Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-OC43FlavivirusesSARS-COV-2DengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions E3 ligase
Localizations Stress granucle
BulkPerturb-seq DataSet_01_233 DataSet_01_248 DataSet_02_136

Description

Ensembl ID ENSG00000089280 Gene ID 2521 Accession 4010
Symbol FUS Alias TLS;ALS6;ETM4;FUS1;POMP75;altFUS;HNRNPP2 Full Name FUS RNA binding protein
Status Confidence Length 11468 bases Strand Plus strand
Position 16 : 31180138 - 31191605 RNA binding domain zf-RanBP , RRM_1
Summary This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000254108 RRM_1 PF00076 3.7e-10 1
ENSP00000254108 zf-RanBP PF00641 1.7e-11 2
ENSP00000369594 RRM_1 PF00076 3.7e-10 1
ENSP00000369594 zf-RanBP PF00641 1.6e-11 2
ENSP00000455282 RRM_1 PF00076 3.7e-10 1
ENSP00000455282 zf-RanBP PF00641 1.7e-11 2

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
22778552 Yeast and the AIDS virus: the odd couple. Marie-Line Andréola 2012-01-01 Journal of biomedicine & biotechnology
26674342 A systematic study of nuclear interactome of C-terminal domain small phosphatase-like 2 using inducible expression system and shotgun proteomics. NaNa Kang 2016-06-01 BMB reports
26391765 RBM45 homo-oligomerization mediates association with ALS-linked proteins and stress granules. Yang Li 2015-09-22 Scientific reports
27225265 A new method for quantifying mitochondrial axonal transport. Mengmeng Chen 2016-11-01 Protein & cell
23200923 The RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site. Xuehui Liu 2013-02-01 Biochimica et biophysica acta
26793054 The Immune Syntax Revisited: Opening New Windows on Language Evolution. Antonio Benítez-Burraco 2015-01-01 Frontiers in molecular neuroscience
16230076 Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing. Satoshi Sato 2005-10-01 Gastroenterology
29021520 HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients. Wenting Guo 2017-10-11 Nature communications
27386217 Diverse roles of FUS in Amyotrophic Lateral Sclerosis. Teresa Maria Carri 2015-01-01 SpringerPlus
26895297 Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Marc Suárez-Calvet 2016-04-01 Acta neuropathologica
22346009 Altered RNA metabolism and amyotrophic lateral sclerosis. Ashok Verma 2011-10-01 Annals of Indian Academy of Neurology
20720006 Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA. Hwa Sang Kim 2010-10-29 The Journal of biological chemistry
27502124 Prion-like propagation as a pathogenic principle in frontotemporal dementia. Eva-Maria Hock 2016-08-01 Journal of neurochemistry
26317359 Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates. P Maggie Wear 2015-01-01 PloS one
31244613 Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses. Dhruva Deshpande 2019-01-01 Frontiers in cellular neuroscience
27150074 Oxidative stress and mitochondrial damage in the pathogenesis of ALS: New perspectives. F Bozzo 2017-01-01 Neuroscience letters
27444227 Non-coding RNAs as drug targets. Masayuki Matsui 2017-03-01 Nature reviews. Drug discovery
28539871 Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Continuum. Hamideh Shahheydari 2017-01-01 Frontiers in molecular neuroscience
