Functions and Diseases

RBP Type Canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000100441 Gene ID 23351 Accession 20166
Symbol KHNYN Alias KIAA0323 Full Name KH and NYN domain containing
Status Confidence Length 12558 bases Strand Plus strand
Position 14 : 24429286 - 24441843 RNA binding domain RNase_Zc3h12a
Summary The protein encoded by this gene contains a ribonuclease NYN domain and belongs to the N4BP1 family. The protein is a cofactor for the zinc finger antiviral protein (ZAP protein) which targets viral RNA for degradation and restricts SARS-CoV-2 infection. [provided by RefSeq, Sep 2021]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000251343 RNase_Zc3h12a PF11977 1.3e-63 1
ENSP00000450799 RNase_Zc3h12a PF11977 1.3e-63 1
ENSP00000451106 RNase_Zc3h12a PF11977 1.3e-63 1
ENSP00000451227 RNase_Zc3h12a PF11977 5e-07 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
31284899 KHNYN is essential for the zinc finger antiviral protein (ZAP) to restrict HIV-1 containing clustered CpG dinucleotides. Mattia Ficarelli 2019-07-09 eLife
36633408 A Nuclear Export Signal in KHNYN Required for Its Antiviral Activity Evolved as ZAP Emerged in Tetrapods. J Maria Lista 2023-01-31 Journal of virology
34695163 S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies. Dorota Kmiec 2021-10-01 PLoS pathogens
32783803 Use of a small DNA virus model to investigate mechanisms of CpG dinucleotide-induced attenuation of virus replication. Lisa Loew 2020-11-01 The Journal of general virology
31319543 CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1. Ridvan Nepravishta 2019-07-17 Biomolecules
33408233 Association of Zinc Finger Antiviral Protein Binding to Viral Genomic RNA with Attenuation of Replication of Echovirus 7. Niluka Goonawardane 2021-01-06 mSphere

Transcripts

Name Transcript ID bp Protein Translation ID
KHNYN-201 ENST00000251343 6725 678aa ENSP00000251343
KHNYN-206 ENST00000556842 2443 678aa ENSP00000451106
KHNYN-202 ENST00000553935 6778 678aa ENSP00000450799
KHNYN-205 ENST00000556510 911 134aa ENSP00000451004
KHNYN-203 ENST00000554268 760 123aa ENSP00000451227
KHNYN-204 ENST00000556255 2198 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000100441homo_sapiensENSP0000034083921.531114.4737homo_sapiensENSP0000045079926.548717.8466
ENSG00000100441homo_sapiensENSP0000038661627.324520.6831homo_sapiensENSP0000045079921.238916.0767
ENSG00000100441homo_sapiensENSP0000026238435.044624.6652homo_sapiensENSP0000045079946.312732.5959
ENSG00000100441homo_sapiensENSP0000027859021.517614.3828homo_sapiensENSP0000045079928.023618.7316
ENSG00000100441homo_sapiensENSP0000036217926.043419.3656homo_sapiensENSP0000045079923.008917.1091
ENSG00000100441homo_sapiensENSP0000037199419.125414.4362homo_sapiensENSP0000045079953.539840.413

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000100441homo_sapiensENSP0000045079995.870295.1327nomascus_leucogenysENSNLEP0000001883197.744496.9925
ENSG00000100441homo_sapiensENSP0000045079999.557599.115pan_paniscusENSPPAP0000002278199.557599.115
ENSG00000100441homo_sapiensENSP0000045079998.820198.5251pongo_abeliiENSPPYP0000000649098.96698.6706
ENSG00000100441homo_sapiensENSP0000045079999.557599.2625pan_troglodytesENSPTRP0000001056299.557599.2625
ENSG00000100441homo_sapiensENSP0000045079999.11598.9676gorilla_gorillaENSGGOP0000001579299.11598.9676
ENSG00000100441homo_sapiensENSP0000045079918.289115.4867sarcophilus_harrisiiENSSHAP0000002316361.083751.7241
ENSG00000100441homo_sapiensENSP0000045079941.150433.4808notamacropus_eugeniiENSMEUP0000000150756.024145.5823
