Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases FlavivirusesSARS-COV-2DengueZika
Drug N.A.
Main interacting RNAs snRNA
Moonlighting functions N.A.
Localizations Stress granucleP-body
BulkPerturb-seq DataSet_01_10 DataSet_01_131

Description

Ensembl ID ENSG00000082516 Gene ID 25929 Accession 20043
Symbol GEMIN5 Alias NEDCAM;GEMIN-5 Full Name gem nuclear organelle associated protein 5
Status Confidence Length 50801 bases Strand Minus strand
Position 5 : 154887411 - 154938211 RNA binding domain N.A.
Summary This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
35859008 Cell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemia. Jianming Shao 2022-07-20 Scientific reports
32363199 The Small-Molecule Flunarizine in Spinal Muscular Atrophy Patient Fibroblasts Impacts on the Gemin Components of the SMN Complex and TDP43, an RNA-Binding Protein Relevant to Motor Neuron Diseases. Delphine Sapaly 2020-01-01 Frontiers in molecular biosciences
19066202 A novel role for Gemin5 in mRNA translation. Almudena Pacheco 2009-02-01 Nucleic acids research
25898402 Gemin5: A Multitasking RNA-Binding Protein Involved in Translation Control. David Piñeiro 2015-04-17 Biomolecules
27507887 The RNA-binding protein Gemin5 binds directly to the ribosome and regulates global translation. Rosario Francisco-Velilla 2016-09-30 Nucleic acids research
25818028 Nuclear proteins hijacked by mammalian cytoplasmic plus strand RNA viruses. E Richard Lloyd 2015-05-01 Virology
31799625 Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assembly. Hongfei Yi 2020-01-24 Nucleic acids research
22362733 Gemin5 proteolysis reveals a novel motif to identify L protease targets. David Piñeiro 2012-06-01 Nucleic acids research
23221635 Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. Nathalie Piazzon 2013-01-01 Nucleic acids research
36056043 Structural basis for Gemin5 decamer-mediated mRNA binding. Qiong Guo 2022-09-02 Nature communications
20150968 Insights into the biology of IRES elements through riboproteomic approaches. Almudena Pacheco 2010-01-01 Journal of biomedicine & biotechnology
36680204 Dancing with the Devil: A Review of the Importance of Host RNA-Binding Proteins to Alphaviral RNAs during Infection. E Claire Westcott 2023-01-05 Viruses
35295849 Autosomal Recessive Cerebellar Atrophy and Spastic Ataxia in Patients With Pathogenic Biallelic Variants in GEMIN5. S Deepa Rajan 2022-01-01 Frontiers in cell and developmental biology
24189219 RNA-binding proteins impacting on internal initiation of translation. Encarnación Martínez-Salas 2013-11-01 International journal of molecular sciences
35987821 Gemin5-dependent RNA association with polysomes enables selective translation of ribosomal and histone mRNAs. Azman Embarc-Buh 2022-08-20 Cellular and molecular life sciences : CMLS
36980979 A Biallelic Truncating Variant in the TPR Domain of GEMIN5 Associated with Intellectual Disability and Cerebral Atrophy. Nazia Ibrahim 2023-03-13 Genes
36420152 Phosphorylation of T897 in the dimerization domain of Gemin5 modulates protein interactions and translation regulation. Rosario Francisco-Velilla 2022-01-01 Computational and structural biotechnology journal
32485878 Emerging Roles of Gemin5: From snRNPs Assembly to Translation Control. Encarnacion Martinez-Salas 2020-05-29 International journal of molecular sciences
32476560 RNA-protein coevolution study of Gemin5 uncovers the role of the PXSS motif of RBS1 domain for RNA binding. Rosario Francisco-Velilla 2020-09-01 RNA biology
19750007 Identification of gemin5 as a novel 7-methylguanosine cap-binding protein. S Shelton Bradrick 2009-09-14 PloS one
31799608 Structural basis for the dimerization of Gemin5 and its role in protein recruitment and translation control. María Moreno-Morcillo 2020-01-24 Nucleic acids research