22713872 fus/TLS orchestrates splicing of developmental regulators during gastrulation. S Darwin Dichmann 2012-06-15 Genes & development
20541619 Fused in sarcoma/translocated in liposarcoma: a multifunctional DNA/RNA binding protein. Shu Yang 2010-09-01 The international journal of biochemistry & cell biology
18698352 P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-Ras. Maria Camats 2008-08-13 PloS one

Transcripts

Name Transcript ID bp Protein Translation ID
FUS-201 ENST00000254108 1824 526aa ENSP00000254108
FUS-209 ENST00000566605 1787 263aa ENSP00000455073
FUS-205 ENST00000487045 952 No protein -
FUS-202 ENST00000380244 1818 525aa ENSP00000369594
FUS-206 ENST00000487509 4920 No protein -
FUS-210 ENST00000568685 1785 527aa ENSP00000455282
FUS-207 ENST00000487974 643 No protein -
FUS-213 ENST00000570090 544 No protein -
FUS-203 ENST00000474990 827 No protein -
FUS-211 ENST00000568901 521 No protein -
FUS-208 ENST00000564766 791 No protein -
FUS-212 ENST00000569760 639 No protein -
FUS-204 ENST00000483853 778 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
39225Platelet Function Tests1.6900000E-006-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000089280homo_sapiensENSP0000038103154.115944.9695homo_sapiensENSP0000025410867.490556.0836
ENSG00000089280homo_sapiensENSP0000047409644.932439.8649homo_sapiensENSP0000025410850.570344.8669

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000089280homo_sapiensENSP0000025410895.817595.4373nomascus_leucogenysENSNLEP0000001973297.109896.7245
ENSG00000089280homo_sapiensENSP0000025410899.049498.8593pan_paniscusENSPPAP0000001181099.617699.4264
ENSG00000089280homo_sapiensENSP0000025410898.28997.9087pongo_abeliiENSPPYP0000000825997.916797.5379
ENSG00000089280homo_sapiensENSP0000025410899.239599.0494pan_troglodytesENSPTRP0000005359299.239599.0494
ENSG00000089280homo_sapiensENSP0000025410898.669298.4791gorilla_gorillaENSGGOP0000001775099.235299.044
ENSG00000089280homo_sapiensENSP0000025410893.155991.2548ornithorhynchus_anatinusENSOANP0000000892394.049992.1305
ENSG00000089280homo_sapiensENSP0000025410893.536192.3954sarcophilus_harrisiiENSSHAP0000003131494.072792.9254
ENSG00000089280homo_sapiensENSP0000025410879.847978.5171notamacropus_eugeniiENSMEUP0000000089381.553480.1942
ENSG00000089280homo_sapiensENSP0000025410862.167361.4068choloepus_hoffmanniENSCHOP0000000954868.267267.4322
ENSG00000089280homo_sapiensENSP0000025410893.916493.1559dasypus_novemcinctusENSDNOP0000001324795.551394.7776
ENSG00000089280homo_sapiensENSP0000025410886.311885.5513erinaceus_europaeusENSEEUP0000000451987.475986.7052
ENSG00000089280homo_sapiensENSP0000025410865.209163.8783echinops_telfairiENSETEP0000000595668.326766.9323
ENSG00000089280homo_sapiensENSP0000025410875.475375.0951echinops_telfairiENSETEP0000001244894.749494.2721
ENSG00000089280homo_sapiensENSP0000025410896.958296.3878cercocebus_atysENSCATP0000002139995.684895.1219
ENSG00000089280homo_sapiensENSP0000025410896.958296.3878macaca_fascicularisENSMFAP0000001730396.408395.8412
ENSG00000089280homo_sapiensENSP0000025410896.768196.1977macaca_mulattaENSMMUP0000002580095.318494.7566
ENSG00000089280homo_sapiensENSP0000025410897.148396.5779macaca_nemestrinaENSMNEP0000000688295.51494.9533
