07348.8953sphenodon_punctatusENSSPUP0000000430564.883349.5136
ENSG00000101916homo_sapiensENSP0000021803260.230548.0307sphenodon_punctatusENSSPUP0000000431472.737858.0046
ENSG00000101916homo_sapiensENSP0000021803264.169147.4544crocodylus_porosusENSCPRP0000500885964.230847.5
ENSG00000101916homo_sapiensENSP0000021803271.373756.3881crocodylus_porosusENSCPRP0000500885769.830855.1692
ENSG00000101916homo_sapiensENSP0000021803214.60139.51009neolamprologus_brichardiENSNBRP0000001128058.687338.2239
ENSG00000101916homo_sapiensENSP0000021803217.963512.1998neolamprologus_brichardiENSNBRP0000001125854.360536.9186
ENSG00000101916homo_sapiensENSP0000021803263.208544.6686erpetoichthys_calabaricusENSECRP0000001734163.821545.1018
ENSG00000101916homo_sapiensENSP0000021803260.806944.4765erpetoichthys_calabaricusENSECRP0000001732462.673345.8416
ENSG00000101916homo_sapiensENSP0000021803257.925142.4592kryptolebias_marmoratusENSKMAP0000002370258.148542.623
ENSG00000101916homo_sapiensENSP0000021803259.558143.1316oryzias_javanicusENSOJAP0000002669660.311343.677
ENSG00000101916homo_sapiensENSP0000021803259.846342.5552amphilophus_citrinellusENSACIP0000001081960.135142.7606
ENSG00000101916homo_sapiensENSP0000021803259.077842.4592amphiprion_perculaENSAPEP0000003392259.941543.0799
ENSG00000101916homo_sapiensENSP0000021803258.213342.4592oryzias_sinensisENSOSIP0000002594360.782344.333
ENSG00000101916homo_sapiensENSP0000021803227.857820.9414pelodiscus_sinensisENSPSIP0000000042768.235351.2941
ENSG00000101916homo_sapiensENSP0000021803228.914522.2863pelodiscus_sinensisENSPSIP0000000043967.187551.7857
ENSG00000101916homo_sapiensENSP0000021803270.605257.0605pelodiscus_sinensisENSPSIP0000001122070.877557.2806
ENSG00000101916homo_sapiensENSP0000021803266.858849.952gopherus_evgoodeiENSGEVP0000500886867.05250.0963
ENSG00000101916homo_sapiensENSP0000021803248.607137.1758gopherus_evgoodeiENSGEVP0000500892468.843552.6531
ENSG00000101916homo_sapiensENSP0000021803270.701256.3881gopherus_evgoodeiENSGEVP0000500904169.76355.6398
ENSG00000101916homo_sapiensENSP0000021803270.797356.7723chelonoidis_abingdoniiENSCABP0000001064870.190556.2857
ENSG00000101916homo_sapiensENSP0000021803266.378549.1835chelonoidis_abingdoniiENSCABP0000001544766.827949.5164
ENSG00000101916homo_sapiensENSP0000021803259.846343.4198seriola_dumeriliENSSDUP0000000437960.485443.8835
ENSG00000101916homo_sapiensENSP0000021803255.907840.5379cottoperca_gobioENSCGOP0000005021358.906942.7126
ENSG00000101916homo_sapiensENSP0000021803258.021141.5946gasterosteus_aculeatusENSGACP0000000523659.273842.4926
ENSG00000101916homo_sapiensENSP0000021803252.545636.5994cynoglossus_semilaevisENSCSEP0000001565555.476738.641
ENSG00000101916homo_sapiensENSP0000021803259.269942.7474poecilia_formosaENSPFOP0000002748760.136543.3723
ENSG00000101916homo_sapiensENSP0000021803259.942443.1316sander_luciopercaENSSLUP0000000060360.937543.8477
ENSG00000101916homo_sapiensENSP0000021803259.173942.5552amphiprion_ocellarisENSAOCP0000001290460.03943.1774
ENSG00000101916homo_sapiensENSP0000021803271.757957.5408terrapene_carolina_triunguisENSTMTP0000000981571.965357.7071