35393353 Functional and structural deficiencies of Gemin5 variants associated with neurological disorders. Rosario Francisco-Velilla 2022-07-01 Life science alliance
23125361 The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. Inga Loedige 2013-01-07 Nucleic acids research
29354113 Insights into Structural and Mechanistic Features of Viral IRES Elements. Encarnacion Martinez-Salas 2017-01-01 Frontiers in microbiology
29771365 The landscape of the non-canonical RNA-binding site of Gemin5 unveils a feedback loop counteracting the negative effect on translation. Rosario Francisco-Velilla 2018-08-21 Nucleic acids research
27881601 Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5. Wenxing Jin 2016-11-01 Genes & development
27748560 Insecticide resistance mediated by an exon skipping event. Madeleine Berger 2016-11-01 Molecular ecology
24598255 Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation. Javier Fernandez-Chamorro 2014-05-01 Nucleic acids research
34424823 The RBS1 domain of Gemin5 is intrinsically unstructured and interacts with RNA through conserved Arg and aromatic residues. Azman Embarc-Buh 2021-10-15 RNA biology
20513430 Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis. Jeongsik Yong 2010-05-28 Molecular cell
27881598 The right pick: structural basis of snRNA selection by Gemin5. C Markus Wahl 2016-11-01 Genes & development
34064059 RNA-Binding Proteins at the Host-Pathogen Interface Targeting Viral Regulatory Elements. Azman Embarc-Buh 2021-05-21 Viruses
32230899 Hepatitis C Virus Translation Regulation. Michael Niepmann 2020-03-27 International journal of molecular sciences
33605051 Uncovering targets of the Leader protease: Linking RNA-mediated pathways and antiviral defense. Margarita Saiz 2021-07-01 Wiley interdisciplinary reviews. RNA

Transcripts

Name Transcript ID bp Protein Translation ID
GEMIN5-201 ENST00000285873 5404 1508aa ENSP00000285873
GEMIN5-202 ENST00000522075 573 No protein -
GEMIN5-203 ENST00000523355 557 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
451Respiratory Function Tests5.60146183386526E-517903307
576Respiratory Function Tests6.66326637042001E-517903307
4680Cholesterol, HDL3.15472351082073E-517903299
4702Cholesterol, HDL8.5299839548396E-517903299
53949Sodium8.0050000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000082516homo_sapiensENSP0000036259243.529422.1176homo_sapiensENSP0000028587312.26796.23342
ENSG00000082516homo_sapiensENSP0000036942741.411821.6471homo_sapiensENSP0000028587311.67116.1008
ENSG00000082516homo_sapiensENSP0000023509040.058525.4386homo_sapiensENSP000002858739.084885.76923
ENSG00000082516homo_sapiensENSP0000031568043.034124.1486homo_sapiensENSP000002858739.217515.17241
ENSG00000082516homo_sapiensENSP0000029388336.582317.8481homo_sapiensENSP0000028587319.16459.35013
ENSG00000082516homo_sapiensENSP0000026214429.568816.1191homo_sapiensENSP0000028587319.098110.4111
ENSG00000082516homo_sapiensENSP0000038798236.772521.9577homo_sapiensENSP000002858739.217515.50398
ENSG00000082516homo_sapiensENSP0000050161435.858619.697homo_sapiensENSP000002858739.416455.17241
ENSG00000082516homo_sapiensENSP0000025323733.856518.1614homo_sapiensENSP0000028587310.01335.37135

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000082516homo_sapiensENSP0000028587398.541197.2812nomascus_leucogenysENSNLEP0000002024398.606597.3457
ENSG00000082516homo_sapiensENSP0000028587399.734799.3369pan_paniscusENSPPAP0000004103999.734799.3369
ENSG00000082516homo_sapiensENSP0000028587399.270698.4748pongo_abeliiENSPPYP0000001788099.270698.4748
ENSG00000082516homo_sapiensENSP0000028587399.734799.4032pan_troglodytesENSPTRP0000002981199.734799.4032
ENSG00000082516homo_sapiensENSP0000028587385.079684.8143gorilla_gorillaENSGGOP0000001043599.766799.4557
