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Eu
RBP
DB
Eu
RBP
DB2 File List
Functions and Diseases
RBP Type
Canonical_RBPs
Diseases
Cancer
SARS-COV-2
Drug
N.A.
Main interacting RNAs
ncRNA
Moonlighting functions
N.A.
Localizations
Stress granucle
BulkPerturb-seq
N.A.
Description
Ensembl ID
ENSG00000083223
Gene ID
79670
Accession
25817
Symbol
TUT7
Alias
PAPD6;TENT3B;ZCCHC6
Full Name
terminal uridylyl transferase 7
Status
Confidence
Length
66722 bases
Strand
Minus strand
Position
9 : 86287733 - 86354454
RNA binding domain
PAP_assoc , zf-CCHC
Summary
Enables RNA uridylyltransferase activity and miRNA binding activity. Involved in RNA metabolic process and negative regulation of transposition, RNA-mediated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
RNA binding domains (RBDs)
Search:
Protein
Domain
Pfam ID
E-value
Domain number
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000277141
PAP_assoc
PF03828
2.2e-14
1
ENSP00000277141
zf-CCHC
PF00098
4.1e-14
2
ENSP00000277141
zf-CCHC
PF00098
4.1e-14
3
ENSP00000277141
zf-CCHC
PF00098
4.1e-14
4
ENSP00000365124
PAP_assoc
PF03828
8.7e-15
1
ENSP00000365124
zf-CCHC
PF00098
4.6e-10
2
ENSP00000365124
zf-CCHC
PF00098
4.6e-10
3
ENSP00000365127
PAP_assoc
PF03828
9e-27
1
ENSP00000365127
PAP_assoc
PF03828
9e-27
2
ENSP00000365127
zf-CCHC
PF00098
4.5e-09
3
ENSP00000365127
zf-CCHC
PF00098
4.5e-09
4
ENSP00000365130
PAP_assoc
PF03828
1.3e-26
1
ENSP00000365130
PAP_assoc
PF03828
1.3e-26
2
ENSP00000365130
zf-CCHC
PF00098
3.6e-13
3
ENSP00000365130
zf-CCHC
PF00098
3.6e-13
4
ENSP00000365130
zf-CCHC
PF00098
3.6e-13
5
Showing 1 to 16 of 16 entries
RNA binding proteomes (RBPomes)
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Pubmed ID
Full Name
Cell
Author
Time
Doi
22658674
RIC_PMID22658674_Hela_human
Hela
Alfredo Castello
2012 Jun 8
doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22658674
RIC_PMID22658674_Hs_HeLa
HeLa
Alfredo Castello?
2012 Jun 8
doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889
RIC_PMID22681889_Hs_HEK293
HEK293
Alexander G Baltz
2012 Jun 8
doi: 10.1016/j.molcel.2012.05.021
26632259
RIC_PMID26632259._Hs_HuH7
HuH7
Benedikt M Beckmann
2015 Dec 3
doi: 10.1038/ncomms10127.
28431233
RIC_PMID28431233_Hs_microRNA
Thomas Treiber
2017 Apr 20
doi: 10.1016/j.molcel.2017.03.014
29636419
CARIC_PMID29636419_Hs_CARIC
Rongbing Huang
2018 Apr 24
doi: 10.1073/pnas.1718406115
30352994
eRIC_PMID30352994_Hs_JURKAT.2018
JURKAT
Joel I Perez-Perri
2018 Oct 23
doi: 10.1038/s41467-018-06557-8
30352994
RIC_PMID30352994_Hs_JURKAT.2018
JURKAT
Joel I Perez-Perri
2018 Oct 23
doi: 10.1038/s41467-018-06557-8
30528433
XRNAX_PMID30528433_Hs_HEK293
HEK293
Jakob Trendel
2019 Jan 10
doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
30528433
XRNAX_PMID30528433_Hs_HeLa
HeLa
Jakob Trendel
2019 Jan 10
doi: 10.1016/j.cell.2018.11.004.?Epub 2018 Dec 6
Showing 1 to 10 of 22 entries
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Literatures on RNA binding capacity
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entries
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Pubmed ID
Title
Author
Time
Journal
25979828
TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.
Boseon Kim
2015-07-02
The EMBO journal
27284165
Nucleotide specificity of the human terminal nucleotidyltransferase Gld2 (TUT2).
Z Christina Chung
2016-08-01
RNA (New York, N.Y.)
28671666
Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
R Christopher Faehnle
2017-08-01
Nature structural & molecular biology
29955037
Global pairwise RNA interaction landscapes reveal core features of protein recognition.
Qin Zhou
2018-06-28
Nature communications
34188032
Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation.