ENSG00000101916homo_sapiensENSP0000021803266.858849.0874terrapene_carolina_triunguisENSTMTP0000000333466.602948.8995
ENSG00000101916homo_sapiensENSP0000021803271.565857.4448terrapene_carolina_triunguisENSTMTP0000000334471.772657.6108
ENSG00000101916homo_sapiensENSP0000021803266.858849.0874terrapene_carolina_triunguisENSTMTP0000001905866.602948.8995
ENSG00000101916homo_sapiensENSP0000021803263.112443.2277hucho_huchoENSHHUP0000004103463.41743.4363
ENSG00000101916homo_sapiensENSP0000021803246.974131.4121hucho_huchoENSHHUP0000000487247.383731.686
ENSG00000101916homo_sapiensENSP0000021803263.016343.9962hucho_huchoENSHHUP0000001167263.442944.294
ENSG00000101916homo_sapiensENSP0000021803246.013432.0845hucho_huchoENSHHUP0000003693246.5532.4587
ENSG00000101916homo_sapiensENSP0000021803246.109530.8357pygocentrus_nattereriENSPNAP0000002441146.920831.3783
ENSG00000101916homo_sapiensENSP0000021803258.981742.171labrus_bergyltaENSLBEP0000002694560.078342.955
ENSG00000101916homo_sapiensENSP0000021803233.909724.7839pundamilia_nyerereiENSPNYP0000001533734.405525.1462
ENSG00000101916homo_sapiensENSP0000021803258.117241.8828pundamilia_nyerereiENSPNYP0000001535858.397742.0849
ENSG00000101916homo_sapiensENSP0000021803260.230542.8434mastacembelus_armatusENSMAMP0000001993660.873843.301
ENSG00000101916homo_sapiensENSP0000021803258.885741.8828stegastes_partitusENSSPAP0000001048659.688442.4538
ENSG00000101916homo_sapiensENSP0000021803262.920343.5159oncorhynchus_tshawytschaENSOTSP0000506842963.223943.7259
ENSG00000101916homo_sapiensENSP0000021803246.974131.9885oncorhynchus_tshawytschaENSOTSP0000504480747.337932.2362
ENSG00000101916homo_sapiensENSP0000021803246.974132.1806oncorhynchus_tshawytschaENSOTSP0000503233847.200832.3359
ENSG00000101916homo_sapiensENSP0000021803262.920343.5159oncorhynchus_tshawytschaENSOTSP0000506093463.223943.7259
ENSG00000101916homo_sapiensENSP0000021803262.343943.5159oncorhynchus_tshawytschaENSOTSP0000504002559.926141.8283
ENSG00000101916homo_sapiensENSP0000021803259.173942.3631acanthochromis_polyacanthusENSAPOP0000001863860.03942.9825
ENSG00000101916homo_sapiensENSP0000021803254.562939.3852nothobranchius_furzeriENSNFUP0001501919858.137241.9652
ENSG00000101916homo_sapiensENSP0000021803258.597543.708cyprinodon_variegatusENSCVAP0000001118232.429624.1893
ENSG00000101916homo_sapiensENSP0000021803260.90342.3631denticeps_clupeoidesENSDCDP0000003442261.07942.4855
ENSG00000101916homo_sapiensENSP0000021803259.077841.8828larimichthys_croceaENSLCRP0000502593658.238641.2879
ENSG00000101916homo_sapiensENSP0000021803260.038443.2277hippocampus_comesENSHCOP0000001908561.214544.0744
ENSG00000101916homo_sapiensENSP0000021803245.148930.2594cyprinus_carpio_carpioENSCCRP0000010350346.442731.1265
ENSG00000101916homo_sapiensENSP0000021803259.36642.9395poecilia_latipinnaENSPLAP0000003108559.825743.272
ENSG00000101916homo_sapiensENSP0000021803245.052830.3554sinocyclocheilus_grahamiENSSGRP0000003543146.252531.1637
ENSG00000101916homo_sapiensENSP0000021803260.806942.6513paramormyrops_kingsleyaeENSPKIP0000003113661.876843.4018
