RBPWorld - a comprehensive database of RNA Binding Proteins

Functions and Diseases

RBP Type	Canonical_RBPs
Diseases	CancerSARS-COV-OC43FlavivirusesHIVRVSARS-COV-2SINVDengueZika
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	N.A.
Localizations	Stress granucle
BulkPerturb-seq	DataSet_01_256 DataSet_01_451

Description

Ensembl ID	ENSG00000070756	Gene ID	26986	Accession	8554
Symbol	PABPC1	Alias	PAB1;PABP;PABP1;PABPC2;PABPL1	Full Name	poly(A) binding protein cytoplasmic 1
Status	Confidence	Length	36994 bases	Strand	Minus strand
Position	8 : 100685816 - 100722809	RNA binding domain	PABP , RRM_5 , RRM_1
Summary	This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]

RNA binding domains (RBDs)

Search:

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000313007	RRM_1	PF00076	5.1e-91	1
ENSP00000313007	RRM_1	PF00076	5.1e-91	2
ENSP00000313007	RRM_1	PF00076	5.1e-91	3
ENSP00000313007	RRM_1	PF00076	5.1e-91	4
ENSP00000313007	PABP	PF00658	1.4e-30	5
ENSP00000313007	RRM_5	PF13893	6.5e-07	6
ENSP00000427805	RRM_1	PF00076	1e-27	1
ENSP00000427805	RRM_1	PF00076	1e-27	2
ENSP00000427914	RRM_1	PF00076	9e-90	1
ENSP00000427914	RRM_1	PF00076	9e-90	2
ENSP00000427914	RRM_1	PF00076	9e-90	3
ENSP00000427914	RRM_1	PF00076	9e-90	4
ENSP00000427914	PABP	PF00658	1.2e-30	5
ENSP00000427914	RRM_5	PF13893	4.8e-07	6
ENSP00000428021	PABP	PF00658	2.2e-31	1
ENSP00000428030	PABP	PF00658	4.6e-20	1
ENSP00000428749	RRM_1	PF00076	5.1e-91	1
ENSP00000428749	RRM_1	PF00076	5.1e-91	2
ENSP00000428749	RRM_1	PF00076	5.1e-91	3
ENSP00000428749	RRM_1	PF00076	5.1e-91	4
ENSP00000428749	PABP	PF00658	1.4e-30	5
ENSP00000428749	RRM_5	PF13893	6.5e-07	6
ENSP00000428840	RRM_1	PF00076	5.1e-91	1
ENSP00000428840	RRM_1	PF00076	5.1e-91	2
ENSP00000428840	RRM_1	PF00076	5.1e-91	3
ENSP00000428840	RRM_1	PF00076	5.1e-91	4
ENSP00000428840	PABP	PF00658	1.4e-30	5
ENSP00000428840	RRM_5	PF13893	6.5e-07	6
ENSP00000428937	RRM_1	PF00076	4.9e-14	1
ENSP00000428948	RRM_1	PF00076	9.8e-13	1
ENSP00000429032	RRM_1	PF00076	5.4e-05	1
ENSP00000429119	RRM_1	PF00076	5.1e-91	1
ENSP00000429119	RRM_1	PF00076	5.1e-91	2
ENSP00000429119	RRM_1	PF00076	5.1e-91	3
ENSP00000429119	RRM_1	PF00076	5.1e-91	4
ENSP00000429119	PABP	PF00658	1.4e-30	5
ENSP00000429119	RRM_5	PF13893	6.5e-07	6
ENSP00000429395	RRM_1	PF00076	1.8e-78	1
ENSP00000429395	RRM_1	PF00076	1.8e-78	2
ENSP00000429395	RRM_1	PF00076	1.8e-78	3
ENSP00000429395	RRM_1	PF00076	1.8e-78	4
ENSP00000429395	PABP	PF00658	1.6e-30	5
ENSP00000429594	RRM_1	PF00076	9.5e-75	1
ENSP00000429594	RRM_1	PF00076	9.5e-75	2
ENSP00000429594	RRM_1	PF00076	9.5e-75	3
ENSP00000429594	RRM_1	PF00076	9.5e-75	4
