Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions Metabolic enzymeKinase
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000072062 Gene ID 5566 Accession 9380
Symbol PRKACA Alias CAFD1;PKACA;PPNAD4 Full Name protein kinase cAMP-activated catalytic subunit alpha
Status Confidence Length 26397 bases Strand Minus strand
Position 19 : 14091688 - 14118084 RNA binding domain N.A.
Summary This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
PRKACA-212 ENST00000677971 3996 134aa ENSP00000502958
PRKACA-211 ENST00000677951 2582 293aa ENSP00000504551
PRKACA-201 ENST00000308677 2695 351aa ENSP00000309591
PRKACA-202 ENST00000350356 3105 427aa ENSP00000513361
PRKACA-209 ENST00000590853 1101 124aa ENSP00000466976
PRKACA-204 ENST00000587372 824 251aa ENSP00000468352
PRKACA-208 ENST00000589994 1257 343aa ENSP00000466651
PRKACA-206 ENST00000588209 942 No protein -
PRKACA-213 ENST00000679067 2171 No protein -
PRKACA-205 ENST00000587533 2095 No protein -
PRKACA-203 ENST00000536649 1524 230aa ENSP00000503953
PRKACA-210 ENST00000593092 922 207aa ENSP00000466289
PRKACA-207 ENST00000589284 403 25aa ENSP00000466660

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000287enables magnesium ion binding1IEAHomo_sapiens(9606)Function
GO:0001669located_in acrosomal vesicle1ISSHomo_sapiens(9606)Component
GO:0001707involved_in mesoderm formation1IEAHomo_sapiens(9606)Process
GO:0001843involved_in neural tube closure1IEAHomo_sapiens(9606)Process
GO:0002027involved_in regulation of heart rate1TASHomo_sapiens(9606)Process
GO:0003091involved_in renal water homeostasis1TASHomo_sapiens(9606)Process
GO:0004672enables protein kinase activity1IDAHomo_sapiens(9606)Function
GO:0004674enables protein serine/threonine kinase activity3IDA,IMP,TASHomo_sapiens(9606)Function
GO:0004679enables AMP-activated protein kinase activity1IEAHomo_sapiens(9606)Function
GO:0004691enables cAMP-dependent protein kinase activity5IBA,IDA,ISS,NAS,TASHomo_sapiens(9606)Function
GO:0004712enables protein serine/threonine/tyrosine kinase activity1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634located_in nucleus3HDA,IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm1IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IEAHomo_sapiens(9606)Component
GO:0005813located_in centrosome1IDAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol2IBA,TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0005930colocalizes_with axoneme1IDAHomo_sapiens(9606)Component
GO:0005952part_of cAMP-dependent protein kinase complex3IBA,IDA,NASHomo_sapiens(9606)Component
GO:0006397involved_in mRNA processing1IDAHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation2IDA,NASHomo_sapiens(9606)Process
GO:0006611involved_in protein export from nucleus1IEAHomo_sapiens(9606)Process
GO:0007189involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway1IEAHomo_sapiens(9606)Process
GO:0010737involved_in protein kinase A signaling1IBAHomo_sapiens(9606)Process
GO:0010881involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion1TASHomo_sapiens(9606)Process
GO:0016241involved_in regulation of macroautophagy1TASHomo_sapiens(9606)Process
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0018105involved_in peptidyl-serine phosphorylation4IBA,IDA,IMP,TASHomo_sapiens(9606)Process
GO:0018107involved_in peptidyl-threonine phosphorylation1IEAHomo_sapiens(9606)Process
GO:0019221involved_in cytokine-mediated signaling pathway1TASHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding1IPIHomo_sapiens(9606)Function
GO:0019904enables protein domain specific binding1IEAHomo_sapiens(9606)Function
GO:0030145enables manganese ion binding1IEAHomo_sapiens(9606)Function
GO:0031594located_in neuromuscular junction1IEAHomo_sapiens(9606)Component
GO:0031625enables ubiquitin protein ligase binding1IDAHomo_sapiens(9606)Function
GO:0032024involved_in positive regulation of insulin secretion1IEAHomo_sapiens(9606)Process
GO:0034237enables protein kinase A regulatory subunit binding2IBA,IPIHomo_sapiens(9606)Function
GO:0034380involved_in high-density lipoprotein particle assembly1TASHomo_sapiens(9606)Process
GO:0034605involved_in cellular response to heat1IDAHomo_sapiens(9606)Process
GO:0034704part_of calcium channel complex1TASHomo_sapiens(9606)Component
GO:0035584involved_in calcium-mediated signaling using intracellular calcium source1TASHomo_sapiens(9606)Process
GO:0036126located_in sperm flagellum1IEAHomo_sapiens(9606)Component
GO:0043197located_in dendritic spine1IEAHomo_sapiens(9606)Component
GO:0043393involved_in regulation of protein binding1TASHomo_sapiens(9606)Process
GO:0044853located_in plasma membrane raft1IDAHomo_sapiens(9606)Component
GO:0045667involved_in regulation of osteoblast differentiation1IDAHomo_sapiens(9606)Process
GO:0045722involved_in positive regulation of gluconeogenesis1IEAHomo_sapiens(9606)Process
GO:0046777involved_in protein autophosphorylation1IEAHomo_sapiens(9606)Process
GO:0046827involved_in positive regulation of protein export from nucleus1IEAHomo_sapiens(9606)Process
GO:0048240involved_in sperm capacitation1ISSHomo_sapiens(9606)Process
GO:0048471located_in perinuclear region of cytoplasm1IDAHomo_sapiens(9606)Component
GO:0051480involved_in regulation of cytosolic calcium ion concentration1TASHomo_sapiens(9606)Process
GO:0051726involved_in regulation of cell cycle1ISSHomo_sapiens(9606)Process
GO:0055117involved_in regulation of cardiac muscle contraction1TASHomo_sapiens(9606)Process
GO:0060314involved_in regulation of ryanodine-sensitive calcium-release channel activity1TASHomo_sapiens(9606)Process
GO:0061136involved_in regulation of proteasomal protein catabolic process1IDAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070417involved_in cellular response to cold1IEAHomo_sapiens(9606)Process
GO:0070613involved_in regulation of protein processing1IEAHomo_sapiens(9606)Process
GO:0071333involved_in cellular response to glucose stimulus1IDAHomo_sapiens(9606)Process
GO:0071374involved_in cellular response to parathyroid hormone stimulus1IEAHomo_sapiens(9606)Process
GO:0071377involved_in cellular response to glucagon stimulus1IEAHomo_sapiens(9606)Process
GO:0071872involved_in cellular response to epinephrine stimulus1TASHomo_sapiens(9606)Process
GO:0086064involved_in cell communication by electrical coupling involved in cardiac conduction1TASHomo_sapiens(9606)Process
GO:0097546located_in ciliary base1TASHomo_sapiens(9606)Component
GO:0098978located_in glutamatergic synapse1IEAHomo_sapiens(9606)Component
GO:0099170involved_in postsynaptic modulation of chemical synaptic transmission1IEAHomo_sapiens(9606)Process
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:1901621involved_in negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning1IEAHomo_sapiens(9606)Process
GO:1903779involved_in regulation of cardiac conduction1TASHomo_sapiens(9606)Process
GO:1904539involved_in negative regulation of glycolytic process through fructose-6-phosphate1IEAHomo_sapiens(9606)Process
GO:1990044involved_in protein localization to lipid droplet1IEAHomo_sapiens(9606)Process
GO:2000810involved_in regulation of bicellular tight junction assembly1IDAHomo_sapiens(9606)Process

Expression