Chia-Ching Lin
2021-06-29
Nature communications
36071058
TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
Acong Yang
2022-09-07
Nature communications
Showing 1 to 6 of 6 entries
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Transcripts
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entries
Search:
Name
Transcript ID
bp
Protein
Translation ID
TUT7-201
ENST00000277141
5724
784aa
ENSP00000277141
TUT7-202
ENST00000375947
611
168aa
ENSP00000365114
TUT7-203
ENST00000375948
958
124aa
ENSP00000365115
TUT7-204
ENST00000375957
2262
395aa
ENSP00000365124
TUT7-205
ENST00000375960
4939
1259aa
ENSP00000365127
TUT7-206
ENST00000375963
5603
1495aa
ENSP00000365130
TUT7-207
ENST00000469004
625
No protein
-
Showing 1 to 7 of 7 entries
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Gene Model
Click here to download ENSG00000083223's gene model file
Pathways
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entries
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Pathway ID
Pathway Name
Source
Showing 1 to 1 of 1 entries
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Phenotypes
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entries
Search:
ensgID
Trait
pValue
Pubmed ID
2050
Body Weight
1.12917880014149E-8
17903300
3358
Cholesterol, HDL
1.29340570804229E-6
17903299
10560
Osteoporosis
1.4183572339066E-5
17903296
64177
Asthma
5E-6
25918132
64178
Toluene 2,4-Diisocyanate
5E-6
25918132
Showing 1 to 5 of 5 entries
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GWAS
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entries
Search:
ensgID
SNP
Chromosome
Position
Trait
PubmedID
Or or BEAT
EFO ID
ENSG00000083223
rs17461620
9
86348093
Diisocyanate-induced asthma
25918132
2.34
EFO_0006995|EFO_0000270
ENSG00000083223
rs7037424
9
86306375
Body mass index
30595370
EFO_0004340
ENSG00000083223
rs700768
9
86322702
Lung function (FEV1/FVC)
30595370
EFO_0004713
Showing 1 to 3 of 3 entries
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Protein-Protein Interaction (PPI)
Click here to download ENSG00000083223's PPI file
Paralogs
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entries
Search:
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000083223
homo_sapiens
ENSP00000263063
37.6289
18.3849
homo_sapiens
ENSP00000365130
14.6488
7.15719
ENSG00000083223
homo_sapiens
ENSP00000257177
49.6049
36.231
homo_sapiens
ENSP00000365130
54.5819
39.8662
ENSG00000083223
homo_sapiens
ENSP00000397563
45.8678
29.3388
homo_sapiens
ENSP00000365130
14.8495
9.49833
ENSG00000083223
homo_sapiens
ENSP00000419607
28.7185
15.9039
homo_sapiens
ENSP00000365130
16.7893
9.29766
Showing 1 to 4 of 4 entries
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Orthologs
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entries
Search:
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000083223
homo_sapiens
ENSP00000365130
98.796
98.0602
nomascus_leucogenys
ENSNLEP00000006331
98.9283
98.1916
ENSG00000083223
homo_sapiens
ENSP00000365130
99.5987
99.5987
pan_paniscus
ENSPPAP00000031366
96.6883
96.6883
ENSG00000083223
homo_sapiens
ENSP00000365130
99.0635
98.5953
pongo_abelii
ENSPPYP00000024377
99.1299
98.6613
ENSG00000083223
homo_sapiens
ENSP00000365130
99.6656
99.6656
pan_troglodytes
ENSPTRP00000083292
96.7533
96.7533
ENSG00000083223
homo_sapiens
ENSP00000365130
99.6656
99.5318
gorilla_gorilla
ENSGGOP00000025218
99.7323
99.5984
ENSG00000083223
homo_sapiens
ENSP00000365130
81.6722
70.1672
sarcophilus_harrisii
ENSSHAP00000043762
79.6478
68.4279
ENSG00000083223
homo_sapiens
ENSP00000365130
62.6087
55.3177
notamacropus_eugenii
ENSMEUP00000005993
63.587
56.1821
ENSG00000083223
homo_sapiens
ENSP00000365130
88.8294
82.1405
choloepus_hoffmanni
ENSCHOP00000009869
88.9484
82.2505
ENSG00000083223
homo_sapiens
ENSP00000365130
91.4381
85.3512
dasypus_novemcinctus
ENSDNOP00000022621
87.7407
81.8999
ENSG00000083223
homo_sapiens
ENSP00000365130
77.4582
71.3712
erinaceus_europaeus
ENSEEUP00000011703
79.6424
73.3838
Showing 1 to 10 of 257 entries
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Gene Ontology
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entries
Search:
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0050265
enables RNA uridylyltransferase activity
3
IBA,IDA,TAS
Homo_sapiens(9606)
Function
GO:0071076
involved_in RNA 3 uridylation
3
IBA,IDA,ISS
Homo_sapiens(9606)
Process
GO:0005829
located_in cytosol
2
IDA,TAS
Homo_sapiens(9606)
Component
GO:0000289
involved_in nuclear-transcribed mRNA poly(A) tail shortening
1
TAS
Homo_sapiens(9606)
Process
GO:0001556
involved_in oocyte maturation
1
ISS
Homo_sapiens(9606)
Process
GO:0003723
enables RNA binding
1
HDA
Homo_sapiens(9606)
Function
GO:0005515
enables protein binding
1
IPI
Homo_sapiens(9606)
Function
GO:0005654
located_in nucleoplasm
1
IDA
Homo_sapiens(9606)
Component
GO:0005737
located_in cytoplasm
1
IDA
Homo_sapiens(9606)
Component
GO:0008270
enables zinc ion binding
1
IEA
Homo_sapiens(9606)
Function
Showing 1 to 10 of 18 entries
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Expression
−1
0
1
2
3
4
TPM
plotly-logomark
Contents
Description
RBDs
RBPomes
Literatures
Transcripts
Gene Model
Phenotypes
GWAS
PPI
Paralogs
Orthologs
Gene Ontology
Expression