RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq

Ensembl ID	ENSG00000081721	Gene ID	11266	Accession	3067
Symbol	DUSP12	Alias	YVH1;DUSP1	Full Name	dual specificity phosphatase 12
Status	Confidence	Length	7481 bases	Strand	Plus strand
Position	1 : 161749758 - 161757238	RNA binding domain	N.A.
Summary	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
DUSP12-204	ENST00000484291	1252	137aa	ENSP00000476528
DUSP12-203	ENST00000464004	740	137aa	ENSP00000476912
DUSP12-201	ENST00000367943	1330	340aa	ENSP00000356920
DUSP12-205	ENST00000490591	657	82aa	ENSP00000477122
DUSP12-202	ENST00000463365	398	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
16856	Neuroblastoma	2.42e-005	23222812
16905	Neuroblastoma	3.23e-006	23222812
16997	Neuroblastoma	8.04e-005	23222812
37039	Platelet Function Tests	8.0800000E-006	-
37046	Platelet Function Tests	1.0086800E-005	-
37777	Platelet Function Tests	1.4400000E-007	-
37784	Platelet Function Tests	9.3800000E-008	-
39377	Platelet Function Tests	1.0608500E-005	-
39381	Platelet Function Tests	1.1171700E-005	-
54384	Alkaline Phosphatase	1.6460000E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004725	enables protein tyrosine phosphatase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IEA	Homo_sapiens(9606)	Component
GO:0006470	involved_in protein dephosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0008138	enables protein tyrosine/serine/threonine phosphatase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0008270	enables zinc ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0016311	involved_in dephosphorylation	1	IDA	Homo_sapiens(9606)	Process
GO:0016791	enables phosphatase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0017018	enables myosin phosphatase activity	1	IEA	Homo_sapiens(9606)	Function
GO:0019900	enables kinase binding	1	IEA	Homo_sapiens(9606)	Function
GO:0033133	involved_in positive regulation of glucokinase activity	1	IBA	Homo_sapiens(9606)	Process
GO:0036211	involved_in protein modification process	1	TAS	Homo_sapiens(9606)	Process