ENSG00000082516homo_sapiensENSP0000028587381.830271.2202ornithorhynchus_anatinusENSOANP0000000808581.77671.173
ENSG00000082516homo_sapiensENSP0000028587383.620774.2706sarcophilus_harrisiiENSSHAP0000001391283.454774.1231
ENSG00000082516homo_sapiensENSP0000028587369.230861.87notamacropus_eugeniiENSMEUP0000000681170.683863.1686
ENSG00000082516homo_sapiensENSP0000028587388.660584.1512choloepus_hoffmanniENSCHOP0000001054889.07484.5436
ENSG00000082516homo_sapiensENSP0000028587378.647274.4032dasypus_novemcinctusENSDNOP0000000992994.577489.4737
ENSG00000082516homo_sapiensENSP0000028587376.193670.0265erinaceus_europaeusENSEEUP0000001113980.013973.5376
ENSG00000082516homo_sapiensENSP0000028587388.196380.9019echinops_telfairiENSETEP0000000708788.372181.0631
ENSG00000082516homo_sapiensENSP0000028587397.612795.557callithrix_jacchusENSCJAP0000001378397.677595.6204
ENSG00000082516homo_sapiensENSP0000028587398.408597.3475cercocebus_atysENSCATP0000003085698.213197.1542
ENSG00000082516homo_sapiensENSP0000028587398.673797.6127macaca_fascicularisENSMFAP0000001790798.412797.3545
ENSG00000082516homo_sapiensENSP0000028587398.740197.679macaca_mulattaENSMMUP0000002795198.478897.4206
ENSG00000082516homo_sapiensENSP0000028587398.740197.5464macaca_nemestrinaENSMNEP0000001805998.478897.2884
ENSG00000082516homo_sapiensENSP0000028587398.541197.4138papio_anubisENSPANP0000005243698.280497.1561
ENSG00000082516homo_sapiensENSP0000028587396.684395.4244mandrillus_leucophaeusENSMLEP0000001748498.380697.0985
ENSG00000082516homo_sapiensENSP0000028587390.384685.809tursiops_truncatusENSTTRP0000001512090.504685.923
ENSG00000082516homo_sapiensENSP0000028587393.567687.9973vulpes_vulpesENSVVUP0000000590693.567687.9973
ENSG00000082516homo_sapiensENSP0000028587389.389982.0292mus_spretusMGP_SPRETEiJ_P002818089.389982.0292
ENSG00000082516homo_sapiensENSP0000028587393.037188.5942equus_asinusENSEASP0000500122893.037188.5942
ENSG00000082516homo_sapiensENSP0000028587392.506687.7321capra_hircusENSCHIP0000003212792.506687.7321
ENSG00000082516homo_sapiensENSP0000028587392.838288.0637loxodonta_africanaENSLAFP0000000826292.715287.947
ENSG00000082516homo_sapiensENSP0000028587394.098188.8594panthera_leoENSPLOP0000000177494.098188.8594
ENSG00000082516homo_sapiensENSP0000028587394.49689.2573ailuropoda_melanoleucaENSAMEP0000001758094.49689.2573
ENSG00000082516homo_sapiensENSP0000028587392.771987.6658bos_indicus_hybridENSBIXP0000504053592.710487.6077
ENSG00000082516homo_sapiensENSP0000028587393.965589.191oryctolagus_cuniculusENSOCUP0000004761493.346588.6034
ENSG00000082516homo_sapiensENSP0000028587393.103488.7268equus_caballusENSECAP0000001826592.551188.2004
ENSG00000082516homo_sapiensENSP0000028587394.031888.5279canis_lupus_familiarisENSCAFP0084500388294.031888.5279
ENSG00000082516homo_sapiensENSP0000028587394.098188.7268panthera_pardusENSPPRP0000001228694.098188.7268
ENSG00000082516homo_sapiensENSP0000028587394.164590.5172marmota_marmota_marmotaENSMMMP0000001537694.414990.758
ENSG00000082516homo_sapiensENSP0000028587393.965589.0584balaenoptera_musculusENSBMSP0001000445493.77988.8815
ENSG00000082516homo_sapiensENSP0000028587389.257382.626cavia_porcellusENSCPOP0000000313386.615280.1802
ENSG00000082516homo_sapiensENSP0000028587394.297189.0584felis_catusENSFCAP0000000055394.297189.0584
ENSG00000082516homo_sapiensENSP0000028587394.69589.5225ursus_americanusENSUAMP0000002476694.69589.5225
ENSG00000082516homo_sapiensENSP0000028587383.819674.6021monodelphis_domesticaENSMODP0000001069383.653274.454
ENSG00000082516homo_sapiensENSP0000028587392.771987.7321bison_bison_bisonENSBBBP0000001869492.710487.674
ENSG00000082516homo_sapiensENSP0000028587393.43588.7268monodon_monocerosENSMMNP0001500554093.311388.6093
