RBP Type	Non-canonical_RBPs
Diseases	FlavivirusesSARS-COV-2
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000100038	Gene ID	8940	Accession	11993
Symbol	TOP3B	Alias	TOP3B1	Full Name	DNA topoisomerase III beta
Status	Confidence	Length	25789 bases	Strand	Minus strand
Position	22 : 21957025 - 21982813	RNA binding domain	N.A.
Summary	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
36328071	Topoisomerase 3b is dispensable for replication of a positive-sense RNA virus--murine coronavirus.	Tianyi Zhang	2022-12-01	Antiviral research
24507716	Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.	Yanzhong Yang	2014-02-06	Molecular cell
34228902	Identification of a special cell type as a determinant of the kidney tropism of SARS-CoV-2.	Hongchun Lin	2021-09-01	The FEBS journal
29471495	Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization.	Lifeng Huang	2018-04-06	Nucleic acids research
32511318	Topoisomerase III-ß is required for efficient replication of positive-sense RNA viruses.	Reddisiva K Prasanth	2020-03-27	bioRxiv : the preprint server for biology
35228717	Human topoisomerases and their roles in genome stability and organization.	Yves Pommier	2022-06-01	Nature reviews. Molecular cell biology

Name	Transcript ID	bp	Protein	Translation ID
TOP3B-201	ENST00000357179	2834	862aa	ENSP00000349705
TOP3B-214	ENST00000457270	2956	525aa	ENSP00000408282
TOP3B-213	ENST00000457179	3061	129aa	ENSP00000397221
TOP3B-202	ENST00000398793	3107	862aa	ENSP00000381773
TOP3B-210	ENST00000444502	4163	129aa	ENSP00000392480
TOP3B-206	ENST00000436282	2890	168aa	ENSP00000416451
TOP3B-215	ENST00000470338	624	No protein	-
TOP3B-203	ENST00000424393	824	246aa	ENSP00000390977
TOP3B-216	ENST00000487485	725	No protein	-
TOP3B-208	ENST00000437929	550	122aa	ENSP00000402622
TOP3B-204	ENST00000430142	582	121aa	ENSP00000414538
TOP3B-217	ENST00000489581	789	No protein	-
TOP3B-212	ENST00000456075	561	61aa	ENSP00000391857
TOP3B-211	ENST00000449704	543	60aa	ENSP00000404600
TOP3B-209	ENST00000442653	400	46aa	ENSP00000390209
TOP3B-207	ENST00000437103	571	42aa	ENSP00000387554
TOP3B-205	ENST00000434517	736	21aa	ENSP00000390824

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
15033	Myocardial Infarction	3.2441856E-004	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000100038	homo_sapiens	ENSP00000321636	42.2577	29.5704	homo_sapiens	ENSP00000349705	49.0719	34.3387

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000100038	homo_sapiens	ENSP00000349705	89.0951	87.935	nomascus_leucogenys	ENSNLEP00000000317	93.6585	92.439
ENSG00000100038	homo_sapiens	ENSP00000349705	99.884	99.884	pan_paniscus	ENSPPAP00000029417	99.884	99.884
ENSG00000100038	homo_sapiens	ENSP00000349705	99.884	99.652	pongo_abelii	ENSPPYP00000013399	99.884	99.652
ENSG00000100038	homo_sapiens	ENSP00000349705	100	99.884	pan_troglodytes	ENSPTRP00000046803	100	99.884
ENSG00000100038	homo_sapiens	ENSP00000349705	100	100	gorilla_gorilla	ENSGGOP00000024484	100	100
ENSG00000100038	homo_sapiens	ENSP00000349705	92.8074	86.5429	ornithorhynchus_anatinus	ENSOANP00000046213	92.9152	86.6434
ENSG00000100038	homo_sapiens	ENSP00000349705	95.8237	91.0673	sarcophilus_harrisii	ENSSHAP00000010265	95.8237	91.0673
ENSG00000100038	homo_sapiens	ENSP00000349705	89.7912	85.9629	notamacropus_eugenii	ENSMEUP00000011816	96.5087	92.394
