RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	E3 ligaseTF
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000089094	Gene ID	84678	Accession	13610
Symbol	KDM2B	Alias	CXXC2;Fbl10;PCCX2;FBXL10;JHDM1B	Full Name	lysine demethylase 2B
Status	Confidence	Length	151928 bases	Strand	Minus strand
Position	12 : 121429096 - 121581023	RNA binding domain	N.A.
Summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
19001877	KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state.	David Frescas	2008-11-15	Cell cycle (Georgetown, Tex.)

Name	Transcript ID	bp	Protein	Translation ID
KDM2B-201	ENST00000377069	5224	1265aa	ENSP00000366269
KDM2B-214	ENST00000542973	3170	704aa	ENSP00000437821
KDM2B-208	ENST00000538503	6676	No protein	-
KDM2B-202	ENST00000377071	5315	1336aa	ENSP00000366271
KDM2B-215	ENST00000543025	2522	104aa	ENSP00000438138
KDM2B-204	ENST00000536036	500	No protein	-
KDM2B-206	ENST00000538243	4110	No protein	-
KDM2B-205	ENST00000538046	2301	507aa	ENSP00000474307
KDM2B-203	ENST00000446152	1549	510aa	ENSP00000398279
KDM2B-213	ENST00000542030	460	125aa	ENSP00000444846
KDM2B-207	ENST00000538379	574	171aa	ENSP00000445102
KDM2B-217	ENST00000545022	544	154aa	ENSP00000437497
KDM2B-211	ENST00000541318	600	41aa	ENSP00000443052
KDM2B-216	ENST00000543852	1188	123aa	ENSP00000440942
KDM2B-212	ENST00000541511	528	97aa	ENSP00000442293
KDM2B-209	ENST00000539394	892	180aa	ENSP00000440373
KDM2B-210	ENST00000540191	574	No protein	-
KDM2B-218	ENST00000611216	3434	559aa	ENSP00000480847

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
35469	Platelet Function Tests	1.0800000E-007	-
37644	Platelet Function Tests	1.8100000E-006	-
44911	Platelet Function Tests	3.6452840E-007	-
61597	Glucose	2E-6	22581228
61598	Body Mass Index	2E-6	22581228

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000122	involved_in negative regulation of transcription by RNA polymerase II	1	ISS	Homo_sapiens(9606)	Process
GO:0000978	enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0003677	enables DNA binding	1	NAS	Homo_sapiens(9606)	Function
GO:0003712	enables transcription coregulator activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005694	located_in chromosome	1	IEA	Homo_sapiens(9606)	Component
GO:0005730	located_in nucleolus	1	IEA	Homo_sapiens(9606)	Component
GO:0006338	involved_in chromatin remodeling	1	IDA	Homo_sapiens(9606)	Process
GO:0006351	involved_in DNA-templated transcription	1	IEA	Homo_sapiens(9606)	Process
GO:0006357	involved_in regulation of transcription by RNA polymerase II	1	IBA	Homo_sapiens(9606)	Process
GO:0006482	involved_in protein demethylation	1	IBA	Homo_sapiens(9606)	Process
GO:0007283	involved_in spermatogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0008270	enables zinc ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0019843	enables rRNA binding	1	IEA	Homo_sapiens(9606)	Function
GO:0021555	involved_in midbrain-hindbrain boundary morphogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0021592	involved_in fourth ventricle development	1	ISS	Homo_sapiens(9606)	Process
GO:0021670	involved_in lateral ventricle development	1	ISS	Homo_sapiens(9606)	Process
GO:0021678	involved_in third ventricle development	1	ISS	Homo_sapiens(9606)	Process
GO:0021993	involved_in initiation of neural tube closure	1	ISS	Homo_sapiens(9606)	Process
GO:0030307	involved_in positive regulation of cell growth	1	IEA	Homo_sapiens(9606)	Process
GO:0030900	involved_in forebrain development	1	ISS	Homo_sapiens(9606)	Process
GO:0030901	involved_in midbrain development	1	ISS	Homo_sapiens(9606)	Process
GO:0030902	involved_in hindbrain development	1	ISS	Homo_sapiens(9606)	Process
GO:0031519	part_of PcG protein complex	1	IDA	Homo_sapiens(9606)	Component
GO:0032452	enables histone demethylase activity	2	IBA,TAS	Homo_sapiens(9606)	Function
GO:0043524	involved_in negative regulation of neuron apoptotic process	1	ISS	Homo_sapiens(9606)	Process
GO:0045322	enables unmethylated CpG binding	1	IDA	Homo_sapiens(9606)	Function
GO:0048596	involved_in embryonic camera-type eye morphogenesis	1	ISS	Homo_sapiens(9606)	Process
GO:0051864	enables histone H3K36 demethylase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0140680	enables histone H3K36me/H3K36me2 demethylase activity	1	IEA	Homo_sapiens(9606)	Function
GO:1902459	involved_in positive regulation of stem cell population maintenance	1	IEA	Homo_sapiens(9606)	Process
GO:2000178	involved_in negative regulation of neural precursor cell proliferation	1	ISS	Homo_sapiens(9606)	Process