ENSP00000429594	PABP	PF00658	1.2e-30	5
ENSP00000429594	RRM_5	PF13893	9e-07	6
ENSP00000429790	RRM_1	PF00076	5.1e-91	1
ENSP00000429790	RRM_1	PF00076	5.1e-91	2
ENSP00000429790	RRM_1	PF00076	5.1e-91	3
ENSP00000429790	RRM_1	PF00076	5.1e-91	4
ENSP00000429790	PABP	PF00658	1.4e-30	5
ENSP00000429790	RRM_5	PF13893	6.5e-07	6
ENSP00000429892	RRM_1	PF00076	5.1e-91	1
ENSP00000429892	RRM_1	PF00076	5.1e-91	2
ENSP00000429892	RRM_1	PF00076	5.1e-91	3
ENSP00000429892	RRM_1	PF00076	5.1e-91	4
ENSP00000429892	PABP	PF00658	1.4e-30	5
ENSP00000429892	RRM_5	PF13893	6.5e-07	6
ENSP00000430012	RRM_1	PF00076	5.1e-91	1
ENSP00000430012	RRM_1	PF00076	5.1e-91	2
ENSP00000430012	RRM_1	PF00076	5.1e-91	3
ENSP00000430012	RRM_1	PF00076	5.1e-91	4
ENSP00000430012	PABP	PF00658	1.4e-30	5
ENSP00000430012	RRM_5	PF13893	6.5e-07	6
ENSP00000430159	RRM_1	PF00076	1.2e-24	1
ENSP00000430159	RRM_1	PF00076	1.2e-24	2
ENSP00000478108	RRM_1	PF00076	9.8e-78	1
ENSP00000478108	RRM_1	PF00076	9.8e-78	2
ENSP00000478108	RRM_1	PF00076	9.8e-78	3
ENSP00000478108	RRM_1	PF00076	9.8e-78	4
ENSP00000478108	PABP	PF00658	1.5e-30	5
ENSP00000503044	RRM_1	PF00076	5.4e-86	1
ENSP00000503044	RRM_1	PF00076	5.4e-86	2
ENSP00000503044	RRM_1	PF00076	5.4e-86	3
ENSP00000503044	RRM_1	PF00076	5.4e-86	4
ENSP00000503044	PABP	PF00658	1.4e-30	5
ENSP00000503044	RRM_5	PF13893	6.9e-06	6
ENSP00000503058	RRM_1	PF00076	5.1e-80	1
ENSP00000503058	RRM_1	PF00076	5.1e-80	2
ENSP00000503058	RRM_1	PF00076	5.1e-80	3
ENSP00000503058	RRM_1	PF00076	5.1e-80	4
ENSP00000503058	PABP	PF00658	1.3e-30	5
ENSP00000503058	RRM_5	PF13893	3.9e-06	6
ENSP00000503421	RRM_1	PF00076	1.9e-66	1
ENSP00000503421	RRM_1	PF00076	1.9e-66	2
ENSP00000503421	RRM_1	PF00076	1.9e-66	3
ENSP00000503421	PABP	PF00658	1.1e-30	4
ENSP00000503421	RRM_5	PF13893	1.1e-05	5
ENSP00000503455	RRM_1	PF00076	4.9e-14	1
ENSP00000503686	RRM_1	PF00076	1.9e-66	1
ENSP00000503686	RRM_1	PF00076	1.9e-66	2
ENSP00000503686	RRM_1	PF00076	1.9e-66	3
ENSP00000503686	PABP	PF00658	1.1e-30	4
ENSP00000503686	RRM_5	PF13893	1.1e-05	5
ENSP00000503838	RRM_1	PF00076	4.4e-68	1
ENSP00000503838	RRM_1	PF00076	4.4e-68	2
ENSP00000503838	RRM_1	PF00076	4.4e-68	3
ENSP00000503838	PABP	PF00658	1.2e-30	4
ENSP00000503838	RRM_5	PF13893	4.9e-06	5
ENSP00000504369	RRM_1	PF00076	9.5e-75	1
ENSP00000504369	RRM_1	PF00076	9.5e-75	2
ENSP00000504369	RRM_1	PF00076	9.5e-75	3
ENSP00000504369	RRM_1	PF00076	9.5e-75	4
ENSP00000504369	PABP	PF00658	1.2e-30	5
ENSP00000504369	RRM_5	PF13893	9e-07	6
ENSP00000504835	RRM_1	PF00076	2.9e-82	1
ENSP00000504835	RRM_1	PF00076	2.9e-82	2
ENSP00000504835	RRM_1	PF00076	2.9e-82	3
ENSP00000504835	RRM_1	PF00076	2.9e-82	4
ENSP00000504835	PABP	PF00658	1.4e-30	5