ENSG00000100038	homo_sapiens	ENSP00000349705	96.0557	93.2715	dasypus_novemcinctus	ENSDNOP00000002543	98.5714	95.7143
ENSG00000100038	homo_sapiens	ENSP00000349705	59.5128	57.6566	erinaceus_europaeus	ENSEEUP00000008566	72.3554	70.0987
ENSG00000100038	homo_sapiens	ENSP00000349705	72.7378	70.4176	echinops_telfairi	ENSETEP00000014558	82.3916	79.7635
ENSG00000100038	homo_sapiens	ENSP00000349705	99.42	98.9559	callithrix_jacchus	ENSCJAP00000037821	99.42	98.9559
ENSG00000100038	homo_sapiens	ENSP00000349705	99.884	99.42	cercocebus_atys	ENSCATP00000026679	99.884	99.42
ENSG00000100038	homo_sapiens	ENSP00000349705	99.768	99.1879	macaca_fascicularis	ENSMFAP00000007177	99.768	99.1879
ENSG00000100038	homo_sapiens	ENSP00000349705	99.768	99.1879	macaca_mulatta	ENSMMUP00000066861	99.768	99.1879
ENSG00000100038	homo_sapiens	ENSP00000349705	99.768	99.0719	macaca_nemestrina	ENSMNEP00000042549	99.768	99.0719
ENSG00000100038	homo_sapiens	ENSP00000349705	99.884	99.42	papio_anubis	ENSPANP00000015927	99.884	99.42
ENSG00000100038	homo_sapiens	ENSP00000349705	99.884	99.42	mandrillus_leucophaeus	ENSMLEP00000009473	99.884	99.42
ENSG00000100038	homo_sapiens	ENSP00000349705	60.4408	59.1647	tursiops_truncatus	ENSTTRP00000007194	74.2165	72.6496
ENSG00000100038	homo_sapiens	ENSP00000349705	97.6798	95.8237	vulpes_vulpes	ENSVVUP00000027607	97.5666	95.7126
ENSG00000100038	homo_sapiens	ENSP00000349705	97.7958	95.5916	mus_spretus	MGP_SPRETEiJ_P0042400	97.7958	95.5916
ENSG00000100038	homo_sapiens	ENSP00000349705	97.7958	96.0557	equus_asinus	ENSEASP00005032611	97.7958	96.0557
ENSG00000100038	homo_sapiens	ENSP00000349705	96.5197	92.5754	capra_hircus	ENSCHIP00000000086	96.6318	92.6829
ENSG00000100038	homo_sapiens	ENSP00000349705	98.0278	95.5916	loxodonta_africana	ENSLAFP00000015649	98.0278	95.5916
ENSG00000100038	homo_sapiens	ENSP00000349705	97.2158	95.2436	panthera_leo	ENSPLOP00000016552	97.2158	95.2436
ENSG00000100038	homo_sapiens	ENSP00000349705	97.9118	95.8237	ailuropoda_melanoleuca	ENSAMEP00000007894	97.9118	95.8237
ENSG00000100038	homo_sapiens	ENSP00000349705	96.6357	93.7355	bos_indicus_hybrid	ENSBIXP00005034540	96.748	93.8444
ENSG00000100038	homo_sapiens	ENSP00000349705	96.8678	95.4756	oryctolagus_cuniculus	ENSOCUP00000010585	96.7555	95.365
ENSG00000100038	homo_sapiens	ENSP00000349705	97.7958	96.1717	equus_caballus	ENSECAP00000030694	92.1311	90.6011
ENSG00000100038	homo_sapiens	ENSP00000349705	97.5638	95.7077	canis_lupus_familiaris	ENSCAFP00845036878	97.5638	95.7077
ENSG00000100038	homo_sapiens	ENSP00000349705	97.0998	95.0116	panthera_pardus	ENSPPRP00000015782	97.0998	95.0116
ENSG00000100038	homo_sapiens	ENSP00000349705	99.0719	97.2158	marmota_marmota_marmota	ENSMMMP00000000495	99.0719	97.2158
ENSG00000100038	homo_sapiens	ENSP00000349705	96.7517	94.5476	balaenoptera_musculus	ENSBMSP00010019844	96.8641	94.6574
ENSG00000100038	homo_sapiens	ENSP00000349705	98.2599	96.6357	cavia_porcellus	ENSCPOP00000001640	98.2599	96.6357
ENSG00000100038	homo_sapiens	ENSP00000349705	97.2158	95.2436	felis_catus	ENSFCAP00000002424	97.2158	95.2436
ENSG00000100038	homo_sapiens	ENSP00000349705	97.9118	95.8237	ursus_americanus	ENSUAMP00000013492	97.9118	95.8237
ENSG00000100038	homo_sapiens	ENSP00000349705	96.1717	91.6473	monodelphis_domestica	ENSMODP00000022073	96.1717	91.6473
ENSG00000100038	homo_sapiens	ENSP00000349705	96.8678	93.7355	bison_bison_bison	ENSBBBP00000013780	96.9803	93.8444