ENSG00000082516homo_sapiensENSP0000028587393.302488.6605sus_scrofaENSSSCP0000003614493.364388.7193
ENSG00000082516homo_sapiensENSP0000028587394.230891.1804microcebus_murinusENSMICP0000004616894.293391.2409
ENSG00000082516homo_sapiensENSP0000028587386.936381.1671octodon_degusENSODEP0000001256288.104882.2581
ENSG00000082516homo_sapiensENSP0000028587383.289176.3926jaculus_jaculusENSJJAP0000001607786.204579.0666
ENSG00000082516homo_sapiensENSP0000028587392.572987.7984ovis_aries_rambouilletENSOARP0002002615792.572987.7984
ENSG00000082516homo_sapiensENSP0000028587394.628689.2573ursus_maritimusENSUMAP0000000343294.628689.2573
ENSG00000082516homo_sapiensENSP0000028587361.074356.7639ochotona_princepsENSOPRP0000001195461.114856.8016
ENSG00000082516homo_sapiensENSP0000028587393.43588.7268delphinapterus_leucasENSDLEP0000000752193.249588.5506
ENSG00000082516homo_sapiensENSP0000028587373.010669.0981physeter_catodonENSPCTP0000500285789.804284.9918
ENSG00000082516homo_sapiensENSP0000028587389.323682.0292mus_caroliMGP_CAROLIEiJ_P002680889.620882.3021
ENSG00000082516homo_sapiensENSP0000028587389.389982.0955mus_musculusENSMUSP0000013184289.687382.3686
ENSG00000082516homo_sapiensENSP0000028587377.785173.1432dipodomys_ordiiENSDORP0000002326490.719385.3055
ENSG00000082516homo_sapiensENSP0000028587394.098188.7268mustela_putorius_furoENSMPUP0000001343593.911388.5506
ENSG00000082516homo_sapiensENSP0000028587391.777289.6552aotus_nancymaaeENSANAP0000000704997.602395.3456
ENSG00000082516homo_sapiensENSP0000028587392.838290.7162saimiri_boliviensis_boliviensisENSSBOP0000000795897.289895.066
ENSG00000082516homo_sapiensENSP0000028587374.005370.756vicugna_pacosENSVPAP0000000107874.103670.8499
ENSG00000082516homo_sapiensENSP0000028587398.607497.4801chlorocebus_sabaeusENSCSAP0000000698798.346697.2222
ENSG00000082516homo_sapiensENSP0000028587382.360778.6472tupaia_belangeriENSTBEP0000000424682.879.0667
ENSG00000082516homo_sapiensENSP0000028587389.456281.6313mesocricetus_auratusENSMAUP0000000438089.993382.1214
ENSG00000082516homo_sapiensENSP0000028587393.567688.5279phocoena_sinusENSPSNP0000001569193.381988.3521
ENSG00000082516homo_sapiensENSP0000028587393.633988.4615camelus_dromedariusENSCDRP0000500119793.571988.4029
ENSG00000082516homo_sapiensENSP0000028587392.241488.0637carlito_syrichtaENSTSYP0000000970291.815287.6568
ENSG00000082516homo_sapiensENSP0000028587394.031888.7931panthera_tigris_altaicaENSPTIP0000001380794.031888.7931
ENSG00000082516homo_sapiensENSP0000028587389.456282.0955rattus_norvegicusENSRNOP0000005049390.053482.6435
ENSG00000082516homo_sapiensENSP0000028587395.026591.5782prolemur_simusENSPSMP0000001008595.089691.639
ENSG00000082516homo_sapiensENSP0000028587386.8779.6419microtus_ochrogasterENSMOCP0000002049090.096382.5997
ENSG00000082516homo_sapiensENSP0000028587389.522582.2944peromyscus_maniculatus_bairdiiENSPEMP0000001554090.30183.01
ENSG00000082516homo_sapiensENSP0000028587392.639387.5995bos_mutusENSBMUP0000003252492.577987.5414
ENSG00000082516homo_sapiensENSP0000028587388.99281.8302mus_spicilegusENSMSIP0000000342189.228782.0479
ENSG00000082516homo_sapiensENSP0000028587389.19181.2997cricetulus_griseus_chok1gshdENSCGRP0000101975990.147582.1716
ENSG00000082516homo_sapiensENSP0000028587394.562390.1194pteropus_vampyrusENSPVAP0000000214294.499790.0596
ENSG00000082516homo_sapiensENSP0000028587394.031888.9257myotis_lucifugusENSMLUP0000001535493.659288.5733
ENSG00000082516homo_sapiensENSP0000028587383.885974.1379vombatus_ursinusENSVURP0001000636083.66473.9418
ENSG00000082516homo_sapiensENSP0000028587393.899288.1963rhinolophus_ferrumequinumENSRFEP0001002471093.712888.0212
ENSG00000082516homo_sapiensENSP0000028587388.99283.3554neovison_visonENSNVIP0000002545291.106685.3361
ENSG00000082516homo_sapiensENSP0000028587392.705687.5995bos_taurusENSBTAP0000001603792.644187.5414
