Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000066336 Gene ID 6688 Accession 11241
Symbol SPI1 Alias OF;PU.1;AGM10;SFPI1;SPI-1;SPI-A Full Name Spi-1 proto-oncogene
Status Confidence Length 23688 bases Strand Minus strand
Position 11 : 47354860 - 47378547 RNA binding domain N.A.
Summary This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
35361282 Study on the role of transcription factor SPI1 in the development of glioma. Baoshun Du 2022-04-01 Chinese neurosurgical journal
37629534 Narrowing the Relationship between Human CCR5 Gene Polymorphisms and Chagas Disease: Systematic Review and Meta-Analysis. Moisés Jean Ferreira 2023-08-02 Life (Basel, Switzerland)
30482209 Identification of gene expression profiles in myocardial infarction: a systematic review and meta-analysis. Panagiota Kontou 2018-11-27 BMC medical genomics
8626664 The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb. M Hallier 1996-05-10 The Journal of biological chemistry
26207626 A Quantitative Profiling Tool for Diverse Genomic Data Types Reveals Potential Associations between Chromatin and Pre-mRNA Processing. Isaac Kremsky 2015-01-01 PloS one
9478924 The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS. M Hallier 1998-02-27 The Journal of biological chemistry

Transcripts

Name Transcript ID bp Protein Translation ID
SPI1-202 ENST00000378538 1374 270aa ENSP00000367799
SPI1-201 ENST00000227163 1168 271aa ENSP00000227163
SPI1-203 ENST00000533030 661 35aa ENSP00000443865
SPI1-204 ENST00000533968 1290 245aa ENSP00000438846

