RBP Type	Canonical_RBPs
Diseases	N.A.
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000074590	Gene ID	9891	Accession	14311
Symbol	NUAK1	Alias	ARK5	Full Name	NUAK family kinase 1
Status	Confidence	Length	75610 bases	Strand	Minus strand
Position	12 : 106063345 - 106138954	RNA binding domain	RIO1
Summary	Enables p53 binding activity and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of cellular senescence; and regulation of myosin-light-chain-phosphatase activity. Located in cytoplasm; microtubule cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000261402	RIO1	PF01163	0.00021	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
32006464	Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription.	Giacomo Cossa	2020-03-19	Molecular cell

Name	Transcript ID	bp	Protein	Translation ID
NUAK1-201	ENST00000261402	5744	661aa	ENSP00000261402
NUAK1-204	ENST00000553094	547	118aa	ENSP00000446873
NUAK1-203	ENST00000549704	569	74aa	ENSP00000449990
NUAK1-202	ENST00000548902	560	152aa	ENSP00000448288

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
14088	Attention Deficit Disorder with Hyperactivity	8.3490000E-005	18937294
14125	Attention Deficit Disorder with Hyperactivity	1.5560000E-004	18937294
55241	Erythrocyte Indices	1.8080000E-006	-
55242	Erythrocyte Indices	5.7350000E-005	-
78862	Attention	6E-7	26174813
78863	Attention Deficit Disorder with Hyperactivity	6E-7	26174813
83103	Attention	3E-6	26174813
83104	Attention Deficit Disorder with Hyperactivity	3E-6	26174813

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0001650	located_in fibrillar center	1	IDA	Homo_sapiens(9606)	Component
GO:0002039	enables p53 binding	1	IPI	Homo_sapiens(9606)	Function
GO:0004674	enables protein serine/threonine kinase activity	3	IBA,IDA,TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0006974	involved_in DNA damage response	1	IEA	Homo_sapiens(9606)	Process
GO:0007155	involved_in cell adhesion	1	IEA	Homo_sapiens(9606)	Process
GO:0015630	located_in microtubule cytoskeleton	1	IDA	Homo_sapiens(9606)	Component
GO:0030155	involved_in regulation of cell adhesion	1	IDA	Homo_sapiens(9606)	Process
GO:0031588	part_of nucleotide-activated protein kinase complex	1	IBA	Homo_sapiens(9606)	Component
GO:0032007	involved_in negative regulation of TOR signaling	1	IBA	Homo_sapiens(9606)	Process
GO:0035507	involved_in regulation of myosin-light-chain-phosphatase activity	1	IDA	Homo_sapiens(9606)	Process
GO:0035556	involved_in intracellular signal transduction	1	IBA	Homo_sapiens(9606)	Process
GO:0042127	involved_in regulation of cell population proliferation	1	TAS	Homo_sapiens(9606)	Process
GO:0042149	involved_in cellular response to glucose starvation	1	IBA	Homo_sapiens(9606)	Process
GO:0046872	enables metal ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:1901796	involved_in regulation of signal transduction by p53 class mediator	1	TAS	Homo_sapiens(9606)	Process
GO:2000772	involved_in regulation of cellular senescence	1	IDA	Homo_sapiens(9606)	Process