RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000078369	Gene ID	2782	Accession	4396
Symbol	GNB1	Alias	MDS;HG2A;MRD42	Full Name	G protein subunit beta 1
Status	Confidence	Length	107008 bases	Strand	Minus strand
Position	1 : 1785285 - 1892292	RNA binding domain	N.A.
Summary	Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
35604143	G Protein Subunit β1 Facilitates Influenza A Virus Replication by Promoting the Nuclear Import of PB2.	Huabin Zheng	2022-06-22	Journal of virology

Name	Transcript ID	bp	Protein	Translation ID
GNB1-210	ENST00000615252	2750	240aa	ENSP00000483532
GNB1-209	ENST00000610897	3145	340aa	ENSP00000481878
GNB1-201	ENST00000378609	3163	340aa	ENSP00000367872
GNB1-204	ENST00000439272	2902	327aa	ENSP00000399741
GNB1-211	ENST00000703692	3265	340aa	ENSP00000515427
GNB1-212	ENST00000703693	3484	340aa	ENSP00000515428
GNB1-213	ENST00000703694	3139	340aa	ENSP00000515429
GNB1-214	ENST00000703695	2737	194aa	ENSP00000515430
GNB1-215	ENST00000703696	3019	340aa	ENSP00000515431
GNB1-216	ENST00000703697	3247	340aa	ENSP00000515432
GNB1-217	ENST00000703698	2058	No protein	-
GNB1-218	ENST00000703699	3184	340aa	ENSP00000515433
GNB1-219	ENST00000703700	2875	340aa	ENSP00000515434
GNB1-220	ENST00000703701	3214	340aa	ENSP00000515435
GNB1-221	ENST00000703702	3008	340aa	ENSP00000515436
GNB1-222	ENST00000703703	2923	340aa	ENSP00000515437
GNB1-223	ENST00000703704	3141	340aa	ENSP00000515438
GNB1-224	ENST00000703705	2493	296aa	ENSP00000515439
GNB1-225	ENST00000703706	2579	340aa	ENSP00000515440
GNB1-226	ENST00000703707	2340	327aa	ENSP00000515441
GNB1-227	ENST00000703708	2841	340aa	ENSP00000515442
GNB1-228	ENST00000703709	2304	340aa	ENSP00000515443
GNB1-229	ENST00000703710	1789	340aa	ENSP00000515444
GNB1-230	ENST00000703711	1650	340aa	ENSP00000515445
GNB1-205	ENST00000461893	2438	No protein	-
GNB1-206	ENST00000471354	1512	No protein	-
GNB1-202	ENST00000434686	684	165aa	ENSP00000392765
GNB1-203	ENST00000437146	423	107aa	ENSP00000416651
GNB1-208	ENST00000607589	567	No protein	-
GNB1-207	ENST00000472614	708	No protein	-
GNB1-231	ENST00000703712	572	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
31937	Respiratory Function Tests	9.8610000E-005	-
65432	Body Mass Index	8E-7	25673413
71578	Body Mass Index	6E-7	25673413

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003924	enables GTPase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005765	located_in lysosomal membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005834	part_of heterotrimeric G-protein complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	TAS	Homo_sapiens(9606)	Component
GO:0007165	involved_in signal transduction	1	TAS	Homo_sapiens(9606)	Process
GO:0007186	involved_in G protein-coupled receptor signaling pathway	1	IBA	Homo_sapiens(9606)	Process
GO:0007191	involved_in adenylate cyclase-activating dopamine receptor signaling pathway	1	ISS	Homo_sapiens(9606)	Process
GO:0007200	involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	1	IEA	Homo_sapiens(9606)	Process
GO:0007213	involved_in G protein-coupled acetylcholine receptor signaling pathway	1	TAS	Homo_sapiens(9606)	Process
GO:0007265	involved_in Ras protein signal transduction	1	TAS	Homo_sapiens(9606)	Process
GO:0008283	involved_in cell population proliferation	1	IEA	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	ISS	Homo_sapiens(9606)	Component
GO:0030159	enables signaling receptor complex adaptor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0044877	enables protein-containing complex binding	1	IDA	Homo_sapiens(9606)	Function
GO:0045202	located_in synapse	1	IEA	Homo_sapiens(9606)	Component
GO:0050909	involved_in sensory perception of taste	1	IEA	Homo_sapiens(9606)	Process
GO:0051020	enables GTPase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0060041	involved_in retina development in camera-type eye	1	IEA	Homo_sapiens(9606)	Process
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:0071380	involved_in cellular response to prostaglandin E stimulus	1	ISS	Homo_sapiens(9606)	Process
GO:0071870	involved_in cellular response to catecholamine stimulus	1	ISS	Homo_sapiens(9606)	Process
GO:0097381	located_in photoreceptor disc membrane	1	TAS	Homo_sapiens(9606)	Component
GO:1903561	located_in extracellular vesicle	1	HDA	Homo_sapiens(9606)	Component