Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases SARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq

Description

Ensembl ID ENSG00000075624 Gene ID 60 Accession 132
Symbol ACTB Alias BNS;CSMH;DDS1;BKRNS;BRWS1;PS1TP5BP1 Full Name actin beta
Status Confidence Length 37494 bases Strand Minus strand
Position 7 : 5526409 - 5563902 RNA binding domain N.A.
Summary This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ACTB-219 ENST00000674681 2554 375aa ENSP00000502821
ACTB-213 ENST00000642480 2021 375aa ENSP00000495995
ACTB-223 ENST00000676397 1804 334aa ENSP00000502286
ACTB-222 ENST00000676319 811 40aa ENSP00000502193
ACTB-221 ENST00000676189 1815 151aa ENSP00000502538
ACTB-208 ENST00000473257 1687 332aa ENSP00000501773
ACTB-217 ENST00000646664 1812 375aa ENSP00000494750
ACTB-207 ENST00000464611 715 79aa ENSP00000495059
ACTB-209 ENST00000477812 2271 No protein -
ACTB-220 ENST00000675515 1919 375aa ENSP00000501862
ACTB-203 ENST00000425660 1845 125aa ENSP00000409264
ACTB-206 ENST00000462494 2245 No protein -
ACTB-212 ENST00000493945 1495 375aa ENSP00000494269
ACTB-204 ENST00000432588 1300 334aa ENSP00000407473
ACTB-215 ENST00000645576 1009 309aa ENSP00000496101
ACTB-218 ENST00000647275 556 157aa ENSP00000494185
ACTB-211 ENST00000484841 561 No protein -
ACTB-214 ENST00000645025 572 No protein -
ACTB-210 ENST00000480301 657 No protein -
ACTB-205 ENST00000443528 569 102aa ENSP00000393951
ACTB-202 ENST00000417101 472 96aa ENSP00000399487
ACTB-201 ENST00000414620 561 80aa ENSP00000401032
ACTB-216 ENST00000646584 425 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
28820monocyte chemoattractant protein 1 (66-77)7.0700000E-005-
41979Platelet Function Tests3.4368735E-006-
42013Platelet Function Tests3.4722282E-006-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000079involved_in regulation of cyclin-dependent protein serine/threonine kinase activity1ISSHomo_sapiens(9606)Process
GO:0000776located_in kinetochore1NASHomo_sapiens(9606)Component
GO:0000785part_of chromatin2HDA,NASHomo_sapiens(9606)Component
GO:0000786part_of nucleosome1IDAHomo_sapiens(9606)Component
GO:0001738involved_in morphogenesis of a polarized epithelium1IMPHomo_sapiens(9606)Process
GO:0001895involved_in retina homeostasis1HEPHomo_sapiens(9606)Process
GO:0005200enables structural constituent of cytoskeleton1TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005615located_in extracellular space1HDAHomo_sapiens(9606)Component
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm3IBA,IDA,TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005856located_in cytoskeleton3IDA,ISS,TASHomo_sapiens(9606)Component
GO:0005884is_active_in actin filament1IBAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane2ISS,TASHomo_sapiens(9606)Component
GO:0005903located_in brush border1IEAHomo_sapiens(9606)Component
GO:0005911located_in cell-cell junction1IMPHomo_sapiens(9606)Component
GO:0005912located_in adherens junction1IDAHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0006338involved_in chromatin remodeling2HDA,NASHomo_sapiens(9606)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II1NASHomo_sapiens(9606)Process
GO:0007163involved_in establishment or maintenance of cell polarity1IMPHomo_sapiens(9606)Process
GO:0007409involved_in axonogenesis1IBAHomo_sapiens(9606)Process
GO:0008284involved_in positive regulation of cell population proliferation1NASHomo_sapiens(9606)Process
GO:0015629located_in actin cytoskeleton1IDAHomo_sapiens(9606)Component
GO:0016020located_in membrane2HDA,IBAHomo_sapiens(9606)Component
GO:0016363located_in nuclear matrix1NASHomo_sapiens(9606)Component
GO:0016514part_of SWI/SNF complex1NASHomo_sapiens(9606)Component
GO:0016573involved_in histone acetylation1NASHomo_sapiens(9606)Process
GO:0016586part_of RSC-type complex1NASHomo_sapiens(9606)Component
GO:0016787enables hydrolase activity1IEAHomo_sapiens(9606)Function
GO:0019894enables kinesin binding1IPIHomo_sapiens(9606)Function
GO:0019901enables protein kinase binding2IBA,IPIHomo_sapiens(9606)Function
GO:0021762involved_in substantia nigra development1HEPHomo_sapiens(9606)Process
GO:0022898involved_in regulation of transmembrane transporter activity2IGI,ISSHomo_sapiens(9606)Process
GO:0030027located_in lamellipodium1IDAHomo_sapiens(9606)Component
GO:0030071involved_in regulation of mitotic metaphase/anaphase transition1NASHomo_sapiens(9606)Process
GO:0030424is_active_in axon1IBAHomo_sapiens(9606)Component
GO:0030863located_in cortical cytoskeleton1IEAHomo_sapiens(9606)Component
GO:0030957enables Tat protein binding1IPIHomo_sapiens(9606)Function