Showing 1 to 112 of 112 entries

RNA binding proteomes (RBPomes)

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Search:

Pubmed ID	Full Name	Cell	Author	Time	Doi
22658674	RIC_PMID22658674_Hela_human	Hela	Alfredo Castello	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22658674	RIC_PMID22658674_Hs_HeLa	HeLa	Alfredo Castello?	2012 Jun 8	doi: 10.1016/j.cell.2012.04.031.?Epub 2012 May 31
22681889	RIC_PMID22681889_Hs_HEK293	HEK293	Alexander G Baltz	2012 Jun 8	doi: 10.1016/j.molcel.2012.05.021
25173706	Pclap_PMID25173706_Hs_HEK293	HEK293	Katharina Kramer	2014 Oct;11	doi: 10.1038/nmeth.3092.?Epub 2014 Aug 31
26632259	RIC_PMID26632259._Hs_HuH7	HuH7	Benedikt M Beckmann	2015 Dec 3	doi: 10.1038/ncomms10127.
27040163	serIC_PMID27040163_Hs_K562.1	K562	Thomas Conrad?	2016 Apr 4	doi: 10.1038/ncomms11212
27453046	RBDmap_PMID_27453046_Hs_HeLa	HeLa	Alfredo Castello	2016 Aug 18	doi: 10.1016/j.molcel.2016.06.029.?Epub 2016 Jul 21
29431736	RICK_PMID29431736_Hs_HeLa.RICK	HeLa	Xichen Bao	2018 Mar	doi: 10.1038/nmeth.4595.?Epub 2018 Feb 12
29636419	CARIC_PMID29636419_Hela_human	Hela	Xichen Bao	2018 Apr 24	doi: 10.1073/pnas.1718406115.?Epub 2018 Apr 10
29636419	CARIC_PMID29636419_Hs_CARIC		Rongbing Huang	2018 Apr 24	doi: 10.1073/pnas.1718406115

Showing 1 to 10 of 31 entries

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Pubmed ID	Title	Author	Time	Journal
No data available in table

Transcripts

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Name	Transcript ID	bp	Protein	Translation ID
PABPC1-201	ENST00000318607	2861	636aa	ENSP00000313007
PABPC1-202	ENST00000517403	560	187aa	ENSP00000428190
PABPC1-203	ENST00000517921	2485	No protein	-
PABPC1-204	ENST00000517990	487	136aa	ENSP00000428030
PABPC1-205	ENST00000518196	631	108aa	ENSP00000430159
PABPC1-206	ENST00000518293	608	42aa	ENSP00000430716
PABPC1-207	ENST00000518716	694	No protein	-
PABPC1-208	ENST00000519004	2401	591aa	ENSP00000429594
PABPC1-209	ENST00000519100	2207	599aa	ENSP00000427914
PABPC1-210	ENST00000519363	453	38aa	ENSP00000429032

Showing 1 to 10 of 40 entries

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Gene Model

Click here to download ENSG00000070756's gene model file

ensgID	Trait	pValue	Pubmed ID
No data available in table

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID
No data available in table

Protein-Protein Interaction (PPI)

