Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzyme
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000076716 Gene ID 2239 Accession 4452
Symbol GPC4 Alias KPTS;K-glypican Full Name glypican 4
Status Confidence Length 115387 bases Strand Minus strand
Position X : 133300103 - 133415489 RNA binding domain N.A.
Summary Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
GPC4-201 ENST00000370828 4959 556aa ENSP00000359864

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
2127Body Mass Index4.25827720586365E-517903300
2131Body Mass Index4.2582772058708E-517903300
2408Body Mass Index7.15715792974654E-517903300
2409Body Mass Index7.15715792973803E-517903300
2421Body Mass Index9.7391619140625E-517903300
2423Body Mass Index9.73916191406854E-517903300

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1HDAHomo_sapiens(9606)Component
GO:0005796located_in Golgi lumen1TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1TASHomo_sapiens(9606)Component
GO:0009897located_in external side of plasma membrane1IDAHomo_sapiens(9606)Component
GO:0009966involved_in regulation of signal transduction1IEAHomo_sapiens(9606)Process
GO:0009986is_active_in cell surface1IBAHomo_sapiens(9606)Component
GO:0016055involved_in Wnt signaling pathway1IMPHomo_sapiens(9606)Process
GO:0016477involved_in cell migration1IBAHomo_sapiens(9606)Process
GO:0043202located_in lysosomal lumen1TASHomo_sapiens(9606)Component
GO:0045202is_active_in synapse1IBAHomo_sapiens(9606)Component
GO:0060071involved_in Wnt signaling pathway, planar cell polarity pathway1IEAHomo_sapiens(9606)Process
GO:0062023located_in collagen-containing extracellular matrix1IEAHomo_sapiens(9606)Component
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0098696involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane1IBAHomo_sapiens(9606)Process
GO:0098978located_in glutamatergic synapse1IEAHomo_sapiens(9606)Component
GO:0099560involved_in synaptic membrane adhesion1IBAHomo_sapiens(9606)Process
GO:1904929enables coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway1NASHomo_sapiens(9606)Function
GO:1905606involved_in regulation of presynapse assembly1IBAHomo_sapiens(9606)Process

Expression