ENSG00000100441homo_sapiensENSP0000045079940.855539.9705choloepus_hoffmanniENSCHOP0000000476078.693276.9886
ENSG00000100441homo_sapiensENSP0000045079986.578283.1858dasypus_novemcinctusENSDNOP0000003283475.449972.4936
ENSG00000100441homo_sapiensENSP0000045079980.973475.8112erinaceus_europaeusENSEEUP0000000048983.434778.1155
ENSG00000100441homo_sapiensENSP0000045079963.569359.882echinops_telfairiENSETEP0000000575866.104362.2699
ENSG00000100441homo_sapiensENSP0000045079993.952892.7729callithrix_jacchusENSCJAP0000001175793.538992.3642
ENSG00000100441homo_sapiensENSP0000045079997.345196.7552cercocebus_atysENSCATP0000001127497.345196.7552
ENSG00000100441homo_sapiensENSP0000045079997.492696.9027macaca_fascicularisENSMFAP0000000858697.492696.9027
ENSG00000100441homo_sapiensENSP0000045079997.197696.6077macaca_mulattaENSMMUP0000006788297.197696.6077
ENSG00000100441homo_sapiensENSP0000045079997.492696.9027macaca_nemestrinaENSMNEP0000004488897.492696.9027
ENSG00000100441homo_sapiensENSP0000045079997.345196.7552papio_anubisENSPANP0000001772097.345196.7552
ENSG00000100441homo_sapiensENSP0000045079997.492696.7552mandrillus_leucophaeusENSMLEP0000001982197.492696.7552
ENSG00000100441homo_sapiensENSP0000045079988.200684.5133tursiops_truncatusENSTTRP0000001192989.387185.6502
ENSG00000100441homo_sapiensENSP0000045079987.020783.0383vulpes_vulpesENSVVUP0000004103788.191384.1555
ENSG00000100441homo_sapiensENSP0000045079983.923379.4985mus_spretusMGP_SPRETEiJ_P003863584.798880.3279
ENSG00000100441homo_sapiensENSP0000045079987.610684.3658equus_asinusENSEASP0000504939783.66280.5634
ENSG00000100441homo_sapiensENSP0000045079985.398281.7109capra_hircusENSCHIP0000001499286.417982.6866
ENSG00000100441homo_sapiensENSP0000045079986.578283.1858loxodonta_africanaENSLAFP0000002147688.939485.4545
ENSG00000100441homo_sapiensENSP0000045079986.873283.7758panthera_leoENSPLOP0000002770987.001583.8996
ENSG00000100441homo_sapiensENSP0000045079987.020783.6283ailuropoda_melanoleucaENSAMEP0000001680488.323484.8802
ENSG00000100441homo_sapiensENSP0000045079985.693282.3009bos_indicus_hybridENSBIXP0000502634085.946782.5444
ENSG00000100441homo_sapiensENSP0000045079984.218379.941oryctolagus_cuniculusENSOCUP0000000185186.253881.8731
ENSG00000100441homo_sapiensENSP0000045079987.610684.3658equus_caballusENSECAP0000008585883.66280.5634
ENSG00000100441homo_sapiensENSP0000045079987.020783.0383canis_lupus_familiarisENSCAFP0084501099388.191384.1555
ENSG00000100441homo_sapiensENSP0000045079987.020784.0708panthera_pardusENSPPRP0000001195888.455885.4573
ENSG00000100441homo_sapiensENSP0000045079986.578282.3009marmota_marmota_marmotaENSMMMP0000001301387.742983.4081
ENSG00000100441homo_sapiensENSP0000045079988.348184.9557balaenoptera_musculusENSBMSP0001001696889.536686.0987
ENSG00000100441homo_sapiensENSP0000045079982.743478.9086cavia_porcellusENSCPOP0000001903685.388181.4307
ENSG00000100441homo_sapiensENSP0000045079987.315684.3658felis_catusENSFCAP0000002589187.444684.4904
ENSG00000100441homo_sapiensENSP0000045079987.315683.9233ursus_americanusENSUAMP0000000826188.622885.1796
ENSG00000100441homo_sapiensENSP0000045079965.339252.3599monodelphis_domesticaENSMODP0000005806748.788539.0969
ENSG00000100441homo_sapiensENSP0000045079965.339261.7994bison_bison_bisonENSBBBP0000002573283.270778.7594
ENSG00000100441homo_sapiensENSP0000045079916.666716.3717bison_bison_bisonENSBBBP0000001343591.12989.5161
ENSG00000100441homo_sapiensENSP0000045079912.979411.9469monodon_monocerosENSMMNP0001500256172.131166.3934
