RBP Type	Non-canonical_RBPs
Diseases	Disease
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Kinase
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000065883	Gene ID	8621	Accession	1733
Symbol	CDK13	Alias	CHED;CDC2L;CDC2L5;hCDK13;CHDFIDD	Full Name	cyclin dependent kinase 13
Status	Confidence	Length	149460 bases	Strand	Plus strand
Position	7 : 39950121 - 40099580	RNA binding domain	N.A.
Summary	The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
30409083	Therapeutic targeting of transcriptional cyclin-dependent kinases.	D Matthew Galbraith	2019-04-01	Transcription
31652541	CDK12 Activity-Dependent Phosphorylation Events in Human Cells.	Bartlomiej Bartkowiak	2019-10-22	Biomolecules
25561469	Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing.	Kaiwei Liang	2015-03-01	Molecular and cellular biology
26886422	CDK13, a Kinase Involved in Pre-mRNA Splicing, Is a Component of the Perinucleolar Compartment.	Yasmine Even	2016-01-01	PloS one
30988284	CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.	Malgorzata Krajewska	2019-04-15	Nature communications
27571479	Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.	Tinghu Zhang	2016-10-01	Nature chemical biology

Name	Transcript ID	bp	Protein	Translation ID
CDK13-202	ENST00000340829	5455	1452aa	ENSP00000340557
CDK13-201	ENST00000181839	9525	1512aa	ENSP00000181839
CDK13-211	ENST00000643868	1901	279aa	ENSP00000495083
CDK13-217	ENST00000646039	4466	1308aa	ENSP00000494168
CDK13-210	ENST00000643859	3838	1099aa	ENSP00000496440
CDK13-220	ENST00000647518	4190	No protein	-
CDK13-208	ENST00000642626	1150	288aa	ENSP00000493853
CDK13-209	ENST00000642660	948	No protein	-
CDK13-218	ENST00000646437	772	257aa	ENSP00000496618
CDK13-205	ENST00000484589	5166	456aa	ENSP00000494206
CDK13-212	ENST00000643915	3276	915aa	ENSP00000496187
CDK13-219	ENST00000647453	2998	No protein	-
CDK13-206	ENST00000642213	1053	No protein	-
CDK13-215	ENST00000645470	900	239aa	ENSP00000495036
CDK13-221	ENST00000700485	2672	No protein	-
CDK13-222	ENST00000700486	2901	No protein	-
CDK13-223	ENST00000700487	2858	No protein	-
CDK13-207	ENST00000642592	1047	143aa	ENSP00000494207
CDK13-204	ENST00000478563	904	No protein	-
CDK13-213	ENST00000644221	4511	No protein	-
CDK13-214	ENST00000644561	2576	No protein	-
CDK13-216	ENST00000645826	2250	No protein	-
CDK13-203	ENST00000465643	2394	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
37227	Platelet Function Tests	4.3500000E-006	-

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000380	involved_in alternative mRNA splicing, via spliceosome	2	ISS,TAS	Homo_sapiens(9606)	Process
GO:0002945	part_of cyclin K-CDK13 complex	1	IPI	Homo_sapiens(9606)	Component
GO:0003723	enables RNA binding	1	HDA	Homo_sapiens(9606)	Function
GO:0004672	enables protein kinase activity	1	TAS	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005576	located_in extracellular region	1	TAS	Homo_sapiens(9606)	Component
GO:0005615	located_in extracellular space	1	HDA	Homo_sapiens(9606)	Component
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005794	located_in Golgi apparatus	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	IDA	Homo_sapiens(9606)	Component
GO:0006468	involved_in protein phosphorylation	1	IBA	Homo_sapiens(9606)	Process
GO:0008024	part_of cyclin/CDK positive transcription elongation factor complex	1	IBA	Homo_sapiens(9606)	Component
GO:0008353	enables RNA polymerase II CTD heptapeptide repeat kinase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0009966	involved_in regulation of signal transduction	1	IDA	Homo_sapiens(9606)	Process
GO:0016607	located_in nuclear speck	1	IDA	Homo_sapiens(9606)	Component
GO:0019901	enables protein kinase binding	1	IEA	Homo_sapiens(9606)	Function
GO:0019908	part_of nuclear cyclin-dependent protein kinase holoenzyme complex	1	ISS	Homo_sapiens(9606)	Component
GO:0030097	involved_in hemopoiesis	1	IMP	Homo_sapiens(9606)	Process
GO:0030332	enables cyclin binding	2	IBA,IPI	Homo_sapiens(9606)	Function
GO:0032968	involved_in positive regulation of transcription elongation by RNA polymerase II	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0045944	involved_in positive regulation of transcription by RNA polymerase II	1	IDA	Homo_sapiens(9606)	Process
GO:0051726	involved_in regulation of cell cycle	1	IEA	Homo_sapiens(9606)	Process
GO:0106310	enables protein serine kinase activity	1	IEA	Homo_sapiens(9606)	Function
GO:1904813	located_in ficolin-1-rich granule lumen	1	TAS	Homo_sapiens(9606)	Component
GO:2000737	involved_in negative regulation of stem cell differentiation	1	IEA	Homo_sapiens(9606)	Process