ENSG00000100038	homo_sapiens	ENSP00000349705	96.8678	95.0116	monodon_monoceros	ENSMMNP00015005698	96.9803	95.1219
ENSG00000100038	homo_sapiens	ENSP00000349705	97.3318	94.3155	sus_scrofa	ENSSSCP00000010751	97.7855	94.7552
ENSG00000100038	homo_sapiens	ENSP00000349705	99.42	97.5638	microcebus_murinus	ENSMICP00000044437	99.42	97.5638
ENSG00000100038	homo_sapiens	ENSP00000349705	98.3759	96.4037	octodon_degus	ENSODEP00000021084	98.3759	96.4037
ENSG00000100038	homo_sapiens	ENSP00000349705	98.2599	95.8237	jaculus_jaculus	ENSJJAP00000017934	98.2599	95.8237
ENSG00000100038	homo_sapiens	ENSP00000349705	96.7517	92.8074	ovis_aries_rambouillet	ENSOARP00020033894	96.8641	92.9152
ENSG00000100038	homo_sapiens	ENSP00000349705	97.9118	95.8237	ursus_maritimus	ENSUMAP00000004183	97.9118	95.8237
ENSG00000100038	homo_sapiens	ENSP00000349705	88.6311	85.9629	ochotona_princeps	ENSOPRP00000012271	89.7767	87.074
ENSG00000100038	homo_sapiens	ENSP00000349705	96.8678	95.0116	delphinapterus_leucas	ENSDLEP00000021734	96.9803	95.1219
ENSG00000100038	homo_sapiens	ENSP00000349705	96.9838	94.8956	physeter_catodon	ENSPCTP00005019809	97.0964	95.0058
ENSG00000100038	homo_sapiens	ENSP00000349705	97.7958	95.7077	mus_caroli	MGP_CAROLIEiJ_P0040553	97.7958	95.7077
ENSG00000100038	homo_sapiens	ENSP00000349705	97.7958	95.5916	mus_musculus	ENSMUSP00000023465	97.7958	95.5916
ENSG00000100038	homo_sapiens	ENSP00000349705	98.2599	96.1717	dipodomys_ordii	ENSDORP00000001887	98.374	96.2834
ENSG00000100038	homo_sapiens	ENSP00000349705	97.7958	95.7077	mustela_putorius_furo	ENSMPUP00000003103	97.7958	95.7077
ENSG00000100038	homo_sapiens	ENSP00000349705	99.42	98.6079	aotus_nancymaae	ENSANAP00000029291	99.42	98.6079
ENSG00000100038	homo_sapiens	ENSP00000349705	46.1717	45.8237	saimiri_boliviensis_boliviensis	ENSSBOP00000009386	98.0296	97.2906
ENSG00000100038	homo_sapiens	ENSP00000349705	99.768	99.1879	chlorocebus_sabaeus	ENSCSAP00000009886	99.768	99.1879
ENSG00000100038	homo_sapiens	ENSP00000349705	74.71	72.3898	tupaia_belangeri	ENSTBEP00000001852	77.1257	74.7305
ENSG00000100038	homo_sapiens	ENSP00000349705	97.7958	95.4756	mesocricetus_auratus	ENSMAUP00000003091	97.7958	95.4756
ENSG00000100038	homo_sapiens	ENSP00000349705	95.0116	92.6914	phocoena_sinus	ENSPSNP00000018332	94.2463	91.9448
ENSG00000100038	homo_sapiens	ENSP00000349705	97.5638	94.3155	camelus_dromedarius	ENSCDRP00005032280	97.6771	94.4251
ENSG00000100038	homo_sapiens	ENSP00000349705	99.42	97.0998	carlito_syrichta	ENSTSYP00000006392	99.42	97.0998
ENSG00000100038	homo_sapiens	ENSP00000349705	97.2158	95.2436	panthera_tigris_altaica	ENSPTIP00000006052	97.2158	95.2436
ENSG00000100038	homo_sapiens	ENSP00000349705	97.6798	94.6636	rattus_norvegicus	ENSRNOP00000002524	97.6798	94.6636
ENSG00000100038	homo_sapiens	ENSP00000349705	98.6079	97.2158	prolemur_simus	ENSPSMP00000019809	99.4152	98.0117
ENSG00000100038	homo_sapiens	ENSP00000349705	97.6798	95.2436	microtus_ochrogaster	ENSMOCP00000008836	97.6798	95.2436
ENSG00000100038	homo_sapiens	ENSP00000349705	55.1044	54.0603	sorex_araneus	ENSSARP00000003444	74.8031	73.3858
ENSG00000100038	homo_sapiens	ENSP00000349705	97.9118	95.3596	peromyscus_maniculatus_bairdii	ENSPEMP00000004802	97.9118	95.3596
ENSG00000100038	homo_sapiens	ENSP00000349705	92.2274	89.3271	bos_mutus	ENSBMUP00000003499	97.4265	94.3627