ENSG00000082516homo_sapiensENSP0000028587388.196382.4271heterocephalus_glaber_femaleENSHGLP0000001902489.562383.7037
ENSG00000082516homo_sapiensENSP0000028587398.342297.0822rhinopithecus_bietiENSRBIP0000003323698.407497.1467
ENSG00000082516homo_sapiensENSP0000028587394.031888.5279canis_lupus_dingoENSCAFP0002003068194.094288.5866
ENSG00000082516homo_sapiensENSP0000028587393.832989.8541sciurus_vulgarisENSSVLP0000501776793.895289.9137
ENSG00000082516homo_sapiensENSP0000028587383.289173.4085phascolarctos_cinereusENSPCIP0000002555583.123873.2627
ENSG00000082516homo_sapiensENSP0000028587386.803780.9682procavia_capensisENSPCAP0000000808986.861381.0219
ENSG00000082516homo_sapiensENSP0000028587386.140678.0504nannospalax_galiliENSNGAP0000001790488.487780.1771
ENSG00000082516homo_sapiensENSP0000028587392.639387.6658bos_grunniensENSBGRP0000002033992.577987.6077
ENSG00000082516homo_sapiensENSP0000028587389.920485.0133chinchilla_lanigeraENSCLAP0000001738690.159685.2394
ENSG00000082516homo_sapiensENSP0000028587392.771987.5995cervus_hanglu_yarkandensisENSCHYP0000001933692.771987.5995
ENSG00000082516homo_sapiensENSP0000028587393.037188.0637catagonus_wagneriENSCWAP0000000902992.913987.947
ENSG00000082516homo_sapiensENSP0000028587394.098190.5172ictidomys_tridecemlineatusENSSTOP0000003144894.160690.5773
ENSG00000082516homo_sapiensENSP0000028587394.69590.9814otolemur_garnettiiENSOGAP0000001501694.632290.9211
ENSG00000082516homo_sapiensENSP0000028587390.915188.992cebus_imitatorENSCCAP0000000298797.580195.516
ENSG00000082516homo_sapiensENSP0000028587393.700390.1194urocitellus_parryiiENSUPAP0001002216493.762490.1792
ENSG00000082516homo_sapiensENSP0000028587392.37487.5332moschus_moschiferusENSMMSP0000000477692.312887.4752
ENSG00000082516homo_sapiensENSP0000028587398.342297.0159rhinopithecus_roxellanaENSRROP0000002332598.407497.0803
ENSG00000082516homo_sapiensENSP0000028587389.257381.8302mus_pahariMGP_PahariEiJ_P003358189.973382.4866
ENSG00000082516homo_sapiensENSP0000028587391.976188.7268propithecus_coquereliENSPCOP0000000614394.93591.5811
ENSG00000082516homo_sapiensENSP0000028587341.644627.7851ciona_intestinalisENSCINP0000001223357.456538.3349
ENSG00000082516homo_sapiensENSP0000028587315.31836.69761ciona_intestinalisENSCINP0000002250028.695712.5466
ENSG00000082516homo_sapiensENSP0000028587317.639313.5279petromyzon_marinusENSPMAP0000000405058.078644.5415
ENSG00000082516homo_sapiensENSP0000028587355.437737.2016eptatretus_burgeriENSEBUP0000002653053.180735.687
ENSG00000082516homo_sapiensENSP0000028587344.69533.4217callorhinchus_miliiENSCMIP0000001495458.813343.9791
ENSG00000082516homo_sapiensENSP0000028587343.567636.008latimeria_chalumnaeENSLACP0000000218265.11453.8157
ENSG00000082516homo_sapiensENSP0000028587364.920449.5358lepisosteus_oculatusENSLOCP0000001527567.054851.1644
ENSG00000082516homo_sapiensENSP0000028587363.726848.2759clupea_harengusENSCHAP0000000265263.348747.9895
ENSG00000082516homo_sapiensENSP0000028587367.042450.8621danio_rerioENSDARP0000011306770.208353.2639
ENSG00000082516homo_sapiensENSP0000028587367.838252.0557carassius_auratusENSCARP0000008497668.473952.5435
ENSG00000082516homo_sapiensENSP0000028587367.572950.3316astyanax_mexicanusENSAMXP0000000698668.665851.1456
ENSG00000082516homo_sapiensENSP0000028587366.710950.5305ictalurus_punctatusENSIPUP0000000951268.951352.2276
ENSG00000082516homo_sapiensENSP0000028587366.578249.7347esox_luciusENSELUP0000003285667.746350.6073
ENSG00000082516homo_sapiensENSP0000028587365.915150electrophorus_electricusENSEEEP0000004073167.61951.2925
ENSG00000082516homo_sapiensENSP0000028587367.241451.1936oncorhynchus_kisutchENSOKIP0000509443767.962551.7426
ENSG00000082516homo_sapiensENSP0000028587367.108851.3926oncorhynchus_mykissENSOMYP0000004301067.919552.0134
