RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000100804	Gene ID	5693	Accession	9542
Symbol	PSMB5	Alias	MB1;LMPX	Full Name	proteasome 20S subunit beta 5
Status	Confidence	Length	18688 bases	Strand	Minus strand
Position	14 : 23016543 - 23035230	RNA binding domain	N.A.
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
35617426	Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome.	Eun Ha Kong	2022-05-31	Proceedings of the National Academy of Sciences of the United States of America

Name	Transcript ID	bp	Protein	Translation ID
PSMB5-206	ENST00000555895	444	118aa	ENSP00000451816
PSMB5-202	ENST00000361611	1044	263aa	ENSP00000355325
PSMB5-205	ENST00000493471	1117	203aa	ENSP00000452424
PSMB5-204	ENST00000460922	729	84aa	ENSP00000451286
PSMB5-203	ENST00000425762	900	160aa	ENSP00000395206
PSMB5-201	ENST00000334454	796	77aa	ENSP00000334973

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000502	part_of proteasome complex	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:0004175	enables endopeptidase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0004298	enables threonine-type endopeptidase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	3	HDA,IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005813	located_in centrosome	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005839	part_of proteasome core complex	2	IDA,ISS	Homo_sapiens(9606)	Component
GO:0006508	acts_upstream_of_or_within proteolysis	1	IDA	Homo_sapiens(9606)	Process
GO:0006979	involved_in response to oxidative stress	1	IEA	Homo_sapiens(9606)	Process
GO:0008233	enables peptidase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0010498	involved_in proteasomal protein catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0019774	part_of proteasome core complex, beta-subunit complex	2	IBA,ISS	Homo_sapiens(9606)	Component
GO:0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	1	NAS	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component