ENSG00000100038	homo_sapiens	ENSP00000349705	97.9118	95.7077	mus_spicilegus	ENSMSIP00000020701	97.9118	95.7077
ENSG00000100038	homo_sapiens	ENSP00000349705	97.4478	95.2436	cricetulus_griseus_chok1gshd	ENSCGRP00001010076	97.4478	95.2436
ENSG00000100038	homo_sapiens	ENSP00000349705	83.9907	81.9025	pteropus_vampyrus	ENSPVAP00000012869	83.9907	81.9025
ENSG00000100038	homo_sapiens	ENSP00000349705	97.6798	95.4756	myotis_lucifugus	ENSMLUP00000009376	97.6798	95.4756
ENSG00000100038	homo_sapiens	ENSP00000349705	96.2877	91.5313	vombatus_ursinus	ENSVURP00010028482	96.2877	91.5313
ENSG00000100038	homo_sapiens	ENSP00000349705	98.0278	95.8237	rhinolophus_ferrumequinum	ENSRFEP00010026543	98.0278	95.8237
ENSG00000100038	homo_sapiens	ENSP00000349705	97.7958	95.7077	neovison_vison	ENSNVIP00000027835	97.7958	95.7077
ENSG00000100038	homo_sapiens	ENSP00000349705	96.6357	93.7355	bos_taurus	ENSBTAP00000064395	96.748	93.8444
ENSG00000100038	homo_sapiens	ENSP00000349705	98.4919	96.9838	heterocephalus_glaber_female	ENSHGLP00000053816	98.4919	96.9838
ENSG00000100038	homo_sapiens	ENSP00000349705	99.884	99.42	rhinopithecus_bieti	ENSRBIP00000022294	99.884	99.42
ENSG00000100038	homo_sapiens	ENSP00000349705	97.5638	95.7077	canis_lupus_dingo	ENSCAFP00020019030	97.5638	95.7077
ENSG00000100038	homo_sapiens	ENSP00000349705	98.9559	97.2158	sciurus_vulgaris	ENSSVLP00005008628	98.9559	97.2158
ENSG00000100038	homo_sapiens	ENSP00000349705	95.4756	90.6032	phascolarctos_cinereus	ENSPCIP00000036232	95.4756	90.6032
ENSG00000100038	homo_sapiens	ENSP00000349705	93.3875	91.5313	procavia_capensis	ENSPCAP00000005642	93.4959	91.6376
ENSG00000100038	homo_sapiens	ENSP00000349705	97.7958	95.5916	nannospalax_galili	ENSNGAP00000011179	97.7958	95.5916
ENSG00000100038	homo_sapiens	ENSP00000349705	97.0998	94.1995	bos_grunniens	ENSBGRP00000039112	97.2125	94.3089
ENSG00000100038	homo_sapiens	ENSP00000349705	98.3759	96.9838	chinchilla_lanigera	ENSCLAP00000023629	98.3759	96.9838
ENSG00000100038	homo_sapiens	ENSP00000349705	96.9838	93.7355	cervus_hanglu_yarkandensis	ENSCHYP00000017992	97.0964	93.8444
ENSG00000100038	homo_sapiens	ENSP00000349705	97.4478	94.6636	catagonus_wagneri	ENSCWAP00000008342	97.7881	94.9942
ENSG00000100038	homo_sapiens	ENSP00000349705	98.9559	97.2158	ictidomys_tridecemlineatus	ENSSTOP00000021923	98.9559	97.2158
ENSG00000100038	homo_sapiens	ENSP00000349705	99.42	97.5638	otolemur_garnettii	ENSOGAP00000015440	99.42	97.5638
ENSG00000100038	homo_sapiens	ENSP00000349705	81.7865	80.5104	cebus_imitator	ENSCCAP00000006455	97.1074	95.5923
ENSG00000100038	homo_sapiens	ENSP00000349705	98.7239	97.0998	urocitellus_parryii	ENSUPAP00010017154	98.7239	97.0998
ENSG00000100038	homo_sapiens	ENSP00000349705	97.0998	93.8515	moschus_moschiferus	ENSMMSP00000021905	97.2125	93.9605
ENSG00000100038	homo_sapiens	ENSP00000349705	99.884	99.42	rhinopithecus_roxellana	ENSRROP00000038791	99.884	99.42
ENSG00000100038	homo_sapiens	ENSP00000349705	97.5638	95.2436	mus_pahari	MGP_PahariEiJ_P0027947	97.5638	95.2436
ENSG00000100038	homo_sapiens	ENSP00000349705	99.1879	97.5638	propithecus_coquereli	ENSPCOP00000024272	99.1879	97.5638
ENSG00000100038	homo_sapiens	ENSP00000349705	66.5893	52.4362	caenorhabditis_elegans	Y48C3A.14a.1	66.0529	52.0138
ENSG00000100038	homo_sapiens	ENSP00000349705	70.3016	57.4246	drosophila_melanogaster	FBpp0309042	69.2571	56.5714
