RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000071242	Gene ID	6196	Accession	10431
Symbol	RPS6KA2	Alias	RSK;HU-2;RSK3;p90RSK2;p90-RSK3;pp90RSK3;MAPKAPK1C;S6K-alpha;S6K-alpha2	Full Name	ribosomal protein S6 kinase A2
Status	Confidence	Length	497088 bases	Strand	Minus strand
Position	6 : 166409364 - 166906451	RNA binding domain	N.A.
Summary	This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
447	Maximal Midexpiratory Flow Rate	2.30381047463241E-6	17903307
483	Respiratory Function Tests	3.27031057202709E-10	17903307
573	Maximal Midexpiratory Flow Rate	4.71311162658954E-6	17903307
616	Respiratory Function Tests	6.39834499148856E-9	17903307
15615	Heart Failure	5.3537282E-004	-
21955	Personality	2.66e-005	-
28020	Diabetes Mellitus	2.0960000E-005	-
28031	Diabetes Mellitus	2.2780000E-005	-
31641	Platelet Count	2.5980000E-005	-
32053	Fetal Hemoglobin	1.6100000E-005	20018918
32084	Fetal Hemoglobin	7.2100000E-006	20018918
36186	Platelet Function Tests	1.6100000E-006	-
36212	Platelet Function Tests	6.8900000E-008	-
36216	Platelet Function Tests	3.6200000E-007	-
45100	Platelet Function Tests	2.4505074E-006	-
51132	Child Development Disorders, Pervasive	4.6259000E-005	-
52389	Child Development Disorders, Pervasive	2.4000000E-005	-
52600	Blood Urea Nitrogen	5.5580000E-005	-
54676	Creatine Kinase	5.0640000E-005	-
94783	Blood Pressure	8E-7	25189868
94784	Smoking	8E-7	25189868
100749	Dental Caries	1E-7	23259602

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000287	enables magnesium ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0001556	involved_in oocyte maturation	1	IEA	Homo_sapiens(9606)	Process
GO:0002035	involved_in brain renin-angiotensin system	1	IEA	Homo_sapiens(9606)	Process
GO:0004674	enables protein serine/threonine kinase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0004711	enables ribosomal protein S6 kinase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0004712	enables protein serine/threonine/tyrosine kinase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	is_active_in nucleoplasm	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0007165	involved_in signal transduction	1	NAS	Homo_sapiens(9606)	Process
GO:0007268	involved_in chemical synaptic transmission	1	TAS	Homo_sapiens(9606)	Process
GO:0007507	involved_in heart development	1	IEA	Homo_sapiens(9606)	Process
GO:0008285	involved_in negative regulation of cell population proliferation	1	IDA	Homo_sapiens(9606)	Process
GO:0010628	involved_in positive regulation of gene expression	1	IEA	Homo_sapiens(9606)	Process
GO:0010659	involved_in cardiac muscle cell apoptotic process	1	IEA	Homo_sapiens(9606)	Process
GO:0018105	involved_in peptidyl-serine phosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0035556	involved_in intracellular signal transduction	1	IEA	Homo_sapiens(9606)	Process
GO:0043065	involved_in positive regulation of apoptotic process	1	IDA	Homo_sapiens(9606)	Process
GO:0045202	located_in synapse	1	IEA	Homo_sapiens(9606)	Component
GO:0045786	involved_in negative regulation of cell cycle	1	IDA	Homo_sapiens(9606)	Process
GO:0045835	involved_in negative regulation of meiotic nuclear division	1	IEA	Homo_sapiens(9606)	Process
GO:0060047	involved_in heart contraction	1	IEA	Homo_sapiens(9606)	Process
GO:0070613	involved_in regulation of protein processing	1	IEA	Homo_sapiens(9606)	Process
GO:0071322	involved_in cellular response to carbohydrate stimulus	1	IEA	Homo_sapiens(9606)	Process
GO:0072687	located_in meiotic spindle	1	IEA	Homo_sapiens(9606)	Component
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function