ENSG00000082516homo_sapiensENSP0000028587336.671127.1883salmo_salarENSSSAP0000016917067.43950
ENSG00000082516homo_sapiensENSP0000028587367.572951.5252salmo_salarENSSSAP0000012194368.069551.9038
ENSG00000082516homo_sapiensENSP0000028587367.37451.3263salmo_truttaENSSTUP0000002432768.142251.9115
ENSG00000082516homo_sapiensENSP0000028587353.779839.7215gadus_morhuaENSGMOP0000005460264.31447.502
ENSG00000082516homo_sapiensENSP0000028587362.533247.4801fundulus_heteroclitusENSFHEP0000001474565.760149.9303
ENSG00000082516homo_sapiensENSP0000028587363.726848.0106poecilia_reticulataENSPREP0000001963067.249850.6648
ENSG00000082516homo_sapiensENSP0000028587362.135346.618xiphophorus_maculatusENSXMAP0000002396764.844348.6505
ENSG00000082516homo_sapiensENSP0000028587363.1347.2149oryzias_latipesENSORLP0000004512067.469950.4607
ENSG00000082516homo_sapiensENSP0000028587365.848847.6127cyclopterus_lumpusENSCLMP0000502715167.505148.8103
ENSG00000082516homo_sapiensENSP0000028587366.180449.0053oreochromis_niloticusENSONIP0000002070868.076450.4093
ENSG00000082516homo_sapiensENSP0000028587366.047749.2706haplochromis_burtoniENSHBUP0000001204967.9450.6821
ENSG00000082516homo_sapiensENSP0000028587366.114149.2706astatotilapia_callipteraENSACLP0000003674366.867949.8323
ENSG00000082516homo_sapiensENSP0000028587365.318348.5411sparus_aurataENSSAUP0001000791367.465850.137
ENSG00000082516homo_sapiensENSP0000028587361.737445.4244lates_calcariferENSLCAP0001002709567.463849.6377
ENSG00000082516homo_sapiensENSP0000028587371.021255.9019xenopus_tropicalisENSXETP0000009200372.708857.2301
ENSG00000082516homo_sapiensENSP0000028587377.32165.252chrysemys_picta_belliiENSCPBP0000000260374.695763.0365
ENSG00000082516homo_sapiensENSP0000028587374.336962.3342sphenodon_punctatusENSSPUP0000001555477.150764.6937
ENSG00000082516homo_sapiensENSP0000028587375.132663.1963crocodylus_porosusENSCPRP0000501876574.149262.3691
ENSG00000082516homo_sapiensENSP0000028587358.289147.4801laticauda_laticaudataENSLLTP0000000628173.49559.8662
ENSG00000082516homo_sapiensENSP0000028587370.358158.2891notechis_scutatusENSNSUP0000002268375.408762.4733
ENSG00000082516homo_sapiensENSP0000028587373.740160.9416pseudonaja_textilisENSPTXP0000002020175.646362.517
ENSG00000082516homo_sapiensENSP0000028587375.994762.0027anas_platyrhynchos_platyrhynchosENSAPLP0000000645574.804261.0313
ENSG00000082516homo_sapiensENSP0000028587376.127362.5995gallus_gallusENSGALP0001002171774.497161.2589
ENSG00000082516homo_sapiensENSP0000028587345.424437.9973meleagris_gallopavoENSMGAP0000003355473.655961.6129
ENSG00000082516homo_sapiensENSP0000028587374.535860.809serinus_canariaENSSCAP0000001786575.133761.2968
ENSG00000082516homo_sapiensENSP0000028587375.928461.8037parus_majorENSPMJP0000000977374.592860.7166
ENSG00000082516homo_sapiensENSP0000028587373.275960.1459anolis_carolinensisENSACAP0000000388675.170161.7007
ENSG00000082516homo_sapiensENSP0000028587347.811735.8753neolamprologus_brichardiENSNBRP0000001958066.268449.7243
ENSG00000082516homo_sapiensENSP0000028587373.474860.9416naja_najaENSNNAP0000001636774.763862.0108
ENSG00000082516homo_sapiensENSP0000028587375.397961.9363podarcis_muralisENSPMRP0000001137172.651859.6805
ENSG00000082516homo_sapiensENSP0000028587373.673759.9469geospiza_fortisENSGFOP0000000121775.32261.2881
ENSG00000082516homo_sapiensENSP0000028587376.326362.5332taeniopygia_guttataENSTGUP0000000070873.876860.5263
ENSG00000082516homo_sapiensENSP0000028587366.246751.061erpetoichthys_calabaricusENSECRP0000001381169.039453.2135
ENSG00000082516homo_sapiensENSP0000028587363.063746.2865kryptolebias_marmoratusENSKMAP0000000468766.503548.8112
ENSG00000082516homo_sapiensENSP0000028587376.259962.0027salvator_merianaeENSSMRP0000001939376.058261.8386
ENSG00000082516homo_sapiensENSP0000028587361.074345.9549amphilophus_citrinellusENSACIP0000001711467.128350.5102