ENSG00000100038	homo_sapiens	ENSP00000349705	74.2459	60.7889	ciona_intestinalis	ENSCINP00000016196	78.0488	63.9024
ENSG00000100038	homo_sapiens	ENSP00000349705	9.86079	5.22042	ciona_intestinalis	ENSCINP00000034108	47.486	25.1397
ENSG00000100038	homo_sapiens	ENSP00000349705	12.297	9.74478	petromyzon_marinus	ENSPMAP00000001980	64.2424	50.9091
ENSG00000100038	homo_sapiens	ENSP00000349705	25.522	21.3457	eptatretus_burgeri	ENSEBUP00000001861	71.8954	60.1307
ENSG00000100038	homo_sapiens	ENSP00000349705	47.7958	38.2831	eptatretus_burgeri	ENSEBUP00000023676	56.5934	45.3297
ENSG00000100038	homo_sapiens	ENSP00000349705	90.7193	81.9025	callorhinchus_milii	ENSCMIP00000012230	90.8246	81.9977
ENSG00000100038	homo_sapiens	ENSP00000349705	88.7471	81.6705	latimeria_chalumnae	ENSLACP00000015352	88.6443	81.5759
ENSG00000100038	homo_sapiens	ENSP00000349705	87.123	79.4664	lepisosteus_oculatus	ENSLOCP00000002387	87.022	79.3743
ENSG00000100038	homo_sapiens	ENSP00000349705	59.2807	51.8561	clupea_harengus	ENSCHAP00000057806	90.4425	79.115
ENSG00000100038	homo_sapiens	ENSP00000349705	90.7193	82.0186	danio_rerio	ENSDARP00000035935	90.8246	82.1138
ENSG00000100038	homo_sapiens	ENSP00000349705	90.8353	81.9025	carassius_auratus	ENSCARP00000124089	90.9408	81.9977
ENSG00000100038	homo_sapiens	ENSP00000349705	91.5313	82.3666	astyanax_mexicanus	ENSAMXP00000001259	91.6376	82.4622
ENSG00000100038	homo_sapiens	ENSP00000349705	90.1392	81.3225	ictalurus_punctatus	ENSIPUP00000030138	90.2439	81.417
ENSG00000100038	homo_sapiens	ENSP00000349705	89.7912	81.3225	esox_lucius	ENSELUP00000023554	90.3151	81.797
ENSG00000100038	homo_sapiens	ENSP00000349705	90.6032	82.0186	electrophorus_electricus	ENSEEEP00000018762	90.4983	81.9235
ENSG00000100038	homo_sapiens	ENSP00000349705	90.1392	81.0905	oncorhynchus_kisutch	ENSOKIP00005003875	90.6651	81.5636
ENSG00000100038	homo_sapiens	ENSP00000349705	90.1392	81.0905	oncorhynchus_mykiss	ENSOMYP00000003141	90.6651	81.5636
ENSG00000100038	homo_sapiens	ENSP00000349705	88.7471	79.2343	salmo_salar	ENSSSAP00000177803	60.4265	53.9494
ENSG00000100038	homo_sapiens	ENSP00000349705	89.9072	80.9745	salmo_trutta	ENSSTUP00000007101	90.3263	81.352
ENSG00000100038	homo_sapiens	ENSP00000349705	87.703	79.5824	gadus_morhua	ENSGMOP00000017419	88.5246	80.3279
ENSG00000100038	homo_sapiens	ENSP00000349705	89.7912	80.8585	fundulus_heteroclitus	ENSFHEP00000034014	90.2098	81.2354
ENSG00000100038	homo_sapiens	ENSP00000349705	90.3712	80.3944	poecilia_reticulata	ENSPREP00000025236	90.7925	80.7692
ENSG00000100038	homo_sapiens	ENSP00000349705	90.0232	80.2784	xiphophorus_maculatus	ENSXMAP00000004377	90.4429	80.6527
ENSG00000100038	homo_sapiens	ENSP00000349705	90.2552	81.2065	oryzias_latipes	ENSORLP00000021638	90.676	81.5851
ENSG00000100038	homo_sapiens	ENSP00000349705	89.7912	80.0464	cyclopterus_lumpus	ENSCLMP00005000342	90.2098	80.4196
ENSG00000100038	homo_sapiens	ENSP00000349705	89.9072	80.7425	oreochromis_niloticus	ENSONIP00000013154	90.3263	81.1189
ENSG00000100038	homo_sapiens	ENSP00000349705	14.2691	13.109	haplochromis_burtoni	ENSHBUP00000034351	89.1304	81.8841
ENSG00000100038	homo_sapiens	ENSP00000349705	89.7912	80.6264	astatotilapia_calliptera	ENSACLP00000008574	90.4206	81.1916
ENSG00000100038	homo_sapiens	ENSP00000349705	89.7912	80.8585	sparus_aurata	ENSSAUP00010025195	89.0679	80.2071