ENSG00000101916homo_sapiensENSP0000021803235.350623.1508scleropages_formosusENSSFOP0001500717647.545231.137
ENSG00000101916homo_sapiensENSP0000021803265.898249.3756leptobrachium_leishanenseENSLLEP0000000574766.344349.7099
ENSG00000101916homo_sapiensENSP0000021803266.666749.0874leptobrachium_leishanenseENSLLEP0000000573266.730849.1346
ENSG00000101916homo_sapiensENSP0000021803259.269943.0355oryzias_melastigmaENSOMEP0000000575360.019543.5798

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000139located_in Golgi membrane1TASHomo_sapiens(9606)Component
GO:0001932involved_in regulation of protein phosphorylation1IEAHomo_sapiens(9606)Process
GO:0002224involved_in toll-like receptor signaling pathway1IBAHomo_sapiens(9606)Process
GO:0003677enables DNA binding1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1TASHomo_sapiens(9606)Function
GO:0003725enables double-stranded RNA binding1IDAHomo_sapiens(9606)Function
GO:0003727enables single-stranded RNA binding1IDAHomo_sapiens(9606)Function
GO:0005789located_in endoplasmic reticulum membrane1TASHomo_sapiens(9606)Component
GO:0005886is_active_in plasma membrane1IBAHomo_sapiens(9606)Component
GO:0006954involved_in inflammatory response1IEAHomo_sapiens(9606)Process
GO:0007249involved_in I-kappaB kinase/NF-kappaB signaling2IBA,IDAHomo_sapiens(9606)Process
GO:0009615involved_in response to virus1IDAHomo_sapiens(9606)Process
GO:0009897located_in external side of plasma membrane1IDAHomo_sapiens(9606)Component
GO:0010008located_in endosome membrane1TASHomo_sapiens(9606)Component
GO:0016064involved_in immunoglobulin mediated immune response1TASHomo_sapiens(9606)Process
GO:0032695involved_in negative regulation of interleukin-12 production1IDAHomo_sapiens(9606)Process
GO:0032727involved_in positive regulation of interferon-alpha production1IDAHomo_sapiens(9606)Process
GO:0032728involved_in positive regulation of interferon-beta production1IDAHomo_sapiens(9606)Process
GO:0032729involved_in positive regulation of type II interferon production1IDAHomo_sapiens(9606)Process
GO:0032731involved_in positive regulation of interleukin-1 beta production1IDAHomo_sapiens(9606)Process
GO:0032755involved_in positive regulation of interleukin-6 production2IBA,IDAHomo_sapiens(9606)Process
GO:0032757involved_in positive regulation of interleukin-8 production1IMPHomo_sapiens(9606)Process
GO:0034158involved_in toll-like receptor 8 signaling pathway1IDAHomo_sapiens(9606)Process
GO:0036020located_in endolysosome membrane1TASHomo_sapiens(9606)Component
GO:0038023enables signaling receptor activity1NASHomo_sapiens(9606)Function
GO:0038187enables pattern recognition receptor activity1IBAHomo_sapiens(9606)Function
GO:0045087involved_in innate immune response1NASHomo_sapiens(9606)Process
GO:0045089involved_in positive regulation of innate immune response1IDAHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus4IBA,IDA,IEP,IMPHomo_sapiens(9606)Process
GO:0071260involved_in cellular response to mechanical stimulus1IEPHomo_sapiens(9606)Process

Expression