RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000085415	Gene ID	81929	Accession	30379
Symbol	SEH1L	Alias	Seh1;SEH1A;SEH1B;SEC13L	Full Name	SEH1 like nucleoporin
Status	Confidence	Length	40404 bases	Strand	Plus strand
Position	18 : 12947133 - 12987536	RNA binding domain	N.A.
Summary	The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
SEH1L-209	ENST00000592170	787	77aa	ENSP00000467605
SEH1L-201	ENST00000262124	3494	360aa	ENSP00000262124
SEH1L-202	ENST00000399892	1851	421aa	ENSP00000382779
SEH1L-203	ENST00000585730	582	158aa	ENSP00000466959
SEH1L-206	ENST00000589446	655	189aa	ENSP00000467276
SEH1L-204	ENST00000587761	863	263aa	ENSP00000466234
SEH1L-205	ENST00000588251	789	No protein	-
SEH1L-210	ENST00000592582	4072	No protein	-
SEH1L-208	ENST00000590843	5206	No protein	-
SEH1L-207	ENST00000590032	764	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
36695	Platelet Function Tests	2.0150400E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000776	colocalizes_with kinetochore	1	IDA	Homo_sapiens(9606)	Component
GO:0005198	enables structural molecule activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005635	located_in nuclear envelope	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005643	part_of nuclear pore	1	NAS	Homo_sapiens(9606)	Component
GO:0005765	located_in lysosomal membrane	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0006913	involved_in nucleocytoplasmic transport	1	NAS	Homo_sapiens(9606)	Process
GO:0006999	involved_in nuclear pore organization	1	IMP	Homo_sapiens(9606)	Process
GO:0007080	involved_in mitotic metaphase plate congression	1	IMP	Homo_sapiens(9606)	Process
GO:0015031	involved_in protein transport	1	IEA	Homo_sapiens(9606)	Process
GO:0031080	part_of nuclear pore outer ring	3	IBA,IDA,NAS	Homo_sapiens(9606)	Component
GO:0031503	involved_in protein-containing complex localization	1	IMP	Homo_sapiens(9606)	Process
GO:0032008	involved_in positive regulation of TOR signaling	1	IMP	Homo_sapiens(9606)	Process
GO:0034198	involved_in cellular response to amino acid starvation	2	IBA,IMP	Homo_sapiens(9606)	Process
GO:0035859	part_of Seh1-associated complex	1	IBA	Homo_sapiens(9606)	Component
GO:0050830	involved_in defense response to Gram-positive bacterium	1	IEA	Homo_sapiens(9606)	Process
GO:0051028	involved_in mRNA transport	1	IEA	Homo_sapiens(9606)	Process
GO:0051301	involved_in cell division	1	IEA	Homo_sapiens(9606)	Process
GO:0051315	involved_in attachment of mitotic spindle microtubules to kinetochore	1	IMP	Homo_sapiens(9606)	Process
GO:0061700	part_of GATOR2 complex	2	IDA,NAS	Homo_sapiens(9606)	Component
GO:1904262	involved_in negative regulation of TORC1 signaling	1	NAS	Homo_sapiens(9606)	Process
GO:1904263	involved_in positive regulation of TORC1 signaling	3	IBA,IMP,NAS	Homo_sapiens(9606)	Process