ENSG00000100038	homo_sapiens	ENSP00000349705	90.2552	81.0905	lates_calcarifer	ENSLCAP00010052460	90.676	81.4685
ENSG00000100038	homo_sapiens	ENSP00000349705	92.5754	85.2668	xenopus_tropicalis	ENSXETP00000063718	93.007	85.6643
ENSG00000100038	homo_sapiens	ENSP00000349705	94.6636	88.5151	chrysemys_picta_bellii	ENSCPBP00000014169	95.1049	88.9277
ENSG00000100038	homo_sapiens	ENSP00000349705	94.7796	88.7471	sphenodon_punctatus	ENSSPUP00000020436	94.7796	88.7471
ENSG00000100038	homo_sapiens	ENSP00000349705	94.0835	87.471	crocodylus_porosus	ENSCPRP00005000882	94.0835	87.471
ENSG00000100038	homo_sapiens	ENSP00000349705	55.8005	51.3921	laticauda_laticaudata	ENSLLTP00000008392	91.4449	84.2205
ENSG00000100038	homo_sapiens	ENSP00000349705	31.6705	29.5824	laticauda_laticaudata	ENSLLTP00000008742	88.0645	82.2581
ENSG00000100038	homo_sapiens	ENSP00000349705	35.1508	32.2506	notechis_scutatus	ENSNSUP00000005417	90.1786	82.7381
ENSG00000100038	homo_sapiens	ENSP00000349705	14.6172	13.8051	notechis_scutatus	ENSNSUP00000003010	92.6471	87.5
ENSG00000100038	homo_sapiens	ENSP00000349705	35.1508	32.2506	notechis_scutatus	ENSNSUP00000005414	90.1786	82.7381
ENSG00000100038	homo_sapiens	ENSP00000349705	92.9234	87.007	pseudonaja_textilis	ENSPTXP00000011792	92.8158	86.9061
ENSG00000100038	homo_sapiens	ENSP00000349705	92.6914	86.6589	anas_platyrhynchos_platyrhynchos	ENSAPLP00000032306	90.5896	84.6939
ENSG00000100038	homo_sapiens	ENSP00000349705	92.1114	85.2668	gallus_gallus	ENSGALP00010036229	91.8981	85.0694
ENSG00000100038	homo_sapiens	ENSP00000349705	93.9675	87.703	meleagris_gallopavo	ENSMGAP00000000430	93.9675	87.703
ENSG00000100038	homo_sapiens	ENSP00000349705	94.3155	88.051	serinus_canaria	ENSSCAP00000005902	94.3155	88.051
ENSG00000100038	homo_sapiens	ENSP00000349705	94.4316	88.051	parus_major	ENSPMJP00000019019	94.4316	88.051
ENSG00000100038	homo_sapiens	ENSP00000349705	94.5476	87.587	anolis_carolinensis	ENSACAP00000001569	94.5476	87.587
ENSG00000100038	homo_sapiens	ENSP00000349705	89.9072	80.7425	neolamprologus_brichardi	ENSNBRP00000016936	90.5374	81.3084
ENSG00000100038	homo_sapiens	ENSP00000349705	93.2715	87.239	naja_naja	ENSNNAP00000017325	93.1634	87.1379
ENSG00000100038	homo_sapiens	ENSP00000349705	91.9954	85.3828	podarcis_muralis	ENSPMRP00000029796	93.6246	86.8949
ENSG00000100038	homo_sapiens	ENSP00000349705	91.5313	85.6149	geospiza_fortis	ENSGFOP00000000322	94.2652	88.172
ENSG00000100038	homo_sapiens	ENSP00000349705	94.4316	88.1671	taeniopygia_guttata	ENSTGUP00000008929	94.4316	88.1671
ENSG00000100038	homo_sapiens	ENSP00000349705	92.2274	83.4107	erpetoichthys_calabaricus	ENSECRP00000029649	92.2274	83.4107
ENSG00000100038	homo_sapiens	ENSP00000349705	89.7912	80.8585	kryptolebias_marmoratus	ENSKMAP00000002874	90.2098	81.2354
ENSG00000100038	homo_sapiens	ENSP00000349705	94.0835	87.123	salvator_merianae	ENSSMRP00000012336	94.0835	87.123
ENSG00000100038	homo_sapiens	ENSP00000349705	90.0232	81.3225	oryzias_javanicus	ENSOJAP00000016428	90.4429	81.7016
ENSG00000100038	homo_sapiens	ENSP00000349705	86.0789	76.5661	amphilophus_citrinellus	ENSACIP00000008916	89.6135	79.7101
ENSG00000100038	homo_sapiens	ENSP00000349705	90.4872	80.3944	dicentrarchus_labrax	ENSDLAP00005060775	91.1215	80.9579
ENSG00000100038	homo_sapiens	ENSP00000349705	90.2552	80.0464	amphiprion_percula	ENSAPEP00000034438	90.676	80.4196