ENSG00000100441homo_sapiensENSP0000045079987.905683.9233monodon_monocerosENSMMNP0001502211088.955284.9254
ENSG00000100441homo_sapiensENSP0000045079987.020783.0383sus_scrofaENSSSCP0000004728088.989484.917
ENSG00000100441homo_sapiensENSP0000045079988.200686.1357microcebus_murinusENSMICP0000001299589.789887.6877
ENSG00000100441homo_sapiensENSP0000045079982.743477.2861octodon_degusENSODEP0000000212785.779880.1223
ENSG00000100441homo_sapiensENSP0000045079982.743477.5811jaculus_jaculusENSJJAP0000001372586.707981.2983
ENSG00000100441homo_sapiensENSP0000045079984.808381.1209ovis_aries_rambouilletENSOARP0002000815383.212779.5948
ENSG00000100441homo_sapiensENSP0000045079987.020783.6283ursus_maritimusENSUMAP0000003185288.323484.8802
ENSG00000100441homo_sapiensENSP0000045079948.525146.3127ochotona_princepsENSOPRP0000001528790.13786.0274
ENSG00000100441homo_sapiensENSP0000045079968.289163.7168delphinapterus_leucasENSDLEP0000002498786.542180.7477
ENSG00000100441homo_sapiensENSP0000045079923.598822.8614delphinapterus_leucasENSDLEP0000002495589.385586.5922
ENSG00000100441homo_sapiensENSP0000045079988.643185.3982physeter_catodonENSPCTP0000500809889.835686.5471
ENSG00000100441homo_sapiensENSP0000045079983.185879.056mus_caroliMGP_CAROLIEiJ_P003691384.053679.8808
ENSG00000100441homo_sapiensENSP0000045079983.038378.7611mus_musculusENSMUSP0000002283183.904679.5827
ENSG00000100441homo_sapiensENSP0000045079916.814216.3717dipodomys_ordiiENSDORP0000002728394.214991.7355
ENSG00000100441homo_sapiensENSP0000045079986.430782.5959mustela_putorius_furoENSMPUP0000000556986.943683.0861
ENSG00000100441homo_sapiensENSP0000045079989.23388.3481aotus_nancymaaeENSANAP0000001150794.236893.3022
ENSG00000100441homo_sapiensENSP0000045079994.247892.9204saimiri_boliviensis_boliviensisENSSBOP0000004034182.98781.8182
ENSG00000100441homo_sapiensENSP0000045079996.755296.3127chlorocebus_sabaeusENSCSAP0000001192496.755296.3127
ENSG00000100441homo_sapiensENSP0000045079981.858477.4336mesocricetus_auratusENSMAUP0000000233083.208478.7106
ENSG00000100441homo_sapiensENSP0000045079987.758184.0708phocoena_sinusENSPSNP0000001952988.80685.0746
ENSG00000100441homo_sapiensENSP0000045079988.053184.9557camelus_dromedariusENSCDRP0000500999389.104585.9701
ENSG00000100441homo_sapiensENSP0000045079988.93885.3982carlito_syrichtaENSTSYP0000003201889.732186.1607
ENSG00000100441homo_sapiensENSP0000045079987.020784.0708panthera_tigris_altaicaENSPTIP0000002076388.855485.8434
ENSG00000100441homo_sapiensENSP0000045079984.365880.0885rattus_norvegicusENSRNOP0000002780283.748279.5022
ENSG00000100441homo_sapiensENSP0000045079987.758185.5457prolemur_simusENSPSMP0000002109489.339387.0871
ENSG00000100441homo_sapiensENSP0000045079983.333378.9086microtus_ochrogasterENSMOCP0000000083484.454479.9701
ENSG00000100441homo_sapiensENSP0000045079971.976466.0767sorex_araneusENSSARP0000000620982.993276.1905
ENSG00000100441homo_sapiensENSP0000045079982.890978.7611peromyscus_maniculatus_bairdiiENSPEMP0000001167883.755679.5827
ENSG00000100441homo_sapiensENSP0000045079985.693282.1534bos_mutusENSBMUP0000001036885.946782.3964
ENSG00000100441homo_sapiensENSP0000045079983.775879.351mus_spicilegusENSMSIP0000003737982.318877.971
ENSG00000100441homo_sapiensENSP0000045079983.923379.2035cricetulus_griseus_chok1gshdENSCGRP0000101868984.421479.6736
ENSG00000100441homo_sapiensENSP0000045079988.348185.6932pteropus_vampyrusENSPVAP0000000664889.805187.1064
ENSG00000100441homo_sapiensENSP0000045079980.23677.1386myotis_lucifugusENSMLUP0000001613286.212482.8843