ENSG00000089280homo_sapiensENSP0000025410897.148396.3878papio_anubisENSPANP0000001257995.872495.1219
ENSG00000089280homo_sapiensENSP0000025410896.958296.3878mandrillus_leucophaeusENSMLEP0000002766997.701197.1264
ENSG00000089280homo_sapiensENSP0000025410875.665475.0951tursiops_truncatusENSTTRP0000001474578.656178.0632
ENSG00000089280homo_sapiensENSP0000025410879.847978.5171vulpes_vulpesENSVVUP0000001777288.050386.5828
ENSG00000089280homo_sapiensENSP0000025410890.304289.1635vulpes_vulpesENSVVUP0000003896788.951387.8277
ENSG00000089280homo_sapiensENSP0000025410895.817595.4373mus_spretusMGP_SPRETEiJ_P008599397.297396.9112
ENSG00000089280homo_sapiensENSP0000025410886.882185.3612equus_asinusENSEASP0000501610592.510190.8907
ENSG00000089280homo_sapiensENSP0000025410894.676894.1065equus_asinusENSEASP0000505030695.953895.3757
ENSG00000089280homo_sapiensENSP0000025410893.536192.7757capra_hircusENSCHIP0000000202694.252993.4866
ENSG00000089280homo_sapiensENSP0000025410890.684489.7338loxodonta_africanaENSLAFP0000000137392.084991.1197
ENSG00000089280homo_sapiensENSP0000025410894.296693.7262panthera_leoENSPLOP0000002287896.498195.9144
ENSG00000089280homo_sapiensENSP0000025410890.684490.4943ailuropoda_melanoleucaENSAMEP0000000755495.783195.5823
ENSG00000089280homo_sapiensENSP0000025410893.726292.7757bos_indicus_hybridENSBIXP0000502470896.289195.3125
ENSG00000089280homo_sapiensENSP0000025410895.05793.9164oryctolagus_cuniculusENSOCUP0000002089996.711895.5513
ENSG00000089280homo_sapiensENSP0000025410880.228179.2776equus_caballusENSECAP0000002749094.407293.2886
ENSG00000089280homo_sapiensENSP0000025410894.486793.5361equus_caballusENSECAP0000007419973.088272.3529
ENSG00000089280homo_sapiensENSP0000025410894.486794.1065canis_lupus_familiarisENSCAFP0084501680894.666794.2857
ENSG00000089280homo_sapiensENSP0000025410894.866994.2966panthera_pardusENSPPRP0000000983296.705496.124
ENSG00000089280homo_sapiensENSP0000025410895.817595.2471marmota_marmota_marmotaENSMMMP0000000081097.109896.5318
ENSG00000089280homo_sapiensENSP0000025410894.676894.1065balaenoptera_musculusENSBMSP0001002017596.69996.1165
ENSG00000089280homo_sapiensENSP0000025410873.574172.8137balaenoptera_musculusENSBMSP0001002570296.508795.5112
ENSG00000089280homo_sapiensENSP0000025410890.114188.9734cavia_porcellusENSCPOP0000002883996.734795.5102
ENSG00000089280homo_sapiensENSP0000025410894.866994.2966felis_catusENSFCAP0000002195396.705496.124
ENSG00000089280homo_sapiensENSP0000025410892.585592.3954ursus_americanusENSUAMP0000001038195.866195.6693
ENSG00000089280homo_sapiensENSP0000025410895.437394.2966monodelphis_domesticaENSMODP0000000230095.075893.9394
ENSG00000089280homo_sapiensENSP0000025410893.916493.346bison_bison_bisonENSBBBP0000000746796.296395.7115
ENSG00000089280homo_sapiensENSP0000025410894.676894.2966monodon_monocerosENSMMNP0001500945196.69996.3107
ENSG00000089280homo_sapiensENSP0000025410894.676893.7262sus_scrofaENSSSCP0000003102896.13995.1737
ENSG00000089280homo_sapiensENSP0000025410894.486793.9164microcebus_murinusENSMICP0000003166096.881196.2963
ENSG00000089280homo_sapiensENSP0000025410889.733888.0228octodon_degusENSODEP0000001070593.650891.8651