ENSG00000100038	homo_sapiens	ENSP00000349705	90.3712	81.3225	oryzias_sinensis	ENSOSIP00000036670	90.7925	81.7016
ENSG00000100038	homo_sapiens	ENSP00000349705	89.2111	82.9466	pelodiscus_sinensis	ENSPSIP00000017978	95.4094	88.7097
ENSG00000100038	homo_sapiens	ENSP00000349705	89.9072	83.5267	gopherus_evgoodei	ENSGEVP00005014874	95.2088	88.4521
ENSG00000100038	homo_sapiens	ENSP00000349705	95.4756	89.0951	chelonoidis_abingdonii	ENSCABP00000028247	95.365	88.9919
ENSG00000100038	homo_sapiens	ENSP00000349705	90.4872	80.6264	seriola_dumerili	ENSSDUP00000012675	90.9091	81.0023
ENSG00000100038	homo_sapiens	ENSP00000349705	89.5592	79.2343	cottoperca_gobio	ENSCGOP00000019029	90.2924	79.883
ENSG00000100038	homo_sapiens	ENSP00000349705	94.1995	88.051	struthio_camelus_australis	ENSSCUP00000005555	94.1995	88.051
ENSG00000100038	homo_sapiens	ENSP00000349705	94.3155	88.3991	anser_brachyrhynchus	ENSABRP00000016569	94.3155	88.3991
ENSG00000100038	homo_sapiens	ENSP00000349705	87.935	78.4223	gasterosteus_aculeatus	ENSGACP00000005014	89.1765	79.5294
ENSG00000100038	homo_sapiens	ENSP00000349705	90.4872	80.2784	cynoglossus_semilaevis	ENSCSEP00000012966	90.4872	80.2784
ENSG00000100038	homo_sapiens	ENSP00000349705	90.0232	80.1624	poecilia_formosa	ENSPFOP00000010096	90.4429	80.5361
ENSG00000100038	homo_sapiens	ENSP00000349705	90.8353	80.8585	myripristis_murdjan	ENSMMDP00005020580	91.1525	81.1409
ENSG00000100038	homo_sapiens	ENSP00000349705	89.6752	80.8585	sander_lucioperca	ENSSLUP00000027228	89.4676	80.6713
ENSG00000100038	homo_sapiens	ENSP00000349705	94.1995	87.935	strigops_habroptila	ENSSHBP00005010552	94.3089	88.0372
ENSG00000100038	homo_sapiens	ENSP00000349705	90.2552	80.0464	amphiprion_ocellaris	ENSAOCP00000007708	90.676	80.4196
ENSG00000100038	homo_sapiens	ENSP00000349705	94.5476	88.3991	terrapene_carolina_triunguis	ENSTMTP00000009101	94.9883	88.8112
ENSG00000100038	homo_sapiens	ENSP00000349705	15.7773	13.8051	hucho_hucho	ENSHHUP00000028090	78.6127	68.7861
ENSG00000100038	homo_sapiens	ENSP00000349705	15.0812	13.2251	hucho_hucho	ENSHHUP00000021639	84.4156	74.026
ENSG00000100038	homo_sapiens	ENSP00000349705	43.1555	37.819	hucho_hucho	ENSHHUP00000039158	83.7838	73.4234
ENSG00000100038	homo_sapiens	ENSP00000349705	91.1833	82.1346	betta_splendens	ENSBSLP00000044636	91.6084	82.5175
ENSG00000100038	homo_sapiens	ENSP00000349705	91.1833	82.5986	pygocentrus_nattereri	ENSPNAP00000014659	91.2892	82.6945
ENSG00000100038	homo_sapiens	ENSP00000349705	90.8353	81.2065	anabas_testudineus	ENSATEP00000016435	91.2587	81.5851
ENSG00000100038	homo_sapiens	ENSP00000349705	53.2483	44.4316	ciona_savignyi	ENSCSAVP00000007968	72.2835	60.315
ENSG00000100038	homo_sapiens	ENSP00000349705	90.4872	80.5104	seriola_lalandi_dorsalis	ENSSLDP00000013408	90.9091	80.8858
ENSG00000100038	homo_sapiens	ENSP00000349705	90.0232	80.9745	labrus_bergylta	ENSLBEP00000003995	90.8665	81.733
ENSG00000100038	homo_sapiens	ENSP00000349705	89.6752	80.5104	pundamilia_nyererei	ENSPNYP00000026496	90.3037	81.0748
ENSG00000100038	homo_sapiens	ENSP00000349705	89.3271	80.6264	mastacembelus_armatus	ENSMAMP00000027332	89.7436	81.0023
ENSG00000100038	homo_sapiens	ENSP00000349705	90.7193	80.5104	stegastes_partitus	ENSSPAP00000018756	91.1422	80.8858
ENSG00000100038	homo_sapiens	ENSP00000349705	77.3782	67.1694	oncorhynchus_tshawytscha	ENSOTSP00005090813	82.2441	71.3933