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000122involved_in negative regulation of transcription by RNA polymerase II2IMP,ISSHomo_sapiens(9606)Process
GO:0000785part_of chromatin2IDA,ISAHomo_sapiens(9606)Component
GO:0000976enables transcription cis-regulatory region binding2IDA,IMPHomo_sapiens(9606)Function
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding2IDA,ISSHomo_sapiens(9606)Function
GO:0000981enables DNA-binding transcription factor activity, RNA polymerase II-specific3IBA,ISA,ISSHomo_sapiens(9606)Function
GO:0000987enables cis-regulatory region sequence-specific DNA binding2IDA,ISSHomo_sapiens(9606)Function
GO:0001216enables DNA-binding transcription activator activity1IDAHomo_sapiens(9606)Function
GO:0001217enables DNA-binding transcription repressor activity1IDAHomo_sapiens(9606)Function
GO:0001227enables DNA-binding transcription repressor activity, RNA polymerase II-specific1IEAHomo_sapiens(9606)Function
GO:0001228enables DNA-binding transcription activator activity, RNA polymerase II-specific1IEAHomo_sapiens(9606)Function
GO:0002314involved_in germinal center B cell differentiation1IEAHomo_sapiens(9606)Process
GO:0002316involved_in follicular B cell differentiation1IEAHomo_sapiens(9606)Process
GO:0002327involved_in immature B cell differentiation1IEAHomo_sapiens(9606)Process
GO:0002357involved_in defense response to tumor cell1IMPHomo_sapiens(9606)Process
GO:0002572involved_in pro-T cell differentiation1ISSHomo_sapiens(9606)Process
GO:0002573involved_in myeloid leukocyte differentiation1IMPHomo_sapiens(9606)Process
GO:0003682enables chromatin binding1ISSHomo_sapiens(9606)Function
GO:0003700enables DNA-binding transcription factor activity2IDA,ISSHomo_sapiens(9606)Function
GO:0003723enables RNA binding1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005667part_of transcription regulator complex1IDAHomo_sapiens(9606)Component
GO:0006355involved_in regulation of DNA-templated transcription1IDAHomo_sapiens(9606)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II1IBAHomo_sapiens(9606)Process
GO:0007179involved_in transforming growth factor beta receptor signaling pathway1IEAHomo_sapiens(9606)Process
GO:0010629involved_in negative regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0030154involved_in cell differentiation1IBAHomo_sapiens(9606)Process
GO:0030218involved_in erythrocyte differentiation1IEAHomo_sapiens(9606)Process
GO:0030225involved_in macrophage differentiation1IEAHomo_sapiens(9606)Process
GO:0030851involved_in granulocyte differentiation1IEAHomo_sapiens(9606)Process
GO:0031663involved_in lipopolysaccharide-mediated signaling pathway1IEAHomo_sapiens(9606)Process
GO:0032088involved_in negative regulation of NF-kappaB transcription factor activity1IDAHomo_sapiens(9606)Process
GO:0035019involved_in somatic stem cell population maintenance1IEAHomo_sapiens(9606)Process
GO:0036462acts_upstream_of_positive_effect TRAIL-activated apoptotic signaling pathway1IMPHomo_sapiens(9606)Process
GO:0042826enables histone deacetylase binding1ISSHomo_sapiens(9606)Function
GO:0043011involved_in myeloid dendritic cell differentiation1IEAHomo_sapiens(9606)Process
GO:0043314involved_in negative regulation of neutrophil degranulation1ISSHomo_sapiens(9606)Process
GO:0043565enables sequence-specific DNA binding1IDAHomo_sapiens(9606)Function
GO:0045347involved_in negative regulation of MHC class II biosynthetic process1IEAHomo_sapiens(9606)Process
GO:0045579involved_in positive regulation of B cell differentiation1IMPHomo_sapiens(9606)Process
GO:0045646involved_in regulation of erythrocyte differentiation1IMPHomo_sapiens(9606)Process
GO:0045815involved_in transcription initiation-coupled chromatin remodeling2IMP,ISSHomo_sapiens(9606)Process
GO:0045892involved_in negative regulation of DNA-templated transcription2IDA,ISSHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II4IDA,IGI,IMP,ISSHomo_sapiens(9606)Process
GO:0051090involved_in regulation of DNA-binding transcription factor activity1ISSHomo_sapiens(9606)Process
GO:0051525enables NFAT protein binding1ISSHomo_sapiens(9606)Function
GO:0060033involved_in anatomical structure regression1IEAHomo_sapiens(9606)Process
GO:0060090enables molecular adaptor activity1EXPHomo_sapiens(9606)Function
GO:0061629enables RNA polymerase II-specific DNA-binding transcription factor binding2IPI,ISSHomo_sapiens(9606)Function
GO:0070102involved_in interleukin-6-mediated signaling pathway1IDAHomo_sapiens(9606)Process
GO:0090402involved_in oncogene-induced cell senescence1ISSHomo_sapiens(9606)Process
GO:0097677enables STAT family protein binding1IPIHomo_sapiens(9606)Function
GO:0098508involved_in endothelial to hematopoietic transition1ISSHomo_sapiens(9606)Process
GO:0120186involved_in negative regulation of protein localization to chromatin1ISSHomo_sapiens(9606)Process
GO:0140297enables DNA-binding transcription factor binding2IPI,ISSHomo_sapiens(9606)Function
GO:0140311enables protein sequestering activity1ISSHomo_sapiens(9606)Function
GO:1900745involved_in positive regulation of p38MAPK cascade1ISSHomo_sapiens(9606)Process
GO:1901223involved_in negative regulation of NIK/NF-kappaB signaling1IMPHomo_sapiens(9606)Process
GO:1902262involved_in apoptotic process involved in blood vessel morphogenesis1IEAHomo_sapiens(9606)Process
GO:1902895involved_in positive regulation of miRNA transcription2IDA,ISSHomo_sapiens(9606)Process
GO:1904151involved_in positive regulation of microglial cell mediated cytotoxicity1ISSHomo_sapiens(9606)Process
GO:1904178involved_in negative regulation of adipose tissue development1ISSHomo_sapiens(9606)Process
GO:1904238involved_in pericyte cell differentiation1ISSHomo_sapiens(9606)Process
GO:1905036involved_in positive regulation of antifungal innate immune response1ISSHomo_sapiens(9606)Process
GO:1905453involved_in regulation of myeloid progenitor cell differentiation1ISSHomo_sapiens(9606)Process
GO:2000529involved_in positive regulation of myeloid dendritic cell chemotaxis1IEAHomo_sapiens(9606)Process

Expression