RBP Type	Canonical_RBPs
Diseases	Disease
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Transmemebrane
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000072682	Gene ID	8974	Accession	8547
Symbol	P4HA2	Alias	MYP25;lncRNA-PE	Full Name	prolyl 4-hydroxylase subunit alpha 2
Status	Confidence	Length	105125 bases	Strand	Minus strand
Position	5 : 132190147 - 132295271	RNA binding domain	2OG-FeII_Oxy
Summary	This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000166534	2OG-FeII_Oxy	PF03171	2.3e-05	1
ENSP00000368398	2OG-FeII_Oxy	PF03171	2.3e-05	1
ENSP00000384999	2OG-FeII_Oxy	PF03171	2.3e-05	1
ENSP00000353772	2OG-FeII_Oxy	PF03171	2.9e-05	1
ENSP00000368379	2OG-FeII_Oxy	PF03171	2.9e-05	1
ENSP00000368394	2OG-FeII_Oxy	PF03171	2.9e-05	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
31278071	Aspirin targets P4HA2 through inhibiting NF-κB and LMCD1-AS1/let-7g to inhibit tumour growth and collagen deposition in hepatocellular carcinoma.	Tianjiao Wang	2019-07-01	EBioMedicine

Name	Transcript ID	bp	Protein	Translation ID
P4HA2-202	ENST00000360568	4547	533aa	ENSP00000353772
P4HA2-205	ENST00000379104	4553	535aa	ENSP00000368398
P4HA2-207	ENST00000401867	3349	535aa	ENSP00000384999
P4HA2-203	ENST00000379086	2223	533aa	ENSP00000368379
P4HA2-201	ENST00000166534	2230	535aa	ENSP00000166534
P4HA2-204	ENST00000379100	2625	533aa	ENSP00000368394
P4HA2-218	ENST00000474628	743	No protein	-
P4HA2-211	ENST00000428369	2397	146aa	ENSP00000396495
P4HA2-221	ENST00000506807	463	No protein	-
P4HA2-216	ENST00000467587	456	No protein	-
P4HA2-209	ENST00000417528	1023	204aa	ENSP00000389523
P4HA2-213	ENST00000431054	724	236aa	ENSP00000391257
P4HA2-214	ENST00000439698	866	184aa	ENSP00000405406
P4HA2-206	ENST00000395164	568	167aa	ENSP00000378593
P4HA2-215	ENST00000453286	819	153aa	ENSP00000413542
P4HA2-210	ENST00000418055	568	114aa	ENSP00000403883
P4HA2-219	ENST00000478055	929	No protein	-
P4HA2-208	ENST00000416053	582	101aa	ENSP00000394953
P4HA2-212	ENST00000428841	427	50aa	ENSP00000395956
P4HA2-217	ENST00000471826	2508	No protein	-
P4HA2-220	ENST00000481636	496	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
8566	Blood Pressure	2.3369131189499E-5	17903302
8581	Blood Pressure	4.2951713158379E-5	17903302
8963	Blood Pressure	4.0782724970212E-5	17903302
8974	Blood Pressure	8.28509725157023E-5	17903302
59732	Blood Pressure	9.7798852E-006	-
60319	Blood Pressure	7.8124131E-006	-
105212	Giant Cell Arteritis	5E-9	28041642

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004656	enables procollagen-proline 4-dioxygenase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005506	enables iron ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005654	located_in nucleoplasm	1	IDA	Homo_sapiens(9606)	Component
GO:0005783	is_active_in endoplasmic reticulum	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005788	located_in endoplasmic reticulum lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0009055	enables electron transfer activity	1	TAS	Homo_sapiens(9606)	Function
GO:0018401	involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline	1	IBA	Homo_sapiens(9606)	Process
GO:0022900	involved_in electron transport chain	1	IEA	Homo_sapiens(9606)	Process
GO:0031418	enables L-ascorbic acid binding	1	IEA	Homo_sapiens(9606)	Function
GO:0043231	located_in intracellular membrane-bounded organelle	1	IDA	Homo_sapiens(9606)	Component