RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000092010	Gene ID	5720	Accession	9568
Symbol	PSME1	Alias	PA28A;IFI5111;REGalpha;PA28alpha;HEL-S-129m	Full Name	proteasome activator subunit 1
Status	Confidence	Length	2805 bases	Strand	Plus strand
Position	14 : 24136163 - 24138967	RNA binding domain	N.A.
Summary	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
PSME1-205	ENST00000559123	1033	90aa	ENSP00000452843
PSME1-201	ENST00000206451	965	249aa	ENSP00000206451
PSME1-208	ENST00000561059	947	No protein	-
PSME1-209	ENST00000561142	865	No protein	-
PSME1-202	ENST00000382708	1136	250aa	ENSP00000372155
PSME1-210	ENST00000561435	945	233aa	ENSP00000453976
PSME1-203	ENST00000470718	476	No protein	-
PSME1-206	ENST00000559741	763	No protein	-
PSME1-207	ENST00000560420	922	No protein	-
PSME1-204	ENST00000558112	651	114aa	ENSP00000453340

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000502	part_of proteasome complex	1	TAS	Homo_sapiens(9606)	Component
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005654	is_active_in nucleoplasm	2	IBA,TAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0008537	part_of proteasome activator complex	1	IEA	Homo_sapiens(9606)	Component
GO:0010950	involved_in positive regulation of endopeptidase activity	1	IBA	Homo_sapiens(9606)	Process
GO:0019884	involved_in antigen processing and presentation of exogenous antigen	1	IEA	Homo_sapiens(9606)	Process
GO:0061133	enables endopeptidase activator activity	1	IBA	Homo_sapiens(9606)	Function
GO:0061136	involved_in regulation of proteasomal protein catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:2000045	involved_in regulation of G1/S transition of mitotic cell cycle	1	IBA	Homo_sapiens(9606)	Process