ENSG00000082516homo_sapiensENSP0000028587365.915148.5411dicentrarchus_labraxENSDLAP0000503591268.363150.3439
ENSG00000082516homo_sapiensENSP0000028587364.19148.2095amphiprion_perculaENSAPEP0000000871766.758650.1379
ENSG00000082516homo_sapiensENSP0000028587363.262647.2812oryzias_sinensisENSOSIP0000000143368.045650.8559
ENSG00000082516homo_sapiensENSP0000028587365.915155.4377pelodiscus_sinensisENSPSIP0000000413676.520464.3572
ENSG00000082516homo_sapiensENSP0000028587377.851565.7162gopherus_evgoodeiENSGEVP0000501652477.186165.1545
ENSG00000082516homo_sapiensENSP0000028587376.193664.1247chelonoidis_abingdoniiENSCABP0000003010877.582765.2937
ENSG00000082516homo_sapiensENSP0000028587363.1346.9496seriola_dumeriliENSSDUP0000000626765.973749.0644
ENSG00000082516homo_sapiensENSP0000028587364.920447.679cottoperca_gobioENSCGOP0000003150667.377849.4838
ENSG00000082516homo_sapiensENSP0000028587373.541161.4721struthio_camelus_australisENSSCUP0000001748777.12164.4645
ENSG00000082516homo_sapiensENSP0000028587374.801161.8037anser_brachyrhynchusENSABRP0000001992275.704762.5503
ENSG00000082516homo_sapiensENSP0000028587364.920447.878gasterosteus_aculeatusENSGACP0000002753267.285249.622
ENSG00000082516homo_sapiensENSP0000028587362.466844.0318cynoglossus_semilaevisENSCSEP0000003190965.235545.9834
ENSG00000082516homo_sapiensENSP0000028587363.859447.8117poecilia_formosaENSPFOP0000001135767.484250.5256
ENSG00000082516homo_sapiensENSP0000028587364.058447.9443poecilia_formosaENSPFOP0000001219767.647150.6303
ENSG00000082516homo_sapiensENSP0000028587365.649949.5358myripristis_murdjanENSMMDP0000501743667.301250.7818
ENSG00000082516homo_sapiensENSP0000028587365.318348.0769sander_luciopercaENSSLUP0000000180767.558349.7257
ENSG00000082516homo_sapiensENSP0000028587376.657863.3289strigops_habroptilaENSSHBP0000501028475.358562.2555
ENSG00000082516homo_sapiensENSP0000028587364.389948.4748amphiprion_ocellarisENSAOCP0000002522767.243850.6233
ENSG00000082516homo_sapiensENSP0000028587378.050466.0477terrapene_carolina_triunguisENSTMTP0000000725177.383365.4832
ENSG00000082516homo_sapiensENSP0000028587343.43534.2838hucho_huchoENSHHUP0000004348874.771759.0183
ENSG00000082516homo_sapiensENSP0000028587320.822314.3236hucho_huchoENSHHUP0000003067556.678738.9892
ENSG00000082516homo_sapiensENSP0000028587363.660547.2812betta_splendensENSBSLP0000001614966.344249.2744
ENSG00000082516homo_sapiensENSP0000028587368.103451.4589pygocentrus_nattereriENSPNAP0000001072669.204852.2911
ENSG00000082516homo_sapiensENSP0000028587364.721548.3422anabas_testudineusENSATEP0000004136566.575749.7271
ENSG00000082516homo_sapiensENSP0000028587329.774520.3581ciona_savignyiENSCSAVP0000000930060.268541.2081
ENSG00000082516homo_sapiensENSP0000028587316.04776.89655ciona_savignyiENSCSAVP0000001885430.099512.9353
ENSG00000082516homo_sapiensENSP000002858739.084884.37666saccharomyces_cerevisiaeYEL056W34.164616.4589
ENSG00000082516homo_sapiensENSP0000028587310.34485.03979saccharomyces_cerevisiaeYDR030C30.8315.0198
ENSG00000082516homo_sapiensENSP0000028587319.49610.8753saccharomyces_cerevisiaeYDR128W25.609814.2857
ENSG00000082516homo_sapiensENSP0000028587362.798446.817seriola_lalandi_dorsalisENSSLDP0000001393367.163150.0709
ENSG00000082516homo_sapiensENSP0000028587359.615444.1645labrus_bergyltaENSLBEP0000001270065.957448.8628
ENSG00000082516homo_sapiensENSP0000028587343.236132.0955labrus_bergyltaENSLBEP0000002869267.775550.3119
ENSG00000082516homo_sapiensENSP0000028587364.058448.2759pundamilia_nyerereiENSPNYP0000001764268.076151.3037
ENSG00000082516homo_sapiensENSP0000028587364.721548.1432mastacembelus_armatusENSMAMP0000003245967.403350.1381
ENSG00000082516homo_sapiensENSP0000028587364.986748.0106stegastes_partitusENSSPAP0000001014267.773250.0692
