RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000078124	Gene ID	55331	Accession	16066
Symbol	ACER3	Alias	APHC;PHCA;PLDECO	Full Name	alkaline ceramidase 3
Status	Confidence	Length	165939 bases	Strand	Plus strand
Position	11 : 76860859 - 77026797	RNA binding domain	N.A.
Summary	Enables N-acylsphingosine amidohydrolase activity and metal ion binding activity. Involved in several processes, including myelination; positive regulation of cell population proliferation; and sphingolipid metabolic process. Is integral component of Golgi membrane and integral component of endoplasmic reticulum membrane. Biomarker of hepatocellular carcinoma and non-alcoholic steatohepatitis. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
ACER3-216	ENST00000679754	4495	274aa	ENSP00000505416
ACER3-214	ENST00000534206	834	205aa	ENSP00000435733
ACER3-219	ENST00000679866	4509	165aa	ENSP00000505175
ACER3-225	ENST00000680842	4569	80aa	ENSP00000506534
ACER3-228	ENST00000681257	4527	179aa	ENSP00000506160
ACER3-230	ENST00000681354	4310	74aa	ENSP00000505846
ACER3-234	ENST00000681732	4551	71aa	ENSP00000504927
ACER3-223	ENST00000680583	4533	172aa	ENSP00000505842
ACER3-212	ENST00000532485	7333	267aa	ENSP00000434480
ACER3-202	ENST00000525194	846	51aa	ENSP00000432109
ACER3-226	ENST00000681004	4437	74aa	ENSP00000505132
ACER3-231	ENST00000681375	4735	71aa	ENSP00000506417
ACER3-207	ENST00000530182	1695	No protein	-
ACER3-204	ENST00000525861	2058	80aa	ENSP00000432379
ACER3-211	ENST00000531461	1292	74aa	ENSP00000433368
ACER3-215	ENST00000679611	4629	No protein	-
ACER3-232	ENST00000681411	4938	200aa	ENSP00000504918
ACER3-235	ENST00000681955	4768	71aa	ENSP00000505191
ACER3-205	ENST00000526597	1269	172aa	ENSP00000431149
ACER3-220	ENST00000679924	4418	112aa	ENSP00000506405
ACER3-208	ENST00000530334	1491	150aa	ENSP00000435048
ACER3-227	ENST00000681251	4461	150aa	ENSP00000505549
ACER3-213	ENST00000533873	929	230aa	ENSP00000436252
ACER3-210	ENST00000531352	2093	51aa	ENSP00000431504
ACER3-201	ENST00000278544	3500	76aa	ENSP00000278544
ACER3-222	ENST00000680351	4661	No protein	-
ACER3-233	ENST00000681591	817	No protein	-
ACER3-206	ENST00000527508	4152	No protein	-
ACER3-229	ENST00000681258	5048	No protein	-
ACER3-203	ENST00000525325	560	No protein	-
ACER3-221	ENST00000680164	3215	No protein	-
ACER3-217	ENST00000679759	5440	No protein	-
ACER3-218	ENST00000679813	3424	No protein	-
ACER3-224	ENST00000680624	5366	No protein	-
ACER3-209	ENST00000530921	567	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
9660	Echocardiography	7.94676133021755E-5	17903301
33366	Urine	7.3688249E-005	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000139	located_in Golgi membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0005509	enables calcium ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0005789	located_in endoplasmic reticulum membrane	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0006954	involved_in inflammatory response	1	IEA	Homo_sapiens(9606)	Process
GO:0008270	enables zinc ion binding	1	IDA	Homo_sapiens(9606)	Function
GO:0008284	involved_in positive regulation of cell population proliferation	1	IMP	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	IDA	Homo_sapiens(9606)	Component
GO:0017040	enables N-acylsphingosine amidohydrolase activity	2	IDA,IMP	Homo_sapiens(9606)	Function
GO:0030148	involved_in sphingolipid biosynthetic process	1	TAS	Homo_sapiens(9606)	Process
GO:0042552	involved_in myelination	1	IMP	Homo_sapiens(9606)	Process
GO:0043067	involved_in regulation of programmed cell death	1	IDA	Homo_sapiens(9606)	Process
GO:0046512	involved_in sphingosine biosynthetic process	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0046514	involved_in ceramide catabolic process	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0070774	enables phytoceramidase activity	4	IBA,IDA,IMP,TAS	Homo_sapiens(9606)	Function
GO:0071602	involved_in phytosphingosine biosynthetic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0071633	enables dihydroceramidase activity	2	IDA,IMP	Homo_sapiens(9606)	Function
GO:0102121	enables ceramidase activity	1	IEA	Homo_sapiens(9606)	Function