Click here to download ENSG00000070756's PPI file

Paralogs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000070756	homo_sapiens	ENSP00000281589	95.0872	92.8685	homo_sapiens	ENSP00000313007	94.3396	92.1384
ENSG00000070756	homo_sapiens	ENSP00000286070	33.7553	15.6118	homo_sapiens	ENSP00000313007	25.1572	11.6352
ENSG00000070756	homo_sapiens	ENSP00000294904	47.2906	26.8473	homo_sapiens	ENSP00000313007	30.1887	17.1384
ENSG00000070756	homo_sapiens	ENSP00000352162	41.6894	22.3433	homo_sapiens	ENSP00000313007	24.0566	12.8931
ENSG00000070756	homo_sapiens	ENSP00000304405	33.4913	21.0111	homo_sapiens	ENSP00000313007	33.3333	20.9119
ENSG00000070756	homo_sapiens	ENSP00000358635	33.8684	22.1509	homo_sapiens	ENSP00000313007	33.1761	21.6981
ENSG00000070756	homo_sapiens	ENSP00000308012	78.7958	63.6126	homo_sapiens	ENSP00000313007	47.327	38.2075
ENSG00000070756	homo_sapiens	ENSP00000385269	42.638	23.9264	homo_sapiens	ENSP00000313007	21.8553	12.2642
ENSG00000070756	homo_sapiens	ENSP00000262031	46.4373	25.5528	homo_sapiens	ENSP00000313007	29.717	16.3522
ENSG00000070756	homo_sapiens	ENSP00000386226	32.3256	14.8837	homo_sapiens	ENSP00000313007	21.8553	10.0629

Showing 1 to 10 of 24 entries

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Orthologs

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Ensembl ID	Source				Target
Ensembl ID	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000070756	homo_sapiens	ENSP00000313007	33.1761	29.8742	nomascus_leucogenys	ENSNLEP00000046978	81.4672	73.3591
ENSG00000070756	homo_sapiens	ENSP00000313007	76.2579	74.0566	pan_paniscus	ENSPPAP00000027355	93.4489	90.7514
ENSG00000070756	homo_sapiens	ENSP00000313007	97.7987	97.1698	pan_paniscus	ENSPPAP00000029188	96.4341	95.814
ENSG00000070756	homo_sapiens	ENSP00000313007	75.6289	71.2264	pan_paniscus	ENSPPAP00000030015	88.582	83.4254
ENSG00000070756	homo_sapiens	ENSP00000313007	100	100	pongo_abelii	ENSPPYP00000021076	100	100
ENSG00000070756	homo_sapiens	ENSP00000313007	100	100	pan_troglodytes	ENSPTRP00000069297	100	100
ENSG00000070756	homo_sapiens	ENSP00000313007	90.7233	90.0943	gorilla_gorilla	ENSGGOP00000006641	97.4662	96.7905
ENSG00000070756	homo_sapiens	ENSP00000313007	75.6289	72.7987	gorilla_gorilla	ENSGGOP00000037882	90.4135	87.0301
ENSG00000070756	homo_sapiens	ENSP00000313007	72.6415	69.0252	gorilla_gorilla	ENSGGOP00000045643	90.5882	86.0784
ENSG00000070756	homo_sapiens	ENSP00000313007	99.5283	99.0566	ornithorhynchus_anatinus	ENSOANP00000011633	99.5283	99.0566

Showing 1 to 10 of 167 entries

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Gene Ontology

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Go ID	Go term	No. evidence	Entries	Species	Category
GO:0003723	enables RNA binding	3	HDA,IDA,IPI	Homo_sapiens(9606)	Function
GO:0005829	is_active_in cytosol	3	IBA,IDA,TAS	Homo_sapiens(9606)	Component
GO:0008143	enables poly(A) binding	3	IBA,IDA,TAS	Homo_sapiens(9606)	Function
GO:0003730	enables mRNA 3-UTR binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005737	located_in cytoplasm	2	IDA,TAS	Homo_sapiens(9606)	Component
GO:0008266	enables poly(U) RNA binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0010494	is_active_in cytoplasmic stress granule	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:1990904	part_of ribonucleoprotein complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0000184	involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	1	IEA	Homo_sapiens(9606)	Process

Showing 1 to 10 of 32 entries

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Welcome to

RBP World!

Functions and Diseases

Description

RNA binding domains (RBDs)

RNA binding proteomes (RBPomes)

Literatures on RNA binding capacity

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

Protein-Protein Interaction (PPI)

Paralogs

Orthologs

Gene Ontology

Expression