ENSG00000089280homo_sapiensENSP0000025410871.292869.3916octodon_degusENSODEP0000000641185.421483.1435
ENSG00000089280homo_sapiensENSP0000025410887.452586.8821octodon_degusENSODEP0000000970596.033495.4071
ENSG00000089280homo_sapiensENSP0000025410894.676894.1065octodon_degusENSODEP0000002077496.511695.9302
ENSG00000089280homo_sapiensENSP0000025410890.304289.1635octodon_degusENSODEP0000000645796.153894.9393
ENSG00000089280homo_sapiensENSP0000025410894.676894.1065jaculus_jaculusENSJJAP0000000738696.69996.1165
ENSG00000089280homo_sapiensENSP0000025410892.585592.2053ovis_aries_rambouilletENSOARP0002003091396.055295.6608
ENSG00000089280homo_sapiensENSP0000025410858.745257.9848ochotona_princepsENSOPRP0000000991560.826860.0394
ENSG00000089280homo_sapiensENSP0000025410894.486793.9164delphinapterus_leucasENSDLEP0000002182989.549689.009
ENSG00000089280homo_sapiensENSP0000025410894.296693.7262physeter_catodonENSPCTP0000501785096.310795.7282
ENSG00000089280homo_sapiensENSP0000025410895.817595.4373mus_caroliMGP_CAROLIEiJ_P008258197.297396.9112
ENSG00000089280homo_sapiensENSP0000025410895.817595.6274mus_musculusENSMUSP0000010185897.297397.1042
ENSG00000089280homo_sapiensENSP0000025410895.247194.8669dipodomys_ordiiENSDORP0000001336997.09396.7054
ENSG00000089280homo_sapiensENSP0000025410876.235774.3346mustela_putorius_furoENSMPUP0000000400187.363885.1852
ENSG00000089280homo_sapiensENSP0000025410894.486794.1065mustela_putorius_furoENSMPUP0000001133494.847394.4657
ENSG00000089280homo_sapiensENSP0000025410896.197795.2471aotus_nancymaaeENSANAP0000000705196.38195.4286
ENSG00000089280homo_sapiensENSP0000025410883.460182.5095aotus_nancymaaeENSANAP0000002125793.205992.1444
ENSG00000089280homo_sapiensENSP0000025410896.007695.4373saimiri_boliviensis_boliviensisENSSBOP0000003682995.463194.896
ENSG00000089280homo_sapiensENSP0000025410865.969665.019vicugna_pacosENSVPAP0000000391772.746371.6981
ENSG00000089280homo_sapiensENSP0000025410896.768196.3878chlorocebus_sabaeusENSCSAP0000000202195.676795.3008
ENSG00000089280homo_sapiensENSP0000025410895.627495.057mesocricetus_auratusENSMAUP0000000812597.292196.7118
ENSG00000089280homo_sapiensENSP0000025410894.676894.1065phocoena_sinusENSPSNP0000001577789.729789.1892
ENSG00000089280homo_sapiensENSP0000025410894.296693.5361camelus_dromedariusENSCDRP0000502032296.12495.3488
ENSG00000089280homo_sapiensENSP0000025410894.486793.9164carlito_syrichtaENSTSYP0000001079496.692696.1089
ENSG00000089280homo_sapiensENSP0000025410894.296693.346panthera_tigris_altaicaENSPTIP0000001190396.12495.155
ENSG00000089280homo_sapiensENSP0000025410891.444990.4943rattus_norvegicusENSRNOP0000008529893.217192.2481
ENSG00000089280homo_sapiensENSP0000025410895.817595.2471rattus_norvegicusENSRNOP0000003302997.297396.7181
ENSG00000089280homo_sapiensENSP0000025410892.205391.8251prolemur_simusENSPSMP0000001137595.472495.0787
ENSG00000089280homo_sapiensENSP0000025410895.627495.2471microtus_ochrogasterENSMOCP0000000713397.292196.9052
ENSG00000089280homo_sapiensENSP0000025410878.897377.7567microtus_ochrogasterENSMOCP0000002200889.632888.3369
ENSG00000089280homo_sapiensENSP0000025410895.817595.4373peromyscus_maniculatus_bairdiiENSPEMP0000002726397.297396.9112