ENSG00000100038	homo_sapiens	ENSP00000349705	90.4872	79.8144	acanthochromis_polyacanthus	ENSAPOP00000007462	90.9091	80.1865
ENSG00000100038	homo_sapiens	ENSP00000349705	94.3155	87.819	aquila_chrysaetos_chrysaetos	ENSACCP00020005518	94.3155	87.819
ENSG00000100038	homo_sapiens	ENSP00000349705	90.0232	80.6264	nothobranchius_furzeri	ENSNFUP00015037415	90.4429	81.0023
ENSG00000100038	homo_sapiens	ENSP00000349705	14.1531	13.4571	cyprinodon_variegatus	ENSCVAP00000018266	93.8462	89.2308
ENSG00000100038	homo_sapiens	ENSP00000349705	92.2274	83.4107	denticeps_clupeoides	ENSDCDP00000048973	92.2274	83.4107
ENSG00000100038	homo_sapiens	ENSP00000349705	89.5592	79.8144	larimichthys_crocea	ENSLCRP00005050623	87.8271	78.2708
ENSG00000100038	homo_sapiens	ENSP00000349705	88.6311	79.1183	takifugu_rubripes	ENSTRUP00000067299	89.2523	79.6729
ENSG00000100038	homo_sapiens	ENSP00000349705	94.6636	88.5151	ficedula_albicollis	ENSFALP00000008263	94.6636	88.5151
ENSG00000100038	homo_sapiens	ENSP00000349705	87.935	77.7262	hippocampus_comes	ENSHCOP00000011959	88.5514	78.271
ENSG00000100038	homo_sapiens	ENSP00000349705	91.1833	82.0186	cyprinus_carpio_carpio	ENSCCRP00000059038	91.2892	82.1138
ENSG00000100038	homo_sapiens	ENSP00000349705	90.8353	81.5545	cyprinus_carpio_carpio	ENSCCRP00000047081	89.8967	80.7118
ENSG00000100038	homo_sapiens	ENSP00000349705	93.6195	87.471	coturnix_japonica	ENSCJPP00005024062	93.6195	87.471
ENSG00000100038	homo_sapiens	ENSP00000349705	90.0232	80.1624	poecilia_latipinna	ENSPLAP00000008547	90.4429	80.5361
ENSG00000100038	homo_sapiens	ENSP00000349705	68.6775	57.4246	sinocyclocheilus_grahami	ENSSGRP00000086493	79.4631	66.443
ENSG00000100038	homo_sapiens	ENSP00000349705	82.8306	73.7819	sinocyclocheilus_grahami	ENSSGRP00000074465	88.3663	78.7129
ENSG00000100038	homo_sapiens	ENSP00000349705	89.7912	80.5104	maylandia_zebra	ENSMZEP00005005616	90.4206	81.0748
ENSG00000100038	homo_sapiens	ENSP00000349705	19.2575	16.9374	tetraodon_nigroviridis	ENSTNIP00000008181	91.2088	80.2198
ENSG00000100038	homo_sapiens	ENSP00000349705	75.406	65.7773	tetraodon_nigroviridis	ENSTNIP00000007863	84.088	73.3506
ENSG00000100038	homo_sapiens	ENSP00000349705	91.4153	82.1346	paramormyrops_kingsleyae	ENSPKIP00000033277	91.3094	82.0394
ENSG00000100038	homo_sapiens	ENSP00000349705	91.9954	83.5267	scleropages_formosus	ENSSFOP00015023710	91.8888	83.4299
ENSG00000100038	homo_sapiens	ENSP00000349705	92.4594	84.9188	leptobrachium_leishanense	ENSLLEP00000014986	92.8904	85.3147
ENSG00000100038	homo_sapiens	ENSP00000349705	90.2552	80.7425	scophthalmus_maximus	ENSSMAP00000021131	91.1007	81.4988
ENSG00000100038	homo_sapiens	ENSP00000349705	89.3271	80.8585	oryzias_melastigma	ENSOMEP00000002177	89.6391	81.1409

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000793	located_in condensed chromosome	1	IEA	Homo_sapiens(9606)	Component
GO:0003677	enables DNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0003916	enables DNA topoisomerase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0003917	enables DNA topoisomerase type I (single strand cut, ATP-independent) activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0006265	involved_in DNA topological change	2	IBA,NAS	Homo_sapiens(9606)	Process
GO:0007059	involved_in chromosome segregation	1	IEA	Homo_sapiens(9606)	Process
GO:0140225	part_of DNA topoisomerase III-beta-TDRD3 complex	1	IPI	Homo_sapiens(9606)	Component