GO:0031492contributes_to nucleosomal DNA binding1HDAHomo_sapiens(9606)Function
GO:0031982located_in vesicle1HDAHomo_sapiens(9606)Component
GO:0032091involved_in negative regulation of protein binding1ISSHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex2HDA,IDAHomo_sapiens(9606)Component
GO:0034333involved_in adherens junction assembly1IMPHomo_sapiens(9606)Process
GO:0035060part_of brahma complex1NASHomo_sapiens(9606)Component
GO:0035267part_of NuA4 histone acetyltransferase complex2IBA,IDAHomo_sapiens(9606)Component
GO:0035633acts_upstream_of_or_within maintenance of blood-brain barrier1NASHomo_sapiens(9606)Process
GO:0036464located_in cytoplasmic ribonucleoprotein granule1IDAHomo_sapiens(9606)Component
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042981involved_in regulation of apoptotic process1NASHomo_sapiens(9606)Process
GO:0043296located_in apical junction complex1IDAHomo_sapiens(9606)Component
GO:0043967involved_in histone H4 acetylation1IDAHomo_sapiens(9606)Process
GO:0043968involved_in histone H2A acetylation1IDAHomo_sapiens(9606)Process
GO:0044305located_in calyx of Held1IEAHomo_sapiens(9606)Component
GO:0045176involved_in apical protein localization1IMPHomo_sapiens(9606)Process
GO:0045202is_active_in synapse1IBAHomo_sapiens(9606)Component
GO:0045582involved_in positive regulation of T cell differentiation1NASHomo_sapiens(9606)Process
GO:0045596involved_in negative regulation of cell differentiation1NASHomo_sapiens(9606)Process
GO:0045597involved_in positive regulation of cell differentiation1NASHomo_sapiens(9606)Process
GO:0045663involved_in positive regulation of myoblast differentiation1NASHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1NASHomo_sapiens(9606)Process
GO:0048156enables tau protein binding1NASHomo_sapiens(9606)Function
GO:0048870involved_in cell motility2IBA,IMPHomo_sapiens(9606)Process
GO:0050998enables nitric-oxide synthase binding1IPIHomo_sapiens(9606)Function
GO:0051621involved_in regulation of norepinephrine uptake2IGI,ISSHomo_sapiens(9606)Process
GO:0051623involved_in positive regulation of norepinephrine uptake1TASHomo_sapiens(9606)Process
GO:0051726involved_in regulation of cell cycle1IMPHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070160located_in tight junction1IDAHomo_sapiens(9606)Component
GO:0070316involved_in regulation of G0 to G1 transition1NASHomo_sapiens(9606)Process
GO:0070527involved_in platelet aggregation1HMPHomo_sapiens(9606)Process
GO:0071564part_of npBAF complex1NASHomo_sapiens(9606)Component
GO:0071565part_of nBAF complex1NASHomo_sapiens(9606)Component
GO:0071896involved_in protein localization to adherens junction1IMPHomo_sapiens(9606)Process
GO:0072562located_in blood microparticle1HDAHomo_sapiens(9606)Component
GO:0072749involved_in cellular response to cytochalasin B1IMPHomo_sapiens(9606)Process
GO:0097433located_in dense body1ISSHomo_sapiens(9606)Component
GO:0098685located_in Schaffer collateral - CA1 synapse1IEAHomo_sapiens(9606)Component
GO:0098793located_in presynapse1TASHomo_sapiens(9606)Component
GO:0098871is_active_in postsynaptic actin cytoskeleton2IDA,IMPHomo_sapiens(9606)Component
GO:0098973enables structural constituent of postsynaptic actin cytoskeleton4EXP,IBA,IDA,IMPHomo_sapiens(9606)Function
GO:0098974involved_in postsynaptic actin cytoskeleton organization1IDAHomo_sapiens(9606)Process
GO:0098978is_active_in glutamatergic synapse3EXP,IDA,IMPHomo_sapiens(9606)Component
GO:0140092part_of bBAF complex1NASHomo_sapiens(9606)Component
GO:0140288part_of GBAF complex1NASHomo_sapiens(9606)Component
GO:0150111involved_in regulation of transepithelial transport1IMPHomo_sapiens(9606)Process
GO:1900242involved_in regulation of synaptic vesicle endocytosis1IEAHomo_sapiens(9606)Process
GO:1902459involved_in positive regulation of stem cell population maintenance1NASHomo_sapiens(9606)Process
GO:1903076involved_in regulation of protein localization to plasma membrane1IMPHomo_sapiens(9606)Process
GO:1905168involved_in positive regulation of double-strand break repair via homologous recombination1IDAHomo_sapiens(9606)Process
GO:1990904part_of ribonucleoprotein complex1IDAHomo_sapiens(9606)Component
GO:2000045involved_in regulation of G1/S transition of mitotic cell cycle1NASHomo_sapiens(9606)Process
GO:2000779involved_in regulation of double-strand break repair1NASHomo_sapiens(9606)Process
GO:2000781involved_in positive regulation of double-strand break repair1NASHomo_sapiens(9606)Process
GO:2000819involved_in regulation of nucleotide-excision repair1NASHomo_sapiens(9606)Process

Expression