ENSG00000089280homo_sapiensENSP0000025410893.726293.1559bos_mutusENSBMUP0000003405196.101495.5166
ENSG00000089280homo_sapiensENSP0000025410895.817595.4373mus_spicilegusENSMSIP0000002939597.297396.9112
ENSG00000089280homo_sapiensENSP0000025410895.627495.2471cricetulus_griseus_chok1gshdENSCGRP0000101568997.292196.9052
ENSG00000089280homo_sapiensENSP0000025410892.585592.0152pteropus_vampyrusENSPVAP0000000292395.866195.2756
ENSG00000089280homo_sapiensENSP0000025410868.25166.5399myotis_lucifugusENSMLUP0000001909090.656688.3838
ENSG00000089280homo_sapiensENSP0000025410893.155992.3954myotis_lucifugusENSMLUP0000000438196.267295.4813
ENSG00000089280homo_sapiensENSP0000025410893.536192.2053vombatus_ursinusENSVURP0001002292792.830291.5094
ENSG00000089280homo_sapiensENSP0000025410892.015290.8745rhinolophus_ferrumequinumENSRFEP0001003162994.716293.5421
ENSG00000089280homo_sapiensENSP0000025410833.840331.5589neovison_visonENSNVIP0000001073373.25168.3128
ENSG00000089280homo_sapiensENSP0000025410893.916493.7262neovison_visonENSNVIP0000003232996.108995.9144
ENSG00000089280homo_sapiensENSP0000025410893.34692.3954bos_taurusENSBTAP0000000757195.898494.9219
ENSG00000089280homo_sapiensENSP0000025410894.106592.9658heterocephalus_glaber_femaleENSHGLP0000004265475.688174.7706
ENSG00000089280homo_sapiensENSP0000025410846.197744.6768heterocephalus_glaber_femaleENSHGLP0000001734687.096884.2294
ENSG00000089280homo_sapiensENSP0000025410897.148396.9582rhinopithecus_bietiENSRBIP0000003720397.892797.7011
ENSG00000089280homo_sapiensENSP0000025410893.34692.9658canis_lupus_dingoENSCAFP0002002306196.463796.0707
ENSG00000089280homo_sapiensENSP0000025410895.627495.057sciurus_vulgarisENSSVLP0000502307597.292196.7118
ENSG00000089280homo_sapiensENSP0000025410892.965892.0152phascolarctos_cinereusENSPCIP0000002091193.678292.7203
ENSG00000089280homo_sapiensENSP0000025410835.551334.0304phascolarctos_cinereusENSPCIP0000004421169.259366.2963
ENSG00000089280homo_sapiensENSP0000025410862.927862.1673procavia_capensisENSPCAP0000000669195.38994.2363
ENSG00000089280homo_sapiensENSP0000025410867.110365.7795nannospalax_galiliENSNGAP0000001819583.451581.7967
ENSG00000089280homo_sapiensENSP0000025410894.676894.1065nannospalax_galiliENSNGAP0000002539296.69996.1165
ENSG00000089280homo_sapiensENSP0000025410893.726293.1559bos_grunniensENSBGRP0000003661195.914495.3307
ENSG00000089280homo_sapiensENSP0000025410896.007695.6274chinchilla_lanigeraENSCLAP0000001518897.678997.2921
ENSG00000089280homo_sapiensENSP0000025410894.296693.9164cervus_hanglu_yarkandensisENSCHYP0000000385196.12495.7364
ENSG00000089280homo_sapiensENSP0000025410894.486793.7262catagonus_wagneriENSCWAP0000000650095.945995.1737
ENSG00000089280homo_sapiensENSP0000025410886.121785.5513ictidomys_tridecemlineatusENSSTOP0000000532197.210396.5665
ENSG00000089280homo_sapiensENSP0000025410895.247194.8669cebus_imitatorENSCCAP0000000455195.610795.229
ENSG00000089280homo_sapiensENSP0000025410895.437394.8669urocitellus_parryiiENSUPAP0001002466596.911296.332
ENSG00000089280homo_sapiensENSP0000025410892.205391.635moschus_moschiferusENSMMSP0000000096796.613596.0159
ENSG00000089280homo_sapiensENSP0000025410889.92489.1635rhinopithecus_roxellanaENSRROP0000001401890.439889.6749