ENSG00000082516homo_sapiensENSP0000028587366.710950.5968oncorhynchus_tshawytschaENSOTSP0000504983466.799550.664
ENSG00000082516homo_sapiensENSP0000028587345.75633.6207acanthochromis_polyacanthusENSAPOP0000002353764.606747.4719
ENSG00000082516homo_sapiensENSP000002858737562.2016aquila_chrysaetos_chrysaetosENSACCP0002001837976.264363.2502
ENSG00000082516homo_sapiensENSP0000028587362.466846.1538nothobranchius_furzeriENSNFUP0001504446066.012648.7737
ENSG00000082516homo_sapiensENSP0000028587363.660547.3475cyprinodon_variegatusENSCVAP0000003166065.618648.8038
ENSG00000082516homo_sapiensENSP0000028587367.838250.1326denticeps_clupeoidesENSDCDP0000005746168.888950.9091
ENSG00000082516homo_sapiensENSP0000028587365.318347.878larimichthys_croceaENSLCRP0000506344367.744249.6561
ENSG00000082516homo_sapiensENSP0000028587376.458962.6658ficedula_albicollisENSFALP0000000871075.310361.7244
ENSG00000082516homo_sapiensENSP0000028587342.108832.4934hippocampus_comesENSHCOP0000001543770.791554.6265
ENSG00000082516homo_sapiensENSP0000028587367.705651.9894cyprinus_carpio_carpioENSCCRP0000014048769.455853.3333
ENSG00000082516homo_sapiensENSP0000028587375.596862.5995coturnix_japonicaENSCJPP0000500797974.852361.9829
ENSG00000082516homo_sapiensENSP0000028587362.533246.817poecilia_latipinnaENSPLAP0000002862263.759347.735
ENSG00000082516homo_sapiensENSP0000028587362.533246.817poecilia_latipinnaENSPLAP0000002934363.759347.735
ENSG00000082516homo_sapiensENSP0000028587349.734736.4721poecilia_latipinnaENSPLAP0000001614863.237846.3744
ENSG00000082516homo_sapiensENSP0000028587366.976150.8621sinocyclocheilus_grahamiENSSGRP0000010684869.083552.4624
ENSG00000082516homo_sapiensENSP0000028587366.246750.2653sinocyclocheilus_grahamiENSSGRP0000007986968.754352.1679
ENSG00000082516homo_sapiensENSP0000028587366.114149.2706maylandia_zebraENSMZEP0000501594168.008250.6821
ENSG00000082516homo_sapiensENSP0000028587363.1345.9549tetraodon_nigroviridisENSTNIP0000001044064.6347.0468
ENSG00000082516homo_sapiensENSP0000028587365.450950.0663paramormyrops_kingsleyaeENSPKIP0000002813568.022152.0331
ENSG00000082516homo_sapiensENSP0000028587367.108850.3316scleropages_formosusENSSFOP0001501668470.180352.6352
ENSG00000082516homo_sapiensENSP0000028587370.623354.5093leptobrachium_leishanenseENSLLEP0000000835872.745956.1475
ENSG00000082516homo_sapiensENSP0000028587362.997346.817oryzias_melastigmaENSOMEP0000002120167.71250.3207

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000340enables RNA 7-methylguanosine cap binding1IDAHomo_sapiens(9606)Function
GO:0000387involved_in spliceosomal snRNP assembly4EXP,IBA,IDA,TASHomo_sapiens(9606)Process
GO:0000398involved_in mRNA splicing, via spliceosome1TASHomo_sapiens(9606)Process
GO:0003723enables RNA binding2HDA,IPIHomo_sapiens(9606)Function
GO:0003730enables mRNA 3-UTR binding2IBA,IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0006412involved_in translation1IEAHomo_sapiens(9606)Process
GO:0006417involved_in regulation of translation1IMPHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016604located_in nuclear body1IDAHomo_sapiens(9606)Component
GO:0017069enables snRNA binding1IDAHomo_sapiens(9606)Function
GO:0030619enables U1 snRNA binding1IDAHomo_sapiens(9606)Function
GO:0030621enables U4 snRNA binding1IDAHomo_sapiens(9606)Function
GO:0030622enables U4atac snRNA binding1IDAHomo_sapiens(9606)Function
GO:0032797part_of SMN complex3IBA,IDA,IPIHomo_sapiens(9606)Component
GO:0034718part_of SMN-Gemin2 complex1IDAHomo_sapiens(9606)Component
GO:0034719part_of SMN-Sm protein complex1IDAHomo_sapiens(9606)Component
GO:0043022enables ribosome binding1IDAHomo_sapiens(9606)Function
GO:0065003involved_in protein-containing complex assembly1TASHomo_sapiens(9606)Process
GO:0097504located_in Gemini of coiled bodies1IEAHomo_sapiens(9606)Component

Expression