ENSG00000100441homo_sapiensENSP0000045079966.961754.1298vombatus_ursinusENSVURP0001002993955.433544.8107
ENSG00000100441homo_sapiensENSP0000045079988.790686.2832rhinolophus_ferrumequinumENSRFEP0001000115787.585.0291
ENSG00000100441homo_sapiensENSP0000045079986.578282.5959neovison_visonENSNVIP0000000139287.09283.0861
ENSG00000100441homo_sapiensENSP0000045079985.693282.3009bos_taurusENSBTAP0000001410885.946782.5444
ENSG00000100441homo_sapiensENSP0000045079984.513381.2684heterocephalus_glaber_femaleENSHGLP0000000228986.295282.9819
ENSG00000100441homo_sapiensENSP0000045079997.050196.3127rhinopithecus_bietiENSRBIP0000000662797.050196.3127
ENSG00000100441homo_sapiensENSP0000045079987.020783.0383canis_lupus_dingoENSCAFP0002003114188.191384.1555
ENSG00000100441homo_sapiensENSP0000045079987.905683.4808sciurus_vulgarisENSSVLP0000500630089.088284.6039
ENSG00000100441homo_sapiensENSP0000045079928.466124.1888phascolarctos_cinereusENSPCIP0000001313063.278753.7705
ENSG00000100441homo_sapiensENSP0000045079984.365878.6136nannospalax_galiliENSNGAP0000001046585.245979.4337
ENSG00000100441homo_sapiensENSP0000045079980.678577.4336bos_grunniensENSBGRP0000003283885.871382.4176
ENSG00000100441homo_sapiensENSP0000045079985.840782.0059chinchilla_lanigeraENSCLAP0000002122586.865782.9851
ENSG00000100441homo_sapiensENSP0000045079987.905683.9233catagonus_wagneriENSCWAP0000002243088.955284.9254
ENSG00000100441homo_sapiensENSP0000045079986.430782.3009ictidomys_tridecemlineatusENSSTOP0000002197887.593483.4081
ENSG00000100441homo_sapiensENSP0000045079987.905684.8083otolemur_garnettiiENSOGAP0000002234488.822785.693
ENSG00000100441homo_sapiensENSP0000045079994.690393.5103cebus_imitatorENSCCAP0000003271195.252294.0653
ENSG00000100441homo_sapiensENSP0000045079985.693282.0059moschus_moschiferusENSMMSP0000000819586.716482.9851
ENSG00000100441homo_sapiensENSP0000045079997.050196.3127rhinopithecus_roxellanaENSRROP0000003931397.050196.3127
ENSG00000100441homo_sapiensENSP0000045079983.480878.9086mus_pahariMGP_PahariEiJ_P008502384.10179.4948
ENSG00000100441homo_sapiensENSP0000045079988.053186.1357propithecus_coquereliENSPCOP0000000640189.639687.6877
ENSG00000100441homo_sapiensENSP0000045079913.71687.66962caenorhabditis_elegansY59E9AR.8.124.28213.577
ENSG00000100441homo_sapiensENSP0000045079913.71687.66962caenorhabditis_elegansY59E9AR.2.124.28213.577
ENSG00000100441homo_sapiensENSP0000045079923.598814.3068caenorhabditis_elegansC30F12.1.125.236615.2997
ENSG00000100441homo_sapiensENSP0000045079916.666710.0295caenorhabditis_elegansY51H4A.13.120.658112.4314
ENSG00000100441homo_sapiensENSP0000045079916.814210.177caenorhabditis_elegansY24D9B.1.120.727312.5455
ENSG00000100441homo_sapiensENSP0000045079922.566417.1091drosophila_melanogasterFBpp008324828.333321.4815
ENSG00000100441homo_sapiensENSP0000045079920.64913.1268drosophila_melanogasterFBpp028923628.225817.9435
ENSG00000100441homo_sapiensENSP0000045079913.421810.177laticauda_laticaudataENSLLTP0000001491766.423450.365

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003674enables molecular_function1NDHomo_sapiens(9606)Function
GO:0003729enables mRNA binding1IBAHomo_sapiens(9606)Function
GO:0004521enables RNA endonuclease activity1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005575is_active_in cellular_component1NDHomo_sapiens(9606)Component
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0008150involved_in biological_process1NDHomo_sapiens(9606)Process
GO:0036464is_active_in cytoplasmic ribonucleoprotein granule1IBAHomo_sapiens(9606)Component

Expression