RBP Type	Non-canonical_RBPs
Diseases	CancerSARS-COV-2
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000100902	Gene ID	5687	Accession	9535
Symbol	PSMA6	Alias	IOTA;p27K;PROS27	Full Name	proteasome 20S subunit alpha 6
Status	Confidence	Length	38861 bases	Strand	Plus strand
Position	14 : 35278633 - 35317493	RNA binding domain	N.A.
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]