ENSG00000089280homo_sapiensENSP0000025410895.817595.4373mus_pahariMGP_PahariEiJ_P001937697.297396.9112
ENSG00000089280homo_sapiensENSP0000025410880.988680.6084propithecus_coquereliENSPCOP0000002063595.730395.2809
ENSG00000089280homo_sapiensENSP0000025410833.460127.9468caenorhabditis_elegansC27H5.3a.139.285732.8125
ENSG00000089280homo_sapiensENSP0000025410835.551329.2776drosophila_melanogasterFBpp007399646.867238.5965
ENSG00000089280homo_sapiensENSP0000025410821.482917.3004ciona_intestinalisENSCINP0000003578165.317952.6012
ENSG00000089280homo_sapiensENSP0000025410848.859338.403eptatretus_burgeriENSEBUP0000002374964.572950.7538
ENSG00000089280homo_sapiensENSP000002541089.885939.31559callorhinchus_miliiENSCMIP0000002598966.666762.8205
ENSG00000089280homo_sapiensENSP0000025410879.847973.1939latimeria_chalumnaeENSLACP0000000514278.947472.3684
ENSG00000089280homo_sapiensENSP0000025410869.581762.5475lepisosteus_oculatusENSLOCP0000000006069.056662.0755
ENSG00000089280homo_sapiensENSP0000025410874.334666.1597danio_rerioENSDARP0000005533972.273664.3253
ENSG00000089280homo_sapiensENSP0000025410872.623666.5399carassius_auratusENSCARP0000003623071.804565.7895
ENSG00000089280homo_sapiensENSP0000025410852.851747.5285carassius_auratusENSCARP0000005866865.56658.9623
ENSG00000089280homo_sapiensENSP0000025410873.003866.73astyanax_mexicanusENSAMXP0000003257368.449262.5668
ENSG00000089280homo_sapiensENSP0000025410816.349815.2091oncorhynchus_kisutchENSOKIP0000507456467.716562.9921
ENSG00000089280homo_sapiensENSP0000025410872.053264.6388oncorhynchus_kisutchENSOKIP0000507447169.926262.7306
ENSG00000089280homo_sapiensENSP0000025410871.292863.8783oncorhynchus_mykissENSOMYP0000003741568.807361.6514
ENSG00000089280homo_sapiensENSP0000025410820.152118.2509oncorhynchus_mykissENSOMYP0000003737766.666760.3774
ENSG00000089280homo_sapiensENSP0000025410852.851746.1977salmo_salarENSSSAP0000000314756.161649.0909
ENSG00000089280homo_sapiensENSP0000025410873.193965.9696salmo_truttaENSSTUP0000005664470.383963.4369
ENSG00000089280homo_sapiensENSP0000025410837.072234.0304gadus_morhuaENSGMOP0000001839165.878460.473
ENSG00000089280homo_sapiensENSP0000025410872.053264.2586haplochromis_burtoniENSHBUP0000001732469.28761.7916
ENSG00000089280homo_sapiensENSP0000025410871.863164.0684astatotilapia_callipteraENSACLP0000002738168.978161.4963
ENSG00000089280homo_sapiensENSP0000025410871.292863.4981sparus_aurataENSSAUP0001005121767.32559.9641
ENSG00000089280homo_sapiensENSP0000025410871.67364.4487lates_calcariferENSLCAP0001002352868.921461.9744
ENSG00000089280homo_sapiensENSP0000025410881.558976.2357xenopus_tropicalisENSXETP0000010559879.005573.849
ENSG00000089280homo_sapiensENSP0000025410882.699678.5171chrysemys_picta_belliiENSCPBP0000001183182.699678.5171
ENSG00000089280homo_sapiensENSP0000025410847.338442.7757sphenodon_punctatusENSSPUP0000000931576.380469.0184
ENSG00000089280homo_sapiensENSP0000025410885.551380.4183sphenodon_punctatusENSSPUP0000000388581.521776.6304
ENSG00000089280homo_sapiensENSP0000025410887.072281.9392laticauda_laticaudataENSLLTP0000000987887.571782.4092
ENSG00000089280homo_sapiensENSP000002541085045.8175notechis_scutatusENSNSUP0000001500882.965376.0252
