Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Kinase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000072518 Gene ID 2011 Accession 3332
Symbol MARK2 Alias EMK1;EMK-1;PAR-1;Par1b;Par-1b Full Name microtubule affinity regulating kinase 2
Status Confidence Length 72093 bases Strand Plus strand
Position 11 : 63838928 - 63911020 RNA binding domain N.A.
Summary This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
MARK2-203 ENST00000377810 4560 732aa ENSP00000367041
MARK2-208 ENST00000508192 2924 724aa ENSP00000425765
MARK2-202 ENST00000361128 3004 719aa ENSP00000355091
MARK2-201 ENST00000350490 2903 709aa ENSP00000294247
MARK2-204 ENST00000402010 4547 788aa ENSP00000385751
MARK2-207 ENST00000502399 2885 778aa ENSP00000423452
MARK2-206 ENST00000425897 2379 763aa ENSP00000415494
MARK2-211 ENST00000513765 2666 779aa ENSP00000421075
MARK2-222 ENST00000679216 2502 718aa ENSP00000504337
MARK2-214 ENST00000543220 595 161aa ENSP00000444956
MARK2-215 ENST00000543674 557 91aa ENSP00000444859
MARK2-213 ENST00000540169 558 111aa ENSP00000437509
MARK2-209 ENST00000509502 2862 745aa ENSP00000423974
MARK2-218 ENST00000677688 4717 561aa ENSP00000503547
MARK2-224 ENST00000707173 2839 676aa ENSP00000516773
MARK2-210 ENST00000512060 411 60aa ENSP00000423844
MARK2-205 ENST00000408948 2112 691aa ENSP00000386128
MARK2-221 ENST00000679213 673 No protein -
MARK2-216 ENST00000676602 5298 No protein -
MARK2-219 ENST00000678482 4869 No protein -
MARK2-220 ENST00000678662 2316 No protein -
MARK2-223 ENST00000679321 3142 No protein -
MARK2-212 ENST00000535116 439 No protein -
MARK2-217 ENST00000677303 2804 128aa ENSP00000503542

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
91191Methylphenidate5E-621130132
105565Schizophrenia1E-626198764

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000226involved_in microtubule cytoskeleton organization1IBAHomo_sapiens(9606)Process
GO:0000287enables magnesium ion binding1IDAHomo_sapiens(9606)Function
GO:0000422involved_in autophagy of mitochondrion1NASHomo_sapiens(9606)Process
GO:0001764involved_in neuron migration1ISSHomo_sapiens(9606)Process
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0004674enables protein serine/threonine kinase activity5IBA,IDA,ISS,NAS,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IDAHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1NASHomo_sapiens(9606)Component
GO:0005884located_in actin filament1IDAHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0006468involved_in protein phosphorylation3IDA,IMP,NASHomo_sapiens(9606)Process
GO:0008289enables lipid binding1IEAHomo_sapiens(9606)Function
GO:0010976involved_in positive regulation of neuron projection development1IDAHomo_sapiens(9606)Process
GO:0016020located_in membrane1IMPHomo_sapiens(9606)Component
GO:0016055involved_in Wnt signaling pathway1IEAHomo_sapiens(9606)Process
GO:0016328located_in lateral plasma membrane1IDAHomo_sapiens(9606)Component
GO:0018105involved_in peptidyl-serine phosphorylation2IDA,ISSHomo_sapiens(9606)Process
GO:0018107involved_in peptidyl-threonine phosphorylation1TASHomo_sapiens(9606)Process
GO:0030010involved_in establishment of cell polarity2IDA,TASHomo_sapiens(9606)Process
GO:0030295enables protein kinase activator activity1TASHomo_sapiens(9606)Function
GO:0030425located_in dendrite1IDAHomo_sapiens(9606)Component
GO:0032147involved_in activation of protein kinase activity1TASHomo_sapiens(9606)Process
GO:0035556involved_in intracellular signal transduction2IBA,IDAHomo_sapiens(9606)Process
GO:0045197involved_in establishment or maintenance of epithelial cell apical/basal polarity1IDAHomo_sapiens(9606)Process
GO:0045296enables cadherin binding1HDAHomo_sapiens(9606)Function
GO:0046777involved_in protein autophosphorylation1ISSHomo_sapiens(9606)Process
GO:0048156enables tau protein binding2ISS,NASHomo_sapiens(9606)Function
GO:0050321enables tau-protein kinase activity4IBA,IMP,ISS,NASHomo_sapiens(9606)Function
GO:0050770involved_in regulation of axonogenesis1IMPHomo_sapiens(9606)Process
GO:0051493involved_in regulation of cytoskeleton organization1ISSHomo_sapiens(9606)Process
GO:0051646involved_in mitochondrion localization1NASHomo_sapiens(9606)Process
GO:0061564involved_in axon development1ISSHomo_sapiens(9606)Process
GO:0070507involved_in regulation of microtubule cytoskeleton organization1IDAHomo_sapiens(9606)Process
GO:0071963involved_in establishment or maintenance of cell polarity regulating cell shape1ISSHomo_sapiens(9606)Process
GO:0097427located_in microtubule bundle1IDAHomo_sapiens(9606)Component
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:1904526involved_in regulation of microtubule binding1ISSHomo_sapiens(9606)Process

Expression