Welcome to
RBP World!
Description
| Ensembl ID | ENSG00000101680 | Gene ID | 284217 | Accession | 6481 |
| Symbol | LAMA1 | Alias | LAMA;PTBHS;S-LAM-alpha | Full Name | laminin subunit alpha 1 |
| Status | Confidence | Length | 176056 bases | Strand | Minus strand |
| Position | 18 : 6941742 - 7117797 | RNA binding domain | N.A. | ||
| Summary | This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014] | ||||
RNA binding domains (RBDs)
| Protein | Domain | Pfam ID | E-value | Domain number |
|---|
RNA binding proteomes (RBPomes)
| Pubmed ID | Full Name | Cell | Author | Time | Doi |
|---|
Literatures on RNA binding capacity
| Pubmed ID | Title | Author | Time | Journal |
|---|
Transcripts
| Name | Transcript ID | bp | Protein | Translation ID |
|---|---|---|---|---|
| LAMA1-201 | ENST00000389658 | 9642 | 3075aa | ENSP00000374309 |
| LAMA1-206 | ENST00000492048 | 2306 | No protein | - |
| LAMA1-203 | ENST00000488064 | 2825 | No protein | - |
| LAMA1-207 | ENST00000579014 | 10374 | No protein | - |
| LAMA1-204 | ENST00000488089 | 4577 | No protein | - |
| LAMA1-205 | ENST00000490190 | 655 | No protein | - |
| LAMA1-202 | ENST00000484335 | 536 | No protein | - |
| LAMA1-208 | ENST00000585178 | 541 | No protein | - |
Phenotypes
| ensgID | Trait | pValue | Pubmed ID |
|---|---|---|---|
| 738 | Respiratory Function Tests | 4.88629715162947E-5 | 17903307 |
| 780 | Respiratory Function Tests | 4.97070819935885E-5 | 17903307 |
| 2149 | Body Mass Index | 2.13668740039596E-6 | 17903300 |
| 11937 | Asthma | 6.480355E-05 | 11022011 |
| 17501 | Triglycerides | 3.451e-005 | 19060910 |
| 23049 | Body Height | 3.7220000E-005 | - |
| 23494 | Body Height | 2.2580000E-005 | - |
| 27549 | Cardiovascular Physiological Phenomena | 4.4770000E-005 | - |
| 36430 | Platelet Function Tests | 1.6862200E-005 | - |
| 42526 | Platelet Function Tests | 8.1584371E-006 | - |
| 50537 | Child Development Disorders, Pervasive | 8.5751300E-006 | - |
| 51174 | Child Development Disorders, Pervasive | 2.0723000E-005 | - |
| 51175 | Child Development Disorders, Pervasive | 1.1038000E-006 | - |
| 51263 | Child Development Disorders, Pervasive | 2.5773300E-005 | - |
| 51853 | Child Development Disorders, Pervasive | 1.0246000E-006 | - |
| 53766 | Calcium | 2.8670000E-005 | - |
| 70139 | Carcinoma, Non-Small-Cell Lung | 7E-6 | 20876614 |
| 72082 | Alzheimer Disease | 6E-7 | 26830138 |
| 72083 | Age of Onset | 6E-7 | 26830138 |
| 82030 | Thrombomodulin | 2E-6 | 26718567 |
| 82031 | Stroke | 2E-6 | 26718567 |
| 82082 | Diabetes Mellitus, Type 2 | 8E-9 | 22693455 |
| 86218 | Antidepressive Agents | 5E-7 | 22760553 |
GWAS
| ensgID | SNP | Chromosome | Position | Trait | PubmedID | Or or BEAT | EFO ID |
|---|
Protein-Protein Interaction (PPI)
Paralogs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Orthologs
| Ensembl ID | Source | Target | ||||||
|---|---|---|---|---|---|---|---|---|
| Species | Protein ID | Perc_pos | Perc_id | Species | Protein ID | Perc_pos | Perc_id | |
Gene Ontology
| Go ID | Go term | No. evidence | Entries | Species | Category |
|---|---|---|---|---|---|
| GO:0002011 | involved_in morphogenesis of an epithelial sheet | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0005102 | enables signaling receptor binding | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0005201 | enables extracellular matrix structural constituent | 1 | ISS | Homo_sapiens(9606) | Function |
| GO:0005515 | enables protein binding | 1 | IPI | Homo_sapiens(9606) | Function |
| GO:0005576 | located_in extracellular region | 1 | TAS | Homo_sapiens(9606) | Component |
| GO:0005604 | located_in basement membrane | 2 | IDA,NAS | Homo_sapiens(9606) | Component |
| GO:0005606 | part_of laminin-1 complex | 2 | IDA,IPI | Homo_sapiens(9606) | Component |
| GO:0005608 | part_of laminin-3 complex | 1 | IPI | Homo_sapiens(9606) | Component |
| GO:0005615 | located_in extracellular space | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0005911 | located_in cell-cell junction | 1 | IEA | Homo_sapiens(9606) | Component |
| GO:0006468 | involved_in protein phosphorylation | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0007155 | involved_in cell adhesion | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0007166 | involved_in cell surface receptor signaling pathway | 1 | ISS | Homo_sapiens(9606) | Process |
| GO:0016020 | located_in membrane | 1 | IDA | Homo_sapiens(9606) | Component |
| GO:0030334 | involved_in regulation of cell migration | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0031012 | located_in extracellular matrix | 1 | ISS | Homo_sapiens(9606) | Component |
| GO:0031175 | involved_in neuron projection development | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0043208 | enables glycosphingolipid binding | 1 | IEA | Homo_sapiens(9606) | Function |
| GO:0045198 | involved_in establishment of epithelial cell apical/basal polarity | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0045785 | involved_in positive regulation of cell adhesion | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0045995 | involved_in regulation of embryonic development | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0051149 | involved_in positive regulation of muscle cell differentiation | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:0060441 | involved_in epithelial tube branching involved in lung morphogenesis | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0060445 | involved_in branching involved in salivary gland morphogenesis | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0061304 | involved_in retinal blood vessel morphogenesis | 1 | IEA | Homo_sapiens(9606) | Process |
| GO:0062023 | located_in collagen-containing extracellular matrix | 2 | HDA,TAS | Homo_sapiens(9606) | Component |
| GO:0098637 | part_of protein complex involved in cell-matrix adhesion | 1 | NAS | Homo_sapiens(9606) | Component |
| GO:0110011 | involved_in regulation of basement membrane organization | 1 | NAS | Homo_sapiens(9606) | Process |
| GO:2001046 | involved_in positive regulation of integrin-mediated signaling pathway | 1 | NAS | Homo_sapiens(9606) | Process |