RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Ensembl ID	ENSG00000083444	Gene ID	5351	Accession	9081
Symbol	PLOD1	Alias	LH;LH1;LLH;EDS6;PLOD;EDSKCL1	Full Name	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Status	Confidence	Length	40844 bases	Strand	Plus strand
Position	1 : 11934694 - 11975537	RNA binding domain	2OG-FeII_Oxy
Summary	Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000196061	2OG-FeII_Oxy	PF03171	1e-05	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
PLOD1-208	ENST00000485046	991	No protein	-
PLOD1-204	ENST00000449038	762	225aa	ENSP00000414443
PLOD1-201	ENST00000196061	2976	727aa	ENSP00000196061
PLOD1-202	ENST00000358133	819	No protein	-
PLOD1-203	ENST00000429000	886	283aa	ENSP00000405372
PLOD1-205	ENST00000465920	871	No protein	-
PLOD1-209	ENST00000491536	639	No protein	-
PLOD1-206	ENST00000470133	362	No protein	-
PLOD1-207	ENST00000481933	2339	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
13820	Myocardial Infarction	4.0880173E-004	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001666	involved_in response to hypoxia	1	IEP	Homo_sapiens(9606)	Process
GO:0005506	enables iron ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005783	is_active_in endoplasmic reticulum	1	IBA	Homo_sapiens(9606)	Component
GO:0005789	located_in endoplasmic reticulum membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0006493	NOT involved_in protein O-linked glycosylation	1	IDA	Homo_sapiens(9606)	Process
GO:0008475	enables procollagen-lysine 5-dioxygenase activity	4	IBA,IDA,IMP,ISS	Homo_sapiens(9606)	Function
GO:0008544	involved_in epidermis development	1	IMP	Homo_sapiens(9606)	Process
GO:0017185	involved_in peptidyl-lysine hydroxylation	3	IBA,IDA,ISS	Homo_sapiens(9606)	Process
GO:0030867	located_in rough endoplasmic reticulum membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0031418	enables L-ascorbic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0033823	NOT enables procollagen glucosyltransferase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:1902494	part_of catalytic complex	1	IEA	Homo_sapiens(9606)	Component