Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000101096 Gene ID 4773 Accession 7776
Symbol NFATC2 Alias JCOSL;NFAT1;NFATP Full Name nuclear factor of activated T cells 2
Status Confidence Length 175875 bases Strand Minus strand
Position 20 : 51386957 - 51562831 RNA binding domain N.A.
Summary This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
31078563 EWSR1/FUS-NFATc2 rearranged round cell sarcoma: clinicopathological series of 4 cases and literature review. A Julio Diaz-Perez 2019-08-01 Human pathology

Transcripts

Name Transcript ID bp Protein Translation ID
NFATC2-201 ENST00000371564 7519 921aa ENSP00000360619
NFATC2-202 ENST00000396009 7437 925aa ENSP00000379330
NFATC2-206 ENST00000609943 5690 905aa ENSP00000477370
NFATC2-207 ENST00000610033 2740 702aa ENSP00000477142
NFATC2-203 ENST00000414705 2974 901aa ENSP00000396471
NFATC2-205 ENST00000609507 2662 702aa ENSP00000477342
NFATC2-204 ENST00000496054 620 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
15006Myocardial Infarction7.8147604E-004-
27000Blood Pressure3.0990000E-005-
46104Platelet Function Tests2.2475200E-005-
46105Platelet Function Tests1.9495000E-005-
46106Platelet Function Tests2.0601244E-006-
46108Platelet Function Tests2.2348702E-006-
59634Blood Pressure5.0781962E-006-
63588Crown-Rump Length8E-1025865494
101164Amyotrophic lateral sclerosis 15E-624529757
103042Hypersensitivity7E-923817569
105676Asparaginase4E-825987655
105677Precursor Cell Lymphoblastic Leukemia-Lymphoma4E-825987655

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0000785part_of chromatin1ISAHomo_sapiens(9606)Component
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding1IBAHomo_sapiens(9606)Function
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific2IBA,ISAHomo_sapiens(9606)Function
GO:0001227enables DNA-binding transcription repressor activity, RNA polymerase II-specific1IEAHomo_sapiens(9606)Function
GO:0001228enables DNA-binding transcription activator activity, RNA polymerase II-specific1IEAHomo_sapiens(9606)Function
GO:0001816involved_in cytokine production1IBAHomo_sapiens(9606)Process
GO:0003677enables DNA binding1TASHomo_sapiens(9606)Function
GO:0003682enables chromatin binding1IEAHomo_sapiens(9606)Function
GO:0003700enables DNA-binding transcription factor activity1TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus2IDA,TASHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005667part_of transcription regulator complex1IBAHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0006355involved_in regulation of DNA-templated transcription1TASHomo_sapiens(9606)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II2IBA,NASHomo_sapiens(9606)Process
GO:0006366involved_in transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response1IMPHomo_sapiens(9606)Process
GO:0008134enables transcription factor binding1IBAHomo_sapiens(9606)Function
GO:0009410involved_in response to xenobiotic stimulus1IMPHomo_sapiens(9606)Process
GO:0010467involved_in gene expression1IEAHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression1IEAHomo_sapiens(9606)Process
GO:0014904involved_in myotube cell development1IEAHomo_sapiens(9606)Process
GO:0016477involved_in cell migration1IDAHomo_sapiens(9606)Process
GO:0019902enables phosphatase binding1IPIHomo_sapiens(9606)Function
GO:0030890involved_in positive regulation of B cell proliferation1IMPHomo_sapiens(9606)Process
GO:0033173involved_in calcineurin-NFAT signaling cascade1IBAHomo_sapiens(9606)Process
GO:0035976part_of transcription factor AP-1 complex1IPIHomo_sapiens(9606)Component
GO:0045893acts_upstream_of_or_within positive regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0050853involved_in B cell receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:0051216involved_in cartilage development1IMPHomo_sapiens(9606)Process
GO:0060090enables molecular adaptor activity1EXPHomo_sapiens(9606)Function
GO:0071277involved_in cellular response to calcium ion1IEAHomo_sapiens(9606)Process
GO:0071889enables 14-3-3 protein binding1EXPHomo_sapiens(9606)Function
GO:0098781involved_in ncRNA transcription1IEAHomo_sapiens(9606)Process
GO:1901741involved_in positive regulation of myoblast fusion1IEAHomo_sapiens(9606)Process
GO:1905064involved_in negative regulation of vascular associated smooth muscle cell differentiation1IDAHomo_sapiens(9606)Process
GO:1990837enables sequence-specific double-stranded DNA binding1IDAHomo_sapiens(9606)Function
GO:1990904part_of ribonucleoprotein complex1IEAHomo_sapiens(9606)Component

Expression