ENSG00000089280homo_sapiensENSP0000025410886.501982.5095anolis_carolinensisENSACAP0000003227386.337882.3529
ENSG00000089280homo_sapiensENSP0000025410865.399258.7452neolamprologus_brichardiENSNBRP0000001120270.204163.0612
ENSG00000089280homo_sapiensENSP0000025410886.882181.749naja_najaENSNNAP0000002336887.380582.218
ENSG00000089280homo_sapiensENSP0000025410848.28939.1635geospiza_fortisENSGFOP0000001089449.609440.2344
ENSG00000089280homo_sapiensENSP0000025410877.376471.1027erpetoichthys_calabaricusENSECRP0000003387879.182972.7626
ENSG00000089280homo_sapiensENSP0000025410886.882182.3194salvator_merianaeENSSMRP0000000877187.213782.6336
ENSG00000089280homo_sapiensENSP0000025410857.034249.4297oryzias_javanicusENSOJAP0000003551365.934157.1429
ENSG00000089280homo_sapiensENSP0000025410859.885953.2319dicentrarchus_labraxENSDLAP0000506751657.481851.0949
ENSG00000089280homo_sapiensENSP0000025410871.292864.8289amphiprion_perculaENSAPEP0000000894568.807362.5688
ENSG00000089280homo_sapiensENSP0000025410848.669246.7681pelodiscus_sinensisENSPSIP0000001039291.428687.8571
ENSG00000089280homo_sapiensENSP0000025410885.361280.6084gopherus_evgoodeiENSGEVP0000501470886.847282.0116
ENSG00000089280homo_sapiensENSP0000025410878.897373.9544chelonoidis_abingdoniiENSCABP0000001390985.04179.7131
ENSG00000089280homo_sapiensENSP0000025410870.912564.0684seriola_dumeriliENSSDUP0000002021868.946462.2921
ENSG00000089280homo_sapiensENSP0000025410873.38469.0114anser_brachyrhynchusENSABRP0000001931673.244868.8805
ENSG00000089280homo_sapiensENSP0000025410863.30854.943gasterosteus_aculeatusENSGACP0000001967265.422456.778
ENSG00000089280homo_sapiensENSP0000025410861.977256.2738myripristis_murdjanENSMMDP0000502356970.107563.6559
ENSG00000089280homo_sapiensENSP0000025410854.182548.8593sander_luciopercaENSSLUP0000001316866.433659.9068
ENSG00000089280homo_sapiensENSP0000025410876.806172.4335strigops_habroptilaENSSHBP0000501797883.471178.719
ENSG00000089280homo_sapiensENSP0000025410857.224352.0913amphiprion_ocellarisENSAOCP0000000972765.434859.5652
ENSG00000089280homo_sapiensENSP0000025410873.764369.962terrapene_carolina_triunguisENSTMTP0000001355085.087780.7018
ENSG00000089280homo_sapiensENSP0000025410872.433564.8289hucho_huchoENSHHUP0000005813270.949763.5009
ENSG00000089280homo_sapiensENSP0000025410871.863164.4487betta_splendensENSBSLP0000002788770.919363.6023
ENSG00000089280homo_sapiensENSP0000025410869.391664.2586pygocentrus_nattereriENSPNAP0000003162671.850466.5354
ENSG00000089280homo_sapiensENSP0000025410857.794751.9011anabas_testudineusENSATEP0000002776867.70660.8018
ENSG00000089280homo_sapiensENSP0000025410865.209158.5551seriola_lalandi_dorsalisENSSLDP0000000444070.721663.5052
ENSG00000089280homo_sapiensENSP0000025410870.342262.3574labrus_bergyltaENSLBEP0000003031263.573956.3574
ENSG00000089280homo_sapiensENSP0000025410864.258657.4144mastacembelus_armatusENSMAMP0000002849862.476955.8226
ENSG00000089280homo_sapiensENSP0000025410866.920260.4563stegastes_partitusENSSPAP0000000838370.119563.3466
ENSG00000089280homo_sapiensENSP0000025410872.623665.2091oncorhynchus_tshawytschaENSOTSP0000507385469.963462.8205
