RBP Type	Non-canonical_RBPs
Diseases	FlavivirusesSARS-COV-2
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000100038	Gene ID	8940	Accession	11993
Symbol	TOP3B	Alias	TOP3B1	Full Name	DNA topoisomerase III beta
Status	Confidence	Length	25789 bases	Strand	Minus strand
Position	22 : 21957025 - 21982813	RNA binding domain	N.A.
Summary	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]