ENSG00000089280homo_sapiensENSP0000025410820.532319.0114oncorhynchus_tshawytschaENSOTSP0000507386061.714357.1429
ENSG00000089280homo_sapiensENSP0000025410864.828959.3156acanthochromis_polyacanthusENSAPOP0000002519469.028363.1579
ENSG00000089280homo_sapiensENSP0000025410866.349863.8783aquila_chrysaetos_chrysaetosENSACCP0002002416069.521966.9323
ENSG00000089280homo_sapiensENSP0000025410866.539957.9848nothobranchius_furzeriENSNFUP0001504176366.287957.7652
ENSG00000089280homo_sapiensENSP0000025410871.482964.4487larimichthys_croceaENSLCRP0000500996468.115961.413
ENSG00000089280homo_sapiensENSP0000025410850.380243.7262hippocampus_comesENSHCOP0000001109959.151851.3393
ENSG00000089280homo_sapiensENSP0000025410873.003866.1597cyprinus_carpio_carpioENSCCRP0000016763671.111164.4444
ENSG00000089280homo_sapiensENSP0000025410869.581763.6882cyprinus_carpio_carpioENSCCRP0000016961971.484465.4297
ENSG00000089280homo_sapiensENSP0000025410873.38466.5399sinocyclocheilus_grahamiENSSGRP0000011167772.967966.1626
ENSG00000089280homo_sapiensENSP0000025410868.060861.0266sinocyclocheilus_grahamiENSSGRP0000008210270.196162.9412
ENSG00000089280homo_sapiensENSP0000025410871.863164.0684maylandia_zebraENSMZEP0000500256568.978161.4963
ENSG00000089280homo_sapiensENSP0000025410867.680660.4563tetraodon_nigroviridisENSTNIP0000001424268.725961.39
ENSG00000089280homo_sapiensENSP0000025410873.003865.019paramormyrops_kingsleyaeENSPKIP0000001138266.782659.4783
ENSG00000089280homo_sapiensENSP0000025410856.083644.2966scleropages_formosusENSSFOP0001505760357.39345.3307
ENSG00000089280homo_sapiensENSP0000025410876.806170.7224leptobrachium_leishanenseENSLLEP0000003583057.714353.1429
ENSG00000089280homo_sapiensENSP0000025410870.152162.3574scophthalmus_maximusENSSMAP0000001906665.194357.9505

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003677enables DNA binding1IEAHomo_sapiens(9606)Function
GO:0003682enables chromatin binding1IDAHomo_sapiens(9606)Function
GO:0003712enables transcription coregulator activity1IBAHomo_sapiens(9606)Function
GO:0003713enables transcription coactivator activity1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding4EXP,HDA,IBA,IDAHomo_sapiens(9606)Function
GO:0003730enables mRNA 3-UTR binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IEAHomo_sapiens(9606)Component
GO:0006351involved_in DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0006355involved_in regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0008380involved_in RNA splicing1IDAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043232is_active_in intracellular non-membrane-bounded organelle1IDAHomo_sapiens(9606)Component
GO:0043484involved_in regulation of RNA splicing1IDAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function
GO:0048255acts_upstream_of_or_within mRNA stabilization1IDAHomo_sapiens(9606)Process
GO:0051260involved_in protein homooligomerization1IDAHomo_sapiens(9606)Process
GO:0140693enables molecular condensate scaffold activity1IDAHomo_sapiens(9606)Function
GO:1905168involved_in positive regulation of double-strand break repair via homologous recombination1IDAHomo_sapiens(9606)Process
GO:1990000involved_in amyloid fibril formation2EXP,IDAHomo_sapiens(9606)Process

Expression